Overview
Hallucinogen dependence in remission refers to a state where an individual previously diagnosed with hallucinogen use disorder no longer meets the criteria for active dependence but may still experience cravings or be at risk for relapse. The management of this condition focuses on preventing relapse and supporting sustained abstinence.Management
Psilocybin-assisted therapy (PAT) has shown promising effects in treating depressive symptoms, with overall large treatment effects in both short-term and long-term follow-up 1.
However, no significant association was found between the number of therapy hours and treatment outcomes in PAT for depression 1.
All included studies in one meta-analysis provided some degree of therapy, ranging from 4.5 to 18 hours 1.Key Recommendations
Psilocybin-assisted therapy demonstrates significant treatment effects for depressive symptoms, though the specific contribution of therapy hours to outcomes remains unclear 1. (Evidence: Moderate)
Further research with greater methodological rigor and standardized reporting of therapeutic components is needed to clarify the role of therapy in psychedelic-assisted interventions 1. (Evidence: Expert opinion)References
1 Hultgren J, Hafsteinsson MH, Brulin JG. A dose of therapy with psilocybin - A meta-analysis of the relationship between the amount of therapy hours and treatment outcomes in psychedelic-assisted therapy. General hospital psychiatry 2025. link