Overview
Cocaine use disorder is a chronic, relapsing brain disorder characterized by compulsive drug seeking and use despite harmful consequences 1. A nondependent harmful pattern of use refers to continued cocaine use that causes significant distress or impairment, but does not meet the full criteria for dependence 1.Diagnosis
Diagnosis is based on clinical assessment of patterns of use and associated impairment 1.
DSM-5 criteria for cocaine use disorder should be considered 1.Management
Treatment approaches for cocaine use disorder are primarily behavioral 1.
Cognitive behavioral therapy (CBT) and contingency management have shown efficacy 1.
No specific pharmacotherapies are FDA-approved for cocaine use disorder, though research is ongoing 1.Special Populations
No specific information regarding special populations was provided in the abstracts.Key Recommendations
Behavioral therapies, such as cognitive behavioral therapy and contingency management, are recommended for the management of cocaine use disorder 1. (Evidence: Moderate)
Screening for cocaine use should be considered in individuals presenting with certain psychiatric or medical conditions 1. (Evidence: Expert opinion)
Ongoing research into pharmacotherapies for cocaine use disorder is warranted 1. (Evidence: Expert opinion)References
1 Charters TJ, Kaufman JS, Nandi A. A Causal Mediation Analysis for Investigating the Effect of a Randomized Cash-Transfer Program in Nicaragua. American journal of epidemiology 2023. link