Overview
Encephalitis is an inflammation of the brain, most commonly caused by infections. Hepatitis A virus (HAV) is a common cause of viral hepatitis, and while typically self-limiting, can lead to complications.Diagnosis
Management
Special Populations
Universal hepatitis A vaccination without screening was found to be cost-effective among children in middle-income countries (9/11 studies) and high-income countries (4/6 studies) 2.
Universal hepatitis A vaccination without screening was cost-effective in 87.5% of studies among children and 20% of studies among adolescents 2.
Universal hepatitis A vaccination without screening was not found to be cost-effective in adults in the reviewed studies 2.Key Recommendations
Hepatitis A vaccination is immunogenic and safe in adults aged 18 years and above 1.
A two-dose hepatitis A vaccine regimen administered with a 6-month interval achieved 100% seropositivity and seroconversion rates in adults 1.
No serious adverse events related to hepatitis A vaccination were reported in a study of adults 1.
Universal hepatitis A vaccination without screening is cost-effective in children 2.References
1 Chang L, Li Z, Liu Y, Fei S, Zhao L, Li J et al.. Immunogenicity and safety of hepatitis A vaccine at different vaccination intervals among adults aged 18 years and above: Interim results. Human vaccines & immunotherapeutics 2025. link
2 Gurav YK, Bagepally BS, Thakkinstian A, Chaikledkaew U, Thavorncharoensap M. Economic evaluation of hepatitis A vaccines by income level of the country: A systematic review. The Indian journal of medical research 2022. link