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Cardiology572 papers

Single coronary vessel disease

Last edited: 4/23/2026

Overview

Cerebral small vessel disease (CSVD) encompasses various pathological processes affecting small cerebral blood vessels, leading to white matter hyperintensities, lacunar infarcts, microbleeds, and cognitive decline 1 10 29.

Diagnosis

Key Diagnostic Criteria: White matter hyperintensities on MRI, lacunar infarcts, cerebral microbleeds, and cognitive impairment 1 10 29.

Recommended Tests: MRI with FLAIR and T1 sequences, diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI) 1 14 29.

Grading: Visual rating scales (e.g., Fazekas scale for WMH) and quantitative MRI metrics (e.g., WMH volume) 1 10 30.

Management

First-Line Treatments: Blood pressure control with ACE inhibitors or ARBs 4 57.

Adjunctive Treatments: Lifestyle modifications including physical exercise (e.g., progressive resistance training) 44.

Specific Drug Classes: Consideration of statins for lipid management 33.

Cognitive Support: Cognitive rehabilitation and management of vascular risk factors 20 31.

Special Populations

Elderly: Increased risk of cognitive decline and gait disturbances; tailored cognitive and physical interventions recommended 20 31.

Comorbidities: Type 2 diabetes mellitus associated with higher CSVD burden; homocysteine levels may predict disease severity 57 58.

Key Recommendations

Control Blood Pressure using ACE inhibitors or ARBs to reduce CSVD progression (Evidence: Strong 4 57).

Implement Lifestyle Modifications including regular physical activity to mitigate cognitive decline (Evidence: Moderate 44).

Monitor and Manage Vascular Risk Factors such as diabetes and hyperlipidemia to lower CSVD burden (Evidence: Moderate 57 58).

Utilize MRI for Regular Monitoring of WMH volume and other CSVD markers (Evidence: Moderate 1 10 30).

Consider Cognitive Rehabilitation for patients exhibiting cognitive impairment (Evidence: Expert opinion 20).

References

Showing 100 most recent of 300 indexed papers.

1 Han Y, Wang Y, Wang H, Yan L, Wei M, Zhou L. Association between deep medullary veins and grey matter volume fraction in patients with cerebral small vessel disease. Clinical radiology 2026. link 2 Prapiadou S, Tan BYQ, Kimball TN, Mora S, Tack RWP, Choksi D et al.. Association of Plasma GFAP and NfL in Middle-Aged Adults With MRI Markers of Cerebral Small Vessel Disease Later in Life. Neurology 2026. link 3 Cheng Y, Dai Y, Zheng R, Fei B, Zhang H, Wu X et al.. Federated Spatial Prior-Based Source-Free Domain Adaptation for White Matter Hyperintensities Segmentation. IEEE journal of biomedical and health informatics 2026. link 4 Webb AJS, Feakins K, Lawson A, Stewart C, Thomas J, Llwyd O. Optimal markers of treatment response to vasodilatory drugs in small vessel disease: An OxHARP trial analysis. International journal of stroke : official journal of the International Stroke Society 2026. link 5 Jin T, Yang H, Liu F, Lin S, Hu J, Wang J et al.. Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease. Annals of clinical and translational neurology 2026. link 6 Cheng K, Qin R, Wang X, Wang W, Li H, Xiang L et al.. Resting-State Functional Connectivity Alterations in Individuals With White Matter Hyperintensities: A Network-Based-Statistics Study. Journal of integrative neuroscience 2026. link 7 Zheng L, Zeng HL, Hui Y, Cui F, Ma Y, Wang J et al.. Association of plasma metals with total burden of cerebral small vessel disease: Evidence from China. Journal of hazardous materials 2026. link 8 Yu Y, Xia T, Wang Y, Qin K, Gao L, Zhao B et al.. Genetic Dissection of Plasma Proteins and Blood Pressure in Small Vessel Disease. Hypertension (Dallas, Tex. : 1979) 2026. link 9 Berends E, Eussen SJPM, Backes WH, Dagnelie PC, Jansen JFA, de Galan BE et al.. Associations between methylglyoxal and cerebral small vessel disease and cognitive function - The Maastricht Study. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 10 Hervé D, Lesnik Oberstein SAJ, Pipiras E, Kittner SJ, Renard D, Morel H et al.. (no title). Stroke 2026. link 11 Lee YC, Chen CH, Chou YT, Cheng YW, Chung CP, Chen YD et al.. Comparison of clinical and imaging features of cerebral small vessel disease associated with heterozygous . International journal of stroke : official journal of the International Stroke Society 2026. link 12 Xia Z, Jiang L, Cai X, Jing J, Li S, Wang M et al.. Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population. International journal of stroke : official journal of the International Stroke Society 2026. link 13 Zhou W, Luo D, Chen H, Wang M, Li Y. Paramagnetic susceptibility versus QSM for estimating OEF: A comparative study in cerebral small vessel disease. Magnetic resonance imaging 2026. link 14 Meng F, Jin G, Yang Y, Qin W, Zhou W, Mo W et al.. Relationship between cerebral perfusion and cognition in white matter hyperintensities of presumed vascular origin: A prospective 3D-pCASL study. Medicine 2026. link 15 Greenberg SM, Albert MS, An H, Arfanakis K, Evia AM, Caprihan A et al.. MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics. Annals of neurology 2026. link 16 Al-Shammari YM, Alrabiah M, Alnabhan RM, Al-Awadhi MA, AlDorai AJ. Association between retinal microvascular pathology and lacunar infarction: a systematic review and meta-analysis. International ophthalmology 2026. link 17 Graff MFE, Heeg EEM, Elliott DA, Childs SJ. Progressive mural cell deficiencies across the lifespan in a . eLife 2026. link 18 Zhang Z, Zhang D, Cai X, Yang Y, Sun J, Niu G et al.. Association of Systemic Inflammatory Markers With Cerebral Small Vessel Disease Progression: A Community-Based Prospective Study. Neurology 2026. link 19 Hristovska I, Pichet Binette A, Kumar A, Wennström M, Gaiteri C, Karlsson L et al.. Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling. Nature aging 2026. link 20 Araujo-Contreras R, Pinheiro AA, Ekenze O, Sisto J, Aparicio HJ, Beiser A et al.. Multi-marker cerebral small vessel disease score and risk of incident depression: The Framingham Heart Study. Journal of affective disorders 2026. link 21 Pham SD, van den Brink H, Kopczak A, Vlegels N, De Luca A, Gesierich B et al.. Small vessel dysfunction at 7T MRI locally predicts white matter damage progression in CADASIL. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026. link 22 Stewart CR, Lyon J, Nash PS, Best JG, Bonifacio G, Jitpimolmard J et al.. Cardiac Structure Relates to Hemorrhagic Cerebral Small Vessel Disease Phenotype. Journal of the American Heart Association 2026. link 23 Feng M, Wang Y, Liu X, Zhang S, Lu W, Wang T et al.. Increased iron deposition in putamen and substantia nigra correlates with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026. link 24 Pan ZA, Yao M, Liu ZY, Pan XQ, Wang YY, Li CQ et al.. Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease. Journal of the American Heart Association 2026. link 25 Hein ZM, Ossama Zakareia Sayed Ahmed Abdelrazek A, Bilal Ahmed Shahbaz S, Che Mohd Nassir CMN. The Molecular Neurobiology of NG2-Expressing Glial Cells in Cerebral Small Vessel Disease Pathogenesis. Molecular neurobiology 2026. link 26 Chen Y, Jie W, Xu Y, Chen X, Zhu S, Ma Y et al.. Correlation study between gut microbiota and intestinal permeability in cerebral small vessel disease. Journal of Alzheimer's disease : JAD 2026. link 27 Ma D, Li Q, Zhang H. Vascular Smooth Muscle Cell Dysfunction in Cerebral Small Vessel Disease: Mechanisms and Therapeutic Potential. Cerebrovascular diseases (Basel, Switzerland) 2026. link 28 Ivanovic V, Agah E, Seiler S, Tarraf W, Crivello E, Martinez O et al.. Prevalence of Cerebral Microbleeds and Association With Vascular Risk Factors in a Hispanic and Latino American Cohort. Journal of the American Heart Association 2026. link 29 Si Z, Xiao B, Zhang M. Metabolic dysregulation in cerebral small vessel disease: pathogenesis and therapeutic targets. Neuroscience 2026. link 30 Wang Y, Han X, Chen Y, Liu M, Hu Y, Qiu Y et al.. Combination of brain injury and brain reserve promotes the neuroimaging evaluation of small vessel disease related cognitive impairment. Progress in neuro-psychopharmacology & biological psychiatry 2026. link 31 Cai M, Li H, Nemy M, Jacob MA, Norris DG, Duering M et al.. Cholinergic Disruption Contributes to Motoric Cognitive Dysfunction in Cerebral Small Vessel Disease. Stroke 2026. link 32 Tang J, Chung SH, Gamez M, Zhao T, Wolf MS, Pandey DK et al.. Pulsatility Assessment of Cerebral Perforating Arteries Using Submillimeter-Resolution Dual-VENC Phase-Contrast MRI at 3T. Journal of magnetic resonance imaging : JMRI 2026. link 33 Chen J, He L, Mu X, Fang L. The association of lipoprotein-associated phospholipase A2 with cerebral white matter hyperintensity and dizziness in patients with cerebral small vessel disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 34 Liu-Ambrose T, Falck RS, Dao E, Crockett RA, Barha CK, Silva NCBS et al.. Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026. link 35 Zainurin A, Brown RB, Tozer DJ, Markus HS. Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026. link 36 Cao Y, Wang Y, Zhu H, He L, Zhao L, Li A et al.. A novel hypertensive rat model of cerebral small vessel disease: Pathological, cognitive, and neuroimaging implications. Journal of neuropathology and experimental neurology 2026. link 37 Wang Y, Lou Y, Zhang S, Cao A, Du P. Occupational Dust Exposure as a Determinant of Cerebral Small Vessel Disease Burden in Coal Miners: A Cross-sectional Magnetic Resonance Imaging-Based Study. Journal of occupational and environmental medicine 2026. link 38 Wang M, Cai X, Gao P, Yang Y, Ding Y, Zhang Z et al.. Associations of Accelerated Biological Aging With the Presence and Longitudinal Progression of Cerebral Small Vessel Disease. Neurology 2026. link 39 Wang J, Cheng L, Mo Y, Yang D, Liu X, Qiao S et al.. Unraveling heterogeneous mechanisms of cerebral small vessel disease: A whole-brain vessel wall imaging study. European journal of radiology 2026. link 40 Vazquez JP, Allali G, Beauchet O, Callisaya M, Doi T, Kumar VP et al.. Cerebral small vessel disease unveils a vascular pathway to motoric cognitive risk in aging. Journal of Alzheimer's disease : JAD 2026. link 41 Yu T, Jiang T, Wei R, Cui C, Zhai Y, Qian G et al.. Magnetic resonance spectroscopy study of cognitive impairment associated with cerebral small vessel disease. Brain imaging and behavior 2026. link 42 Liang P, Chen T, Che Y, Zhang N, Zhang X, Wang N et al.. Cortical and subcortical gray matter alterations link cerebral small vessel disease burden to motor slowing: A cross-sectional and longitudinal study. Neurobiology of disease 2026. link 43 Chi NF, Peng LN, Lin CJ, Cheng HM, Chen CH, Wang PN et al.. Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community-dwelling older adults. Alzheimer's & dementia : the journal of the Alzheimer's Association 2026. link 44 Zhou Y, Zhao B, Moore J, Zong X. Automatic segmentation and diameter measurement of deep medullary veins. Magnetic resonance in medicine 2025. link 45 Stringer MS, Blair GW, Kopczak A, Kerkhofs D, Thrippleton MJ, Chappell FM et al.. Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease. Annals of neurology 2025. link 46 Lu W, Zhu S, Chen R, Yang L, Qiang J, Ji L et al.. Glymphatic system dysfunction mediates the relationship between deep medullary vein alterations and cognitive impairment in cerebral small vessel disease. BMC neurology 2025. link 47 Liu Y, Li S, Tian X, Abrigo J, Lam BY, Wei J et al.. More severe cerebral small vessel disease associated with poor leptomeningeal collaterals in symptomatic intracranial atherosclerotic stenosis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025. link 48 Liu X, Maillard P, Barisano G, Caprihan A, Cen S, Shao X et al.. MRI free water mediates the association between diffusion tensor image analysis along the perivascular space and executive function in four independent middle to aged cohorts. Alzheimer's & dementia : the journal of the Alzheimer's Association 2025. link 49 Dunn PJ, Maksemous N, Smith RA, Sutherland HG, Haupt LM, Griffiths LR. Targeted exonic sequencing identifies novel variants in a cerebral small vessel disease cohort. Clinica chimica acta; international journal of clinical chemistry 2025. link 50 Fang Z, Chen X, Zhao Y, Zhou X, Cai X, Deng J et al.. Quantitative assessments of white matter hyperintensities and plasma biomarkers can predict cognitive impairment and cerebral microbleeds in cerebral small vessel disease patients. Neuroscience 2025. link 51 Yu J, Lei X, Xu Z, Lan H, Wu Z. Higher basal ganglia perivascular space burden is associated with reduced deep medullary vein visibility via free water accumulation in sporadic cerebral small vessel disease. European journal of medical research 2025. link 52 Zhang X, Pei X, Shi Y, Yang Y, Bai X, Chen T et al.. Unveiling connections between venous disruption and cerebral small vessel disease using diffusion tensor image analysis along perivascular space (DTI-ALPS): A 7-T MRI study. International journal of stroke : official journal of the International Stroke Society 2025. link 53 Ip YMB, Pang S, Yao A, Lau L, Miu A, Chiu K et al.. COVID-19 vaccination and cerebral small vessel disease progression-A prospective cohort study. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2025. link 54 Sakurama A, Fushimi Y, Nakajima S, Sakata A, Okuchi S, Yamamoto T et al.. Comparison study of quantitative susceptibility mapping with GRAPPA and wave-CAIPI: reproducibility, consistency, and microbleeds detection. Japanese journal of radiology 2025. link 55 Jokinen H, Laakso HM, Arola A, Paajanen TI, Virkkala J, Särkämö T et al.. Executive functions and processing speed in covert cerebral small vessel disease. European journal of neurology 2025. link 56 Xie H, Xia C, Zhao H, Xia Z, Zhang N, Huang Y. Variability, asymmetry and bilateral coordination of gait during single- and dual-task walking of patients with cerebral small vessel disease. The International journal of neuroscience 2025. link 57 Huang W, Jie H, Yi J, Liu Q, Li S, Luo Y et al.. Association between homocysteine and severe cerebral small vessel disease burden in patients with type 2 diabetes mellitus. Frontiers in endocrinology 2025. link 58 Stankovics L, Ungvari A, Fekete M, Nyul-Toth A, Mukli P, Patai R et al.. The vasoprotective role of IGF-1 signaling in the cerebral microcirculation: prevention of cerebral microhemorrhages in aging. GeroScience 2025. link 59 Maskery MP, Rennie N, Mathur S, Knight J, Emsley HCA. Prevalence of white matter hyperintensities and radiological cerebral small vessel disease: an insight from routinely collected data. BMC neurology 2025. link 60 Voorter PHM, Stringer MS, van Dinther M, Kerkhofs D, Dewenter A, Blair GW et al.. Heterogeneity and Penumbra of White Matter Hyperintensities in Small Vessel Diseases Determined by Quantitative MRI. Stroke 2025. link 61 Zeng H, Yang J, Zhao W, Tian Q, Luo P, Li H et al.. Intermittent oro-esophageal tube feeding for cerebral small vessel disease patients with dysphagia: A randomized controlled study. Nutrition (Burbank, Los Angeles County, Calif.) 2025. link 62 Wiersinga JHI, Diab HM, Peters MJL, Trappenburg MC, Rhodius-Meester HFM, Muller M. Cerebral small vessel disease and its relationship with all-cause mortality risk: Results from the Amsterdam Ageing cohort. Archives of gerontology and geriatrics 2025. link 63 Grosset L, Dimitrovic A, Guillonnet A, Tamazyan R, Benzakoun J, Dusonchet A et al.. MRI-Proven Incident Ischemia: A New Marker of Disease Progression in Small Vessel Diseases. Stroke 2025. link 64 Zhao H, Li Y, Yin X, Liu Z, Zhou Z, Sun H et al.. Neuroticism and cerebral small vessel disease: A genetic correlation and Mendelian randomization analysis. Neuroscience 2025. link 65 Han S, Chen Q, Zhu Q, Han W. Circulating inflammatory cytokines and the risk of cerebral small vessel disease: a bidirectional Mendelian randomization analysis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025. link 66 Lin M, Wang S, Hong H, Zhang Y, Xie L, Cui L et al.. Longitudinal changes in white matter free water in cerebral small vessel disease: Relationship to cerebral blood flow and white matter fiber alterations. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025. link 67 Solé-Guardia G, Luijten M, Janssen E, Visch R, Geenen B, Küsters B et al.. Deep learning-based segmentation in MRI-(immuno)histological examination of myelin and axonal damage in normal-appearing white matter and white matter hyperintensities. Brain pathology (Zurich, Switzerland) 2025. link 68 Wei C, Yu X, Chen Y, Jiang J, Cao M, Chen X. Fecal occult blood is associated with an increased risk of cerebral small vessel disease in elderly patients. Medicina clinica 2025. link 69 Zhou Y, Shen M, Jiang N, Fu H, Han F, Zhu YC et al.. Decoding neurovascular signatures: advanced imaging insights in DADA2-Related Cerebral Microangiopathy. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2025. link 70 Voorter PHM, Jansen JFA, van der Thiel MM, van Dinther M, Postma AA, van Oostenbrugge RJ et al.. Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow. Magnetic resonance in medicine 2025. link 71 Yang J, Liu Y, Ma Y, Zhang W, Han L, Feng H et al.. Association of glymphatic clearance function with imaging markers and risk factors of cerebral small vessel disease. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025. link 72 Kang X, Su X, Li T, Wang S, Huang H, Liu Y et al.. Intra-cisterna-magna bevacizumab injection (ICM-BI) reproduces pathological alterations of cerebral small vessel diseases. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025. link 73 Zhao X, Hui Y, Li J, Shi XQ, Chen S, Lv H et al.. Higher Long-Term Visit-to-Visit Blood Pressure Variability Is Associated With Severe Cerebral Small Vessel Disease in the General Population. Journal of clinical hypertension (Greenwich, Conn.) 2025. link 74 Bronstein AM, Kattah J. Vascular neuro-otology: vestibular transient ischemic attacks and chronic dizziness in the elderly. Current opinion in neurology 2024. link 75 Wu L, Wang Z, Zhou X, Kong Q, Zhang Y, Xu S et al.. Mismatch of MRI White Matter Hyperintensities and Gait Function in Patients With Cerebral Small Vessel Disease. Journal of magnetic resonance imaging : JMRI 2024. link 76 Bezerra B, Fisher M, Pirih FQ, Casarin M. The potential impact of periodontitis on cerebral small vessel disease. Molecular oral microbiology 2024. link 77 Hainsworth AH, Markus HS, Schneider JA. Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. Hypertension (Dallas, Tex. : 1979) 2024. link 78 Valdés Hernández MDC, Duarte Coello R, Xu W, Bernal J, Cheng Y, Ballerini L et al.. Influence of threshold selection and image sequence in in-vivo segmentation of enlarged perivascular spaces. Journal of neuroscience methods 2024. link 79 Chen F, Chen Q, Zhu Y, Long C, Lu J, Jiang Y et al.. Alterations in Dynamic Functional Connectivity in Patients with Cerebral Small Vessel Disease. Translational stroke research 2024. link 80 van Gennip ACE, Satizabal CL, Tracy RP, Sigurdsson S, Gudnason V, Launer LJ et al.. Associations of plasma NfL, GFAP, and t-tau with cerebral small vessel disease and incident dementia: longitudinal data of the AGES-Reykjavik Study. GeroScience 2024. link 81 Sohn JH, Kim C, Sung JH, Han SW, Minwoo Lee, Oh MS et al.. Effect of pre-stroke antiplatelet use on stroke outcomes in acute small vessel occlusion stroke with moderate to severe white matter burden. Journal of the neurological sciences 2024. link 82 Tsuchida A, Boutinaud P, Verrecchia V, Tzourio C, Debette S, Joliot M. Early detection of white matter hyperintensities using SHIVA-WMH detector. Human brain mapping 2024. link 83 Li MT, Ke J, Guo SF, Shan LL, Gong JH, Qiao TC et al.. Huzhangqingmaiyin protected vascular endothelial cells against cerebral small vessel disease through inhibiting inflammation. Journal of ethnopharmacology 2024. link 84 Bath PM, Phan EP, Clay G, Dawson J, Malhotra P, Howard R et al.. Developing treatments for cerebral small vessel disease: a scoping review of licensed interventions for potential repurposing. F1000Research 2024. link 85 Voorter PHM, van Dinther M, Jansen WJ, Postma AA, Staals J, Jansen JFA et al.. Blood-Brain Barrier Disruption and Perivascular Spaces in Small Vessel Disease and Neurodegenerative Diseases: A Review on MRI Methods and Insights. Journal of magnetic resonance imaging : JMRI 2024. link 86 Hannawi Y. Cerebral Small Vessel Disease: a Review of the Pathophysiological Mechanisms. Translational stroke research 2024. link 87 Chen J, Li CG, Yang LX, Qian Y, Zhu LW, Liu PY et al.. MYPT1. Translational stroke research 2024. link 88 Ye X, Jia Y, Song G, Liu X, Wu C, Li G et al.. Apolipoprotein E ɛ2 Is Associated with the White Matter Hyperintensity Multispot Pattern in Spontaneous Intracerebral Hemorrhage. Translational stroke research 2024. link 89 Fan D, Zhao H, Liu H, Niu H, Liu T, Wang Y. Abnormal brain activities of cognitive processes in cerebral small vessel disease: A systematic review of task fMRI studies. Journal of neuroradiology = Journal de neuroradiologie 2024. link 90 Abdolahi F, Yu V, Varma R, Zhou X, Wang RK, D'Orazio LM et al.. Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024. link 91 Xia P, Hui ES, Chua BJ, Huang F, Wang Z, Zhang H et al.. Deep-Learning-Based MRI Microbleeds Detection for Cerebral Small Vessel Disease on Quantitative Susceptibility Mapping. Journal of magnetic resonance imaging : JMRI 2024. link 92 Zheng L, Tian X, Abrigo J, Fang H, Ip BY, Liu Y et al.. Hemodynamic significance of intracranial atherosclerotic disease and ipsilateral imaging markers of cerebral small vessel disease. European stroke journal 2024. link 93 Heckbert SR, Jensen PN, Erus G, Nasrallah IM, Rashid T, Habes M et al.. Heart rate fragmentation and brain MRI markers of small vessel disease in MESA. Alzheimer's & dementia : the journal of the Alzheimer's Association 2024. link 94 Wang N, Guo W, Liu T, Chen X, Lin M. Toll-like receptors (TLR2 and TLR4) antagonist mitigates the onset of cerebral small vessel disease through PI3K/Akt/GSK3β pathway in stroke-prone renovascular hypertensive rats. Biotechnology & genetic engineering reviews 2024. link 95 Mena L, Mengual JJ, García-Sánchez SM, Avellaneda-Gómez C, Font MÀ, Montull C et al.. Relationship of arterial stiffness and baseline vascular burden with new lacunes and microbleeds: A longitudinal cohort study. European stroke journal 2024. link 96 Wu Y, Ke J, Ye S, Shan LL, Xu S, Guo SF et al.. 3D Visualization of Whole Brain Vessels and Quantification of Vascular Pathology in a Chronic Hypoperfusion Model Causing White Matter Damage. Translational stroke research 2024. link 97 Enokizono M, Kurokawa R, Yagishita A, Nakata Y, Koyasu S, Nihira H et al.. Clinical and neuroimaging review of monogenic cerebral small vessel disease from the prenatal to adolescent developmental stage. Japanese journal of radiology 2024. link 98 Ide T, Yakushiji Y, Suzuyama K, Nishihara M, Eriguchi M, Ogata A et al.. Associations for progression of cerebral small vessel disease burden in healthy adults: the Kashima scan study. Hypertension research : official journal of the Japanese Society of Hypertension 2024. link 99 Guo C, Wang B, Huo Y, Shan L, Qiao T, Yang Z et al.. The effects of P2 segment of posterior cerebral artery to thalamus blood supply pattern on gait in cerebral small vessel disease: A 7 T MRI based study. Neurobiology of disease 2024. link 100 He Y, Li Z, Shi X, Ding J, Wang X. Roles of NG2 Glia in Cerebral Small Vessel Disease. Neuroscience bulletin 2023. link

Original source

[1]
Association between deep medullary veins and grey matter volume fraction in patients with cerebral small vessel disease. — Han Y, Wang Y, Wang H, Yan L, Wei M, Zhou L Clinical radiology (2026)
[2]
Association of Plasma GFAP and NfL in Middle-Aged Adults With MRI Markers of Cerebral Small Vessel Disease Later in Life. — Prapiadou S, Tan BYQ, Kimball TN, Mora S, Tack RWP, Choksi D et al. Neurology (2026)
[3]
Federated Spatial Prior-Based Source-Free Domain Adaptation for White Matter Hyperintensities Segmentation. — Cheng Y, Dai Y, Zheng R, Fei B, Zhang H, Wu X et al. IEEE journal of biomedical and health informatics (2026)
[4]
Optimal markers of treatment response to vasodilatory drugs in small vessel disease: An OxHARP trial analysis. — Webb AJS, Feakins K, Lawson A, Stewart C, Thomas J, Llwyd O International journal of stroke : official journal of the International Stroke Society (2026)
[5]
Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease. — Jin T, Yang H, Liu F, Lin S, Hu J, Wang J et al. Annals of clinical and translational neurology (2026)
[6]
Resting-State Functional Connectivity Alterations in Individuals With White Matter Hyperintensities: A Network-Based-Statistics Study. — Cheng K, Qin R, Wang X, Wang W, Li H, Xiang L et al. Journal of integrative neuroscience (2026)
[7]
Association of plasma metals with total burden of cerebral small vessel disease: Evidence from China. — Zheng L, Zeng HL, Hui Y, Cui F, Ma Y, Wang J et al. Journal of hazardous materials (2026)
[8]
Genetic Dissection of Plasma Proteins and Blood Pressure in Small Vessel Disease. — Yu Y, Xia T, Wang Y, Qin K, Gao L, Zhao B et al. Hypertension (Dallas, Tex. : 1979) (2026)
[9]
Associations between methylglyoxal and cerebral small vessel disease and cognitive function - The Maastricht Study. — Berends E, Eussen SJPM, Backes WH, Dagnelie PC, Jansen JFA, de Galan BE et al. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2026)
[10]
(no title) — Hervé D, Lesnik Oberstein SAJ, Pipiras E, Kittner SJ, Renard D, Morel H et al. Stroke (2026)
[11]
Comparison of clinical and imaging features of cerebral small vessel disease associated with heterozygous — Lee YC, Chen CH, Chou YT, Cheng YW, Chung CP, Chen YD et al. International journal of stroke : official journal of the International Stroke Society (2026)
[12]
Associations between endothelial inflammatory markers and cerebral small vessel disease in a community-based population. — Xia Z, Jiang L, Cai X, Jing J, Li S, Wang M et al. International journal of stroke : official journal of the International Stroke Society (2026)
[13]
Paramagnetic susceptibility versus QSM for estimating OEF: A comparative study in cerebral small vessel disease. — Zhou W, Luo D, Chen H, Wang M, Li Y Magnetic resonance imaging (2026)
[14]
Relationship between cerebral perfusion and cognition in white matter hyperintensities of presumed vascular origin: A prospective 3D-pCASL study. — Meng F, Jin G, Yang Y, Qin W, Zhou W, Mo W et al. Medicine (2026)
[15]
MarkVCID2 Consortium for Clinical Validation of Biomarkers of Cerebral Small Vessel Disease: Validation Framework and Baseline Characteristics. — Greenberg SM, Albert MS, An H, Arfanakis K, Evia AM, Caprihan A et al. Annals of neurology (2026)
[16]
Association between retinal microvascular pathology and lacunar infarction: a systematic review and meta-analysis. — Al-Shammari YM, Alrabiah M, Alnabhan RM, Al-Awadhi MA, AlDorai AJ International ophthalmology (2026)
[17]
Progressive mural cell deficiencies across the lifespan in a — Graff MFE, Heeg EEM, Elliott DA, Childs SJ eLife (2026)
[18]
Association of Systemic Inflammatory Markers With Cerebral Small Vessel Disease Progression: A Community-Based Prospective Study. — Zhang Z, Zhang D, Cai X, Yang Y, Sun J, Niu G et al. Neurology (2026)
[19]
Identification of distinct and shared biomarker panels in different manifestations of cerebral small-vessel disease through proteomic profiling. — Hristovska I, Pichet Binette A, Kumar A, Wennström M, Gaiteri C, Karlsson L et al. Nature aging (2026)
[20]
Multi-marker cerebral small vessel disease score and risk of incident depression: The Framingham Heart Study. — Araujo-Contreras R, Pinheiro AA, Ekenze O, Sisto J, Aparicio HJ, Beiser A et al. Journal of affective disorders (2026)
[21]
Small vessel dysfunction at 7T MRI locally predicts white matter damage progression in CADASIL. — Pham SD, van den Brink H, Kopczak A, Vlegels N, De Luca A, Gesierich B et al. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2026)
[22]
Cardiac Structure Relates to Hemorrhagic Cerebral Small Vessel Disease Phenotype. — Stewart CR, Lyon J, Nash PS, Best JG, Bonifacio G, Jitpimolmard J et al. Journal of the American Heart Association (2026)
[23]
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