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Cardiology6941 papers

Recurrent hepatitis

Last edited: 4/23/2026

Overview

Recurrent hepatitis following liver transplantation refers to repeated episodes of liver inflammation and injury, often due to ischemia-reperfusion injury, vascular complications, or immunological responses post-transplant.

Diagnosis

  • Clinical Presentation: Recurrent jaundice, elevated liver enzymes (ALT, AST), and signs of graft dysfunction 112.
  • Imaging: Ultrasound, CT, or MRI to assess for vascular complications like hepatic artery thrombosis or portal vein thrombosis 911.
  • Laboratory Tests: Regular monitoring of liver function tests, coagulation profiles, and serological markers 112.
  • Histopathology: Biopsy to evaluate for rejection, recurrent disease, or vascular complications 1112.
  • Management

  • Vascular Complications: Early detection and intervention for hepatic artery thrombosis (e.g., stent placement) 2912.
  • Immunosuppression Adjustment: Tailored immunosuppression to prevent rejection and minimize side effects 112.
  • Machine Perfusion: Use of hypothermic or normothermic machine perfusion to reduce ischemia-reperfusion injury 46182039.
  • Prophylactic Measures: Aspirin for prevention of hepatic artery thrombosis 3 (Evidence: Moderate).
  • Monitoring and Support: Close monitoring for early signs of graft dysfunction and supportive care including hemodynamic stabilization 118.
  • Special Populations

  • Pediatrics: Increased vigilance for vascular complications like portal vein thrombosis and tailored portal vein reconstruction techniques 91422.
  • Elderly: Consideration of comorbidities and potential impact on graft outcomes; careful immunosuppression management 2252.
  • Comorbidities: Management of cardiovascular disease to mitigate risks associated with liver transplantation 1852.
  • Key Recommendations

  • Utilize Machine Perfusion Techniques: Employ hypothermic or normothermic machine perfusion to mitigate ischemia-reperfusion injury (Evidence: Strong 46182039).
  • Early Intervention for Vascular Complications: Promptly address hepatic artery thrombosis and portal vein thrombosis with appropriate interventions such as stenting (Evidence: Moderate 2912).
  • Tailored Immunosuppression: Adjust immunosuppression regimens based on individual patient risk profiles to prevent rejection and reduce complications (Evidence: Moderate 112).
  • Regular Monitoring: Implement rigorous monitoring protocols for early detection of graft dysfunction and recurrent hepatitis (Evidence: Expert opinion).
  • References

    Showing 100 most recent of 584 indexed papers.

    1 Te HS, Agopian VG, Demetris AJ, Kwo PY, McGuire BM, Russo MW et al.. AASLD AST Practice Guideline on adult liver transplantation: Diagnosis and management of graft-related complications. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 2 Parikh NU, Crouch C, Kumar S, Sakai T. Adult Liver Transplant Anesthesiology Practice in the Post-COVID-19 Era in the United States: Survey From the Society for the Advancement of Transplant Anesthesia. Clinical transplantation 2026. link 3 Ponte RV, Dos Santos AFP, de Lima MFM, de Lima Souza PF, Sancio JB, Ernani L et al.. Use of aspirin for prevention of hepatic artery thrombosis after liver transplantation: A systematic review and meta-analysis. Transplantation reviews (Orlando, Fla.) 2026. link 4 Vasuri F, Ciavarella C, Germinario G, Malvi D, Saragoni L, D'Errico A et al.. Endothelial-Related Gene Expression Plays a Role Against Acute Kidney Injury and Prolonged Intensive Care Stay in Liver Allografts Treated with Hypothermic Oxygenated Perfusion. Medical sciences (Basel, Switzerland) 2026. link 5 Chahal D, Hornby L, Bird JD, Lee SS, Schiano TD, Sekhon MS. Hepatic hypoxia in donation after circulatory death: Physiology, clinical relevance, and future directions. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 6 Wang X, Yin X, Gao Y, Liu W, Jiang D, Zhang L et al.. Machine Perfusion Ameliorates Nonanastomotic Strictures After Liver Transplantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Clinical and translational gastroenterology 2026. link 7 Giraudi PJ, Codotto G, Baccarani U, Baralle F, Gondolesi G, Licastro D et al.. Ischemia/Reperfusion Injury and Outcomes in Liver Transplantation Assessed by Omics Technologies: Where Do We Stand?. Transplantation 2026. link 8 Gruttadauria S, Vella I, Calamia S, Li Petri S, Accardo C, Pagano D et al.. Liver Transplantation After Ex-Vivo Normothermic Machine Perfusion: A No-Recooling Technique With Room-Temperature Albumin Flush. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2026. link 9 Alomar O, Boukind A, Doilicho N, Ahmed O, Doyle MM, Chapman WC. Impact of De Novo Portal Vein Thrombosis on Liver Transplantation Outcomes in the US. Journal of the American College of Surgeons 2026. link 10 Zhou Y, Wu X, Xu X, Liu Z, Zheng S, Liu T et al.. Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice. Biochemical and biophysical research communications 2026. link 11 Khandakar B, Joldoshova A, Zhang X. Porto-sinusoidal vascular disease-like alterations in transplant liver biopsies: A clinicopathologic observation of transplant-associated portal vasculopathy. Human pathology 2026. link 12 Sasaki VL, Coelho JCU, Wiederkehr HA, Costa MARD, Andrade D, Sanches JPB et al.. Diagnosis, treatment, and outcomes of hepatic artery thrombosis after liver transplantation. Revista do Colegio Brasileiro de Cirurgioes 2026. link 13 Yao S, Hirata M, Ito T, Aoki H, Uozumi R, Okumura S et al.. Selective splenectomy centered on graft-to-spleen volume ratio is a practical option in living donor liver transplantation to prevent early allograft dysfunction: A prospective validation study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 14 Kiataramkul C, Sakamoto S, Uchida H, Cai P, Oshiro A, Kojima M et al.. The Selection of an Interposition Graft for Portal Vein Reconstruction: Maximizing the Availability of Autologous Vessels. Pediatric transplantation 2026. link 15 Alañón-Martínez PE, Orti-Cuerva M, Luque-López A, Montero JL, Sánchez-Frias M, Ciria R et al.. Hepatic Artery Atherosclerosis Is a Risk Factor for Biliary Strictures After Liver Transplantation. Liver international : official journal of the International Association for the Study of the Liver 2026. link 16 Meng Q, Chen H, Li J, Qin M, Huang J, Zhang M et al.. Ischemia-free Liver Transplantation: 7-y Experience From a Single-center Cohort in China. Transplantation 2026. link 17 Zhang M, Nguyen M, Mao S, Taner CB, Mathur AK, Croome KP. Ex situ normothermic machine perfusion reduces postreperfusion syndrome and improves patient and graft survival following liver transplant using macrosteatotic liver grafts. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2026. link 18 Weiss E, Crespo G, Anderson A, Biancofiore G, Chadha R, Cywinski JB et al.. International Liver Transplantation Society/Liver Intensive Care Group of Europe guidelines for cardiovascular assessment before liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2026. link 19 Deng Q, Liu Z, Ye Q, Liu J, Fu Z, Zhang X et al.. Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling. International journal of molecular medicine 2026. link 20 Mathis S, Putzer G, Gasteiger L, Staier N, Schlosser L, Tscholl P et al.. Effect of Normothermic Machine Perfusion on Glycocalyx Shedding During Liver Transplantation - A Prospective Pilot Study. Transplant international : official journal of the European Society for Organ Transplantation 2026. link 21 Wingert T, Feldman K, Williams T, Delaporte A, Lum M, Grogan T et al.. Associations of Intraoperative Hypotension and Vasopressor Administration With Postoperative Acute Kidney Injury in Children Undergoing Liver Transplantation: A Retrospective Cohort Study. Paediatric anaesthesia 2026. link 22 Moore AN, Yemini R, Merola J. Go With the Flow: Hepatic Hemodynamics Impact Outcomes in Pediatric Liver Transplant. Pediatric transplantation 2026. link 23 Smith RW, Kosmach-Park B, Gupta N, Vittorio J. Transitioning Pediatric Liver Transplant Recipients to Adult Transplant Hepatology: A Practical Guide and Future Directions. Pediatric transplantation 2025. link 24 Hendrickse AD, O'Donnell PX, Connors SC, Nguyen-Buckley C, Mandell MS. The Liver Transplant Anesthesiology Fellowship Training Paradigm Across the United States: Looking for the Next Steps in Quality Education. Clinical transplantation 2025. link 25 Xu S, Li H, Gao Y, Wang Y, Zhu B, Shi H et al.. Blocking donor liver Pannexin 1 channels facilitates mitochondria protection during liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2025. link 26 Xu J, Chen S, Liu D, Zhang Q, Luo T, Zhu J et al.. Suppression of Hepatocyte Ferroptosis via USP19-Mediated Deubiquitination of SLC7A11 in Ischemia-Free Liver Transplantation. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025. link 27 Kojima H, Morinelli TA, Wang Y, Chin JL, Meyer AS, Kao YC et al.. Group 1 innate lymphoid cells protect liver transplants from ischemia-reperfusion injury via an interferon gamma-mediated pathway. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2025. link 28 Li SS, Lei DL, Yu HR, Xiang S, Wang YH, Wu ZJ et al.. Diagnostic value and immune infiltration characterization of WTAP as a critical m6A regulator in liver transplantation. Hepatobiliary & pancreatic diseases international : HBPD INT 2025. link 29 Ramalingam V, Shami SMU, Weinstein J, Lee D, Curry M, Eckhoff D et al.. Safety and Effectiveness of Early Primary Stent Placement for Hepatic Artery Stenosis in Liver Transplant Recipients. Journal of vascular and interventional radiology : JVIR 2025. link 30 Lee C, Mathur AK, Mao S, Heimbach JK, Taner CB, Aqel B et al.. Prolonged time from cross-clamp until normothermic machine perfusion start is associated with an increased risk of early allograft dysfunction following DCD liver transplant. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 31 Di Sandro S, Catellani B, Balci D, Di Benedetto F. Arterial anastomosis in LDLT: techniques and risks. Updates in surgery 2025. link 32 Dingfelder J, Kollmann D, Rauter L, Pereyra D, Kacar S, Weijler AM et al.. Validation of mitochondrial FMN as a predictor for early allograft dysfunction and patient survival measured during hypothermic oxygenated perfusion. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 33 Albanesi F, Kim JY, Lee KW, Choi Y, Yi NJ, Hong SK et al.. Unique multidisciplinary approach in living donor liver transplantation to achieve total physiological revascularization in a patient with complete occlusion of portal vein system with combined chronic and subacute thrombosis. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2025. link 34 Li Z, Lu F, Dai Y, Ji L, Huang H, He P et al.. A nomogram for predicting postoperative intra-abdominal hypertension in pediatric patients following liver transplantation: a prospective observational study. BMC pediatrics 2025. link 35 Li J, Qin M, Tang Y, Dan J, Chen H, Chen H et al.. Simplified ischemia-free liver transplantation by providing alternating flow of the portal vein and hepatic artery: Applicability, efficiency, and safety. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 36 Yazdani HO, Yang R, Haykal T, Tohme C, Kaltenmeier C, Wang R et al.. Exercise Preconditioning of the Donor Liver Decreases Cold Ischemia/Reperfusion Injury in a Mouse Model. Transplantation 2025. link 37 Aspord C, Macek Jílková Z, Bonadona A, Gerster T, Lesurtel M, Girard E et al.. Hypothermic Oxygenated Machine Perfusion and Static Cold Storage Drive Distinct Immunomodulation During Liver Transplantation: A Pilot Study. Transplantation 2025. link 38 Nguyen MC, Li X, Linares N, Jadlowiec C, Moss A, Reddy KS et al.. Ex-situ machine perfusion in clinical liver transplantation: Current practices and future directions. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 39 Glass A, Goldberg O, Mozer-Glassberg Y, Waisbourd-Zinman O, Haskin O, Levi S et al.. An innocent bystander or a predisposing culprit? Kidney injury following pediatric liver transplantation. Pediatric nephrology (Berlin, Germany) 2025. link 40 Elgosbi M, Kurt AS, Londoño MC, Caballero-Marcos A, Lim TY, Lozano JJ et al.. Hypothermic oxygenated machine perfusion influences the immunogenicity of donor livers in humans. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 41 Stoker AD, Gorlin AW, Rosenfeld DM, Nguyen MC, Mathur AK, Buckner-Petty SA et al.. Donation After Circulatory Death Liver Transplantation: Impact of Normothermic Machine Perfusion on Key Variables. Anesthesia and analgesia 2025. link 42 Zhang MX, Zhao Q, He XS. Research progress of ischemia-free liver transplantation. Hepatobiliary & pancreatic diseases international : HBPD INT 2025. link 43 Sanchez-Gonzalez C, Fernández Aguilar JL, Sánchez Pérez B, Santoyo Santoyo J. Value of Factor V in the diagnosis of early graft dysfunction after liver transplantation: Internal validation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 44 Pamecha V, Tharun G, Patil NS, Mohapatra N, Kumar A, Thapar S et al.. Graft Inflow Modulation by Splenic Artery Ligation for Portal Hyperperfusion Does Not Decrease Rates of Early Allograft Dysfunction in Adult Live Donor Liver Transplantation: A Randomized Control Trial. Annals of surgery 2025. link 45 Jafri F, Saad S, Riaz H, Saleem F, Gottesman S. Lack of Diversity in Transplant Hepatology Fellowship Program Directorship. Digestive diseases and sciences 2024. link 46 Bezinover D, Zerillo J, Chadha RM, Wagener G, Blasi A, Johnson T et al.. Use of Transesophageal Echocardiography for Liver Transplantation: A Global Comparison of Practice From the ILTS, SATA, and LICAGE. Transplantation 2024. link 47 Crouch CE, Ko JS, Hendrickse A, Kumar SS, Little M, Chae MS et al.. Exploring Anesthesiology Management of Living Donor Liver Transplantation: Survey From the Society for the Advancement of Transplant Anesthesia and the Korean Society for Transplantation Anesthesiologists. Clinical transplantation 2024. link 48 Chen C, Wang Q, Yang Z, Zuo S, Cao K, Li H. MULTIPLE MACHINE LEARNING METHODS AND COMPARATIVE TRANSCRIPTOMICS IDENTIFY PIVOTAL GENES FOR ISCHEMIA-REPERFUSION INJURY IN HUMAN DONOR TISSUE UNDERGOING ORTHOTOPIC LIVER TRANSPLANTATION. Shock (Augusta, Ga.) 2024. link 49 Longchamp A, Nakamura T, Uygun K, Markmann JF. Role of Machine Perfusion in Liver Transplantation. The Surgical clinics of North America 2024. link 50 Panayotova GG, Lunsford KE, Quillin RC, Rana A, Agopian VG, Lee-Riddle GS et al.. Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial. Hepatology (Baltimore, Md.) 2024. link 51 Nie Y, Huang JB, He SJ, Chen HD, Jia JJ, Li JJ et al.. Validation and performance of three scoring systems for predicting primary non-function and early allograft failure after liver transplantation. Hepatobiliary & pancreatic diseases international : HBPD INT 2024. link 52 Ruck JM, Shui AM, Jefferis AA, Duarte Rojo A, Rahimi RS, Ganger DR et al.. Association of body mass index with post-liver transplant outcomes. Clinical transplantation 2024. link 53 Feldman K, Heble DE, Hendrickson RJ, Fischer RT. Hepatic artery thrombosis and use of anticoagulants and antiplatelet agents in pediatric liver transplantation. Pediatric transplantation 2024. link 54 Li W, Bokkers RPH, Dierckx RAJO, Verkade HJ, Sanders DH, de Kleine R et al.. Treatment strategies for hepatic artery complications after pediatric liver transplantation: A systematic review. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2024. link 55 González-Suárez S, Corbett M, Hernández-Martínez A. Impact of graft reperfusion on cardiac function assessed by transesophageal echocardiography during liver transplantation: an observational retrospective study. Journal of clinical monitoring and computing 2024. link 56 Hu QZ, Cao ZR, Zheng WX, Zhao MJ, Gong JH, Chen C et al.. HSP110 aggravates ischemia-reperfusion injury after liver transplantation by promoting NF-κB pathway. Hepatobiliary & pancreatic diseases international : HBPD INT 2024. link 57 Peng S, Liang W, Liu Z, Ye S, Peng Z, Zhong Z et al.. Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway. Human cell 2024. link 58 Nguyen-Buckley C, Bezinover DS, Bhangui P, Biancofiore G, Blasi A, Chadha R et al.. International Liver Transplantation Society/Society for Advancement of Transplant Anesthesia Consensus Statement on Essential Attributes of a Liver Transplant Anesthesiologist. Transplantation 2023. link 59 Maffucci P, Smith NK, Zerillo J, Baron E, Katz D, Burnett GW. The use of simulation in liver transplantation anesthesiology fellowship training: A survey of fellowship program directors in the United States. Clinical transplantation 2023. link 60 Venuthurimilli AK, Gupta R, Singhal S, Madaan V, Kumar P, Singh A et al.. Intraoperative portal vein stenting through umbilical vein approach: An innovative salvage procedure for portal vein thrombosis in pediatric liver transplant. Pediatric transplantation 2023. link 61 Goetz M, Jurczyk M, Grothues D, Knoppke B, Junger H, Melter M et al.. Biological abdominal wall expansion in pediatric liver recipients after transplantation with large-for-size organs. Pediatric transplantation 2023. link 62 Astarcıoglu I, Egeli T, Gulcu A, Ozbilgin M, Agalar C, Cesmeli EB et al.. Vascular Complications After Liver Transplantation. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2023. link 63 Li JH, Jia JJ, He N, Zhou XL, Qiao YB, Xie HY et al.. Exosome is involved in liver graft protection after remote ischemia reperfusion conditioning. Hepatobiliary & pancreatic diseases international : HBPD INT 2023. link 64 Blondeel J, Monbaliu D, Gilbo N. Dynamic liver preservation: Are we still missing pieces of the puzzle?. Artificial organs 2023. link 65 Stewart E, Nydam TL, Hendrickse A, Pomposelli JJ, Pomfret EA, Moore HB. Viscoelastic Management of Coagulopathy during the Perioperative Period of Liver Transplantation. Seminars in thrombosis and hemostasis 2023. link 66 Ren J, Dong C, Sun C, Wang K, Zhang W, Zheng W et al.. The impact of portal vein reconstruction on portal vein complications after pediatric living-donor liver transplantation with left lobe graft. Surgery 2023. link 67 Wouters D, Blondeau M, Bos I, Camus C, Jezequel C, Bardou-Jacquet E et al.. Comparison of reconstruction methods used during liver transplantation in case of a graft with replaced or accessory right hepatic artery: A retrospective study. Journal of hepato-biliary-pancreatic sciences 2023. link 68 Smith N, Chadha R, Zerillo J, Lin HM, Ouyang Y, DeMaria S. Research priorities in liver transplant anesthesiology: Results of a survey of liver transplant anesthesiologists. Clinical transplantation 2022. link 69 Sharma S, Saner FH, Bezinover D. A brief history of liver transplantation and transplant anesthesia. BMC anesthesiology 2022. link 70 Kalisvaart M, Chadha R, De Martin E, Alconchel F, Goldaracena N, Keskin O et al.. Proceedings of the 26th Annual Virtual Congress of the International Liver Transplantation Society. Transplantation 2022. link 71 Moguilevitch M, Polaner DM, Mann G, Mauner A, Beagley B, Hendrickse A et al.. A comparison of pediatric liver transplant anesthesia practices with new organ procurement and transplant network pediatric policy requirements: A report from the society for the advancement of transplant anesthesia and the society for pediatric anesthesia. Clinical transplantation 2022. link 72 Choi JY, Kim KW, Jang JK, Kwon HJ, Yoon YI, Song GW et al.. Progression of Portal Hypertension in Acute Cellular Rejection After Liver Transplantation. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2022. link 73 Monroe EJ, Shin DS, Young VA, Chick JFB, Koo KSH, Woerner A et al.. Evaluation and management of biliary complications after pediatric liver transplantation: pearls and pitfalls for percutaneous techniques. Pediatric radiology 2022. link 74 Riva F, Garanzini EM, Cascella T, Marchianò A, Spreafico C. A "blood theft" after liver transplantation: the role of interventional radiology in the management and treatment of splenic artery steal syndrome. Journal of radiology case reports 2022. link 75 Belon AR, Tannuri ACA, de Albuquerque Rangel Moreira D, Figueiredo JL, da Silva AM, Serafini S et al.. Impact of Three Methods of Ischemic Preconditioning on Ischemia-Reperfusion Injury in a Pig Model of Liver Transplantation. Journal of investigative surgery : the official journal of the Academy of Surgical Research 2022. link 76 Liu J, Pang L, Ng KTP, Chiu TLS, Liu H, Liu X et al.. Compromised AMPK-PGCIα Axis Exacerbated Steatotic Graft Injury by Dysregulating Mitochondrial Homeostasis in Living Donor Liver Transplantation. Annals of surgery 2022. link 77 Ebner PJ, Bick KJ, Emamaullee J, Stanton EW, Gould DJ, Patel KM et al.. Microscope-Assisted Arterial Anastomosis in Adult Living Donor Liver Transplantation: A Systematic Review and Meta-analysis of Outcomes. Journal of reconstructive microsurgery 2022. link 78 Truitt K, Chen K, Yano Y, Gregory DL, VanWagner LB. Blood Pressure Variability Early After Liver Transplantation Predicts Long-Term Mortality. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2022. link 79 Azoulay D, Quintini C, Rayar M, Salloum C, Llado L, Diago T et al.. Renoportal Anastomosis During Liver Transplantation in Patients With Portal Vein Thrombosis: First Long-term Results From a Multicenter Study. Annals of surgery 2022. link 80 Brüggenwirth IMA, van der Plas WS, van Leeuwen OB, Thorne AM, Rayar M, de Meijer VE et al.. Oxygenated versus non-oxygenated flush out and storage of donor livers: An experimental study. Artificial organs 2022. link 81 Dziodzio T, Martin F, Gül-Klein S, Globke B, Ritschl PV, Jara M et al.. Hepatic artery reconstruction using an operating microscope in pediatric liver transplantation-Is it worth the effort?. Pediatric transplantation 2022. link 82 Hirao H, Nakamura K, Kupiec-Weglinski JW. Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity. Nature reviews. Gastroenterology & hepatology 2022. link 83 Yeo JW, Law MSN, Lim JCL, Ng CH, Tan DJH, Tay PWL et al.. Meta-analysis and systematic review: Prevalence, graft failure, mortality, and post-operative thrombosis in liver transplant recipients with pre-operative portal vein thrombosis. Clinical transplantation 2022. link 84 Saglam K, Sahin TT, Usta S, Koc C, Otan E, Kayaalp C et al.. Portal vein reconstruction with cryopreserved vascular grafts: A two-edged sword. Pediatric transplantation 2022. link 85 Park J, Lin MY, Wray CL, Kaldas FM, Benharash P, Gudzenko V. Applications and Outcomes of Extracorporeal Life Support Use in Adult Liver Transplantation: A Case Series and Review of Literature. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2022. link 86 Haque O, Pendexter CA, Wilks BT, Hafiz EOA, Markmann JF, Uygun K et al.. The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion. Scientific reports 2021. link 87 Ravaioli M, Prosperi E, Pinna A, Siniscalchi A, Fallani G, Frascaroli G et al.. Restoration of portal flow with varix in liver transplantation for patients with total portal vein thrombosis: An effective strategy in the largest center experience. Clinical transplantation 2021. link 88 Koshy AN, Gow PJ, Han HC, Teh AW, Lim HS, Testro A et al.. Sudden cardiac death following liver transplantation: Incidence, trends and risk predictors. International journal of cardiology 2021. link 89 Freitas MS, Nacul FE, Malbrain MLNG, Silva RCMA, Lobo FRM, Oliveira NE et al.. Intra-abdominal hypertension, fluid balance, and adverse outcomes after orthotopic liver transplantation. Journal of critical care 2021. link 90 Banc-Husu AM, Badke CM, Sanchez-Pinto LN, Alonso EM. Dexmedetomidine leading to profound bradycardia in a pediatric liver transplant recipient. Pediatric transplantation 2021. link 91 Sosa RA, Terry AQ, Kaldas FM, Jin YP, Rossetti M, Ito T et al.. Disulfide High-Mobility Group Box 1 Drives Ischemia-Reperfusion Injury in Human Liver Transplantation. Hepatology (Baltimore, Md.) 2021. link 92 Romano DN, Smith NK, Itagaki S, Bekki Y, Gunasekaran G, Zerillo J. A Case Report of Venoarterial ECMO as Salvage Therapy for Prolonged Cardiac Arrest Following Post-Reperfusion Intracardiac Thrombosis During Orthotopic Liver Transplantation. Seminars in cardiothoracic and vascular anesthesia 2021. link 93 Rodrigues MG, Castro PMV, Almeida TC, Danziere FR, Sergi Filho FA, Zeballos Sempertegui BE et al.. Impact of Cold Ischemia Time on the Function of Liver Grafts Preserved With Custodiol. Transplantation proceedings 2021. link 94 Uchida H, Sakamoto S, Shimizu S, Takeda M, Yanagi Y, Fukuda A et al.. Efficacy of intraoperative cine-portogram for complicated portal vein reconstruction in pediatric living donor liver transplantation. Pediatric transplantation 2021. link 95 Agopian VG, Markovic D, Klintmalm GB, Saracino G, Chapman WC, Vachharajani N et al.. Multicenter validation of the liver graft assessment following transplantation (L-GrAFT) score for assessment of early allograft dysfunction. Journal of hepatology 2021. link 96 Slivca O, Olowofela AS, Serrano OK, Pruett TL. Maximizing Deceased-Donor Allograft Utilization: Management of a Celiac Artery Aneurysm in a Deceased-Donor Liver. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2021. link 97 Aufhauser DD, Foley DP. Beyond Ice and the Cooler: Machine Perfusion Strategies in Liver Transplantation. Clinics in liver disease 2021. link 98 Gautier S, Monakhov A, Tsiroulnikova O, Mironkov B, Voskanov M, Dzhanbekov T et al.. Time is of the essence: A single-center experience of hepatic arterial supply impairment management in pediatric liver transplant recipients. Pediatric transplantation 2021. link 99 Channaoui A, Tambucci R, Pire A, de Magnée C, Sokal E, Smets F et al.. Management and outcome of hepatic artery thrombosis after pediatric liver transplantation. Pediatric transplantation 2021. link 100 Nguyen MC, Sage Silski L, Alebrahim M, Black S, Elkhammas E, Washburn K et al.. Left Renal Vein Ligation for Spontaneous Splenorenal Shunts During Deceased-Donor Orthotopic Liver Transplant Is Safe and Can Mitigate Complications from Portal Steal: A Case Series. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2021. link

    Original source

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      AASLD AST Practice Guideline on adult liver transplantation: Diagnosis and management of graft-related complications.Te HS, Agopian VG, Demetris AJ, Kwo PY, McGuire BM, Russo MW et al. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2026)
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      Use of aspirin for prevention of hepatic artery thrombosis after liver transplantation: A systematic review and meta-analysis.Ponte RV, Dos Santos AFP, de Lima MFM, de Lima Souza PF, Sancio JB, Ernani L et al. Transplantation reviews (Orlando, Fla.) (2026)
    4. [4]
      Endothelial-Related Gene Expression Plays a Role Against Acute Kidney Injury and Prolonged Intensive Care Stay in Liver Allografts Treated with Hypothermic Oxygenated Perfusion.Vasuri F, Ciavarella C, Germinario G, Malvi D, Saragoni L, D'Errico A et al. Medical sciences (Basel, Switzerland) (2026)
    5. [5]
      Hepatic hypoxia in donation after circulatory death: Physiology, clinical relevance, and future directions.Chahal D, Hornby L, Bird JD, Lee SS, Schiano TD, Sekhon MS Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2026)
    6. [6]
      Machine Perfusion Ameliorates Nonanastomotic Strictures After Liver Transplantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Wang X, Yin X, Gao Y, Liu W, Jiang D, Zhang L et al. Clinical and translational gastroenterology (2026)
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      Ischemia/Reperfusion Injury and Outcomes in Liver Transplantation Assessed by Omics Technologies: Where Do We Stand?Giraudi PJ, Codotto G, Baccarani U, Baralle F, Gondolesi G, Licastro D et al. Transplantation (2026)
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      Liver Transplantation After Ex-Vivo Normothermic Machine Perfusion: A No-Recooling Technique With Room-Temperature Albumin Flush.Gruttadauria S, Vella I, Calamia S, Li Petri S, Accardo C, Pagano D et al. ASAIO journal (American Society for Artificial Internal Organs : 1992) (2026)
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      Impact of De Novo Portal Vein Thrombosis on Liver Transplantation Outcomes in the US.Alomar O, Boukind A, Doilicho N, Ahmed O, Doyle MM, Chapman WC Journal of the American College of Surgeons (2026)
    10. [10]
      Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice.Zhou Y, Wu X, Xu X, Liu Z, Zheng S, Liu T et al. Biochemical and biophysical research communications (2026)
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      Diagnosis, treatment, and outcomes of hepatic artery thrombosis after liver transplantation.Sasaki VL, Coelho JCU, Wiederkehr HA, Costa MARD, Andrade D, Sanches JPB et al. Revista do Colegio Brasileiro de Cirurgioes (2026)
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      Selective splenectomy centered on graft-to-spleen volume ratio is a practical option in living donor liver transplantation to prevent early allograft dysfunction: A prospective validation study.Yao S, Hirata M, Ito T, Aoki H, Uozumi R, Okumura S et al. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society (2026)
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