Overview
Toxic liver disease encompasses a range of liver injuries caused by various toxins, including alcohol, medications, and environmental exposures, leading to conditions such as alcoholic liver disease, drug-induced liver injury, and others. These conditions can progress to fibrosis, cirrhosis, and liver failure if not managed appropriately 2232.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 1015 indexed papers.
1 Friedman SL. Landmarks in modern hepatology: A personal perspective. Med (New York, N.Y.) 2026. link 2 Shroff H, Shankar A, Baron A, Yoxheimer L, Fix OK. A Large Language Model Assistant for Summarizing Hepatology Referral Documents. The American journal of gastroenterology 2026. link 3 Hoppmann N, Bakitas M, Stockdill M, DeNofrio J, Navarro V, Verma M. Palliative Care for Advanced Liver Disease: Hepatology and Palliative Care Specialists Experiences. Journal of pain and symptom management 2026. link 4 Tagiling N, Simadibrata DM, Makharia GK, Sadgehi A, Moreira L, Leung WK et al.. Future Global Outlook in Gastrointestinal and Liver Disorders: Consensus and Perspectives from the Leaders of Member Societies of the World Gastroenterology Organization. Journal of gastrointestinal and liver diseases : JGLD 2026. link 5 Ahn JC, Noh YK, Hu M, Shen X, Simonetto DA, Kamath PS et al.. AI-driven synthetic data generation for accelerating hepatology research: A study of the United Network for Organ Sharing (UNOS) database. Hepatology (Baltimore, Md.) 2026. link 6 Gitto S, Gabrielli F, Addolorato G, Tarli C, Zaccherini G, Calia R et al.. Unmet needs in hepatology: The guidance of the Italian association for the study of the liver (AISF). Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2026. link 7 Rikard BK, Williams DN, Donovan K, Dimov I, Nguyen MT, Dasari A et al.. Evaluation of a Virtual Reality CT-Guided Focal Liver Biopsy Module. Academic radiology 2026. link 8 Karmeli S, Chillon TS, Sane R, Schwarz M, Gröber U, Hackler J et al.. Vitamin A acts as a potent suppressor of selenoprotein P with potential relevance for multivitamin supplementation. The Journal of nutritional biochemistry 2026. link 9 Nie R, Yu B, Li Q, Han M, Zhang S, Li CSZ et al.. Hepatobiliary disorders associated with triazole antifungal agents: a disproportionality and Bayesian analysis based on the FAERS database. Naunyn-Schmiedeberg's archives of pharmacology 2026. link 10 Lo Yau Y, Gupta D, Purlee MS, Brinkley LM, Saulino DM, Lopez-Colon D et al.. Do Hemodynamic and Echocardiographic Derangements After the Fontan Operation Correlate with Severity of Liver Disease on Biopsy?. Pediatric cardiology 2026. link 11 Wu J, Qin J, Yuan X, Zhu Z, Su C, Nashan B et al.. A Case Report of Posterior Reversible Encephalopathy Syndrome With Intracranial Hemorrhage After Split-Liver Transplantation. Transplantation proceedings 2026. link 12 Patel F, Simons J, Prasad KR, Lerret SM. Terlipressin Therapy for Portal Hyperperfusion Secondary to Portal Vein Size Discrepancy After Pediatric Liver Transplant. Pediatric transplantation 2026. link 13 Liu Z, Wang M, Li L, Zhang W, Meng W, Cao C et al.. Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. International immunopharmacology 2026. link 14 Carrier FM, Trottier H, Soucy-Proulx M, Joosten A, McCluskey SA, Luzzi C et al.. Risk factors for in-hospital postoperative complications and 6-month graft survival after liver transplantation: A multicenter cohort study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 15 Yang Z, Zhang W, Gao W, Song J, Kuang H, Hong X et al.. Targeting STARD10 Alleviates Steatotic Liver Injury by Suppressing YBX1/ACSL1-Mediated Ferroptosis. International journal of biological sciences 2026. link 16 Jamalinia M, Zare F, Mantovani A, Targher G, Lonardo A. Meta-Analysis: Liver Disease Burden and Associated Factors in Turner Syndrome. Alimentary pharmacology & therapeutics 2026. link 17 Tian N, Xiao T, Xia T, Yuan HY, Shapiro MD, Lip GYH et al.. Liver Fibrosis and the Risk of Coronary Artery Disease, Stent Thrombosis, Restenosis and Adverse Clinical Outcomes. Alimentary pharmacology & therapeutics 2026. link 18 Liu R, Wang G, Jiang Z, Zou T, Wang C, Wang W et al.. Adenosine metabolic clearance maintains liver homeostasis by licensing arginine methylation of RIPK1. The Journal of experimental medicine 2026. link 19 An P, An Y, Chen M, Wu L, Wang R. Bimodal regulation and precision therapy of neutrophil extracellular traps in liver ischemia-reperfusion injury: recent advances. Frontiers in immunology 2026. link 20 Hughes BR, Kriss M, Arrigain S, Lopez R, Schold JD, Rice J. Pre-Transplant Coronary CT Angiography as a Predictor of Early Post-Liver Transplant Major Adverse Cardiac Events. Clinical transplantation 2026. link 21 Zhang Y, Xie H, Shao Y, Lu Y, Wang Y. A superoxide anion-responsive supramolecular polymer from peptide-H. Biomaterials 2026. link 22 Li Z, Jones O, Rajendran L, Sierra LA, Magyar CTJ, Jaeckel E et al.. Comparing outcomes of deceased-donor and living-donor liver transplants in patients with PVT. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2026. link 23 Fukumori D, Tschuor C, Hamada T, Krohn PS, Burgdorf S, Jans Ø et al.. Evaluating pneumoperitoneum pressure in robotic liver surgery: a propensity-score matched analysis in a high-volume center in Scandinavia. Surgical endoscopy 2026. link 24 Jose A, Elwing JM. Management of hepatopulmonary syndrome and portopulmonary hypertension. Current opinion in critical care 2026. link 25 Singal AK, Wong RJ, Dasarathy S, Abdelmalek MF, Neuschwander-Tetri BA, Limketkai BN et al.. ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease. The American journal of gastroenterology 2025. link 26 Nana M, Medina V, Maxwell C, McCormick C, Taliani G, Beuers U et al.. FIGO guideline on liver disease and pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 2025. link 27 Zamani M, Alizadeh-Tabari S, Ajmera V, Singh S, Murad MH, Loomba R. Global Prevalence of Advanced Liver Fibrosis and Cirrhosis in the General Population: A Systematic Review and Meta-analysis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2025. link 28 Wang Z, Li Y, Wang X, Zhang W, Chen Y, Lu X et al.. Precision Strike Strategy for Liver Diseases Trilogy with Xiao-Chai-Hu Decoction: A Meta-Analysis with Machine Learning. Phytomedicine : international journal of phytotherapy and phytopharmacology 2025. link 29 Tampaki M, Tsochatzis E, Lekakis V, Cholongitas E. Prevalence, characteristics and outcomes of patients with metabolic and alcohol related/associated liver disease (MetALD): a systematic review and meta-analysis. Metabolism: clinical and experimental 2025. link 30 Fan Y, Dong Z, Wu Y, Wen H. Molecular mechanisms and therapeutic strategies of cGAS-STING pathway in liver disease: the quest continues. Frontiers in immunology 2025. link 31 Morin CE, Cao JY, Griffin LM, Macdonald EB, McBee MP, McHam BL et al.. Best practices for pediatric liver MRI: guidelines from members of the Society for Pediatric Radiology Magnetic Resonance and Abdominal Imaging Committees. Pediatric radiology 2025. link 32 Mayerová E. Alcohol-related liver disease. Casopis lekaru ceskych 2025. link 33 Hooper LV, Koh AY. A fungal ally wards off liver disease. Science (New York, N.Y.) 2025. link 34 VanHook AM. Bypassing senescence. Science signaling 2025. link 35 Weiskirchen R. Exploring Molecular Mechanisms of Liver Fibrosis. International journal of molecular sciences 2025. link 36 Byeon H. Unveiling Liver Disease Risk-The Public Health Implications of Visceral Adiposity Assessment with the Chinese Visceral Adiposity Index: A Letter to the Editor. Iranian journal of medical sciences 2025. link 37 Bloomberg L, Rubin JN. Hepatology in the Digital Era: A Review of Telehealth Care for Liver Disease. Current gastroenterology reports 2025. link 38 Lu P, Ovchinsky N, Goldner D. The evolving landscape of pediatric hepatology: key updates and future directions. Current opinion in pediatrics 2025. link 39 Seicean A, Dragomir I, Procopet B. Endoscopic ultrasound in hepatology: ushering a new era in liver disease management. Current opinion in gastroenterology 2025. link 40 Henson JB, Patel YA, Wall AH, Muir AJ. Decreased Completion of Ordered Laboratories and Imaging in Telehealth Compared With In-person Hepatology Encounters. Journal of clinical gastroenterology 2025. link 41 Han JW, Shin EC. Investigating Human Liver Tissue-Resident Memory T Cells from the Perspectives of Gastroenterologists and Hepatologists. Gut and liver 2025. link 42 Hudson D, Valentin Cortez FJ, León IHD, Malhi G, Rivas A, Afzaal T et al.. Advancements in MELD Score and Its Impact on Hepatology. Seminars in liver disease 2025. link 43 Huang HYR, Schneider KM, Schneider C. Big Data Analytics in Large Cohorts: Opportunities and Challenges for Research in Hepatology. Seminars in liver disease 2025. link 44 Zheng Y, Li H, Wang R, Jiang CS, Zhao YT. Multi-model applications and cutting-edge advancements of artificial intelligence in hepatology in the era of precision medicine. World journal of gastroenterology 2025. link 45 Spann A, Strauss AT, Davis SE, Bhat M. The Role of Artificial Intelligence in Chronic Liver Diseases and Liver Transplantation. Gastroenterology 2025. link 46 Haque LY, Choi HY, Justen M, Deng Y, Edelman EJ, Fiellin DA. Hepatology clinician readiness to provide addiction treatment in hepatology clinics: A mixed-methods formative evaluation. Hepatology communications 2025. link 47 Bazarbashi AN, Schulman AR. Endohepatology: Current perspectives and future directions. Hepatology communications 2025. link 48 Mätzold L, Roßner F, Tacke F. Liver biopsy and acute hepatology in intensive care unit patients. Expert review of gastroenterology & hepatology 2025. link 49 Devauchelle P, Bignon A, Breteau I, Defaye M, Degravi L, Despres C et al.. Perioperative Management During Liver Transplantation: A National Survey From the French Special Interest Group in "Liver Anesthesiology and Intensive Care". Transplantation 2025. link 50 Ruprecht KK, Furuya KN, Swanson JO, Monroe EJ. Time-driven cost analysis of pediatric liver biopsy completed in pediatric sedation clinic and operating room. Pediatric radiology 2025. link 51 Lucatelli P, Borsetti F, Basilico F, Vetri P, Rocco B, Parisse S et al.. Could we Safely Perform Liver Ablation Without Deep Sedation or General Anesthesia? Preliminary Experience on Erector Spinae Plane Block (Espb) in the Management of Intra- and Post-Procedural Pain for Liver Microwave Ablation (with video). Cardiovascular and interventional radiology 2025. link 52 Callaghan JP, Freimane KZ, Brown RM, Cratchley AL, Kendall TJ. Entropy and expertise: assessing changes in pathologists' language over time using the UK Liver Pathology External Quality Assessment scheme. The journal of pathology. Clinical research 2025. link 53 Juanola A, Tiwari N, Solé C, Adebayo D, Wong F, Ginès P. Organ dysfunction and failure in liver disease. Liver international : official journal of the International Association for the Study of the Liver 2025. link 54 Lu Y, Wang T, Yu B, Xia K, Guo J, Liu Y et al.. Mechanism of action of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its regulation in liver injury. Chinese medical journal 2025. link 55 Sethasathien S, Leemasawat K, Sittiwangkul R, Makonkawkeyoon K, Leerapun A, Kongkarnka S et al.. Magnetic resonance elastography is useful to determine the severity of liver fibrosis according to liver biopsy in post-fontan patients. The international journal of cardiovascular imaging 2025. link 56 Turon F, Shalaby S, García-Pagán JC, Hernández-Gea V. Management of portal vein thrombosis in candidates for liver transplant. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2025. link 57 Sorbini M, Carradori T, Patrono D, Togliatto G, Caorsi C, Vaisitti T et al.. Circulating cell-free DNA in liver transplantation: A pre- and post-transplant biomarker of graft dysfunction. Artificial organs 2025. link 58 Parikh NS, Zhang C, Bruce SS, Murthy SB, Rosenblatt R, Liberman AL et al.. Association between elevated fibrosis-4 index of liver fibrosis and risk of hemorrhagic stroke. European stroke journal 2025. link 59 Zhao X, Xu C, Bera C, Arisar FAQ, Naghibzadeh M, Azhie A et al.. Long-Term Survival of Canadian Liver Transplant Recipients Remains Stagnant- A Cohort Study on the Evolution of Cause-Specific Mortality. Digestive diseases and sciences 2025. link 60 Yu S, Zhang M, Guo Y, Zhang L. Serum Leucine Aminopeptidase Activity Patterns Across Various Disease States: Potential Implications for Bleeding and Thrombosis Risk. Thrombosis and haemostasis 2025. link 61 Burger CD, Saunders H, Hodge DO, Safford RE, Helgeson SA, Moss JE et al.. Echocardiography Screening of Consecutive Patients With Portal Hypertension Referred to Mayo Clinic for Liver Transplant Evaluation. Mayo Clinic proceedings 2025. link 62 Hirao H, Watanabe T, Uchida Y, Hatano E. Exploring cell death mechanisms in liver transplantation: implications for graft survival. Frontiers in immunology 2025. link 63 Caturano A, di Martino A, Albanese G, Coppola C, Russo V, Koudelková K et al.. The impact of new onset diabetes on cardiovascular risks in orthotopic liver transplant recipients: findings from the COLT study. Acta diabetologica 2025. link 64 Kholaif N, Batha L, Elmahi I, Alnaser S, Alzaher S, Almallohi N et al.. Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2025. link 65 Richter M, Moschovas A, Bargenda S, Freiburger S, Mukharyamov M, Caldonazo T et al.. Off-Pump Reduces Risk of Coronary Bypass Grafting in Patients with High MELD-XI Score. The Thoracic and cardiovascular surgeon 2025. link 66 . EASL Clinical Practice Guidelines on liver transplantation. Journal of hepatology 2024. link 67 Wang XM, Zhang XJ. Role of radiomics in staging liver fibrosis: a meta-analysis. BMC medical imaging 2024. link 68 Sudhabose S, Sooryakanth B, Rajan MR. Acute Toxicity, Hematological Profile, and Histopathological Effects of MgO Nanoparticles on Gills, Muscle, Liver of Mrigal, Cirrhinus mrigala. Biological trace element research 2024. link 69 Strandberg R, Jepsen P, Hagström H. Developing and validating clinical prediction models in hepatology - An overview for clinicians. Journal of hepatology 2024. link 70 Selvanderan SP, Lam E, Shahidi N. Endohepatology: Arrival at the frontier of interventional endosonography. World journal of gastroenterology 2024. link 71 Varghese J, Chapiro J. ChatGPT: The transformative influence of generative AI on science and healthcare. Journal of hepatology 2024. link 72 Laleman W, Peiffer KH, Tischendorf M, Ullerich HJ, Praktiknjo M, Trebicka J. Role of endoscopy in hepatology. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024. link 73 Laborde N, Barange K, Girard C, Marbach C, Bureau C, Broué P. Transition care to adolescent hepatology in a tertiary center for rare adult-child liver disease. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2024. link 74 Brennan PN, Tavabie OD, Li W, Marjot T, Corless L, Fallowfield JA et al.. Progress is impossible without change: understanding the evolving nomenclature of steatotic liver disease and its effect on hepatology practice. The lancet. Gastroenterology & hepatology 2024. link00453-3) 75 Alvarado-Tapias E, Maya-Miles D, Albillos A, Aller R, Ampuero J, Andrade RJ et al.. Proceedings of the 5th Meeting of Translational Hepatology, organized by the Spanish Association for the Study of the Liver (AEEH). Gastroenterologia y hepatologia 2024. link 76 Calvanese C, Fusaroli P. Endo-hepatology: Why should we do endoscopic ultrasound-guided interventions to the liver that we could do through the skin?. World journal of gastroenterology 2024. link 77 Bergquist A, Ekstedt M, Hagström H, Järnerot G, Lindgren S, Nilsson E et al.. Forty years of successful national research collaboration in liver disease - the Swedish experience. Scandinavian journal of gastroenterology 2024. link 78 Commins N, Subhaharan D, Kurup R, Wickremeratne T, Mitchell J, Elmes J et al.. Indications and outcomes of transjugular intrahepatic portosystemic shunt insertion in two regional Australian hepatology centres. Internal medicine journal 2024. link 79 Hoang T, Frydman A, Dowdy RAE. Dental Sedation and General Anesthesia Considerations for Patients Posthepatic Transplantation. Anesthesia progress 2024. link 80 Lee EW, Liang JJ, McNamara GP. Interventional Radiology Management of Hepatic Encephalopathy. Clinics in liver disease 2024. link 81 Jiao Y, Liu Y, Jin M. Exploring the dark side of diagnostic dyes with a focus on Indocyanine green's adverse reactions. Scientific reports 2024. link 82 Zhao S, Widman L, Hagström H, Shang Y. Disentangling the contributions of alcohol use disorder and alcohol-related liver disease towards dementia: A population-based cohort study. Addiction (Abingdon, England) 2024. link 83 Deep A, Alexander EC, Khatri A, Kumari N, Sudheendhra K, Patel P et al.. Epoprostenol (Prostacyclin Analog) as a Sole Anticoagulant in Continuous Renal Replacement Therapy for Critically Ill Children With Liver Disease: Single-Center Retrospective Study, 2010-2019. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2024. link 84 Palaniyappan N, Peach E, Pearce F, Dhaliwal A, Campos-Varela I, Cant MR et al.. Long-term outcomes (beyond 5 years) of liver transplant recipients-A transatlantic multicenter study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2024. link 85 Martinez-Perez S, McCluskey SA, Davierwala PM, Kalra S, Nguyen E, Bhat M et al.. Perioperative Cardiovascular Risk Assessment and Management in Liver Transplant Recipients: A Review of the Literature Merging Guidelines and Interventions. Journal of cardiothoracic and vascular anesthesia 2024. link 86 Thomas J, Snih SA. Liver disease, heart failure, and 13-year mortality among Mexican American older adults: Nativity differences. Annals of epidemiology 2024. link 87 Hydes TJ, Kennedy OJ, Glyn-Owen K, Buchanan R, Parkes J, Cuthbertson DJ et al.. Liver Fibrosis Assessed Via Noninvasive Tests Is Associated With Incident Heart Failure in a General Population Cohort. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2024. link 88 Carrión JA, Graupera I, Vergara M, Morillas RM, Pericàs JM, Poca M et al.. Clinical practice guidelines of the Catalan Society of Gastroenterology about hepatic elastography 2022. Gastroenterologia y hepatologia 2023. link 89 . EASL Clinical Practice Guidelines on the management of liver diseases in pregnancy. Journal of hepatology 2023. link 90 Luo D, Chen XP, Dai Y, Kuang F, Kang MJ, Li B et al.. Cholecystectomy and risk of liver disease: a systematic review and meta-analysis of 27 million individuals. International journal of surgery (London, England) 2023. link 91 Kanda T. Molecular Mechanism of Chronic Viral and Non-Viral Liver Diseases. International journal of molecular sciences 2023. link 92 Zhang C, Zhou Y, Ma J. How to perform laparoscopic right hepatic pedicle dissection: cystic plate approach based on the 'red/yellow demarcation line'. ANZ journal of surgery 2023. link 93 Ranjan A, Kumar S, Sahu NP, Deo AD, Jain KK. Complimentary effect of exogenous enzymes, essential amino acids and essential fatty acids supplemented de-oiled rice bran (DORB) based diets on hematology, liver and intestinal histoarchitecture in . Animal biotechnology 2023. link 94 Wells G, Spiers J, Williams FR, Li W, Tavabie OD, Brennan PN. An overview of the challenges and key initiatives in hepatology practice in the UK in 2022: a cautionary tale, but reasons for optimism - British Association for the Study of the Liver (BASL) Annual Meeting 2022 Conference Report. Clinical medicine (London, England) 2023. link 95 Buchanan RM, Smith A, Rowe I. The role of natural experiments in hepatology research: filling the gap between clinical trials and service evaluations. Hepatology communications 2023. link 96 Schattenberg JM, Chalasani N, Alkhouri N. Artificial Intelligence Applications in Hepatology. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. link 97 Vanderschueren E, Trebicka J, Laleman W. Endoscopic Advances in Hepatology. Seminars in liver disease 2023. link 98 Alqahtani SA, Ausloos F, Park JS, Jang S. The Role of Endoscopic Ultrasound in Hepatology. Gut and liver 2023. link 99 Tang X, Luo B, Huang S, Jiang J, Chen Y, Shi X et al.. Gender differences of authors of major Hepatology society guidelines during the past 15 years. Liver international : official journal of the International Association for the Study of the Liver 2023. link 100 Khalifa A, Obeid JS, Erno J, Rockey DC. The role of artificial intelligence in hepatology research and practice. Current opinion in gastroenterology 2023. link