Overview
Acute pancreatitis is an inflammatory condition of the pancreas characterized by varying degrees of severity, often leading to systemic complications such as organ failure and increased mortality 12728.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 780 indexed papers.
1 Sun X, Li X, Wang F, Chen Z, Zhang L. Double Plasma Molecular Adsorption System Plus Sequential Half-Dose Plasmapheresis in Tandem With Continuous Renal Replacement Therapy: A Case Report. Journal of clinical apheresis 2026. link 2 Zhang XT, Zhu H, Chen XC, Gao T, Chen M, Zhu ZH et al.. New-onset persistent organ failure predicts adverse outcomes in patients with severe acute pancreatitis. World journal of gastroenterology 2026. link 3 Gaitanidis A, Christensen MA, Albutt K, Luckhurst CM, Fernandez-Del Castillo C, Hernandez-Barco Y et al.. Genome-wide Association Analysis for Organ Failure in Acute Pancreatitis. Pancreas 2026. link 4 Bandi AS, Ancil S, Gorsi U, Kang M, Jearth V, Kishore K et al.. Impact of Splanchnic Vein Thrombosis on Outcomes of Interventions in Patients With Pancreatic Fluid Collections Following Acute Pancreatitis-A Prospective Observational Study. Pancreas 2026. link 5 Wan J, Xiong S, Zou Y, Kuang M, He W, Zhu Y et al.. Cumulative burden and dynamic trajectories of heart rate as predictors of prognosis in acute pancreatitis: an 18-year cohort study. International journal of surgery (London, England) 2026. link 6 Lu J, Wang Z, Mei W, Peng K, Zhang L, Wang G et al.. A systematic review of the epidemiology and risk factors for severity and recurrence of hypertriglyceridemia-induced acute pancreatitis. BMC gastroenterology 2025. link 7 . International Association of Pancreatology Revised Guidelines on Acute Pancreatitis 2025: Supported and Endorsed by the American Pancreatic Association, European Pancreatic Club, Indian Pancreas Club, and Japan Pancreas Society. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2025. link 8 Pacella D, De Simone A, Pisanu A, Pellino G, Selvaggi L, Murzi V et al.. A systematic review of the predictive factors for the recurrence of acute pancreatitis. World journal of emergency surgery : WJES 2025. link 9 Ding L, Jian L, Xu J, He Q, Wang Y, Sun C et al.. Pharmacological Interventions for Acute Pancreatitis in Adults: An Overview of Systematic Reviews. Journal of evidence-based medicine 2025. link 10 Jaya Pragadeesh G, Abu Sali SA, Rajesh Kumar S, Babu D, Dheepthi D. Gliptin induced acute pancreatitis: a literature review. Acta gastro-enterologica Belgica 2025. link 11 Mahapatra SJ, Garg PK. Organ Failure and Prediction of Severity in Acute Pancreatitis. Gastroenterology clinics of North America 2025. link 12 Li H, Wen H, Liu J, Luo X, Pei B, Ge P et al.. The glycocalyx: a key target for treatment of severe acute pancreatitis-associated multiple organ dysfunction syndrome. Human cell 2025. link 13 Li L, Zhang Q, Feng Y, Kong F, Sun F, Xie P et al.. A Novel Serum Exosomal MicroRNA Signature in the Early Prediction of Persistent Organ Failure in Patients With Acute Pancreatitis. Annals of surgery 2025. link 14 Liu W, Wu DH, Wang T, Wang M, Xu Y, Ren Y et al.. CIRP contributes to multiple organ damage in acute pancreatitis by increasing endothelial permeability. Communications biology 2025. link 15 Zhou J, Wang L, Chen T, Li C, Long Y, Zou X et al.. Effect of plasmapheresis versus standard medical treatment in patients with hypertriglyceridemia-associated acute pancreatitis complicated by early organ failure (PERFORM-R): Study design and rationale of a multicenter, pragmatic, registry-based randomized controlled trial. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2025. link 16 Mu T, Yin S, Pu R, Yang X, Mai C. Clinical efficacy of continuous blood purification (CBP) in the treatment of severe acute pancreatitis with multiple organ dysfunction syndrome (MODS): A retrospective study. Medicine 2025. link 17 Piñerúa-Gonsálvez JF, Ruiz-Rebollo ML, Fernández-Salazar L. ASSESSING THE PREDICTIVE VALUE OF THE C-REACTIVE PROTEIN AND NEUTROPHIL-TO-LYMPHOCYTE RATIO COMBINED SCORE FOR ORGAN FAILURE IN ACUTE PANCREATITIS. Arquivos de gastroenterologia 2025. link 18 Bu M, Zhang Y, Xie X, Li K, Li G, Tong Z et al.. Influencing factor analysis and clinical efficacy of early intervention in severe acute pancreatitis with persistent organ failure. Scientific reports 2025. link 19 Rao JW, Li JR, Wu Y, Lai TM, Zhou ZG, Gong Y et al.. Ascites characteristics in acute pancreatitis: A prognostic indicator of organ failure and mortality. World journal of gastroenterology 2025. link 20 Luo X, Li X, Lai X, Mao W, Ke L, Fu L et al.. Triglyceride lowering in patients with different severities of hypertriglyceridaemia-associated acute pancreatitis: secondary analysis of a multicentre, prospective cohort study. BMJ open gastroenterology 2025. link 21 Bu M, Zhang Y, Chen F, Xie X, Li K, Ye B et al.. Contrast-enhanced CT-based prediction models for early intervention efficacy and in-hospital mortality risk in acute necrotizing pancreatitis with persistent organ failure. European radiology 2025. link 22 Almutary KH, Zaghloul MS, Nader MA, Elsheakh AR. Mechanistic insights into the protective potential of ambrisentan against L-arginine induced acute pancreatitis and multiorgan damage (role of NRF2/HO-1 and TXNIP/NLRP3 pathways). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025. link 23 Zhao T, Zhao S, Fang R, Liu Y, Ding J, Shi X et al.. Disulfiram Protects Against Multiorgan Injuries and Cell Pyroptosis via Inhibiting GSDMD in Severe Acute Pancreatitis Mice. Journal of cellular and molecular medicine 2025. link 24 Scott M, Ghazanfar M, Windsor J, Ramsay G, Bekheit M. The management of splanchnic vein thrombosis in acute pancreatitis: a global DELPHI consensus study. HPB : the official journal of the International Hepato Pancreato Biliary Association 2025. link 25 Amin NEL, Lahchich M, Werge MP, Hadi A, Ebrahim M, Schmidt PN et al.. Vascular Complications in Patients With Pancreatic Walled-Off Necrosis-A Retrospective, Single Cohort Study. Pancreas 2025. link 26 Darweesh M, El-Kurdi B, Mahfouz R, Haddaden M, Mansour M, Obeidat AE et al.. Intra-abdominal Hypertension Is a Strong Predictor of Mortality and Poor Clinical Outcome in Severe Acute Pancreatitis. Digestive diseases and sciences 2025. link 27 Ju H, Cao S, Wang G, He C, Wang W. Association between atrial fibrillation and both the in-hospital mortality and disease severity in acute pancreatitis: insights from a multicenter study. BMC gastroenterology 2025. link 28 Tenner S, Vege SS, Sheth SG, Sauer B, Yang A, Conwell DL et al.. American College of Gastroenterology Guidelines: Management of Acute Pancreatitis. The American journal of gastroenterology 2024. link 29 Masson W, Lobo M, Barbagelata L, Lavalle-Cobo A, Nogueira JP. Acute pancreatitis due to different semaglutide regimens: An updated meta-analysis. Endocrinologia, diabetes y nutricion 2024. link 30 Wang Z, Shi K, Mo S, Liu Z, Yao J. A meta-analysis of Lactate Ringer's solution versus Normal Saline in the treatment of acute pancreatitis. Gastroenterologia y hepatologia 2024. link 31 Hong J, Li Q, Wang Y, Xiang L, Zhou Y, Fan M et al.. Comparison of Fluid Resuscitation with Lactate Ringer's Versus Normal Saline in Acute Pancreatitis: An Updated Meta-Analysis. Digestive diseases and sciences 2024. link 32 Kashintsev AA, Kunda R, Proutski V. Early selective enteral feeding in combination with active decompression of duodenum in treatment of moderate and severe acute pancreatitis - A proof-of-concept clinical study. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024. link 33 Yu X, Zhang N, Wu J, Zhao Y, Liu C, Liu G. Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis. BMC gastroenterology 2024. link 34 Wang WJ, Zhang LW, Feng SY. Diagnostic performance of acoustic radiation force impulse for acute pancreatitis: A meta-analysis. Medicine 2024. link 35 Wang B, Dron JS, Wang Y, Choi SH, Huffman JE, Cho K et al.. Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization. Scientific reports 2024. link 36 Augustin G, Lai Q, Cigrovski Berkovic M. Primary hyperparathyroidism-induced acute pancreatitis in pregnancy: A systematic review with a diagnostic-treatment algorithm. World journal of gastroenterology 2024. link 37 Rojas-Victoria EJ, Hernández-Ruiz SI, García-Perdomo HA. Effectiveness of the pharmacological therapy to prevent post ERCP acute pancreatitis: a network meta-analysis. Expert review of gastroenterology & hepatology 2024. link 38 Xia CC, Chen HT, Deng H, Huang YT, Xu GQ. Reactive oxygen species and oxidative stress in acute pancreatitis: Pathogenesis and new therapeutic interventions. World journal of gastroenterology 2024. link 39 Mott T, DePriest T, Fry P, Linder T. Less Aggressive Hydration May Be More in Acute Pancreatitis?. Journal of the American Board of Family Medicine : JABFM 2024. link 40 Klimek M, Fecko M, Zieliński T, Koziołek H, Gawrychowski J, Mackiewicz M et al.. Acute pancreatitis associated with primary hyperparathyroidism during pregnancy. Endokrynologia Polska 2024. link 41 Öğütmen Koç D, Bengi G, Gül Ö, Özen Alahdab Y, Altıntaş E, Barutçu S et al.. Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024. link 42 Ge P, Luo Y, Zhang G, Chen H. The role of proteomics in acute pancreatitis: new and old knowledge. Expert review of proteomics 2024. link 43 Sairam PS, Chowdhury SD, Thomas A, John A, Jaleel R, Kurien RT et al.. Imbalance in the vWF - ADAMTS13 axis exists early in acute pancreatitis and predicts persistent organ failure and pancreatic necrosis-a prospective study. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024. link 44 Wang H, Lü M, Li W, Shi J, Peng L. Early Predictive Value of Different Indicators for Persistent Organ Failure in Acute Pancreatitis: A Systematic Review and Network Meta-Analysis. Journal of clinical gastroenterology 2024. link 45 Cheng X, Zhan Y, Wang Z, Wang F, Zeng X, Mao Y et al.. A single-center experience of non-bioartificial DFAPP support systems among Chinese patients with hyperlipidemic moderate/severe acute pancreatitis. Scientific reports 2024. link 46 Wu HC, Chien KL, Jhuang JR, Yang YY, Liao WC. Peri-onset non-steroidal anti-inflammatory drugs use and organ failure in acute pancreatitis: A multicenter retrospective analysis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024. link 47 Phan NT, Vo DMT, Huynh TM, Ho PT, Phuoc Ma N, Vo TD. Evaluating the prognostic performance of the novel ERAP score in Vietnamese acute pancreatitis patients. Medicine 2024. link 48 Coskun E, Yang AL. Marathon pancreatitis: a case of acute pancreatitis caused by distance running. BMJ case reports 2024. link 49 Ocal S, Cerci K, Buldukoglu OC, Atar GE, Harmandar FA, Cekin AH. Effect of serum vitamin D levels on the severity of acute pancreatitis: A prospective study. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2024. link 50 Yang H, An Z, Zhao Y, Lu H. Tacrolimus Related Acute Pancreatitis: An Observational, Retrospective, Pharmacovigilance Study. Clinical therapeutics 2024. link 51 Li D, Wang H, Qin C, Du D, Wang Y, Du Q et al.. Drug-Induced Acute Pancreatitis: A Real-World Pharmacovigilance Study Using the FDA Adverse Event Reporting System Database. Clinical pharmacology and therapeutics 2024. link 52 Dai JJ, He Y, Ma G, Hu YY, Jiang MJ. Insulin Use Is Associated With Improved Outcomes in Critically Ill Patients With Acute Pancreatitis: A Retrospective Matched Cohort Study. Journal of intensive care medicine 2024. link 53 Giorga A, Hughes M, Parker S, Smith A, Young A. Quality of life after severe acute pancreatitis: systematic review. BJS open 2023. link 54 Bourgault J, Abner E, Manikpurage HD, Pujol-Gualdo N, Laisk T, Gobeil É et al.. Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis. Gastroenterology 2023. link 55 Capurso G, Ponz de Leon Pisani R, Lauri G, Archibugi L, Hegyi P, Papachristou GI et al.. Clinical usefulness of scoring systems to predict severe acute pancreatitis: A systematic review and meta-analysis with pre and post-test probability assessment. United European gastroenterology journal 2023. link 56 Freedman S, de-Madaria E, Singh VK, Bruckert E, Löhr M, Sutton R et al.. A simple core dataset for triglyceride-induced acute pancreatitis. Current medical research and opinion 2023. link 57 Tao X, Yang Y, Xu S, Xiong Q. Efficacy of immune nutrients in severe acute pancreatitis: A network meta-analysis. Medicine 2023. link 58 Meng Y, Zheng X, Gao F, Chen L, Qiu J, Li H et al.. Incidence and outcomes of pancreatic encephalopathy in patients with acute pancreatitis: a systematic review and meta-analysis. Internal and emergency medicine 2023. link 59 Yan LH, Hu XH, Chen RX, Pan MM, Han YC, Gao M et al.. Plasmapheresis compared with conventional treatment for hypertriglyceridemia-induced acute pancreatitis: A systematic review and meta-analysis. Journal of clinical apheresis 2023. link 60 de-Madaria E. Chasing WATERFALLs - The Journey from Question to Answer. NEJM evidence 2023. link 61 Yin Y, Wang L, Gao F, Liu L, Qi X. Anticoagulation Therapy for Splanchnic Vein Thrombosis Associated With Acute Pancreatitis: A Systematic Review and Meta-Analysis. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2023. link 62 Toçoğlu AG, Köksal AŞ, Toka B, Mutlu F, Eminler AT, Uslan Mİ et al.. Validation of the Revised Atlanta Criteria in determining the severity of acute pancreatitis. European journal of gastroenterology & hepatology 2023. link 63 Su W, Gao Y, Wang X, Wang D, Feng B, Wu Y et al.. Initiation time of double-filtration plasma apheresis affects the risk of persistent organ failure in hypertriglyceridaemia-induced acute pancreatitis: a retrospective study. Scientific reports 2023. link 64 Phillips AE, Wilson AS, Greer PJ, Hinton A, Culp S, Paragomi P et al.. Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis. American journal of physiology. Gastrointestinal and liver physiology 2023. link 65 Hayes AJ, Zheng X, O'Kelly J, Neyton LPA, Bochkina NA, Uings I et al.. Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. Cell reports 2023. link 66 Susngi T, Shah J, Bhujade H, Jearth V, Singh AK, Mandavdhare HS et al.. Deep Venous Thrombosis in Acute Pancreatitis Is Associated with High Mortality: A Prospective Study. Digestive diseases and sciences 2023. link 67 Gupta M, Liti B, Barrett C, Thompson PD, Fernandez AB. Prevention and Management of Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy: A Systematic Review. The American journal of medicine 2022. link 68 Haiyan Z, Na P, Yong G, Xiumei B, Jianying B. Impact of acute pancreatitis during pregnancy in Chinese women: a meta-analysis. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2022. link 69 Zhang Y, Lin J, Wu L, Lin J, Liang Y. Blood Purification for Hypertriglyceridemia-Induced Acute Pancreatitis: A Meta-analysis. Pancreas 2022. link 70 Iannuzzi JP, King JA, Leong JH, Quan J, Windsor JW, Tanyingoh D et al.. Global Incidence of Acute Pancreatitis Is Increasing Over Time: A Systematic Review and Meta-Analysis. Gastroenterology 2022. link 71 Zhou Y, Ge YT, Shi XL, Wu KY, Chen WW, Ding YB et al.. Machine learning predictive models for acute pancreatitis: A systematic review. International journal of medical informatics 2022. link 72 Takada T, Isaji S, Mayumi T, Yoshida M, Takeyama Y, Itoi T et al.. JPN clinical practice guidelines 2021 with easy-to-understand explanations for the management of acute pancreatitis. Journal of hepato-biliary-pancreatic sciences 2022. link 73 Jaber S, Garnier M, Asehnoune K, Bounes F, Buscail L, Chevaux JB et al.. Guidelines for the management of patients with severe acute pancreatitis, 2021. Anaesthesia, critical care & pain medicine 2022. link 74 Serrano J, Laughlin MR, Bellin MD, Yadav D, Chinchilli VM, Andersen DK. Type 1 Diabetes in Acute Pancreatitis Consortium: From Concept to Reality. Pancreas 2022. link 75 Wang G, Shang D, Zhang G, Zhang S, Jiang N, Liu H et al.. Effects of QingYi decoction on inflammatory markers in patients with acute pancreatitis: A meta-analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology 2022. link 76 Tang Y, Sun M, Liu Z. Phytochemicals with protective effects against acute pancreatitis: a review of recent literature. Pharmaceutical biology 2022. link 77 Jaiswal V, Mukherjee D, Batra N, Ruchika F, Susheela AT, Chia JE et al.. Acute pancreatitis as a rare adverse event among cannabis users: A systematic review. Medicine 2022. link 78 Chen L, Jiang J. The Diagnostic Value of Procalcitonin in Patients with Severe Acute Pancreatitis: A Meta-Analysis. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2022. link 79 Azam C, Buscail L, Culetto A, Lapeyre-Mestre M. Cannabinoid-Related Acute Pancreatitis: An Update from International Literature and Individual Case Safety Reports. Drug safety 2022. link 80 Cienfuegos JA, Valentí V, Rotellar F. Acute pancreatitis: an opportunity for gastroenterology hospitalists?. Revista espanola de enfermedades digestivas 2022. link 81 Liu Y, Zhou X, Xiong H, Song C, Xie Y. Emerging Trends in Intestinal Knowledge Structure Associated With Acute Pancreatitis From 1981 to 2021: A Bibliometric Analysis. Pancreas 2022. link 82 Hidalgo NJ, Pando E, Alberti P, Vidal L, Mata R, Fernandez N et al.. Elevated Serum Triglyceride Levels in Acute Pancreatitis: A Parameter to be Measured and Considered Early. World journal of surgery 2022. link 83 Wilden A, Glaubitz J, Otto O, Biedenweg D, Nauck M, Mack M et al.. Mobilization of CD11b. Frontiers in immunology 2022. link 84 van den Berg FF, Issa Y, Vreijling JP, Lerch MM, Weiss FU, Besselink MG et al.. Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis. Annals of surgery 2022. link 85 Cai YL, Wang SQ, Zhong HJ, He XX. The effect of anemia on the severity and prognosis of patients with acute pancreatitis: A single-center retrospective study. Medicine 2022. link 86 Lin Y, Yu S, Wu X, Huang L, Huang S, Huang Y et al.. Clinical analysis of the therapeutic effect of plasma exchange on hypertriglyceridemic acute pancreatitis: A retrospective study. Transfusion 2022. link 87 Zhang H, Gao L, Mao WJ, Yang J, Zhou J, Tong ZH et al.. Early versus delayed intervention in necrotizing acute pancreatitis complicated by persistent organ failure. Hepatobiliary & pancreatic diseases international : HBPD INT 2022. link 88 Tan Q, Hu C, Chen Z, Jin T, Li L, Zhu P et al.. Growth differentiation factor 15 is an early predictor for persistent organ failure and mortality in acute pancreatitis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022. link 89 Anis FS, Adiamah A, Lobo DN, Sanyal S. Incidence and treatment of splanchnic vein thrombosis in patients with acute pancreatitis: A systematic review and meta-analysis. Journal of gastroenterology and hepatology 2022. link 90 Sissingh NJ, Groen JV, Koole D, Klok FA, Boekestijn B, Bollen TL et al.. Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A systematic review and meta-analysis. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022. link 91 Yan F, Wang P, Xiong Z, Yang F, Cai W, Wang GX et al.. Pulmonary Artery Catheter in Patients with Severe Acute Pancreatitis: A Single-Center Retrospective Study. Digestive diseases and sciences 2022. link 92 Simons-Linares CR, Imam Z, Chahal P. Viral-Attributed Acute Pancreatitis: A Systematic Review. Digestive diseases and sciences 2021. link 93 Liu M, Gao C. A systematic review and meta-analysis of the effect of total parenteral nutrition and enteral nutrition on the prognosis of patients with acute pancreatitis. Annals of palliative medicine 2021. link 94 Alves JR, Ferrazza GH, Nunes Junior IN, Teive MB. THE ACCEPTANCE OF CHANGES IN THE MANAGEMENT OF PATIENTS WITH ACUTE PANCREATITIS AFTER THE REVISED ATLANTA CLASSIFICATION. Arquivos de gastroenterologia 2021. link 95 Ramírez-Maldonado E, López Gordo S, Pueyo EM, Sánchez-García A, Mayol S, González S et al.. Immediate Oral Refeeding in Patients With Mild and Moderate Acute Pancreatitis: A Multicenter, Randomized Controlled Trial (PADI trial). Annals of surgery 2021. link 96 Aune D, Mahamat-Saleh Y, Norat T, Riboli E. High Body Mass Index and Central Adiposity Is Associated with Increased Risk of Acute Pancreatitis: A Meta-Analysis. Digestive diseases and sciences 2021. link 97 Goraya MHN, Malik A, Inayat F, Ishtiaq R, Zaman MA, Arslan HM et al.. Acute pancreatitis secondary to cocaine use: a case-based systematic literature review. Clinical journal of gastroenterology 2021. link 98 Macedo C, Gravito-Soares E, Gravito-Soares M. Pseudoaneurysm of the gastroduodenal artery with arterio-duodenal fistulization secondary to acute pancreatitis: an unusual endoscopic diagnosis. Revista espanola de enfermedades digestivas 2021. link 99 Chivato Martín-Falquina I, García-Morán S, Jiménez Moreno MA. Acute pancreatitis related to SARS-CoV-2 infection. Disclaimer. Revista espanola de enfermedades digestivas 2021. link 100 Chivato Martín-Falquina I, García-Morán S, Jiménez Moreno MA. Acute pancreatitis in SARS-CoV-2 infection. Beyond respiratory distress. Revista espanola de enfermedades digestivas 2021. link