Management
The study [PMID:32057521] demonstrates synergistic antibacterial effects of bupivacaine/lidocaine and ketorolac/gentamicin combinations against MSSA, as evidenced by fractional inhibitory concentration indices below 0.4 and pronounced synergistic effects observed in time-kill curves.
By leveraging the synergistic antibacterial activity identified in [PMID:32057521], clinicians could consider combining specific analgesics like ketorolac with antibiotics such as gentamicin to enhance treatment outcomes in complex cases of staphylococcal arthritis.
Key Recommendations
Based on the findings from [PMID:32057521], future guidelines might recommend evaluating the inclusion of synergistic analgesic-antibiotic combinations to improve clinical outcomes in patients with severe staphylococcal arthritis and polyarthritis. (Evidence: Expert opinion)
References
1 Gil D, Daffinee K, Friedman R, Bhushan B, Muratoglu OK, LaPlante K et al.. Synergistic antibacterial effects of analgesics and antibiotics against Staphylococcus aureus. Diagnostic microbiology and infectious disease 2020. link
1 papers cited of 3 indexed.