Management
A retrospective review of 14 patients with total intestinal aganglionosis showed that AIR procedures significantly reduced median stoma output from 197 to 31 mL·kg·day (P=0.0001) [PMID:30614951].
Among 8 patients who underwent AIR procedures, enteral tolerance improved in 63% of patients in the long term, leading to a reduction in parenteral nutrition dependency from 100% to 70% (P=0.0231) [PMID:30614951].
Prognosis & Follow-up
While AIR procedures improved outcomes for many, outcomes varied, with some patients maintaining improved enteral tolerance and reduced need for parenteral nutrition, highlighting the potential for sustained improvements in these patients [PMID:30614951].
References
1 Fusaro F, Morini F, Mutanen A, De Angelis P, Tambucci R, Capriati T et al.. Autologous Intestinal Reconstructive Surgery in the Management of Total Intestinal Aganglionosis. Journal of pediatric gastroenterology and nutrition 2019. link
1 papers cited of 3 indexed.