Overview
Whipple's disease is a rare, systemic infectious disorder caused by the bacterium Tropheryma whippleii, primarily affecting the gastrointestinal tract but often involving multiple organ systems, including the central nervous system (CNS) leading to neuro-ophthalmic manifestations such as cranial nerve palsies, ataxia, and visual disturbances 123456789101112131415161718192021222324252627282930313233343536373839404142434445464748495051525354555657585960616263646566676869707172737475767778798081828384Diagnosis
References
Showing 100 most recent of 103 indexed papers.
1 AlShawabkeh M, Khalaf RA, Fakhouri SRI, Alshammari TO. Artificial Intelligence in Neurology and Neuro-Ophthalmology: Current Applications and Future Directions. Neurologic clinics 2026. link 2 Tea HRH, Roberson K, El-Dairi M. Using Optical Coherence Tomography in Pediatric Neuro-ophthalmology. International ophthalmology clinics 2026. link 3 Jafari S, Margolin EA, Micieli JA. Prevalence and Clinical Significance of Incidental Neuroimaging Findings in Neuro-Ophthalmology: A Retrospective Analysis of 5,000 Cases. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2026. link 4 Hughes JG, Cozzi FM, Phillips V, Price SJ. Shared decision-making interventions in neuro-oncology practice: a systematic review. Journal of neuro-oncology 2025. link 5 Tailor PD, Dalvin LA, Starr MR, Tajfirouz DA, Chodnicki KD, Brodsky MC et al.. A Comparative Study of Large Language Models, Human Experts, and Expert-Edited Large Language Models to Neuro-Ophthalmology Questions. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2025. link 6 Sarvestani MT, Cugati S, Chen C. Correlation of Structure With Function: Future Utilities for Optical Coherence Tomography Angiography in Neuro-Ophthalmology. Clinical & experimental ophthalmology 2025. link 7 Zhao FF, Zhan-Chi H, Liang JJ, Liu Z, He X, Chen Y et al.. Evaluating the diagnostic reasoning of large language models in complex neuro-ophthalmological cases: a comparative analysis of GPT-o1 Pro, GPT-4o, Gemini, Grok 2 and DeepSeek. BMJ open ophthalmology 2025. link 8 Rasool N, Barkovich M. Neuroimaging in Neuro-Ophthalmology: Past, Present, and Future. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2025. link 9 Sheth S, Ramirez-Sanchez L, Rincón-Lopez JV, Mejia-Vergara AJ. Neuro-Ophthalmology Referral Patterns: Learnings From Colombia. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2025. link 10 Carrabba NV, Ong J, Vogt AZ, Panzo NJ, Memon H, Lee VA et al.. National Football League Game Officials Self-Rating of Knowledge in Neuro-Ophthalmic Principles and Practice: A Pilot Program to Improve Precision and Accuracy of Game Official Calls. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2025. link 11 Wang X, Liu Y, Ao Y, Wang J, Liu J, Xu Y et al.. Infliximab for parenchymal neuro-Behçet's syndrome: case series and meta-analysis. Clinical and experimental rheumatology 2024. link 12 Bassi ST, Newman NJ, Chen JJ, Tisavipat NY, Mollan SP, Moss HE et al.. Recent advances in neuro-ophthalmology. Indian journal of ophthalmology 2024. link 13 Waisberg E, Ong J, Zaman N, Kamran SA, Tavakkoli A, Lee AG. Impact of COVID-19 on Neuro-Ophthalmology in the United States: A National Survey. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2024. link 14 Barton JJS, Hershenfeld SA, Johnston JL, Kim JS, Ranalli PJ, Salman MS et al.. James Sharpe's Contributions to Neurology and Neuro-ophthalmology: A Posthumous Tribute 10 Years On. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 2024. link 15 Pakravan P, Lai J, Cavuoto KM. Demographics, Practice Analysis, and Geographic Distribution of Neuro-Ophthalmologists in the United States in 2023. Ophthalmology 2024. link 16 Lapka M, Straňák Z. The Current State of Artificial Intelligence in Neuro-Ophthalmology. A Review. Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 2024. link 17 Madadi Y, Delsoz M, Lao PA, Fong JW, Hollingsworth TJ, Kahook MY et al.. ChatGPT Assisting Diagnosis of Neuro-Ophthalmology Diseases Based on Case Reports. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 18 Vogt AZ, Woodland MB, Carter MJ, Lee AG. Curriculum in Neuro-Ophthalmic Principles for National Football League Game Officials: Comparison of Pretraining and Posttraining Ratings of Knowledge. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 19 Prihatningtias R, Hardiyanti D, Valencia L. Converting LEA to Pelli-Robson contrast sensitivity score in neuro-ophthalmology patients. Indian journal of ophthalmology 2024. link 20 Ge JY, Teo ZL, Loo JL. Recent advances in the use of optical coherence tomography in neuro-ophthalmology: A review. Clinical & experimental ophthalmology 2024. link 21 Colman BD, Zhu Z, Qi Z, van der Walt A. From real world data to real world evidence to improve outcomes in neuro-ophthalmology. Eye (London, England) 2024. link 22 Tao BK, Handzic A, Hua NJ, Vosoughi AR, Margolin EA, Micieli JA. Utility of ChatGPT for Automated Creation of Patient Education Handouts: An Application in Neuro-Ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 23 Kenney RC, Requarth TW, Jack AI, Hyman SW, Galetta SL, Grossman SN. AI in Neuro-Ophthalmology: Current Practice and Future Opportunities. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 24 Xie JS, Sverdlichenko I, Micieli JA, Margolin E. Neuro-ophthalmology output in high-impact clinical ophthalmology and neurology journals. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 2024. link 25 Sayal AP, Jhaveri A, Diouf AA, Lam CTY, Suthiphosuwan S, Micieli JA. Empty Sella in Neuro-Ophthalmology Patients Without Raised Intracranial Pressure. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 26 Lal AP, Dimmick S, Roche O, Wang W, Sheth S, Chakrabarti R et al.. Developing a Quality Assurance Framework for Neuro-Ophthalmology Using a Multisite Data Registry. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 27 Majeed HA, Al-Rubiay Y, Abbas AA, Al Nuaimi ME, Khammas HM, Alsaedi ZA et al.. An overview of neuro-ophthalmic disorders at Jenna Ophthalmic Center, Baghdad, Iraq (2021-2022). Journal of medicine and life 2024. link 28 Simao LM, de Almeida ACV, Viana MTSA, Vanazzi MAM, Andrade TN, Oliveira AFAO et al.. The Patient's Clinical Profile From a Neuro-Ophthalmology Center in Brazil: A Retrospective Study. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2024. link 29 Douglas VP, Douglas KAA, Torun N. Optical coherence tomography angiography in neuro-ophthalmology. Current opinion in ophthalmology 2023. link 30 Lai KE, Ko MW. Can Tele-Neuro-Ophthalmology Be Useful Beyond the Pandemic?. Current neurology and neuroscience reports 2023. link 31 Okrent Smolar AL, Ray HJ, Dattilo M, Bouthour W, Berman G, Peragallo JH et al.. Neuro-ophthalmology Emergency Department and Inpatient Consultations at a Large Academic Referral Center. Ophthalmology 2023. link 32 Lai KE, Antonio AA, Ko MW, Epling JP, Nguyen AX, Carey AR. Social Media in Neuro-Ophthalmology: Paradigms, Opportunities, and Strategies. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2023. link 33 Patel AN, Tian J, Henderson AD. Identification of Factors that May Predict Career Trajectory Among Neuro-Ophthalmology Fellows. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2023. link 34 Feng Y, Lin CC, Hamedani AG, De Lott LB. A Validated Method to Identify Neuro-Ophthalmologists in a Large Administrative Claims Database. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2023. link 35 Garg A, Margolin E, Micieli JA. No Light Perception Vision in Neuro-Ophthalmology Practice. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2022. link 36 Leong YY, Vasseneix C, Finkelstein MT, Milea D, Najjar RP. Artificial Intelligence Meets Neuro-Ophthalmology. Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) 2022. link 37 Zhu D, Wong A, Shah PP, Pomeranz HD. Neuro-ophthalmology malpractice: A review of the Westlaw Database. The Medico-legal journal 2022. link 38 Aziz R, Bindiganavale MP, Chang RT, Moss HE. Patient Personality and Illness Perceptions in Relation to Follow-Up Appointment Adherence in Neuro-Ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2022. link 39 Muro-Fuentes EA, Stunkel L. Diagnostic Error in Neuro-ophthalmology: Avenues to Improve. Current neurology and neuroscience reports 2022. link 40 DeBusk A, Subramanian PS, Scannell Bryan M, Moster ML, Calvert PC, Frohman LP. Mismatch in Supply and Demand for Neuro-Ophthalmic Care. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2022. link 41 Moss HE. Neuro-ophthalmology and Pregnancy. Continuum (Minneapolis, Minn.) 2022. link 42 Solomon AM, Patel VR, Francis CE. Factors Affecting Ophthalmology Resident Choice to Pursue Neuro-Ophthalmology Fellowship Training. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2022. link 43 Spiegel SJ, Moss HE. Neuro-Ophthalmic Emergencies. Neurologic clinics 2021. link 44 Liu YA, Ko MW, Moss HE. Telemedicine for neuro-ophthalmology: challenges and opportunities. Current opinion in neurology 2021. link 45 Moss HE, Ko MW, Mackay DD, Chauhan D, Gutierrez KG, Villegas NC et al.. The Impact of COVID-19 on Neuro-Ophthalmology Office Visits and Adoption of Telemedicine Services. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2021. link 46 Ramakrishnan MS, Gilbert AL. Telemedicine in neuro-ophthalmology. Current opinion in ophthalmology 2021. link 47 Cohen DA, Gise R, Gaier ED. Serum Biomarkers in Neuro-Ophthalmology: When to Test. Seminars in ophthalmology 2021. link 48 Conway J, Krieger P, Hasanaj L, Sun L, Scharf JM, Odel JG et al.. Telemedicine Evaluations in Neuro-Ophthalmology During the COVID-19 Pandemic: Patient and Physician Surveys. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2021. link 49 Yamane MLM, Odel JG. Introducing the 24-2C Visual Field Test in Neuro-Ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2021. link 50 Jurkute N, Robson AG. Electrophysiology in neuro-ophthalmology. Handbook of clinical neurology 2021. link 51 Calix R, Grossman SN, Rasool N, Small L, Cho C, Galetta SL et al.. Practical Approach to the Tele-Neuro-Ophthalmology and Neuro-Otology Visits: Instructional Videos. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2021. link 52 Cherayil NR, Tamhankar MA. Neuro-Ophthalmology for Internists. The Medical clinics of North America 2021. link 53 Pujari A, Bhaskaran K, Sharma P, Singh P, Phuljhele S, Saxena R et al.. Optical coherence tomography angiography in neuro-ophthalmology: Current clinical role and future perspectives. Survey of ophthalmology 2021. link 54 Kavuncu SK, Nalçacıoğlu P, Acaroğlu G. Clinical and demographic characteristics of childhood neuro-ophthalmology diseases at a tertiary eye care center. The Turkish journal of pediatrics 2021. link 55 Vinny PW, Takkar A, Lal V, Padma MV, Sylaja PN, Narasimhan L et al.. Mobile application as a complementary tool for differential diagnosis in Neuro-ophthalmology: A multicenter cross-sectional study. Indian journal of ophthalmology 2021. link 56 Morris SE, Sannes TS. Bereavement care for family caregivers of neuro-oncology patients. Annals of palliative medicine 2021. link 57 da Cruz Escaleira ALR, Kalogeropoulos D, Kalogeropoulos C, Ch'Ng SW, Sung VCT, Asproudis I et al.. Four common diseases causing sudden blindness or death in the eye emergency department. Postgraduate medical journal 2021. link 58 Chen PY, Wei KC. Editorial: advances in neuro-oncology and clinical treatment-from ASNO 2019. Journal of neuro-oncology 2020. link 59 Stunkel L, Mackay DD, Bruce BB, Newman NJ, Biousse V. Referral Patterns in Neuro-Ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020. link 60 Lai KE, Ko MW, Rucker JC, Odel JG, Sun LD, Winges KM et al.. Tele-Neuro-Ophthalmology During the Age of COVID-19. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020. link 61 Ko MW, Busis NA. Tele-Neuro-Ophthalmology: Vision for 20/20 and Beyond. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020. link 62 Hamedani AG, De Lott LB, Deveney T, Moss HE. Validity of International Classification of Diseases Codes for Identifying Neuro-Ophthalmic Disease in Large Data Sets: A Systematic Review. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020. link 63 Liu TYA, Ting DSW, Yi PH, Wei J, Zhu H, Subramanian PS et al.. Deep Learning and Transfer Learning for Optic Disc Laterality Detection: Implications for Machine Learning in Neuro-Ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2020. link 64 Herdman D, Sharma H, Simpson A, Murdin L. Integrating mental and physical health assessment in a neuro-otology clinic: feasibility, acceptability, associations and prevalence of common mental health disorders. Clinical medicine (London, England) 2020. link 65 Stunkel L, Newman NJ, Biousse V. Diagnostic error and neuro-ophthalmology. Current opinion in neurology 2019. link 66 Moss HE, Joslin CE, Rubin DS, Roth S. Big Data Research in Neuro-Ophthalmology: Promises and Pitfalls. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2019. link 67 Dhiman R, Singh D, Gantayala SP, Ganesan VL, Sharma P, Saxena R. Neuro-Ophthalmology at a Tertiary Eye Care Centre in India. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2018. link 68 Frohman LP. A Profile of Neuro-Ophthalmic Practice Around the World. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2018. link 69 Myrna KE. Neuro-ophthalmology in the Horse. The Veterinary clinics of North America. Equine practice 2017. link 70 Frohman LP. Neuro-Ophthalmology: Transitioning From Old to New Models of Health Care Delivery. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2017. link 71 Chan NCY, Chan CKM. The use of optical coherence tomography in neuro-ophthalmology. Current opinion in ophthalmology 2017. link 72 Layat I, Challe G, LeHoang P, Bodaghi B, Touitou V. Neuro-ophthalmological conditions: Study of the clinical care pathway. Journal francais d'ophtalmologie 2017. link 73 Safari MJ, Wong JHD, Jong WL, Thorpe N, Cutajar D, Rosenfeld A et al.. Influence of exposure and geometric parameters on absorbed doses associated with common neuro-interventional procedures. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) 2017. link 74 Blankshain KD, Moss HE. Research Registries: A Tool to Advance Understanding of Rare Neuro-Ophthalmic Diseases. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2016. link 75 Crompton J. Teaching Neuro-Ophthalmology in the Asia-Pacific Region and China: A Personal Perspective. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2015. link 76 Spitze A, Al-Zubidi N, Lam P, Yalamanchili S, Lee AG. Neuro-ophthalmology as a career. Indian journal of ophthalmology 2014. link 77 Weber KP, Straumann D. Neuro-ophthalmology update. Journal of neurology 2014. link 78 Cordonnier M, Van Nechel C. Neuro-ophthalmological emergencies: which ocular signs or symptoms for which diseases?. Acta neurologica Belgica 2013. link 79 Cohen BH. Coding issues: evaluation and management tips for neuro-oncology visits. Continuum (Minneapolis, Minn.) 2012. link 80 Rizzo WB, Jenkens SM, Boucher P. Recognition and diagnosis of neuro-ichthyotic syndromes. Seminars in neurology 2012. link 81 Kruger JM, Lessell S, Cestari DM. Neuro-imaging: a review for the general ophthalmologist. Seminars in ophthalmology 2012. link 82 Mehta S, Loevner LA, Mikityansky I, Langlotz C, Ying GS, Tamhankar MA et al.. The diagnostic and economic yield of neuroimaging in neuro-ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2012. link 83 Costello FE, Goyal M. Neuroimaging in neuro-ophthalmology. Neurologic clinics 2010. link 84 Hottinger AF, Khakoo Y. Neurooncology of familial cancer syndromes. Journal of child neurology 2009. link 85 Frohman LP. The human resource crisis in neuro-ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2008. link 86 Biousse V, Newman NJ. Advances in neuro-ophthalmology. Reviews in neurological diseases 2007. link 87 Grzybowski A, Aydin P. Edme Mariotte (1620-1684): Pioneer of Neurophysiology. Survey of ophthalmology 2007. link 88 Lee AG, Brazis PW. Case studies in neuro-ophthalmology for the neurologist. Neurologic clinics 2006. link 89 Mut M, Lopes MB, Shaffrey M. Lucien J. Rubinstein: enduring contributions to neuro-oncology. Neurosurgical focus 2005. link 90 Lim SA, Siatkowski RM. Pediatric neuro-ophthalmology. Current opinion in ophthalmology 2004. link 91 Bennett JL. Developmental neurogenetics and neuro-ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 2002. link 92 Lepore FE. False and non-localizing signs in neuro-ophthalmology. Current opinion in ophthalmology 2002. link 93 Lee AG, Hayman LA, Ross AW. Neuroimaging contrast agents in ophthalmology. Survey of ophthalmology 2000. link00152-1) 94 Lippmann O. Alfred Bielschowsky's 1940 legacy for neuro-ophthalmology. Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society 1998. link 95 Martin TJ, Robison GD. Instrument for measuring relative brightness perception. American journal of ophthalmology 1994. link70068-6) 96 Dillon EC, Sergott RC, Savino PJ, Bosley TM. Diagnostic management by gatekeepers is not cost effective for neuro-ophthalmology. Ophthalmology 1994. link31127-4) 97 Mills RP. Automated perimetry in neuro-ophthalmology. International ophthalmology clinics 1991. link 98 Slamovits TL, Gardner TA. Neuroimaging in neuro-ophthalmology. Ophthalmology 1989. link32877-6) 99 Savino PJ. The present role of magnetic resonance imaging in neuro-ophthalmology. Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 1987. link 100 Coston TO. A personal sketch of Frank Burton Walsh. Survey of ophthalmology 1983. link90179-0)