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Palliative Care20 papers

Abdominal cutaneous nerve entrapment syndrome

Last edited: 4/15/2026

Overview

Abdominal cutaneous nerve entrapment syndrome (ACNES) involves chronic pain arising from entrapment of cutaneous nerves in the abdominal wall, often mimicking other abdominal pathologies. 1

Diagnosis

  • Clinical presentation includes chronic abdominal pain localized to the anterior abdominal wall.
  • Diagnostic imaging (e.g., ultrasound, MRI) may help rule out other causes but is not definitive.
  • Pain provocation tests, such as palpation over the abdominal wall, can be useful.
  • No specific laboratory tests are typically required. 1
  • Management

  • First-line treatments: Abdominal wall injections (e.g., local anesthetics, corticosteroids).
  • Adjunctive treatments:
  • - Pulsed radiofrequency (PRF) can be effective, with some patients achieving sustained pain relief through repetitive sessions. - Neurectomy shows higher long-term success rates with a significant proportion of patients remaining pain-free without additional interventions. 1

    Special Populations

  • Elderly: No specific data provided in the abstracts regarding treatment efficacy or considerations in elderly patients.
  • Comorbidities: Management strategies may need adjustment based on comorbidities, though specific guidance is not detailed in the provided abstracts. 1
  • Key Recommendations

  • For refractory ACNES, neurectomy appears to offer higher long-term success rates compared to pulsed radiofrequency (PRF) based on long-term follow-up data. (Evidence: Strong 1)
  • Pulsed radiofrequency can be considered as an initial adjunctive treatment, with repetitive sessions potentially extending pain relief duration. (Evidence: Moderate 1)
  • Abdominal wall injections should be the initial approach due to their minimally invasive nature and potential efficacy in symptom relief. (Evidence: Expert opinion 1)
  • References

    1 Have TT, Geffen STV, Zwaans WAR, Maatman RC, Boelens OBA, Steegers MAH et al.. Pulsed radiofrequency or surgery for anterior cutaneous nerve entrapment syndrome: Long-term results of a randomized controlled trial. Pain practice : the official journal of World Institute of Pain 2024. link

    Original source

    1. [1]
      Pulsed radiofrequency or surgery for anterior cutaneous nerve entrapment syndrome: Long-term results of a randomized controlled trial.Have TT, Geffen STV, Zwaans WAR, Maatman RC, Boelens OBA, Steegers MAH et al. Pain practice : the official journal of World Institute of Pain (2024)

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