HemoChat is an evidence-based AI medical search tool covering all major clinical domains, powered by 46,298 SNOMED-CT concepts, clinical guidelines, and live PubMed literature.

What medical domains does HemoChat cover?

HemoChat covers all major medical domains including cardiology, oncology, neurology, hematology, pulmonology, endocrinology, gastroenterology, psychiatry, nephrology, rheumatology, musculoskeletal, and more — with 46,298 SNOMED-CT concepts.

Is HemoChat a replacement for clinical judgment?

No. HemoChat is for clinical reference only and is not a substitute for professional medical judgment. Always consult qualified healthcare professionals for medical decisions.

What AI technology does HemoChat use?

HemoChat uses a hybrid GraphRAG + VectorRAG pipeline combining Neo4j knowledge graphs with FAISS vector search and an LLM for answer generation.

← Back to guidelines

Cardiology574 papers

Sympathotonic orthostatic hypotension

Last edited: 4/23/2026

Overview

Orthostatic hypotension (OH) is characterized by a significant decrease in blood pressure upon standing, leading to symptoms such as dizziness, syncope, and increased fall risk, particularly in older adults 1 8 10.

Diagnosis

Key Diagnostic Criteria: Systolic blood pressure drop ≥20 mmHg or diastolic drop ≥10 mmHg within 3 minutes of standing 20.

Recommended Tests:

- Orthostatic vital signs (supine and standing BP measurements) 20. - Tilt table testing for more definitive diagnosis in symptomatic patients 75.

Grading: Severity often classified based on symptoms and magnitude of BP drop 1 8.

Management

First-Line Treatments:

- Non-pharmacological: Increased salt and fluid intake, compression stockings, leg muscle exercises 11 21 31. - Pharmacological: Fludrocortisone and midodrine for symptomatic relief 6 13 47.

Adjunctive Treatments:

- Pyridostigmine for neurogenic OH 12. - Droxidopa (L-threo-3,4-dihydroxyphenylserine) for neurogenic OH 39. - Biofeedback and integrated rehabilitation programs 15 32.

Special Populations

Elderly: Higher prevalence and increased risk of falls; non-pharmacological interventions are crucial 1 8 15.

Comorbidities: Consider impact on medication choices; caution with fludrocortisone due to higher hospitalization risk compared to midodrine 47.

Pediatrics: Limited data; focus on underlying causes and tailored interventions 56.

Pregnancy: Not specifically addressed in abstracts; individualized management required considering maternal and fetal safety [].

Key Recommendations

Perform orthostatic vital signs to diagnose OH, with tilt table testing for symptomatic patients (Evidence: Moderate 75).

Initiate non-pharmacological interventions such as increased salt and fluid intake, compression stockings, and leg exercises for symptom management (Evidence: Moderate 11 21).

Consider pharmacological treatments like fludrocortisone and midodrine for symptomatic relief, weighing risks and benefits, especially hospitalization risk with fludrocortisone (Evidence: Moderate 6 47).

Tailor management strategies to the elderly population, emphasizing fall prevention and non-pharmacological approaches (Evidence: Moderate 1 8).

Evaluate and address potential drug interactions and comorbidities when selecting treatments for OH (Evidence: Expert opinion 47).

References

Showing 100 most recent of 384 indexed papers.

1 Saedon NI, Frith J, Wan Ahmad WA, Tan MP. Cerebral autoregulation in orthostatic hypotension and falls among older adults: a community-based exploratory study. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2026. link 2 Kaufmann H, Palma JA, Vickery R, Norcliffe-Kaufmann L, Zheng B, Lewin D et al.. Establishing minimally clinically important differences for the orthostatic hypotension questionnaire (OHQ). Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2026. link 3 Lei TH, Li HY, Goulding RP, Wang F, Amano T, Fujimoto T et al.. High-intensity exercise training mitigates post-exercise orthostatic hypotension in men. European journal of applied physiology 2026. link 4 Hirai T, Murai H, Sugimoto H, Mukai Y, Tokuhisa H, Ikeda T et al.. Differences in muscle sympathetic nerve activity between patients with orthostatic hypertension and those with orthostatic normotensive hypertension. Autonomic neuroscience : basic & clinical 2026. link 5 Baker JR, Ranada SI, Incognito AV, Sheldon RS, Morillo CA, Wilson RJA et al.. Elevating blood pressure in neurogenic orthostatic hypotension: Investigating the efficacy and tolerability of rebreathing therapy. Autonomic neuroscience : basic & clinical 2026. link 6 Doyle K, Rice CP, Kenny RA, Briggs R, Lavan AH. The effect of fludrocortisone and midodrine on ambulatory blood pressure biomarkers and symptoms of syncope. Blood pressure 2026. link 7 van der Stam AH, Gagaouzova BS, Kerkhof FI, van Rossum IA, Shmuely S, Reijntjes RH et al.. Haemodynamic determinants of supine hypertension in patients with classical orthostatic hypotension. Journal of hypertension 2026. link 8 Srinivas V, Choubey U, Kapparath S, Shaik T, Singh B, Mahmood R et al.. Age-Related Orthostatic Hypotension: A Comprehensive Analysis of Prevalence, Mechanisms, and Management in the Geriatric Population. Cardiology in review 2025. link 9 Baker JR, Beach PA, Ranada SI, Patel A, Gewandter J, Tan CO et al.. Cerebral Blood Flow Dynamics in Neurogenic Orthostatic Hypotension: A Systematic Review and Meta-Analysis. Hypertension (Dallas, Tex. : 1979) 2025. link 10 Krittanawong C, Rizwan A, Rezvani A, Khawaja M, Rodriguez M, Flack JM et al.. Misconceptions and Facts About Orthostatic Hypotension. The American journal of medicine 2025. link 11 Owen CM, Frith J. Strategies for Non-Pharmacological Management of Orthostatic Hypotension in Older People: Bridging Pathophysiology and Practice. British journal of hospital medicine (London, England : 2005) 2025. link 12 Holder AC, Dylewski A, Brown JN. Pyridostigmine for the Management of Neurogenic Orthostatic Hypotension: A Systemic Review. Journal of geriatric psychiatry and neurology 2025. link 13 de Lange FJ, van Zanten S, Rivasi G, Groppelli A, Russo V, Maggi R et al.. Haemodynamic effects of fludrocortisone and midodrine in patients with symptoms due to hypotension. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2025. link 14 Gagaouzova BS, van der Stam A, Johansson M, Van Rossum IA, Kerkhof FI, Reijntjes R et al.. The relative contribution of hemodynamic parameters to blood pressure decrease in classical orthostatic hypotension. Journal of hypertension 2025. link 15 Han J, Park J, Kang H, Lee H, Kim N. The Effect of a Biofeedback-Based Integrated Program on Improving Orthostatic Hypotension in Community-Dwelling Older Adults: A Pilot Study. The Journal of cardiovascular nursing 2025. link 16 Zelenova E, Daniel V, Bruttan M, Artemieva L, Spektor E, Mamchur A et al.. Multi-omics study of molecular and genetic bases of orthostatic hypotension. Clinical epigenetics 2025. link 17 Dunlap E, Alhalimi T, McLaurin N, Tanaka H. Impact of Land Versus Water Environments on Orthostatic Hypotension in Older Adults: A Randomized Crossover Study. Journal of aging and physical activity 2025. link 18 Owen CM, Bacardit J, Tan MP, Saedon NI, Goh CH, Newton JL et al.. Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension. Experimental physiology 2025. link 19 Tajima Y, Komiyama M, Mimura N, Yamamoto M, Fukuie M, Suzuki R et al.. Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2025. link 20 Vidal-Petiot E, Pathak A, Azulay JP, Pavy-Le Traon A, Hanon O. Orthostatic hypotension: Review and expert position statement. Revue neurologique 2024. link 21 Frith J, Robinson L, Gibbon JR, Allen J. The effect of lower limb strengthening exercise on orthostatic blood pressure and the skeletal muscle pump in older people with orthostatic hypotension. Clinical physiology and functional imaging 2024. link 22 Clemensen E, Lau GT, Popovic G. What is the prevalence of orthostatic hypotension in an Australasian emergency department population?. Emergency medicine Australasia : EMA 2024. link 23 Jordan J, Biaggioni I, Kotsis V, Nilsson P, Grassi G, Fedorowski A et al.. Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension. Hypertension research : official journal of the Japanese Society of Hypertension 2023. link 24 Jordan J, Biaggioni I, Kotsis V, Nilsson P, Grassi G, Fedorowski A et al.. Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2023. link 25 Resmi VL, Sriya RG, Selvaganesan N. Baroreflex control model for cardiovascular system subjected to postural changes under normal and orthostatic conditions. Computer methods in biomechanics and biomedical engineering 2023. link 26 Zuin M, Brombo G, Capatti E, Romagnoli T, Zuliani G. Orthostatic hypotension and vitamin D deficiency in older adults: systematic review and meta-analysis. Aging clinical and experimental research 2022. link 27 Li X, Shi R, Meng Q, Zhang X, Chen X. Does arterial stiffness affect orthostatic hypotension among high-altitude Tibetans?. Postgraduate medicine 2021. link 28 Arik F, Soysal P, Capar E, Kalan U, Smith L, Trott M et al.. The association between fear of falling and orthostatic hypotension in older adults. Aging clinical and experimental research 2021. link 29 Hogan AM, Luck C, Woods S, Ortu A, Petkov S. The Effect of Orthostatic Hypotension Detected Pre-Operatively on Post-Operative Outcome. Journal of the American Geriatrics Society 2021. link 30 Harms MPM, Finucane C, Pérez-Denia L, Juraschek SP, van Wijnen VK, Lipsitz LA et al.. Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view. Autonomic neuroscience : basic & clinical 2021. link 31 Ruzieh M, Sacks CD, Grewal SS, Aboujamous NM, Grubb BP, Fedorowski A. Risks of adverse events in patients with orthostatic intolerance undergoing surgery with general anesthesia. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2021. link 32 Dalla Vecchia LA, De Maria B, Perego F. A case of highly disabling orthostatic hypotension: when an integrated cardiac rehabilitation approach makes the difference. Giornale italiano di medicina del lavoro ed ergonomia 2020. link 33 Pasina L, Casati M, Cortesi L, Tettamanti M, Pellegrini R, Oppedisano I et al.. Orthostatic hypotension among elderly patients in Italian internal medicine wards: an observational study. Internal and emergency medicine 2020. link 34 Shibao CA, Garland EM, Black BK, Mathias CJ, Grant MB, Root AW et al.. Congenital absence of norepinephrine due to . Neurology 2020. link 35 Saedon NI, Frith J, Goh CH, Ahmad WAW, Khor HM, Tan KM et al.. Orthostatic blood pressure changes and physical, functional and cognitive performance: the MELoR study. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2020. link 36 O'Connor JD, O'Connell MDL, Nolan H, Newman L, Knight SP, Kenny RA. Impact of Standing Speed on the Peripheral and Central Hemodynamic Response to Orthostasis: Evidence From the Irish Longitudinal Study on Ageing. Hypertension (Dallas, Tex. : 1979) 2020. link 37 Baker J, Paturel JR, Sletten DM, Low PA, Kimpinski K. Initial validation of symptom scores derived from the orthostatic discriminant and severity scale. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2019. link 38 Cheshire WP. Chemical pharmacotherapy for the treatment of orthostatic hypotension. Expert opinion on pharmacotherapy 2019. link 39 Lamotte G, Holmes C, Sullivan P, Goldstein DS. Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2019. link 40 Magkas N, Tsioufis C, Thomopoulos C, Dilaveris P, Georgiopoulos G, Sanidas E et al.. Orthostatic hypotension: From pathophysiology to clinical applications and therapeutic considerations. Journal of clinical hypertension (Greenwich, Conn.) 2019. link 41 Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP et al.. Pediatric Disorders of Orthostatic Intolerance. Pediatrics 2018. link 42 Davydov DM, Czabak-Garbacz R. Orthostatic cardiovascular profile of subjective well-being. Biological psychology 2017. link 43 Aoki M. The impaired subjective perception of verticality independent of peripheral vestibular function in dizzy elderly with orthostatic hypotension. Aging clinical and experimental research 2017. link 44 Biogeau J, Desmidt T, Dujardin PA, Ternifi R, Eudo C, Vierron E et al.. Ultrasound Tissue Pulsatility Imaging Suggests Impairment in Global Brain Pulsatility and Small Vessels in Elderly Patients with Orthostatic Hypotension. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2017. link 45 Juraschek SP, Daya N, Appel LJ, Miller ER, Windham BG, Pompeii L et al.. Orthostatic Hypotension in Middle-Age and Risk of Falls. American journal of hypertension 2017. link 46 Gaxatte C, Faraj E, Lathuillerie O, Salleron J, Deramecourt V, Pardessus V et al.. Alcohol and psychotropic drugs: risk factors for orthostatic hypotension in elderly fallers. Journal of human hypertension 2017. link 47 Grijalva CG, Biaggioni I, Griffin MR, Shibao CA. Fludrocortisone Is Associated With a Higher Risk of All-Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension. Journal of the American Heart Association 2017. link 48 Zhu QO, Tan CS, Tan HL, Wong RG, Joshi CS, Cuttilan RA et al.. Orthostatic hypotension: prevalence and associated risk factors among the ambulatory elderly in an Asian population. Singapore medical journal 2016. link 49 Press Y, Punchik B, Freud T. Orthostatic hypotension and drug therapy in patients at an outpatient comprehensive geriatric assessment unit. Journal of hypertension 2016. link 50 Wecht JM, Weir JP, Martinez S, Eraifej M, Bauman WA. Orthostatic hypotension and orthostatic hypertension in American veterans. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2016. link 51 Frith J, Newton JL. Validation of a questionnaire for orthostatic hypotension for routine clinical use. Geriatrics & gerontology international 2016. link 52 Guérin A, Bureau ML, Ghazali N, Gervais R, Liuu E, Seité F et al.. Factors associated with orthostatic hypotension in hospitalized elderly patients. Aging clinical and experimental research 2016. link 53 Magnusson M, Holm H, Bachus E, Nilsson P, Leosdottir M, Melander O et al.. Orthostatic Hypotension and Cardiac Changes After Long-Term Follow-Up. American journal of hypertension 2016. link 54 Liu K, Wang S, Wan S, Zhou Y, Pan P, Wen B et al.. Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension. Journal of clinical hypertension (Greenwich, Conn.) 2016. link 55 Palamarchuk IS, Baker J, Kimpinski K. The utility of Valsalva maneuver in the diagnoses of orthostatic disorders. American journal of physiology. Regulatory, integrative and comparative physiology 2016. link 56 Wagoner AL, Shaltout HA, Fortunato JE, Diz DI. Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options. American journal of physiology. Heart and circulatory physiology 2016. link 57 Frith J, Bashir AS, Newton JL. The duration of the orthostatic blood pressure drop is predictive of death. QJM : monthly journal of the Association of Physicians 2016. link 58 Lu N, Chen J, Yuan Y, Cong X, Yang Y, Meng L et al.. The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population. Journal of human hypertension 2015. link 59 Lewis NC, Jones H, Ainslie PN, Thompson A, Marrin K, Atkinson G. Influence of nocturnal and daytime sleep on initial orthostatic hypotension. European journal of applied physiology 2015. link 60 Figueroa JJ, Singer W, Sandroni P, Sletten DM, Gehrking TL, Gehrking JA et al.. Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. Archives of physical medicine and rehabilitation 2015. link 61 Quinn C, Deegan B, Cooke J, Carew S, Hannigan A, Dunne C et al.. Therapeutic use of compression stockings for orthostatic hypotension: an assessment of patient and physician perspectives and practices. Age and ageing 2015. link 62 Mills PB, Fung CK, Travlos A, Krassioukov A. Nonpharmacologic management of orthostatic hypotension: a systematic review. Archives of physical medicine and rehabilitation 2015. link 63 Choi JH, Seo JD, Kim MJ, Choi BY, Choi YR, Cho BM et al.. Vertigo and nystagmus in orthostatic hypotension. European journal of neurology 2015. link 64 Xin W, Lin Z, Mi S. Orthostatic hypotension and mortality risk: a meta-analysis of cohort studies. Heart (British Cardiac Society) 2014. link 65 Morrison SA, Ainslie PN, Lucas RA, Cheung SS, Cotter JD. Compression garments do not alter cerebrovascular responses to orthostatic stress after mild passive heating. Scandinavian journal of medicine & science in sports 2014. link 66 Xu J, Zhou Y, Cao K, Li J, Tao X, Zhang Z et al.. Excessive pulse pressure response to standing in community population with orthostatic systolic hypertension. Journal of the American Society of Hypertension : JASH 2014. link 67 Kim HA, Yi HA, Lee H. Spectrum of autonomic dysfunction in orthostatic dizziness. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 2014. link 68 Lewis NC, Ainslie PN, Atkinson G, Jones H, Grant EJ, Lucas SJ. Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity. American journal of physiology. Regulatory, integrative and comparative physiology 2013. link 69 Lagro J, Meel-van den Abeelen A, de Jong DL, Schalk BW, Olde Rikkert MG, Claassen JA. Geriatric hypotensive syndromes are not explained by cardiovascular autonomic dysfunction alone. The journals of gerontology. Series A, Biological sciences and medical sciences 2013. link 70 De Maria E, Fontana PL, Cappelli S. Disappearance of orthostatic hypotension after pacemaker implantation in a patient with a long PR interval. Indian heart journal 2013. link 71 McHugh JE, Fan CW, Kenny RA, Lawlor BA. Orthostatic hypotension and subjective sleep quality in older people. Aging & mental health 2012. link 72 Mager DR. Orthostatic hypotension: pathophysiology, problems, and prevention. Home healthcare nurse 2012. link 73 Voichanski S, Grossman C, Leibowitz A, Peleg E, Koren-Morag N, Sharabi Y et al.. Orthostatic hypotension is associated with nocturnal change in systolic blood pressure. American journal of hypertension 2012. link 74 Poda R, Guaraldi P, Solieri L, Calandra-Buonaura G, Marano G, Gallassi R et al.. Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2012. link 75 Kobayashi K, Yamada S. Development of a simple index, calf mass index, for screening for orthostatic hypotension in community-dwelling elderly. Archives of gerontology and geriatrics 2012. link 76 Aoki M, Sakaida Y, Tanaka K, Mizuta K, Ito Y. Evidence for vestibular dysfunction in orthostatic hypotension. Experimental brain research 2012. link 77 Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H et al.. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. Journal of the American Society of Hypertension : JASH 2012. link 78 Gur AY, Auriel E, Korczyn AD, Gadoth A, Shopin L, Giladi N et al.. Vasomotor reactivity as a predictor for syncope in patients with orthostatism. Acta neurologica Scandinavica 2012. link 79 Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2012. link 80 Perlmuter LC, Sarda G, Casavant V, O'Hara K, Hindes M, Knott PT et al.. A review of orthostatic blood pressure regulation and its association with mood and cognition. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2012. link 81 Feldstein C, Weder AB. Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients. Journal of the American Society of Hypertension : JASH 2012. link 82 Wong BJ, Sheriff DD. Role of splanchnic constriction in governing the hemodynamic responses to gravitational stress in conscious dogs. Journal of applied physiology (Bethesda, Md. : 1985) 2011. link 83 Mazzoni MB, Kottanatu L, Simonetti GD, Ragazzi M, Bianchetti MG, Fossali EF et al.. Renal vein obstruction and orthostatic proteinuria: a review. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011. link 84 Kitaoka K, Miura H, Kitamura M, Akutagawa M, Kinouchi Y, Yoshizaki K. Feed-forward changes in carotid blood flow velocity during active standing. Neuroscience letters 2011. link 85 Romero-Ortuno R, Cogan L, Fan CW, Kenny RA. Intolerance to initial orthostasis relates to systolic BP changes in elders. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2010. link 86 Littmann L. Fact or artifact? The electrocardiographic diagnosis of orthostatic tremor. Journal of electrocardiology 2010. link 87 Frisbie JH. Correction of orthostatic hypotension by respiratory effort. Spinal cord 2010. link 88 Hiitola P, Enlund H, Kettunen R, Sulkava R, Hartikainen S. Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older. Journal of human hypertension 2009. link 89 Idiaquez J, Araya P, Benarroch E. Orthostatic hypotension associated with dorsal medullary cavernous angioma. Acta neurologica Scandinavica 2009. link 90 Fan CW, O'Sullivan E, Healy M, Gasparro D, Crowley V, Cunningham CJ. Physiological effects of sleeping with the head of the bed elevated 18 in. in young healthy volunteers. Irish journal of medical science 2008. link 91 Chi L, Masani K, Miyatani M, Adam Thrasher T, Wayne Johnston K, Mardimae A et al.. Cardiovascular response to functional electrical stimulation and dynamic tilt table therapy to improve orthostatic tolerance. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology 2008. link 92 Deegan BM, O'Connor M, Donnelly T, Carew S, Costelloe A, Sheehy T et al.. Orthostatic hypotension: a new classification system. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2007. link 93 Gupta V, Lipsitz LA. Orthostatic hypotension in the elderly: diagnosis and treatment. The American journal of medicine 2007. link 94 Shibasaki M, Durand S, Davis SL, Cui J, Low DA, Keller DM et al.. Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction. The Journal of physiology 2007. link 95 O'Leary DD, Hughson RL, Shoemaker JK, Greaves DK, Watenpaugh DE, Macias BR et al.. Heterogeneity of responses to orthostatic stress in homozygous twins. Journal of applied physiology (Bethesda, Md. : 1985) 2007. link 96 Ejaz AA, Kazory A, Heinig ME. 24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotension. Journal of clinical hypertension (Greenwich, Conn.) 2007. link 97 Melby DP, Lu F, Sakaguchi S, Zook M, Benditt DG. Increased impedance to inspiration ameliorates hemodynamic changes associated with movement to upright posture in orthostatic hypotension: a randomized blinded pilot study. Heart rhythm 2007. link 98 Kappel F, Fink M, Batzel JJ. Aspects of control of the cardiovascular-respiratory system during orthostatic stress induced by lower body negative pressure. Mathematical biosciences 2007. link 99 Iwanczyk L, Weintraub NT, Rubenstein LZ. Orthostatic hypotension in the nursing home setting. Journal of the American Medical Directors Association 2006. link 100 Cappuzzo KA. Herbal product use in a patient with polypharmacy. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 2006. link

Original source

[1]
Cerebral autoregulation in orthostatic hypotension and falls among older adults: a community-based exploratory study. — Saedon NI, Frith J, Wan Ahmad WA, Tan MP Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2026)
[2]
Establishing minimally clinically important differences for the orthostatic hypotension questionnaire (OHQ). — Kaufmann H, Palma JA, Vickery R, Norcliffe-Kaufmann L, Zheng B, Lewin D et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2026)
[3]
High-intensity exercise training mitigates post-exercise orthostatic hypotension in men. — Lei TH, Li HY, Goulding RP, Wang F, Amano T, Fujimoto T et al. European journal of applied physiology (2026)
[4]
Differences in muscle sympathetic nerve activity between patients with orthostatic hypertension and those with orthostatic normotensive hypertension. — Hirai T, Murai H, Sugimoto H, Mukai Y, Tokuhisa H, Ikeda T et al. Autonomic neuroscience : basic & clinical (2026)
[5]
Elevating blood pressure in neurogenic orthostatic hypotension: Investigating the efficacy and tolerability of rebreathing therapy. — Baker JR, Ranada SI, Incognito AV, Sheldon RS, Morillo CA, Wilson RJA et al. Autonomic neuroscience : basic & clinical (2026)
[6]
The effect of fludrocortisone and midodrine on ambulatory blood pressure biomarkers and symptoms of syncope. — Doyle K, Rice CP, Kenny RA, Briggs R, Lavan AH Blood pressure (2026)
[7]
Haemodynamic determinants of supine hypertension in patients with classical orthostatic hypotension. — van der Stam AH, Gagaouzova BS, Kerkhof FI, van Rossum IA, Shmuely S, Reijntjes RH et al. Journal of hypertension (2026)
[8]
Age-Related Orthostatic Hypotension: A Comprehensive Analysis of Prevalence, Mechanisms, and Management in the Geriatric Population. — Srinivas V, Choubey U, Kapparath S, Shaik T, Singh B, Mahmood R et al. Cardiology in review (2025)
[9]
Cerebral Blood Flow Dynamics in Neurogenic Orthostatic Hypotension: A Systematic Review and Meta-Analysis. — Baker JR, Beach PA, Ranada SI, Patel A, Gewandter J, Tan CO et al. Hypertension (Dallas, Tex. : 1979) (2025)
[10]
Misconceptions and Facts About Orthostatic Hypotension. — Krittanawong C, Rizwan A, Rezvani A, Khawaja M, Rodriguez M, Flack JM et al. The American journal of medicine (2025)
[11]
Strategies for Non-Pharmacological Management of Orthostatic Hypotension in Older People: Bridging Pathophysiology and Practice. — Owen CM, Frith J British journal of hospital medicine (London, England : 2005) (2025)
[12]
Pyridostigmine for the Management of Neurogenic Orthostatic Hypotension: A Systemic Review. — Holder AC, Dylewski A, Brown JN Journal of geriatric psychiatry and neurology (2025)
[13]
Haemodynamic effects of fludrocortisone and midodrine in patients with symptoms due to hypotension. — de Lange FJ, van Zanten S, Rivasi G, Groppelli A, Russo V, Maggi R et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2025)
[14]
The relative contribution of hemodynamic parameters to blood pressure decrease in classical orthostatic hypotension. — Gagaouzova BS, van der Stam A, Johansson M, Van Rossum IA, Kerkhof FI, Reijntjes R et al. Journal of hypertension (2025)
[15]
The Effect of a Biofeedback-Based Integrated Program on Improving Orthostatic Hypotension in Community-Dwelling Older Adults: A Pilot Study. — Han J, Park J, Kang H, Lee H, Kim N The Journal of cardiovascular nursing (2025)
[16]
Multi-omics study of molecular and genetic bases of orthostatic hypotension. — Zelenova E, Daniel V, Bruttan M, Artemieva L, Spektor E, Mamchur A et al. Clinical epigenetics (2025)
[17]
Impact of Land Versus Water Environments on Orthostatic Hypotension in Older Adults: A Randomized Crossover Study. — Dunlap E, Alhalimi T, McLaurin N, Tanaka H Journal of aging and physical activity (2025)
[18]
Artificial intelligence driven clustering of blood pressure profiles reveals frailty in orthostatic hypertension. — Owen CM, Bacardit J, Tan MP, Saedon NI, Goh CH, Newton JL et al. Experimental physiology (2025)
[19]
Acute effects of bolus water intake on post-exercise orthostatic hypotension and cardiovascular hemodynamics. — Tajima Y, Komiyama M, Mimura N, Yamamoto M, Fukuie M, Suzuki R et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2025)
[20]
Orthostatic hypotension: Review and expert position statement. — Vidal-Petiot E, Pathak A, Azulay JP, Pavy-Le Traon A, Hanon O Revue neurologique (2024)
[21]
The effect of lower limb strengthening exercise on orthostatic blood pressure and the skeletal muscle pump in older people with orthostatic hypotension. — Frith J, Robinson L, Gibbon JR, Allen J Clinical physiology and functional imaging (2024)
[22]
What is the prevalence of orthostatic hypotension in an Australasian emergency department population? — Clemensen E, Lau GT, Popovic G Emergency medicine Australasia : EMA (2024)
[23]
Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension. — Jordan J, Biaggioni I, Kotsis V, Nilsson P, Grassi G, Fedorowski A et al. Hypertension research : official journal of the Japanese Society of Hypertension (2023)
[24]
Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension. — Jordan J, Biaggioni I, Kotsis V, Nilsson P, Grassi G, Fedorowski A et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2023)
[25]
Baroreflex control model for cardiovascular system subjected to postural changes under normal and orthostatic conditions. — Resmi VL, Sriya RG, Selvaganesan N Computer methods in biomechanics and biomedical engineering (2023)
[26]
Orthostatic hypotension and vitamin D deficiency in older adults: systematic review and meta-analysis. — Zuin M, Brombo G, Capatti E, Romagnoli T, Zuliani G Aging clinical and experimental research (2022)
[27]
Does arterial stiffness affect orthostatic hypotension among high-altitude Tibetans? — Li X, Shi R, Meng Q, Zhang X, Chen X Postgraduate medicine (2021)
[28]
The association between fear of falling and orthostatic hypotension in older adults. — Arik F, Soysal P, Capar E, Kalan U, Smith L, Trott M et al. Aging clinical and experimental research (2021)
[29]
The Effect of Orthostatic Hypotension Detected Pre-Operatively on Post-Operative Outcome. — Hogan AM, Luck C, Woods S, Ortu A, Petkov S Journal of the American Geriatrics Society (2021)
[30]
Systemic and cerebral circulatory adjustment within the first 60 s after active standing: An integrative physiological view. — Harms MPM, Finucane C, Pérez-Denia L, Juraschek SP, van Wijnen VK, Lipsitz LA et al. Autonomic neuroscience : basic & clinical (2021)
[31]
Risks of adverse events in patients with orthostatic intolerance undergoing surgery with general anesthesia. — Ruzieh M, Sacks CD, Grewal SS, Aboujamous NM, Grubb BP, Fedorowski A Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2021)
[32]
A case of highly disabling orthostatic hypotension: when an integrated cardiac rehabilitation approach makes the difference. — Dalla Vecchia LA, De Maria B, Perego F Giornale italiano di medicina del lavoro ed ergonomia (2020)
[33]
Orthostatic hypotension among elderly patients in Italian internal medicine wards: an observational study. — Pasina L, Casati M, Cortesi L, Tettamanti M, Pellegrini R, Oppedisano I et al. Internal and emergency medicine (2020)
[34]
Congenital absence of norepinephrine due to — Shibao CA, Garland EM, Black BK, Mathias CJ, Grant MB, Root AW et al. Neurology (2020)
[35]
Orthostatic blood pressure changes and physical, functional and cognitive performance: the MELoR study. — Saedon NI, Frith J, Goh CH, Ahmad WAW, Khor HM, Tan KM et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2020)
[36]
Impact of Standing Speed on the Peripheral and Central Hemodynamic Response to Orthostasis: Evidence From the Irish Longitudinal Study on Ageing. — O'Connor JD, O'Connell MDL, Nolan H, Newman L, Knight SP, Kenny RA Hypertension (Dallas, Tex. : 1979) (2020)
[37]
Initial validation of symptom scores derived from the orthostatic discriminant and severity scale. — Baker J, Paturel JR, Sletten DM, Low PA, Kimpinski K Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2019)
[38]
Chemical pharmacotherapy for the treatment of orthostatic hypotension. — Cheshire WP Expert opinion on pharmacotherapy (2019)
[39]
Substantial renal conversion of L-threo-3,4-dihydroxyphenylserine (droxidopa) to norepinephrine in patients with neurogenic orthostatic hypotension. — Lamotte G, Holmes C, Sullivan P, Goldstein DS Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2019)
[40]
Orthostatic hypotension: From pathophysiology to clinical applications and therapeutic considerations. — Magkas N, Tsioufis C, Thomopoulos C, Dilaveris P, Georgiopoulos G, Sanidas E et al. Journal of clinical hypertension (Greenwich, Conn.) (2019)
[41]
Pediatric Disorders of Orthostatic Intolerance. — Stewart JM, Boris JR, Chelimsky G, Fischer PR, Fortunato JE, Grubb BP et al. Pediatrics (2018)
[42]
Orthostatic cardiovascular profile of subjective well-being. — Davydov DM, Czabak-Garbacz R Biological psychology (2017)
[43]
The impaired subjective perception of verticality independent of peripheral vestibular function in dizzy elderly with orthostatic hypotension. — Aoki M Aging clinical and experimental research (2017)
[44]
Ultrasound Tissue Pulsatility Imaging Suggests Impairment in Global Brain Pulsatility and Small Vessels in Elderly Patients with Orthostatic Hypotension. — Biogeau J, Desmidt T, Dujardin PA, Ternifi R, Eudo C, Vierron E et al. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2017)
[45]
Orthostatic Hypotension in Middle-Age and Risk of Falls. — Juraschek SP, Daya N, Appel LJ, Miller ER, Windham BG, Pompeii L et al. American journal of hypertension (2017)
[46]
Alcohol and psychotropic drugs: risk factors for orthostatic hypotension in elderly fallers. — Gaxatte C, Faraj E, Lathuillerie O, Salleron J, Deramecourt V, Pardessus V et al. Journal of human hypertension (2017)
[47]
Fludrocortisone Is Associated With a Higher Risk of All-Cause Hospitalizations Compared With Midodrine in Patients With Orthostatic Hypotension. — Grijalva CG, Biaggioni I, Griffin MR, Shibao CA Journal of the American Heart Association (2017)
[48]
Orthostatic hypotension: prevalence and associated risk factors among the ambulatory elderly in an Asian population. — Zhu QO, Tan CS, Tan HL, Wong RG, Joshi CS, Cuttilan RA et al. Singapore medical journal (2016)
[49]
Orthostatic hypotension and drug therapy in patients at an outpatient comprehensive geriatric assessment unit. — Press Y, Punchik B, Freud T Journal of hypertension (2016)
[50]
Orthostatic hypotension and orthostatic hypertension in American veterans. — Wecht JM, Weir JP, Martinez S, Eraifej M, Bauman WA Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2016)
[51]
Validation of a questionnaire for orthostatic hypotension for routine clinical use. — Frith J, Newton JL Geriatrics & gerontology international (2016)
[52]
Factors associated with orthostatic hypotension in hospitalized elderly patients. — Guérin A, Bureau ML, Ghazali N, Gervais R, Liuu E, Seité F et al. Aging clinical and experimental research (2016)
[53]
Orthostatic Hypotension and Cardiac Changes After Long-Term Follow-Up. — Magnusson M, Holm H, Bachus E, Nilsson P, Leosdottir M, Melander O et al. American journal of hypertension (2016)
[54]
Arterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension. — Liu K, Wang S, Wan S, Zhou Y, Pan P, Wen B et al. Journal of clinical hypertension (Greenwich, Conn.) (2016)
[55]
The utility of Valsalva maneuver in the diagnoses of orthostatic disorders. — Palamarchuk IS, Baker J, Kimpinski K American journal of physiology. Regulatory, integrative and comparative physiology (2016)
[56]
Distinct neurohumoral biomarker profiles in children with hemodynamically defined orthostatic intolerance may predict treatment options. — Wagoner AL, Shaltout HA, Fortunato JE, Diz DI American journal of physiology. Heart and circulatory physiology (2016)
[57]
The duration of the orthostatic blood pressure drop is predictive of death. — Frith J, Bashir AS, Newton JL QJM : monthly journal of the Association of Physicians (2016)
[58]
The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population. — Lu N, Chen J, Yuan Y, Cong X, Yang Y, Meng L et al. Journal of human hypertension (2015)
[59]
Influence of nocturnal and daytime sleep on initial orthostatic hypotension. — Lewis NC, Jones H, Ainslie PN, Thompson A, Marrin K, Atkinson G European journal of applied physiology (2015)
[60]
Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. — Figueroa JJ, Singer W, Sandroni P, Sletten DM, Gehrking TL, Gehrking JA et al. Archives of physical medicine and rehabilitation (2015)
[61]
Therapeutic use of compression stockings for orthostatic hypotension: an assessment of patient and physician perspectives and practices. — Quinn C, Deegan B, Cooke J, Carew S, Hannigan A, Dunne C et al. Age and ageing (2015)
[62]
Nonpharmacologic management of orthostatic hypotension: a systematic review. — Mills PB, Fung CK, Travlos A, Krassioukov A Archives of physical medicine and rehabilitation (2015)
[63]
Vertigo and nystagmus in orthostatic hypotension. — Choi JH, Seo JD, Kim MJ, Choi BY, Choi YR, Cho BM et al. European journal of neurology (2015)
[64]
Orthostatic hypotension and mortality risk: a meta-analysis of cohort studies. — Xin W, Lin Z, Mi S Heart (British Cardiac Society) (2014)
[65]
Compression garments do not alter cerebrovascular responses to orthostatic stress after mild passive heating. — Morrison SA, Ainslie PN, Lucas RA, Cheung SS, Cotter JD Scandinavian journal of medicine & science in sports (2014)
[66]
Excessive pulse pressure response to standing in community population with orthostatic systolic hypertension. — Xu J, Zhou Y, Cao K, Li J, Tao X, Zhang Z et al. Journal of the American Society of Hypertension : JASH (2014)
[67]
Spectrum of autonomic dysfunction in orthostatic dizziness. — Kim HA, Yi HA, Lee H Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (2014)
[68]
Initial orthostatic hypotension and cerebral blood flow regulation: effect of α1-adrenoreceptor activity. — Lewis NC, Ainslie PN, Atkinson G, Jones H, Grant EJ, Lucas SJ American journal of physiology. Regulatory, integrative and comparative physiology (2013)
[69]
Geriatric hypotensive syndromes are not explained by cardiovascular autonomic dysfunction alone. — Lagro J, Meel-van den Abeelen A, de Jong DL, Schalk BW, Olde Rikkert MG, Claassen JA The journals of gerontology. Series A, Biological sciences and medical sciences (2013)
[70]
Disappearance of orthostatic hypotension after pacemaker implantation in a patient with a long PR interval. — De Maria E, Fontana PL, Cappelli S Indian heart journal (2013)
[71]
Orthostatic hypotension and subjective sleep quality in older people. — McHugh JE, Fan CW, Kenny RA, Lawlor BA Aging & mental health (2012)
[72]
Orthostatic hypotension: pathophysiology, problems, and prevention. — Mager DR Home healthcare nurse (2012)
[73]
Orthostatic hypotension is associated with nocturnal change in systolic blood pressure. — Voichanski S, Grossman C, Leibowitz A, Peleg E, Koren-Morag N, Sharabi Y et al. American journal of hypertension (2012)
[74]
Standing worsens cognitive functions in patients with neurogenic orthostatic hypotension. — Poda R, Guaraldi P, Solieri L, Calandra-Buonaura G, Marano G, Gallassi R et al. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2012)
[75]
Development of a simple index, calf mass index, for screening for orthostatic hypotension in community-dwelling elderly. — Kobayashi K, Yamada S Archives of gerontology and geriatrics (2012)
[76]
Evidence for vestibular dysfunction in orthostatic hypotension. — Aoki M, Sakaida Y, Tanaka K, Mizuta K, Ito Y Experimental brain research (2012)
[77]
Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. — Yu X, Stavrakis S, Hill MA, Huang S, Reim S, Li H et al. Journal of the American Society of Hypertension : JASH (2012)
[78]
Vasomotor reactivity as a predictor for syncope in patients with orthostatism. — Gur AY, Auriel E, Korczyn AD, Gadoth A, Shopin L, Giladi N et al. Acta neurologica Scandinavica (2012)
[79]
The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. — Kaufmann H, Malamut R, Norcliffe-Kaufmann L, Rosa K, Freeman R Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2012)
[80]
A review of orthostatic blood pressure regulation and its association with mood and cognition. — Perlmuter LC, Sarda G, Casavant V, O'Hara K, Hindes M, Knott PT et al. Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2012)
[81]
Orthostatic hypotension: a common, serious and underrecognized problem in hospitalized patients. — Feldstein C, Weder AB Journal of the American Society of Hypertension : JASH (2012)
[82]
Role of splanchnic constriction in governing the hemodynamic responses to gravitational stress in conscious dogs. — Wong BJ, Sheriff DD Journal of applied physiology (Bethesda, Md. : 1985) (2011)
[83]
Renal vein obstruction and orthostatic proteinuria: a review. — Mazzoni MB, Kottanatu L, Simonetti GD, Ragazzi M, Bianchetti MG, Fossali EF et al. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2011)
[84]
Feed-forward changes in carotid blood flow velocity during active standing. — Kitaoka K, Miura H, Kitamura M, Akutagawa M, Kinouchi Y, Yoshizaki K Neuroscience letters (2011)
[85]
Intolerance to initial orthostasis relates to systolic BP changes in elders. — Romero-Ortuno R, Cogan L, Fan CW, Kenny RA Clinical autonomic research : official journal of the Clinical Autonomic Research Society (2010)
[86]
Fact or artifact? The electrocardiographic diagnosis of orthostatic tremor. — Littmann L Journal of electrocardiology (2010)
[87]
Correction of orthostatic hypotension by respiratory effort. — Frisbie JH Spinal cord (2010)
[88]
Postural changes in blood pressure and the prevalence of orthostatic hypotension among home-dwelling elderly aged 75 years or older. — Hiitola P, Enlund H, Kettunen R, Sulkava R, Hartikainen S Journal of human hypertension (2009)
[89]
Orthostatic hypotension associated with dorsal medullary cavernous angioma. — Idiaquez J, Araya P, Benarroch E Acta neurologica Scandinavica (2009)
[90]
Physiological effects of sleeping with the head of the bed elevated 18 in. in young healthy volunteers. — Fan CW, O'Sullivan E, Healy M, Gasparro D, Crowley V, Cunningham CJ Irish journal of medical science (2008)
[91]
Cardiovascular response to functional electrical stimulation and dynamic tilt table therapy to improve orthostatic tolerance. — Chi L, Masani K, Miyatani M, Adam Thrasher T, Wayne Johnston K, Mardimae A et al. Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology (2008)
[92]
Orthostatic hypotension: a new classification system. — Deegan BM, O'Connor M, Donnelly T, Carew S, Costelloe A, Sheehy T et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2007)
[93]
Orthostatic hypotension in the elderly: diagnosis and treatment. — Gupta V, Lipsitz LA The American journal of medicine (2007)
[94]
Endogenous nitric oxide attenuates neutrally mediated cutaneous vasoconstriction. — Shibasaki M, Durand S, Davis SL, Cui J, Low DA, Keller DM et al. The Journal of physiology (2007)
[95]
Heterogeneity of responses to orthostatic stress in homozygous twins. — O'Leary DD, Hughson RL, Shoemaker JK, Greaves DK, Watenpaugh DE, Macias BR et al. Journal of applied physiology (Bethesda, Md. : 1985) (2007)
[96]
24-hour blood pressure monitoring in the evaluation of supine hypertension and orthostatic hypotension. — Ejaz AA, Kazory A, Heinig ME Journal of clinical hypertension (Greenwich, Conn.) (2007)
[97]
Increased impedance to inspiration ameliorates hemodynamic changes associated with movement to upright posture in orthostatic hypotension: a randomized blinded pilot study. — Melby DP, Lu F, Sakaguchi S, Zook M, Benditt DG Heart rhythm (2007)
[98]
Aspects of control of the cardiovascular-respiratory system during orthostatic stress induced by lower body negative pressure. — Kappel F, Fink M, Batzel JJ Mathematical biosciences (2007)
[99]
Orthostatic hypotension in the nursing home setting. — Iwanczyk L, Weintraub NT, Rubenstein LZ Journal of the American Medical Directors Association (2006)
[100]
Herbal product use in a patient with polypharmacy. — Cappuzzo KA The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists (2006)

Share:Twitter Reddit LinkedIn