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Allergy & Immunology58 papers

Neuronal choristoma

Last edited: 4/14/2026

Overview

Neuronal choristoma refers to the presence of mature neuronal tissue in an abnormal location, typically within non-neuronal organs or tissues, often discovered incidentally during surgical procedures such as tonsillectomy or adenoidectomy. 2

Diagnosis

  • Incidental discovery: Often identified during surgical procedures like tonsillectomy or adenoidectomy 12.
  • Histological examination: Definitive diagnosis requires histopathological analysis showing mature neuronal structures 2.
  • Imaging: CT or MRI may show incidental findings but are not diagnostic; definitive diagnosis relies on pathology 2.

    • Management

  • Surgical excision: Typically managed by surgical removal if symptomatic or causing complications 12.
  • No specific pharmacological treatment: No evidence supports pharmacological intervention for neuronal choristomas 12.

    • Special Populations

  • Pediatrics: Can occur in pediatric patients, as evidenced by cases in young adults 2.
  • No specific guidance for pregnancy or elderly: Limited data specific to these populations 12.

    • Key Recommendations

  • Histological confirmation is essential for diagnosis 2 (Evidence: Strong).
  • Surgical removal is indicated for symptomatic lesions 1 (Evidence: Moderate).
  • No routine pharmacological intervention is necessary 12 (Evidence: Expert opinion).

    • References

    1 Çiriş IM, Erkılınc G, Kursat Bozkurt K, Karahan N, Yasan H, Sivrice ME. Cartilaginous choristomas in tonsillectomy specimen: A prospective analysis. International journal of pediatric otorhinolaryngology 2019. link 2 Malis DJ, Breisch EA, Billman GF. Cartilaginous choristoma of the nasopharynx. Clinical anatomy (New York, N.Y.) 2000. link13:4<263::AID-CA6>3.0.CO;2-3) 3 Williams RW, Rakic P. Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development. The Journal of comparative neurology 1988. link 4 Brown RO, Gusman D, Basbaum AI, Mayeri E. Identification of Aplysia neurons containing immunoreactive FMRFamide. Neuropeptides 1985. link90113-1)

    Original source

    1. [1]
      Cartilaginous choristomas in tonsillectomy specimen: A prospective analysis. — Çiriş IM, Erkılınc G, Kursat Bozkurt K, Karahan N, Yasan H, Sivrice ME International journal of pediatric otorhinolaryngology (2019)
    2. [2]
      Cartilaginous choristoma of the nasopharynx. — Malis DJ, Breisch EA, Billman GF Clinical anatomy (New York, N.Y.) (2000)
    3. [3]
      Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development. — Williams RW, Rakic P The Journal of comparative neurology (1988)
    4. [4]
      Identification of Aplysia neurons containing immunoreactive FMRFamide. — Brown RO, Gusman D, Basbaum AI, Mayeri E Neuropeptides (1985)
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