Overview
Hypochondriacal pain, often characterized by excessive worry about having a serious illness despite medical reassurance, involves persistent or recurrent pain complaints disproportionate to identifiable physical pathology. It overlaps with somatoform disorders and can significantly impact quality of life 5.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 731 indexed papers.
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Long Head of Biceps Tendinopathy Is Associated With Age and Cuff Tendinopathy on MRI Obtained for Evaluation of Shoulder Pain. Clinical orthopaedics and related research 2025. link 15 Baumgartner-Violand S, Brunkert T, Cassidy S, Blatter C, Favez L, Zúñiga F. Association Between Modifiable Structural and Process Factors and the Quality Indicator Pain in Nursing Home Residents: A MultiCentre Cross-Sectional Survey. Journal of advanced nursing 2025. link 16 Perri A, Fattore S, Sbordone A, Rotunno G, De Matteis A, Papacci P et al.. Intranasal Analgesia in Preterm and Term Neonates. Paediatric drugs 2025. link 17 Liu B, Yang C, Mazumdar M, Aldridge M, Morrison RS, Li L. Do Physical Activities Prevent the Occurrence of Bothersome Pain?. Journal of applied gerontology : the official journal of the Southern Gerontological Society 2025. link 18 Camacho D, Aranda MP, Moxley JH, Burnette D, Lukens EP, Reid MC et al.. Differences in Pain Presence and Intensity Among Black, Latino, and White Community-Dwelling Midlife and Older Adults in the U.S. Research on aging 2025. link 19 Oza E, Rateshwar Y, Santhosh A, Dave V. Emerging Use of Low-Dose Ketamine for Pain Management Beyond the ICU. Journal of pain & palliative care pharmacotherapy 2025. link 20 Otte JA, Chu G, Heran B, Bassett K. Tramadol (with or without acetaminophen) efficacy and harm: Systematic review and meta-analysis. Canadian family physician Medecin de famille canadien 2025. link 21 Du Y, Guo Z, Xu B, Yang Y, Hu M, Hu Y et al.. A real-world disproportionality analysis of the FDA adverse event reporting system events for ibuprofen. Expert opinion on drug safety 2025. link 22 Wang J, Feng G, Li D, Zhou X, Chen J, Wang F et al.. Comparison of safety of acetaminophen and ibuprofen in minors: based on the FAERS database. Expert opinion on drug safety 2025. link 23 Yang C, Guo Q, Cheng Y, Liu F, Zhang H, Wang H. In-depth summary of adverse events associated with Flurbiprofen: A real-world pharmacovigilance study from 2004 to 2024 using the FAERS database. PloS one 2025. link 24 Gasparovic L, Burden AM, Senn O, Markun S, Quednow BB, Neuner-Jehle S et al.. Age disparities in adverse reactions of drugs used in pain therapies in Switzerland. Scientific reports 2025. link 25 Kabangu JK, Bah MG, Enogela EM, Judd SE, Hobson JM, Levitan EB et al.. The Association Between Experienced Discrimination and Pain in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Journal of racial and ethnic health disparities 2025. link 26 Abouarab AH, Brülle R, Aboukilila MY, Weibel S, Schnabel A. Efficacy and safety of perioperative ketamine for the prevention of chronic postsurgical pain: A meta-analysis. Pain practice : the official journal of World Institute of Pain 2024. link 27 Chen KC, Ha AS, Bartolotta RJ, Avery R, Bucknor MD, Flug J et al.. ACR Appropriateness Criteria® Acute Elbow and Forearm Pain. Journal of the American College of Radiology : JACR 2024. link 28 Alsabri M, Hafez AH, Singer E, Elhady MM, Waqar M, Gill P. Efficacy and Safety of Intranasal Fentanyl in Pediatric Emergencies: A Systematic Review and Meta-analysis. Pediatric emergency care 2024. link 29 Huang L, Devlin N, Chen G, Dalziel K. A happiness approach to valuing health states for children. Social science & medicine (1982) 2024. link 30 de Barros GAM, Pos AM, Sousa ÂM, Pereira CL, Nobre CDA, Palmeira CCA et al.. Cannabinoid products for pain management: recommendations from the São Paulo State Society of Anesthesiology. Brazilian journal of anesthesiology (Elsevier) 2024. link 31 Nikula A, Rinder MR, Lundeberg S, Lääperi M, Sandholm K, Castrén M et al.. A randomized clinical trial of intranasal dexmedetomidine versus inhaled nitrous oxide for procedural sedation and analgesia in children. 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Rheumatology (Oxford, England) 2024. link 36 Pacitti C, Cairns D, Ward L, Nicholl BI. Investigating pain-related medication use and contribution to polypharmacy in adults with intellectual disabilities: a systematic review. BMC medicine 2024. link 37 Haddick A, Thompson S, Lundy C. Fifteen-minute consultation: Assessment of pain in a non-verbal child. Archives of disease in childhood. Education and practice edition 2024. link 38 Spénard S, Metras ME, Gélinas C, Shah V, Doré-Bergeron MJ, Dekoven K et al.. Morphine versus hydromorphone in pediatrics: a narrative review of latest indications and optimal use in neonates and children. Minerva pediatrics 2024. link 39 Levy E, Alkan M, Gidron Y. Painful Call About the Under-Reporting of Children's Pain During Humanitarian Crises. Disaster medicine and public health preparedness 2024. link 40 McNaughton MA, Quinlan-Colwell A, Lyons MT, Arkin LC. Acute Perioperative Pain Management of the Orthopaedic Patient: Guidance for Operationalizing Evidence Into Practice. Orthopedic nursing 2024. link 41 Turner SG, Brooker H, Ballard C, Corbett A, Hampshire A, Sabatini S. The Role of Awareness of Age-Related Change in the Longitudinal Association between Pain and Physical Activity. International journal of aging & human development 2024. link 42 Rivera LC, Mancilla IA, Bergstrom J, Thompson S, Molina AJ. Relationships Between Self-Reported Pain and Optimism Among Community-Dwelling Older Adults. International journal of aging & human development 2024. link 43 Neuwersch-Sommeregger S, Köstenberger M, Pipam W, Demschar S, Trummer B, Breschan C et al.. Pain in Austrian hospitals: evaluation of 1089 in-patients. Wiener medizinische Wochenschrift (1946) 2024. link 44 Pickering G, Kotlińska-Lemieszek A, Krcevski Skvarc N, O'Mahony D, Monacelli F, Knaggs R et al.. Pharmacological Pain Treatment in Older Persons. 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The association between primary care appointment lengths and opioid prescribing for common pain conditions. BMC health services research 2024. link 49 Camacho D, Burnette D, Aranda MP, Moxley JH, Lukens EP, Reid MC et al.. Loneliness and pain among community-dwelling middle-aged and older Black, Latino, and White adults in the United States. Frontiers in public health 2024. link 50 Shrestha S, Iqbal A, Teoh SL, Khanal S, Gan SH, Lee SWH et al.. Impact of pharmacist-delivered interventions on pain-related outcomes: An umbrella review of systematic reviews and meta-analyses. Research in social & administrative pharmacy : RSAP 2024. link 51 Gastine S, Morse JD, Leung MT, Wong ICK, Howard RF, Harrop E et al.. Diamorphine pharmacokinetics and conversion factor estimates for intranasal diamorphine in paediatric breakthrough pain:systematic review. BMJ supportive & palliative care 2024. link 52 . [Evidence-based guideline for neonatal pain management in China (2023)]. 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Questioning the Right to Pain Relief and Its Role in the Opioid Epidemic. Mayo Clinic proceedings 2023. link 58 Iglesias B, Pérez Zabala J, Argañaraz R, Mantese B. Lumbosacral DREZotomy for oncologic pain treatment: a case-based review. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 2023. link 59 Soyannwo O, Chaudakshetrin P, Garcia JB. The value of the International Association for the Study of Pain to developing countries. Pain 2023. link 60 Timmerman H, van Boekel RLM, van de Linde LS, Bronkhorst EM, Vissers KCP, van der Wal SEI et al.. The effect of preferred music versus disliked music on pain thresholds in healthy volunteers. An observational study. PloS one 2023. link 61 Li S, Brimmers A, van Boekel RLM, Vissers KCP, Coenen MJH. A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses. Pain 2023. link 62 Cole CS, Blackburn J, Carpenter JS, Chen CX, Hickman SE. Pain and Associated Factors in Nursing Home Residents. Pain management nursing : official journal of the American Society of Pain Management Nurses 2023. link 63 Bader CE, Flynn DM, Buckenmaier CC, McDonald CC, Meghani SH, Glaser D et al.. Patterns of Change in Pain-related Physical, Mental, and Social Health Outcomes in a Military Population. Pain management nursing : official journal of the American Society of Pain Management Nurses 2023. link 64 Prescott MG, Iakovleva E, Simpson MR, Pedersen SA, Munblit D, Vallersnes OM et al.. Intranasal analgesia for acute moderate to severe pain in children - a systematic review and meta-analysis. BMC pediatrics 2023. link 65 Rahman A, Waterhouse M, Baxter C, Romero BD, McLeod DSA, Armstrong BK et al.. The effect of vitamin D supplementation on pain: an analysis of data from the D-Health randomised controlled trial. The British journal of nutrition 2023. link 66 Patra PH, Tench B, Hitrec T, Holmes F, Drake R, Cerritelli S et al.. Pro-opiomelanocortin neurons in the nucleus of the solitary tract mediate endorphinergic endogenous analgesia in mice. Pain 2023. link 67 Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports 2022. link 68 Pourali SP, Gutierrez Y, Jones ME, Rajkumar JR, Kucharik AH, Armstrong AW. Are we contributing to the opioid epidemic? A systematic review on systemic opioid use in dermatology. International journal of dermatology 2022. link 69 Huang Q, Lin J, Han R, Peng C, Huang A. Using Virtual Reality Exposure Therapy in Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 2022. link 70 Bode K, Whittaker P, Dressler M, Bauer Y, Ali H. Pain Management Program in Cardiology: A Template for Application of Normalization Process Theory and Social Marketing to Implement a Change in Practice Quality Improvement. International journal of environmental research and public health 2022. link 71 Orak Y, Eroğlu E, Baylan FA, Yıldız S, Boran ÖF, Doganer A et al.. Effects of acupuncture on pain and levels of IL-17 and IL-23 in the treatment of non-thermal endovenous ablation: A randomized clinical trial. Vascular 2022. link 72 Ong T, Thiam CN. Special consideration for pain management in the older person. Clinical medicine (London, England) 2022. link 73 Tripathi S, Venkata M, Hill J, Harrison J. Non-pharmacological interventions for managing pain in community-dwelling older adults. British journal of community nursing 2022. link 74 Jenkins L, Parry R, Faull C. A direct observation of pain scale use in five video-recorded palliative care consultations: Using conversation analysis to show how practitioners support patients to describe pain. Patient education and counseling 2022. link 75 Yalamuru B, Weisbein J, Pearson ACS, Kandil ES. Minimally-invasive pain management techniques in palliative care. Annals of palliative medicine 2022. link 76 Monroe TB, Anderson A, Failla M, Carter M. Study protocol for an integrative theory review of the concept of unidentified pain. BMJ open 2022. link 77 Crawford LS, Boorman DC, Keay KA, Henderson LA. The pain conductor: brainstem modulation in acute and chronic pain. Current opinion in supportive and palliative care 2022. link 78 Zuazua-Rico D, Mosteiro-Diaz MP, Collado-Boira E, Del Carmen Casal-Angulo M, Cobo-Cuenca AI, Fernandez-Garrido J et al.. Knowledge about Pain in Spanish Nursing Students. 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Prevalence and Factors Associated with Pain in Nursing Home Residents: A Systematic Review of the Literature. Journal of the American Medical Directors Association 2022. link 84 Ribeiro H, Rodrigues I, Napoleão L, Lira L, Marques D, Veríssimo M et al.. Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: Adjusting prescription to patient features. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022. link 85 Yang Y, Grol-Prokopczyk H, Reid MC, Pillemer K. The Relationship Between Pain and Psychological Distress During the COVID-19 Pandemic: Is Social Technology Use Protective?. Pain medicine (Malden, Mass.) 2022. link 86 Johnson MI, Paley CA, Wittkopf PG, Mulvey MR, Jones G. Characterising the Features of 381 Clinical Studies Evaluating Transcutaneous Electrical Nerve Stimulation (TENS) for Pain Relief: A Secondary Analysis of the Meta-TENS Study to Improve Future Research. 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Endodontic Emergencies in Mumbai City during COVID-19 Lockdown and Different Phases of Unlock. International journal of environmental research and public health 2021. link 96 Yeaman C, Zillioux J, Boatman K, Krzastek S, Rapp DE. Characterization and Prevalence of Female Pelvic Pain in a General Outpatient Urology Population. Urology 2021. link 97 Bingham K, Gutmann JL. The Roots of Pressure Anesthesia and its Contemporary Similarities. Journal of the history of dentistry 2021. link 98 Tobias JD. Methadone: applications in pediatric anesthesiology and critical care medicine. Journal of anesthesia 2021. link 99 McPherson C, Ortinau CM, Vesoulis Z. Practical approaches to sedation and analgesia in the newborn. Journal of perinatology : official journal of the California Perinatal Association 2021. link 100 McKernan MJ, Schickendantz MS, Frangiamore SJ. Diagnosis and Management of Subcoracoid Impingement. The Journal of the American Academy of Orthopaedic Surgeons 2021. link