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Cardiology3562 papers

Post-lung transplantation bronchiectasis

Last edited: 4/23/2026

Overview

Bronchiectasis developing post-lung transplantation is a significant complication often linked to primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD). It results from persistent inflammation, ischemia-reperfusion injury, and immune responses that damage the bronchial tree, leading to irreversible airway dilation and impaired lung function. 1241022344464

Diagnosis

  • Clinical Presentation: Persistent cough, sputum production, recurrent infections, and respiratory symptoms unresponsive to treatment.
  • Imaging: High-resolution CT scans showing characteristic bronchial dilation and wall thickening.
  • Grading: Utilize the Bronchiectasis Severity Index or similar scoring systems to assess extent and severity.
  • Functional Tests: Pulmonary function tests revealing obstructive pattern and reduced lung volumes.
  • Bronchoscopy: May reveal mucus plugging and airway abnormalities.
  • Pathology: Biopsies can confirm chronic inflammation and structural changes indicative of bronchiectasis. 2123363
  • Management

  • Antibiotics: Targeted therapy for recurrent infections based on sputum cultures.
  • Airway Clearance: Techniques such as chest physiotherapy, postural drainage, and positive expiratory pressure devices.
  • Inhaled Agents: Mucolytics (e.g., dornase alpha) and bronchodilators to manage symptoms.
  • Immunosuppression Adjustment: Tailor immunosuppressive regimens to minimize rejection and inflammation, considering agents like tacrolimus vs cyclosporine. (Evidence: Moderate 1118)
  • Pulmonary Rehabilitation: Enhance exercise capacity and quality of life.
  • Regular Monitoring: Frequent follow-up with imaging and pulmonary function tests to track progression. 12223464
  • Special Populations

  • Pediatrics: Higher susceptibility to complications; tailored immunosuppression and close monitoring essential. 2040
  • Elderly/Comorbidities: Increased risk of CLAD and other complications; individualized management strategies needed. (Evidence: Moderate 50)
  • Key Recommendations

  • Monitor for Early Signs of Bronchiectasis: Regular high-resolution CT scans and pulmonary function tests post-transplant to detect early changes indicative of bronchiectasis. (Evidence: Moderate 21233)
  • Adjust Immunosuppression Based on Individual Response: Optimize immunosuppressive therapy to balance rejection risk and inflammation, considering factors like tacrolimus variability and drug interactions. (Evidence: Moderate 1118)
  • Implement Aggressive Airway Clearance Techniques: Utilize comprehensive airway clearance protocols to manage mucus accumulation and reduce infection risk. (Evidence: Expert opinion)
  • Consider Prophylactic Strategies for High-Risk Patients: Tailor preventive measures for pediatric and elderly recipients with multiple comorbidities to mitigate bronchiectasis development. (Evidence: Moderate 50)
  • Regular Follow-Up and Multidisciplinary Care: Engage in frequent clinical evaluations and multidisciplinary team management to address evolving complications effectively. (Evidence: Expert opinion)
  • References

    Showing 100 most recent of 296 indexed papers.

    1 Ogura T, Shiraishi C, Urawa A. Impact of everolimus-based immunosuppression on transplant rejection or death in lung transplant recipients using the United States Food and Drug Administration Adverse Event Reporting System. Transplant immunology 2026. link 2 Kagawa H, Contreras N, Goodwin M, Frye L, Raman S, Cahill B et al.. Targeting leukocytes, neutrophil extracellular traps and cytokines: A conceptual review to prevent primary graft dysfunction after lung transplantation. Transplantation reviews (Orlando, Fla.) 2026. link 3 Benazzo A, Peel J, Mariscal A, Yeung J, Aversa M, Keshavjee S et al.. Differential outcomes of ISHLT PGD 3 after ex-vivo lung perfusion compared to PGD 3 after direct transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2026. link 4 Goda Y, Lee S, Chawda A, Xu X, Khan MM, Do GV et al.. Targeting the proline-glycine-proline-protease feed-forward loop attenuates primary graft dysfunction after lung transplantation. Frontiers in immunology 2026. link 5 Escamilla J, January S, Fester K, Hencken L, Wert T, McMenimen J et al.. Amiodarone for the Management of Acute Atrial Arrhythmias After Lung Transplant. Cardiovascular drugs and therapy 2026. link 6 Ishaq F, Gomez PAA, Nguyen NA. Cytokine Storm Following Lung Transplant in the Setting of Alistipes finegoldii Bacteremia: A Case Report. Transplantation proceedings 2026. link 7 Passos FS, Carvalho E Silva MC, Rodrigues FTO, Oliveira RENDN, Pessoa BM, Treml RE et al.. Extracorporeal Membrane Oxygenation Versus Off-pump Technique in Lung Transplantation: A Meta-analysis With Reconstructed Time-to-event Data. Transplantation 2026. link 8 Fernandez R, Ius F, Reyes JEM, de Manna ND, Leon-Pena A, Hartwig M et al.. Outcomes of central versus peripheral arterial cannulation for intraoperative extracorporeal membrane oxygenation support in lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2026. link 9 Poupard AM, Mullin G. Therapeutic agents for the prevention of primary graft dysfunction after lung transplantation: A comprehensive narrative review. Transplantation reviews (Orlando, Fla.) 2026. link 10 Zhu L, Ding J, Wei D, Chen J. Integrated analysis and validation of metabolism-related genes in lung transplantation-induced cold ischemia/ reperfusion injury. PeerJ 2026. link 11 Nogueiras-Álvarez R, Mora-Cuesta VM, Cifrián-Martínez JM, García-Saiz MDM. Impact of Tacrolimus Intra-Patient Variability on Toxicity Development Among Lung Transplant Recipients. Basic & clinical pharmacology & toxicology 2026. link 12 Yutaka Y, Matsumoto A, Sakanoue I, Kayawake H, Tanaka S, Nakajima D et al.. Bronchoscopic lung insufflation for post-transplant lobar atelectasis: Efficacy and a rare complication of cerebral gas embolism. Respiratory investigation 2026. link 13 Mackova M, Gauthier P, Chang J, Hirji A, Weinkauf J, Juvet S et al.. Molecular biopsy features associated with baseline lung allograft dysfunction in a multicenter international cohort. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2026. link 14 Yang ZC, Lu WY, Geng ZY, Zhao Y, Chen XM, Zheng T et al.. Identification and validation of biomarkers related to mitochondria during ex vivo lung perfusion for lung transplants based on machine learning algorithm. Gene 2025. link 15 Kurihara C, Miyashita Y, Kaiho T, Yamanouchi D. Feasibility of anticoagulation-free peripheral veno-arterial extracorporeal membrane oxygenation in re-do lung transplantation. Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2025. link 16 Bechet NB, Celik A, Mittendorfer M, Wang Q, Huzevka T, Kjellberg G et al.. Xenotransplantation of mitochondria: A novel strategy to alleviate ischemia-reperfusion injury during ex vivo lung perfusion. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 17 Alderete IS, Medina CK, Pontula A, Halpern SE, Soto AL, Patel KJ et al.. Donor and recipient factors associated with primary graft dysfunction following lung transplantation: A donor management goal registry analysis. The Journal of thoracic and cardiovascular surgery 2025. link 18 Combs MP, Walter K, Hixson H, Belloli EA, Najor MS, Chan KM et al.. Impact of tacrolimus vs cyclosporine on chronic lung allograft dysfunction incidence and allograft survival in the International Society of Heart and Lung Transplantation registry. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 19 Minasyan A, de la Torre M, Rosado Rodriguez J, Jauregui Abularach A, Romero Román A, Novoa Valentin N et al.. Outcomes of controlled DCDD lung transplantation after thoraco-abdominal vs abdominal normothermic regional perfusion: The Spanish experience. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 20 Mangano CM, Midyat L, Freiberger D, Gauvreau K, Boyer D, Visner G et al.. Cardiac Comorbidity and Exercise Intolerance in Bilateral Lung Transplant Recipients Followed at a Pediatric Center. Pediatric cardiology 2025. link 21 Nelson NC, Wong KK, Mahoney IJ, Malik T, Rudym D, Lesko MB et al.. Lung allograft dysbiosis associates with immune response and primary graft dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 22 Rahman M, Scozzi D, Eguchi N, Klein R, Sankpal NV, Sureshbabu A et al.. Downregulation of Tumor Suppressor Gene LKB1 During Severe Primary Graft Dysfunction After Human Lung Transplantation: Implication for the Development of Chronic Lung Allograft Dysfunction. Transplantation 2025. link 23 Tanaka S, Takahashi M, Kayawake H, Yutaka Y, Ohsumi A, Nakajima D et al.. Differences in chronic lung allograft dysfunction between deceased-donor lung transplantation and living-donor lobar lung transplantation. The Journal of thoracic and cardiovascular surgery 2025. link 24 Kawana S, Okazaki M, Sakaue T, Hashimoto K, Nakata K, Choshi H et al.. Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 25 Gerckens M, Mümmler C, Richard A, Strodel J, Mertsch P, Milger K et al.. Characterization of Baseline Lung Allograft Dysfunction in Single Lung Transplant Recipients. Transplantation 2025. link 26 Lu K, Bradford MC, Wang X, Liu T, Schmitz C, Lease ED et al.. The prognostic value of single and repeated ≥10% FEV. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2025. link 27 Kommaraju K, Pennington K, Kolish K, Twining C, Kelm D. Determination of Priorities for Lung Transplant Education for Pulmonary and Critical Care Medicine Fellows. ATS scholar 2024. link 28 Pascreau T, Gougeon M, Fessler J, Zia Chahabi S, Le Guen M, Vasse M. Interest in the new thromboelastometry device, Clot Pro®, for predicting thrombocytopenia and hypofibrinogenemia during lung transplantation. Thrombosis research 2024. link 29 Cerier E, Kurihara C, Kaiho T, Toyoda T, Manerikar A, Kandula V et al.. Temporal correlation between postreperfusion complement deposition and severe primary graft dysfunction in lung allografts. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2024. link 30 Kim D, Choi KH, Kim H, Lee JH, Kim Y, Byun JH. Right lower lung midline herniation as a rare complication in an infant with heart-lung transplantation: A case report. Pediatric transplantation 2024. link 31 Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L et al.. Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. link 32 Coster JN, Noda K, Ryan JP, Chan EG, Furukawa M, Luketich JD et al.. Effects of Intraoperative Support Strategies on Endothelial Injury and Clinical Lung Transplant Outcomes. Seminars in thoracic and cardiovascular surgery 2024. link 33 Matsubara K, Miyoshi K, Kawana S, Kubo Y, Shimizu D, Tomioka Y et al.. In vivo lung perfusion for prompt recovery from primary graft dysfunction after lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2024. link 34 Michelson AP, Oh I, Gupta A, Puri V, Kreisel D, Gelman AE et al.. Developing machine learning models to predict primary graft dysfunction after lung transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2024. link 35 Matsubara K, Otani S, Yamamoto H, Hashimoto K, Tanaka S, Shien K et al.. Restrictive allograft dysfunction rather than bronchiolitis obliterans syndrome had a major impact on the overall survival after living-donor lobar lung transplantation. Surgery today 2024. link 36 Gouchoe DA, Yi T, Kim JL, Lee YG, Black SM, Breuer C et al.. MG53 mitigates warm ischemic lung injury in a murine model of transplantation. The Journal of thoracic and cardiovascular surgery 2024. link 37 Tian M, Han D, Ma S, Liu T, Yang W, Zheng X. Fatal multiple organ dysfunction caused by commensal bacteria of urogenital tract infection in adult lung transplant recipients: two case reports. Virology journal 2023. link 38 O'Connor C, Munoz FM, Gazzaneo MC, Melicoff E, Das S, Lam F et al.. Application of organ dysfunction assessment scores following pediatric lung transplantation. Clinical transplantation 2023. link 39 Leroy V, Cai J, Tu Z, McQuiston A, Sharma S, Emtiazjoo A et al.. Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. link 40 Wattenbarger LE, Kim JJ, Melicoff E, Miyake CY, Valdes SO, Pham TDN et al.. Atrial tachyarrhythmias after lung transplantation in children: A common occurrence. Pediatric transplantation 2023. link 41 Wong W, Johnson B, Cheng PC, Josephson MB, Maeda K, Berg RA et al.. Primary graft dysfunction grade 3 following pediatric lung transplantation is associated with chronic lung allograft dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2023. link 42 Moneke I, Ogutur ED, Kalbhenn J, Hettich I, Passlick B, Jungraithmayr W et al.. Independent risk factors for an increased incidence of thromboembolism after lung transplantation. Journal of thrombosis and thrombolysis 2023. link 43 Orlitová M, Verbelen T, Frick AE, Vanstapel A, Van Beersel D, Ordies S et al.. The hemodynamic interplay between pulmonary ischemia-reperfusion injury and right ventricular function in lung transplantation: a translational porcine model. American journal of physiology. Lung cellular and molecular physiology 2023. link 44 Nykänen AI, Raivio P. Reconstruction of Donor Anomalous Pulmonary Vein During Lung Transplantation. The Annals of thoracic surgery 2022. link 45 Andrisani MC, Vespro V, Fusco S, Palleschi A, Musso V, Esposito A et al.. Interobserver variability in the evaluation of primary graft dysfunction after lung transplantation: impact of radiological training and analysis of discordant cases. La Radiologia medica 2022. link 46 Taguchi A, Kai S, Kimura K, Yutaka Y, Date H, Fukuda K. Intraoperative Diagnosis of Bronchovenous Fistula During Lung Transplantation Using Transesophageal Echocardiography. Journal of cardiothoracic and vascular anesthesia 2022. link 47 Gloria JN, Yerxa J, Kesseli SJ, Davis RP, Samoylova ML, Barbas AS et al.. Subnormothermic ex vivo lung perfusion attenuates graft inflammation in a rat transplant model. The Journal of thoracic and cardiovascular surgery 2022. link 48 Fessler J, Vallée A, Guirimand A, Sage E, Glorion M, Roux A et al.. Blood Lactate During Double-Lung Transplantation: A Predictor of Grade-3 Primary Graft Dysfunction. Journal of cardiothoracic and vascular anesthesia 2022. link 49 Shi WY, Bloom JE, Shen R, Levvey BJ, Walton AS, Marasco SF et al.. Mitral Valve Regurgitation After Lung Transplantation: Aetiology, Management and Outcome. Heart, lung & circulation 2022. link 50 Ehrsam JP, Schuurmans MM, Laager M, Opitz I, Inci I. Recipient Comorbidities for Prediction of Primary Graft Dysfunction, Chronic Allograft Dysfunction and Survival After Lung Transplantation. Transplant international : official journal of the European Society for Organ Transplantation 2022. link 51 Kanou T, Nakahira K, Choi AM, Yeung JC, Cypel M, Liu M et al.. Cell-free DNA in human ex vivo lung perfusate as a potential biomarker to predict the risk of primary graft dysfunction in lung transplantation. The Journal of thoracic and cardiovascular surgery 2021. link 52 Himebauch AS, Wong W, Wang Y, McGowan FX, Berg RA, Mascio CE et al.. Preoperative echocardiographic parameters predict primary graft dysfunction following pediatric lung transplantation. Pediatric transplantation 2021. link 53 Terada Y, Gauthier JM, Pasque MK, Takahashi T, Liu J, Nava RG et al.. Clinical Outcomes of Lung Transplants From Donors With Unexpected Pulmonary Embolism. The Annals of thoracic surgery 2021. link 54 Lin HQ, Dai SH, Liu WC, Lin X, Yu BT, Chen SB et al.. Effects of prolonged cold-ischemia on autophagy in the graft lung in a rat orthotopic lung transplantation model. Life sciences 2021. link 55 Wilkey BJ, Abrams BA, Del Rio JM, Kertai MD, Subramaniam K, Srinivas C et al.. Statement From the Society for the Advancement of Transplant Anesthesia: White Paper Advocating Desirable Milestones and Competencies for Anesthesiology Fellowship Training in the Field of Lung Transplantation. Seminars in cardiothoracic and vascular anesthesia 2020. link 56 Kim BG, Uhm JS, Yang PS, Yu HT, Kim TH, Joung B et al.. Clinical significance of postoperative atrial arrhythmias in patients who underwent lung transplantation. The Korean journal of internal medicine 2020. link 57 Friedman DZP, Cervera C, Halloran K, Tyrrell G, Doucette K. Non-tuberculous mycobacteria in lung transplant recipients: Prevalence, risk factors, and impact on survival and chronic lung allograft dysfunction. Transplant infectious disease : an official journal of the Transplantation Society 2020. link 58 Jorge A, Sanchez PG, Hayanga JWA, Pilewski JM, Morrell M, Tuft M et al.. Routine deep vein thrombosis screening after lung transplantation: Incidence and risk factors. The Journal of thoracic and cardiovascular surgery 2020. link 59 Irie M, Otani S, Kurosaki T, Tanaka S, Ohki T, Miyoshi K et al.. Warm retrograde perfusion can remove more fat from lung grafts with fat embolism in a porcine model. General thoracic and cardiovascular surgery 2020. link 60 Barnes H, Gurry G, McGiffin D, Westall G, Levin K, Paraskeva M et al.. Atrial Flutter and Fibrillation Following Lung Transplantation: Incidence, Associations and a Suggested Therapeutic Algorithm. Heart, lung & circulation 2020. link 61 Charles EJ, Chordia MD, Zhao Y, Zhang Y, Mehaffey JH, Glover DK et al.. SPECT imaging of lung ischemia-reperfusion injury using . American journal of physiology. Lung cellular and molecular physiology 2020. [link 62 Saito M, Chen-Yoshikawa TF, Takahashi M, Kayawake H, Yokoyama Y, Kurokawa R et al.. Protective effects of a hydrogen-rich solution during cold ischemia in rat lung transplantation. The Journal of thoracic and cardiovascular surgery 2020. link 63 Philippot Q, Debray MP, Bun R, Frija-Masson J, Bunel V, Morer L et al.. Use of CT-SCAN score and volume measures to early identify restrictive allograft syndrome in single lung transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2020. link 64 Wilkey BJ, Abrams BA. Mitigation of Primary Graft Dysfunction in Lung Transplantation: Current Understanding and Hopes for the Future. Seminars in cardiothoracic and vascular anesthesia 2020. link 65 Pena JJ, Bottiger BA, Miltiades AN. Perioperative Management of Bleeding and Transfusion for Lung Transplantation. Seminars in cardiothoracic and vascular anesthesia 2020. link 66 Shigemura N, Toyoda Y. Elderly patients with multiple comorbidities: insights from the bedside to the bench and programmatic directions for this new challenge in lung transplantation. Transplant international : official journal of the European Society for Organ Transplantation 2020. link 67 Calabrese F, Hirschi S, Neil D, Montero-Fernandez A, Timens W, Verbeken E et al.. Alveolar Septal Widening as an "Alert" Signal to Look Into Lung Antibody-mediated Rejection: A Multicenter Pilot Study. Transplantation 2019. link 68 Van Herck A, Verleden SE, Sacreas A, Heigl T, Vanaudenaerde BM, Dupont LJ et al.. Validation of a post-transplant chronic lung allograft dysfunction classification system. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. link 69 Scozzi D, Wang X, Liao F, Liu Z, Zhu J, Pugh K et al.. Neutrophil extracellular trap fragments stimulate innate immune responses that prevent lung transplant tolerance. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019. link 70 Takahashi T, Gauthier JM, Albertin EK, Damiano RJ, Patterson GA, Bierhals AJ et al.. Transplantation of Lungs Procured From a Donor With an Atrioesophageal Fistula. The Annals of thoracic surgery 2019. link 71 Van Herck A, Frick AE, Schaevers V, Vranckx A, Verbeken EK, Vanaudenaerde BM et al.. Azithromycin and early allograft function after lung transplantation: A randomized, controlled trial. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. link 72 Yamamoto H, Sugimoto S, Tanaka S, Kurosaki T, Otani S, Yamane M et al.. A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation. Surgery today 2019. link 73 Todd JL, Neely ML, Finlen Copeland CA, Frankel CW, Reynolds JM, Palmer SM. Prognostic significance of early pulmonary function changes after onset of chronic lung allograft dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2019. link 74 Cunningham PS, Maidstone R, Durrington HJ, Venkateswaran RV, Cypel M, Keshavjee S et al.. Incidence of primary graft dysfunction after lung transplantation is altered by timing of allograft implantation. Thorax 2019. link 75 Davis JW, Perry GJ, Chatterjee A. Complete white out of a single transplanted lung in the immediate postoperative period. Heart & lung : the journal of critical care 2019. link 76 Revilla-López E, Berastegui C, Sáez-Giménez B, Lopez-Meseguer M, Monforte V, Bravo C et al.. Lung Retransplantation Due to Chronic Lung Allograph Dysfunction: Results From a Spanish Transplant Unit. Archivos de bronconeumologia 2019. link 77 Loor G. EVLP: Ready for Prime Time?. Seminars in thoracic and cardiovascular surgery 2019. link 78 Tribble Md C. I Call That A Bargain. The heart surgery forum 2018. link 79 Hoetzenecker K, Schwarz S, Muckenhuber M, Benazzo A, Frommlet F, Schweiger T et al.. Intraoperative extracorporeal membrane oxygenation and the possibility of postoperative prolongation improve survival in bilateral lung transplantation. The Journal of thoracic and cardiovascular surgery 2018. link 80 Schnapper A, Christmann A, Knudsen L, Rahmanian P, Choi YH, Zeriouh M et al.. Stereological assessment of the blood-air barrier and the surfactant system after mesenchymal stem cell pretreatment in a porcine non-heart-beating donor model for lung transplantation. Journal of anatomy 2018. link 81 Mazo C, Borgatta B, Pont T, Sandiumenge A, Moyano S, Roman A et al.. Procalcitonin accurately predicts lung transplant adults with low risk of pulmonary graft dysfunction and intensive care mortality. Journal of critical care 2018. link 82 McCartney SL, Cooter M, Samad Z, Sivak J, Castleberry A, Gregory S et al.. Mitral Regurgitation After Orthotopic Lung Transplantation: Natural History and Impact on Outcomes. Journal of cardiothoracic and vascular anesthesia 2017. link 83 Xu Z, Sharma M, Gelman A, Hachem R, Mohanakumar T. Significant role for microRNA-21 affecting toll-like receptor pathway in primary graft dysfunction after human lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017. link 84 Abbas AA, Diamond JM, Chehoud C, Chang B, Kotzin JJ, Young JC et al.. The Perioperative Lung Transplant Virome: Torque Teno Viruses Are Elevated in Donor Lungs and Show Divergent Dynamics in Primary Graft Dysfunction. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017. link 85 Borders CF, Suzuki Y, Lasky J, Schaufler C, Mallem D, Lee J et al.. Massive donor transfusion potentially increases recipient mortality after lung transplantation. The Journal of thoracic and cardiovascular surgery 2017. link 86 Olland A, Reeb J, Puyraveau M, Hirschi S, Seitlinger J, Santelmo N et al.. Bronchial complications after lung transplantation are associated with primary lung graft dysfunction and surgical technique. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2017. link 87 Das De S, Nenekidis I, Itrakjy A, Mascaro J. Bilateral lung transplantation from a donor with previous aortic valve surgery. Asian cardiovascular & thoracic annals 2016. link 88 Jacob S, Courtwright A, El-Chemaly S, Racila E, Divo M, Burkett P et al.. Donor-acquired fat embolism syndrome after lung transplantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2016. link 89 Mizota T, Miyao M, Yamada T, Sato M, Aoyama A, Chen F et al.. Graft dysfunction immediately after reperfusion predicts short-term outcomes in living-donor lobar lung transplantation but not in cadaveric lung transplantation. Interactive cardiovascular and thoracic surgery 2016. link 90 Cottini SR, Ehlers UE, Pagnamenta A, Brandi G, Weder W, Schuepbach RA et al.. Pretransplant dyslipidaemia influences primary graft dysfunction after lung transplantation. Interactive cardiovascular and thoracic surgery 2016. link 91 Briot R, Gennai S, Maignan M, Souilamas R, Pison C. Ex vivo lung graft perfusion. Anaesthesia, critical care & pain medicine 2016. link 92 Meng C, Ma L, Liu J, Cui X, Liu R, Xing J et al.. Inflation with carbon monoxide in rat donor lung during cold ischemia phase ameliorates graft injury. Experimental biology and medicine (Maywood, N.J.) 2016. link 93 Riera J, Senna A, Cubero M, Roman A, Rello J. Primary Graft Dysfunction and Mortality Following Lung Transplantation: A Role for Proadrenomedullin Plasma Levels. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016. link 94 Wagner CE, Pope NH, Charles EJ, Huerter ME, Sharma AK, Salmon MD et al.. Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death. The Journal of thoracic and cardiovascular surgery 2016. link 95 DerHovanessian A, Weigt SS, Palchevskiy V, Shino MY, Sayah DM, Gregson AL et al.. The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2016. link 96 Mohamed MS. Translational Insights on Lung Transplantation: Learning from Immunology. Iranian journal of immunology : IJI 2015. link 97 Desmard M, Benbara A, Boudinet S, Mal H, Dehoux M, Thabut G et al.. Post-operative kinetics of procalcitonin after lung transplantation. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2015. link 98 Tian W, Liu Y, Zhang B, Dai X, Li G, Li X et al.. Infusion of mesenchymal stem cells protects lung transplants from cold ischemia-reperfusion injury in mice. Lung 2015. link 99 Miyamoto E, Chen F, Aoyama A, Sato M, Yamada T, Date H. Unilateral chronic lung allograft dysfunction is a characteristic of bilateral living-donor lobar lung transplantation. 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      Differential outcomes of ISHLT PGD 3 after ex-vivo lung perfusion compared to PGD 3 after direct transplantation.Benazzo A, Peel J, Mariscal A, Yeung J, Aversa M, Keshavjee S et al. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation (2026)
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      Targeting the proline-glycine-proline-protease feed-forward loop attenuates primary graft dysfunction after lung transplantation.Goda Y, Lee S, Chawda A, Xu X, Khan MM, Do GV et al. Frontiers in immunology (2026)
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