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Corticosteroid-induced neutrophilia

Last edited: 4/15/2026

Overview

Corticosteroid-induced neutrophilia refers to an increase in neutrophil count observed during corticosteroid therapy, often associated with the drug's immunomodulatory effects but not extensively detailed in psychiatric-focused literature provided 1.

Diagnosis

  • Elevated neutrophil count on complete blood count (CBC) 1.
  • No specific diagnostic criteria outlined; clinical context and temporal relationship with corticosteroid initiation/dose adjustment are crucial 1.

    • Management

  • Discontinue or taper corticosteroid dose if neutrophilia is suspected to be drug-induced 1.
  • Monitor CBC regularly during corticosteroid therapy to detect changes 1.
  • No specific adjunctive treatments mentioned for neutrophilia alone 1.

    • Special Populations

  • No specific guidance provided for pregnancy, pediatrics, elderly, or comorbid conditions in the given abstracts 1.

    • Key Recommendations

  • Monitor complete blood counts regularly in patients on corticosteroids to detect neutrophilia early (Evidence: Expert opinion 1).
  • Consider tapering or discontinuing corticosteroids if neutrophilia is observed and suspected to be drug-related (Evidence: Expert opinion 1).
  • Further research is needed to establish definitive diagnostic criteria and treatment protocols for corticosteroid-induced neutrophilia (Evidence: Weak 1).

    • References

    1 Ismail K, Wessely S. Psychiatric complications of corticosteroid therapy. British journal of hospital medicine 1995. link

    Original source

    1. [1]
      Psychiatric complications of corticosteroid therapy. — Ismail K, Wessely S British journal of hospital medicine (1995)
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