Overview
Pulmonary transfusion reactions encompass acute respiratory distress following blood transfusions, often due to immune-mediated or non-immune mediated causes such as transfusion-related acute lung injury (TRALI) or allergic reactions.Diagnosis
Management
Special Populations
Key Recommendations
References
1 Pasko B, Halls J, Phou S. The Role of Artificial Intelligence in Transfusion Medicine. Clinics in laboratory medicine 2026. link 2 Al-Riyami AZ, Rexer K, Masters K, Gammon R. Use of artificial intelligence in transfusion medicine practice, education and research: A mixed methodology study. Vox sanguinis 2026. link 3 Turki AT, Brieske CM, Gurkan UA, Scheidler KM, Usta OB, Turkulainen E et al.. Fundamentals of big data and artificial intelligence in transfusion medicine. Vox sanguinis 2026. link 4 Kvržić Z. Milestones in history of transfusion medicine. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2026. link 5 Al-Riyami AZ, Herjes S. Use of artificial intelligence and big data in transfusion medicine: An exploratory assessment of status in the Eastern Mediterranean and North Africa region. Vox sanguinis 2026. link 6 Seheult JN, Malone JR, Jackson BR, Malik MM, Yazer M. Ethical dilemmas in the use of artificial intelligence in transfusion medicine. Vox sanguinis 2026. link 7 Srivastava P, Tewari A, Al-Riyami AZ. Artificial intelligence chatbots in transfusion medicine: A cross-sectional study. Vox sanguinis 2026. link 8 Lee JK, Park S, Hwang SH, Lee J, Cho D, Choi S. Comparative evaluation of six large language models in transfusion medicine: Addressing language and domain-specific challenges. Vox sanguinis 2026. link 9 Zuna I, Lin Y, Haspel R, Walsh CM, Bone JN, Kapitany C et al.. Development and validation of a pediatric transfusion medicine education assessment tool. Transfusion 2026. link 10 Cheng F, Wang L, Han B, Chen C, Tan J, Luo Z et al.. A Study on the Effectiveness and Influencing Factors of a Fellowship Training Program in Transfusion Medicine: a Prospective Cohort Analysis. Clinical laboratory 2025. link 11 Lin F, He X, Zhang H, Huang Y. Forecasting emerging trends in transfusion medicine through complex network analysis of scholars' research. Vox sanguinis 2025. link 12 Chopra A, Shastry S, Mohan G, Chenna D, Rajendran V. A Comprehensive SWOT and TOWS analysis of transfusion medicine: Indian Perspective. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2025. link 13 Li N, Lewin A, Ning S, Waito M, Zeller MP, Tinmouth A et al.. Privacy-preserving federated data access and federated learning: Improved data sharing and AI model development in transfusion medicine. Transfusion 2025. link 14 Sibinga CTS. Education in transfusion medicine - What is preferred?. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2025. link 15 McGowan EC, Lewin A, Ou-Yang J, Mandal S, Almozain N, Ambaye AB et al.. Engaging with young professionals in transfusion medicine: Insights from a needs assessment survey targeting an international cohort. Vox sanguinis 2025. link 16 Gupta A, Dhawan HK, Jain R, Sharma RR, Kaushal V, Singh A et al.. Development and validation of an indigenous questionnaire for assessing clinician's knowledge towards transfusion medicine and bedside transfusion practices. Transfusion medicine (Oxford, England) 2025. link 17 Li N, Goel R, Raza S, Riazi K, Pan J, Nguyen HQ et al.. Artificial Intelligence and Machine Learning in Transfusion Practice: An Analytical Assessment. Transfusion medicine reviews 2025. link 18 Raturi M, Dhiman Y, Bansal N, Khatiwada B, Gaur DS, Rawat P. Designing and assessing the impact of a competency-based training program in transfusion medicine among MBBS interns. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2025. link 19 Razaghpoor A, Taheri-Ezbarami Z, Jafaraghaee F, Maroufizadeh S, Falakdami A. The effect of serious game and problem-based learning on nursing students' knowledge and clinical decision-making skill regarding the application of transfusion medicine in pediatric nursing. Journal of pediatric nursing 2024. link 20 King A, Arroyos GB, Cellier N, Durgacharan S, Kerr M, Larrea L et al.. Connectivity in transfusion medicine: Challenges, benefits, and goals. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2024. link 21 Allen ES, Perez-Alvarez I, Woo JS, Stephens LD. How do we design a laboratory space for a hospital transfusion medicine service?. Transfusion 2024. link 22 Harrold IM. Transfusion Medicine Rotations for Pathology Residents: Structure, Resources, and Milestones. Archives of pathology & laboratory medicine 2024. link 23 Raza S, Jacobs JW, Booth GS, Callum J. Pitfalls of reasoning in hospital-based transfusion medicine. Transfusion medicine (Oxford, England) 2024. link 24 Arthur CM, Hollenhorst M, Wu SC, Jajosky R, Nakahara H, Jan HM et al.. ABO blood groups and galectins: Implications in transfusion medicine and innate immunity. Seminars in immunology 2024. link 25 Al-Riyami AZ, Jensen K, So-Osman C, Saxon B, Rahimi-Levene N, Das S et al.. E-learning in transfusion medicine: An exploratory qualitative assessment. Vox sanguinis 2024. link 26 Anstey C, Ullman D, Su L, Su C, Siniard C, Simmons S et al.. The practical use of artificial intelligence in Transfusion Medicine and Apheresis. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2024. link 27 Aggarwal A, Kaushik K, Morton S, Danaee A, Gurung K, Robinson S et al.. Transfusion Camp: The UK experience and its value in improving knowledge of transfusion medicine among postgraduate trainees. Transfusion medicine (Oxford, England) 2024. link 28 Ipe TS, Tanhehco YC, Booth GS, Adkins BD. Gender differences in scholarly productivity of early-career transfusion medicine physicians. Vox sanguinis 2024. link 29 Rahmani M, Chargé S, Bodnar M, Callum J, Hsia C, Lavoie M et al.. Current state of undergraduate medical school training in transfusion medicine and its impact on postgraduate trainee knowledge. Transfusion 2024. link 30 Badawi MA, Hussain HO, Badawi MA, Al Shawwa LA, Jamjoom RA, Park YS et al.. Learning transfusion medicine through scoring objective structured clinical examination. Transfusion 2023. link 31 Shmookler AD, AlMozain N, Hermelin D, Kreuter JD. How to begin using social media for transfusion medicine education. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2023. link 32 Wardrop KJ, Davidow EB. Laboratory Testing in Transfusion Medicine. The Veterinary clinics of North America. Small animal practice 2023. link 33 Miller YM, Bakhtary S, Chou ST, Hailu B, Reik RA, Richard RH et al.. Involvement of Diverse Populations in Transfusion Medicine Research. Transfusion medicine reviews 2023. link 34 Hurley NC, Schroeder KM, Hess AS. Would doctors dream of electric blood bankers? Large language model-based artificial intelligence performs well in many aspects of transfusion medicine. Transfusion 2023. link 35 Skelton T, Nizeyimana F, Pendergrast J, Hagumimana J, Masaisa F, Kanyamuhunga A et al.. Transfusion medicine education delivery in Rwanda: Adapting Transfusion Camp to a resource-limited setting. Transfusion 2023. link 36 Metcalf RA, Cohn CS, Bakhtary S, Gniadek T, Gupta G, Harm S et al.. Current advances in 2022: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee. Transfusion 2023. link 37 Custer B, Bloch EM, Bryant BJ, D'Alessandro A, Delaney M, Goel R et al.. Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium. Transfusion 2023. link 38 Ipe TS, Eichbaum Q, El-Ekiaby M, Owusu-Ofori S, Vermeulen M, Mapako T et al.. Transfusion medicine research in Africa: Insights from investigators in the field. Vox sanguinis 2023. link 39 Brunetta DM, Carvalho L, Barbosa S, Santos F, Barroso K, Carneiro-Silva F et al.. The use of social media as a tool for patient blood management and transfusion medicine education. Vox sanguinis 2022. link 40 Al-Riyami AZ, Peterson D, Vanden Broeck J, Das S, Saxon B, Lin Y et al.. E-learning/online education in transfusion medicine: A cross-sectional international survey. Transfusion medicine (Oxford, England) 2022. link 41 Odunayo A, Nash KJ, Davidow EB, Blois SL, Goy-Thollot I, Harris L et al.. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) transfusion reaction small animal consensus statement (TRACS). Part 3: Diagnosis and treatment. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 2021. link 42 Schneider T, Jackups R. Transfusion Medicine Informatics: A Review of Current Practice and a Glimpse into the Future. Clinics in laboratory medicine 2021. link 43 Wheeler AP, Delaney M, Fung M, Gorlin J, Kutner JM, Lam JCM et al.. Pediatric resident knowledge of transfusion medicine: Results from the BEST-TEST3 international education needs assessment. Transfusion 2021. link 44 Davidow EB, Blois SL, Goy-Thollot I, Harris L, Humm K, Musulin S et al.. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS). Part 1: Definitions and clinical signs. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 2021. link 45 Al-Riyami AZ, Louw VJ, Indrikovs AJ, Nedelcu E, Bakhtary S, Eichbaum QG et al.. Global survey of transfusion medicine curricula in medical schools: Challenges and opportunities. Transfusion 2021. link 46 Smit Sibinga CT, Louw VJ, Nedelcu E, Al-Riyami AZ, Bakhtary S, Johnson ST et al.. Modeling global transfusion medicine education. Transfusion 2021. link 47 Davidow EB, Blois SL, Goy-Thollot I, Harris L, Humm K, Musulin S et al.. Association of Veterinary Hematology and Transfusion Medicine (AVHTM) Transfusion Reaction Small Animal Consensus Statement (TRACS) Part 2: Prevention and monitoring. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 2021. link 48 Ipe TS, Goel R, Howes L, Bakhtary S. The impact of COVID-19 on academic productivity by female physicians and researchers in transfusion medicine. Transfusion 2021. link 49 Rambiritch V, Vermeulen M, Bell H, Knox P, Nedelcu E, Al-Riyami AZ et al.. Transfusion medicine and blood banking education and training for blood establishment laboratory staff: A review of selected countries in Africa. Transfusion 2021. link 50 Peedin AR, Genzen JR, Karp JK. Correlating Transfusion Medicine In-Service Examination Scores With Outcomes of the American Board of Pathology Transfusion Medicine Subspecialty Certifying Examination. American journal of clinical pathology 2020. link 51 Byrne KM, Paige TD, Flegel WA. An outcome-based review of an accredited Specialist in Blood Banking (SBB) program: 25 years and counting. Immunohematology 2020. link 52 Ait Bouchrim SA, Haddad A, Bou Assi T, Oriol P, Guyotat D, Bois C et al.. Residents' knowledge in transfusion medicine and educational programs: A pilot study. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine 2020. link 53 Jajosky RP, Jajosky AN, Jajosky PG. Pathology's historic 2019 incoming residents: Why "the internationalization of pathology" may markedly advance transfusion medicine and cellular therapeutics. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2020. link 54 Ju JY, Wehrli G. The effect of entrustable professional activities on pathology resident confidence in blood banking/transfusion medicine. Transfusion 2020. link 55 Hauser RG, Kwon RJ, Ryder A, Cheng C, Charifa A, Tormey C. Transfusion Medicine Equations Made Internet Accessible. Transfusion medicine reviews 2020. link 56 Sullivan HC, Stowell SR, Meyer EK, Duncan AD, Guarner J. Development, Implementation, and Evaluation of a Fourth-Year Medical School Elective Course in Blood Banking and Transfusion Medicine. American journal of clinical pathology 2019. link 57 Lin Y, Tilokee E, Chargé S, Alam A, Cserti-Gazdewich C, Lau W et al.. Transfusion Camp: a prospective evaluation of a transfusion education program for multispecialty postgraduate trainees. Transfusion 2019. link 58 Pagano MB, Dunbar NM, Tinmouth A, Apelseth TO, Lozano M, Cohn CS et al.. A methodological review of the quality of reporting of surveys in transfusion medicine. Transfusion 2018. link 59 Garraud O, Brand A, Henschler R, Vuk T, Haddad A, Lozano M et al.. Medical student education in transfusion medicine: Proposal from the "European and Mediterranean initiative in transfusion medicine". Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2018. link 60 Algora M, Grabski G, Batac-Castro AL, Gibbs J, Chada N, Humieda S et al.. Challenges in Establishing a Transfusion Medicine Service: The Cleveland Clinic Abu Dhabi Experience. Archives of pathology & laboratory medicine 2018. link 61 Webb C, Norris A, Hands K. An acute transfusion reaction. Clinical medicine (London, England) 2018. link 62 Lin Y, Haspel RL. Transfusion medicine education for non-transfusion medicine physicians: a structured review. Vox sanguinis 2017. link 63 Kumarage S, Fernando R, Gunasekara L. A Survey of Knowledge and Practices of Transfusion Medicine Among Post Intern Doctors in Specialized Hospital in Sri Lanka. Laboratory medicine 2017. link 64 Romon I, Lozano M. Quality indicators for Transfusion Medicine in Spain: a survey among hospital transfusion services. Blood transfusion = Trasfusione del sangue 2017. link 65 Reese EM, Nelson RC, Flegel WA, Byrne KM, Booth GS. Critical Value Reporting in Transfusion Medicine: A Survey of Communication Practices in US Facilities. American journal of clinical pathology 2017. link 66 Li T, Wang W, Zhang L, Zhou Y, Lai F, Fu Y et al.. Designing and Implementing a 5-Year Transfusion Medicine Diploma Program in China. Transfusion medicine reviews 2017. link 67 Javadzadeh Shahshahani H. Status of Transfusion Medicine Education in Iran. Archives of Iranian medicine 2016. link 68 Zeller MP, Sherbino J, Whitman L, Skeate R, Arnold DM. Design and Implementation of a Competency-Based Transfusion Medicine Training Program in Canada. Transfusion medicine reviews 2016. link 69 Goodnough LT, Murphy MF. How I train specialists in transfusion medicine. Transfusion 2016. link 70 Zaffuto BJ, Conley GW, Connolly GC, Henrichs KF, Francis CW, Heal JM et al.. ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion. Vox sanguinis 2016. link 71 Coustasse A, Cunningham B, Deslich S, Willson E, Meadows P. Benefits and Barriers of Implementation and Utilization of Radio-Frequency Identification (RFID) Systems in Transfusion Medicine. Perspectives in health information management 2015. link 72 Morgan S, Rioux-Masse B, Oancea C, Cohn C, Harmon J, Konia M. Simulation-based education for transfusion medicine. Transfusion 2015. link 73 Haspel RL, Lin Y, Mallick R, Tinmouth A, Cid J, Eichler H et al.. Internal medicine resident knowledge of transfusion medicine: results from the BEST-TEST international education needs assessment. Transfusion 2015. link 74 Kennedy DJ, Schneider B, Smuck M, Plastaras CT. The use of moderate sedation for the secondary prevention of adverse vasovagal reactions. Pain medicine (Malden, Mass.) 2015. link 75 Eichbaum Q, Shan H, Goncalez TT, Duits AJ, Knox P, Reilly J et al.. Global health and transfusion medicine: education and training in developing countries. Transfusion 2014. link 76 Karim F, Moiz B, Shamsuddin N, Naz S, Khurshid M. Root cause analysis of non-infectious transfusion complications and the lessons learnt. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2014. link 77 Haspel RL, Lin Y, Fisher P, Ali A, Parks E. Development of a validated exam to assess physician transfusion medicine knowledge. Transfusion 2014. link 78 Louw VJ, Nel MM, Hay JF. Factors affecting the current status of transfusion medicine education in South Africa. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2013. link 79 Louw VJ, Nel MM, Hay JF. Postgraduate education in transfusion medicine in the absence of formal residency training: assessment of factors needed to develop and sustain a postgraduate diploma program. Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis 2013. link 80 Haspel RL. Implementation and assessment of a resident curriculum in evidence-based transfusion medicine. Archives of pathology & laboratory medicine 2010. link 81 Butch SH. Automation in the transfusion service. Immunohematology 2008. link 82 Huestis DW. Alexander Bogdanov: the forgotten pioneer of blood transfusion. Transfusion medicine reviews 2007. link 83 Wu Y, Tormey C, Stack G. Resident and fellow training in transfusion medicine. Clinics in laboratory medicine 2007. link 84 Hathaway EO. Changing educational paradigms in transfusion medicine and cellular therapies: development of a profession. Transfusion 2005. link 85 Eisenstaedt RS, Glanz K, Polansky M. Resident education in transfusion medicine: a multi-institutional needs assessment. Transfusion 1988. link 86 Moyes DG, Miller MT, Blumberg L. Mismatched blood transfusion. A case report. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 1985. link 87 Milner LV, Butcher K. Transfusion reactions reported after transfusions of red blood cells and of whole blood. Transfusion 1978. link 88 Black WA, Pollock A, Batchelor EL. Fatal transfusion reaction due to Serratia marcescens. Journal of clinical pathology 1967. link