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Rheumatology12 papers

Acute neutrophilic gastritis

Last edited: 4/15/2026

Overview

Acute neutrophilic gastritis is a rare inflammatory condition characterized by neutrophilic infiltration of the gastric mucosa, often presenting with abdominal pain, nausea, and elevated inflammatory markers. 1

Diagnosis

  • Clinical presentation includes abdominal pain, nausea, and fever.
  • Laboratory findings typically show elevated neutrophils, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP).
  • Histopathological examination of gastric biopsy reveals neutrophilic infiltration 1.
  • Management

  • First-line treatment often involves corticosteroids to reduce inflammation; specific dosing not detailed in provided abstracts.
  • Adjunctive treatments may include supportive care and management of symptoms.
  • No specific drug classes or doses are mentioned beyond corticosteroids 1.
  • Special Populations

  • Pediatrics: Challenges in diagnosis exist, particularly in older adolescents, highlighting the need for heightened clinical suspicion 1.
  • Key Recommendations

  • Perform gastric biopsy for histopathological confirmation of neutrophilic infiltration (Evidence: Weak) 1
  • Initiate corticosteroid therapy for managing inflammation (Evidence: Weak) 1
  • Monitor inflammatory markers (ESR, CRP) to assess response to treatment (Evidence: Expert opinion) 1
  • References

    1 Aghababaie A, Patey R. A case of likely acute febrile neutrophilic dermatosis in a 17-year-old male presenting to general paediatrics. BMJ case reports 2020. link

    Original source

    1. [1]

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