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Infectious Disease2 papers

Gastrointestinal anastomotic dehiscence

Last edited: 4/10/2026

Overview

Gastrointestinal anastomotic dehiscence, particularly after rectal resection, is a major contributor to surgical morbidity and mortality 1. The role of mechanical and oral antibiotic bowel preparation (MOABP) in preventing complications of rectal resection is currently disputed 1.

Management

  • Patients undergoing elective rectal resection with primary anastomosis typically receive intravenous antibiotics approximately 30 minutes before surgery 1.
  • Mechanical bowel preparation (MBP) with or without oral antibiotics (neomycin and metronidazole) is an intervention being investigated for its potential to reduce overall complications and surgical site infections, including anastomotic dehiscence, after elective rectal resection 1.

    • References

    1 Koskenvuo L, Lunkka P, Varpe P, Hyöty M, Satokari R, Haapamäki C et al.. Morbidity After Mechanical Bowel Preparation and Oral Antibiotics Prior to Rectal Resection: The MOBILE2 Randomized Clinical Trial. JAMA surgery 2024. link

    Original source

    1. [1]
      Morbidity After Mechanical Bowel Preparation and Oral Antibiotics Prior to Rectal Resection: The MOBILE2 Randomized Clinical Trial. — Koskenvuo L, Lunkka P, Varpe P, Hyöty M, Satokari R, Haapamäki C et al. JAMA surgery (2024)
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