Overview
Cyclosporine A (Cyc-A) is an immunosuppressive agent initially used for solid organ transplant recipients and graft-versus-host disease 1. While systemic administration carries risks, topical formulations are being explored for mucocutaneous disorders 1.Diagnosis
Management
Topical Cyc-A is an effective treatment for oral lichen planus, psoriasis, burning mouth syndrome, pyoderma gangrenosum, and Zoon's balanitis 1.
Adverse effects of Cyc-A mouthwash include dysphagia, burning sensation, lip swelling, and gastrointestinal upset 1.
Adverse effects of Cyc-A lipogel include mild erythema, dryness, and skin fissuring 1.Special Populations
Key Recommendations
Topical Cyc-A is a viable alternative to traditional treatment regimens for immune-mediated mucocutaneous conditions 1. (Evidence: Moderate)
Topical Cyc-A mouthwash may cause dysphagia, burning sensation, lip swelling, and gastrointestinal upset 1. (Evidence: Moderate)
Topical Cyc-A lipogel may cause mild erythema, dryness, and skin fissuring 1. (Evidence: Moderate)References
1 Sadeghi S, Kalantari Y, Seirafianpour F, Goodarzi A. A systematic review of the efficacy and safety of topical cyclosporine in dermatology. Dermatologic therapy 2022. link