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Endocrinology13 papers

Maturity onset diabetes of the young, type 2

Last edited: 4/10/2026

Overview

Maturity onset diabetes of the young, type 2 (MODY2) is a form of diabetes resulting from genetic, environmental, and metabolic causes that vary among individuals and populations 1. It is a subtype of youth-onset type 2 diabetes (T2D) 1.

Diagnosis

  • Diagnostic algorithm for youth with new onset T2D is available 1.
  • Management

  • Updates include algorithms and tables for treatment, management, and assessment of comorbidities and complications 1.
  • Recommendations on recently approved pharmacologic therapies for youth-onset T2D are included 1.
  • Special Populations

  • This summary builds on the 2022 ISPAD guidelines for T2D in children and adolescents 1.
  • Key Recommendations

  • Management strategies for youth-onset T2D are updated 1. (Evidence: Expert opinion)
  • Diagnostic algorithms for youth with new onset T2D are provided 1. (Evidence: Expert opinion)
  • Treatment, management, and assessment of comorbidities and complications for youth-onset T2D are detailed 1. (Evidence: Expert opinion)
  • References

    1 Shah AS, Barrientos-Pérez M, Chang N, Fu JF, Hannon TS, Kelsey M et al.. ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents. Hormone research in paediatrics 2024. link

    Original source

    1. [1]
      ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Shah AS, Barrientos-Pérez M, Chang N, Fu JF, Hannon TS, Kelsey M et al. Hormone research in paediatrics (2024)

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