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Dermatology9 papers

Malignant acanthosis nigricans

Last edited: 4/15/2026

Overview

Malignant acanthosis nigricans is a severe, rapidly progressing form of acanthosis nigricans characterized by hyperpigmented, velvety thickening of the skin, often associated with underlying malignancies 1.

Diagnosis

  • Clinical appearance of hyperpigmented, velvety skin thickening
  • Presence of underlying malignancy strongly suspected 1
  • Biopsy may confirm histopathological features 1
  • No specific grading system universally accepted 1

    • Management

  • Identification and treatment of underlying malignancy is paramount 1
  • Dermatologic interventions may include topical retinoids or corticosteroids for symptomatic relief 1
  • No specific drug doses mentioned for malignant acanthosis nigricans 1

    • Special Populations

  • No specific guidance provided for pregnancy, pediatrics, elderly, or comorbidities in the given abstracts 1

    • Key Recommendations

  • Prioritize thorough investigation for and treatment of any underlying malignancy in patients with malignant acanthosis nigricans (Evidence: Strong 1)
  • Consider dermatologic management with topical agents for symptomatic improvement (Evidence: Moderate 1)
  • Monitor and manage comorbidities as they arise, though specific guidelines are lacking (Evidence: Expert opinion 1)

    • References

    1 Williams DS. Acanthosis nigricans. Journal of insurance medicine (New York, N.Y.) 2005. link

    Original source

    1. [1]
      Acanthosis nigricans. — Williams DS Journal of insurance medicine (New York, N.Y.) (2005)
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