Overview
Acute leukemia encompasses rapidly progressing hematologic malignancies, primarily acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), characterized by the accumulation of immature leukocytes in the bone marrow, leading to impaired hematopoiesis and systemic complications. 39Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 187 indexed papers.
1 Veneziano-Broccia M, Michel G, Dalle JH, Deleuze JF, Olaso R, Munsch G et al.. Genomics of Long-Term Complications of Childhood Leukemia: Rationale and Design of the GenLEA Study. Pediatric blood & cancer 2026. link 2 Alsuliman T, De Lima Prata PH, Musiu P, Stocker N, Garidi R, Alrstom A et al.. Central line-associated thrombosis and infections in patients with acute leukemias: The chicken or the egg dilemma. Thrombosis research 2026. link 3 Pourhassan H, Kareem W, Agrawal V, Aldoss I. Important Considerations in the Intensive Care Management of Acute Leukemias. Journal of intensive care medicine 2024. link 4 Ligia S, Morano SG, Kaiser F, Micozzi A, Chistolini A, Barberi W et al.. Peripherally inserted central venous catheter for pediatric acute leukemia: A retrospective 11-year single-center experience. The journal of vascular access 2024. link 5 Wiemers H, Burchert A, Michel C, Sohlbach K, Schäfer J, Neubauer A et al.. Prospective Assessment of Treatment-Induced Liver Injury as a Cause of Diffuse Pathologic Hepatic Enhancement in Contrast-Enhanced Ultrasound. Ultrasound in medicine & biology 2024. link 6 Mohammad Khuzaini A, Mohd Baharudin JA, Md Fauzi A, Zulkeflee HA, Abdul Halim H, Mazli SK et al.. Tumour lysis syndrome in a neonate with transient abnormal myelopoiesis. Journal of neonatal-perinatal medicine 2024. link 7 Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E et al.. Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis. Nutrients 2023. link 8 Fan YX, Chen LR, Gan RX, Yin SJ, Wang P, Meng R et al.. A meta-analysis of associations of IL-10 gene polymorphisms with acute leukemia susceptibility. Cytokine 2023. link 9 Varabyeva A, Lo CP, Brancaccio A, Perissinotti AJ, Patel T, Sandison K et al.. Impact of number of lumens in central-venous catheters on central-line bloodstream infection (CLABSI) and venous thromboembolism (VTE) risk in patients with acute leukemia. Infection control and hospital epidemiology 2023. link 10 Cueto-Robledo G, Cueto-Romero HD, Carrillo-Rocha DL, Roldan-Valadez E. Review of Acute Leukemia as a New Cause of Dual Thrombosis (Pulmonary Vein Thrombosis and Pulmonary Embolism). Current problems in cardiology 2023. link 11 Chu Q, Wei W, Lao H, Li Y, Tan Y, Wei X et al.. Machine learning algorithms for integrating clinical features to predict intracranial hemorrhage in patients with acute leukemia. The International journal of neuroscience 2023. link 12 Tarlock K, Sulis ML, Chewning JH, Pollard JA, Cooper T, Gamis A et al.. Hematopoietic Cell Transplantation in the Treatment of Pediatric Acute Myelogenous Leukemia and Myelodysplastic Syndromes: Guidelines from the American Society of Transplantation and Cellular Therapy. Transplantation and cellular therapy 2022. link 13 Frater JL, Shirai CL, Brestoff JR. Technological features of blast identification in the cerebrospinal fluid: A systematic review of flow cytometry and laboratory haematology methods. International journal of laboratory hematology 2022. link 14 Meng FX, Yang X, Li ML. Shenqi Fuzheng Injection () Combined with Chemotherapy for Acute Leukemia: A Meta-Analysis. Chinese journal of integrative medicine 2022. link 15 Salas S, Pauly V, Damge M, Orleans V, Fond G, Costello R et al.. Intensive end-of-life care in acute leukemia from a French national hospital database study (2017-2018). BMC palliative care 2022. link 16 Baig MU, Madden K, Moody K. Hyponatremia with Antidepressant: A Rare Side Effect from Duloxetine in a Child with Acute Leukemia. Journal of palliative medicine 2022. link 17 Banerjee R, Lo M, Klein L, Aras M, Logan AC. Anthracyclines in a patient with acute leukemia and severe cardiomyopathy requiring mechanical support: A case report. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 2022. link 18 Bazarbachi AH, Al Hamed R, Labopin M, Halaburda K, Labussiere H, Bernasconi P et al.. Underdiagnosed veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) as a major cause of multi-organ failure in acute leukemia transplant patients: an analysis from the EBMT Acute Leukemia Working Party. Bone marrow transplantation 2021. link 19 Scott BL. Allogeneic stem cell transplantation for high-risk acute leukemia and maintenance therapy: no time to waste. Blood advances 2020. link 20 Soiffer RJ. Maintenance therapy for high-risk acute leukemia after allogeneic hematopoietic cell transplantation: wait a minute. Blood advances 2020. link 21 Alsaid HM, Wahdan AAM, Tahboub IN, Almakadma NM. Hemophagocytic Lymphohistiocytosis and Relapsing Polychondritis with Acute Myelogenous Leukemia: Case Report and Review of the Literature. The American journal of case reports 2020. link 22 Nixon S, Lieberman L, Atenafu EG, Doherty M, Murray C, Wolfe A et al.. Clinical outcomes and transfusion management following intracranial hemorrhage in patients with acute leukemia. Transfusion 2020. link 23 Niscola P, Tendas A, Mazzone C, Efficace F. Pain and related complaints in patients with acute leukemia: time for simultaneous care in hemato-oncology. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019. link 24 Durand M, Lacaria K, Sidsworth M, Davis MK, Sanford D. Management of cardiovascular health in acute leukemia: a national survey. Leukemia & lymphoma 2019. link 25 de Haas V, Ismaila N, Advani A, Arber DA, Dabney RS, Patel-Donelly D et al.. Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019. link 26 Leprêtre P, Clavier T, Ménard AL, Grange S, Girault C, Boyer D. Rescue stem cell allograft in intensive care unit patients during septic shock with multi-organ failure. Journal of critical care 2019. link 27 Shaulov A, Rodin G, Popovic G, Caraiscos VB, Le LW, Rydall A et al.. Pain in patients with newly diagnosed or relapsed acute leukemia. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 2019. link 28 Chellapandian D, Pole JD, Nathan PC, Sung L. Congestive heart failure among children with acute leukemia: a population-based matched cohort study. Leukemia & lymphoma 2019. link 29 Corella Aznar EG, Ayerza Casas A, Carboné Bañeres A, Calvo Escribano MÁC, Labarta Aizpún JI, Samper Villagrasa P. Quality of life and chronic health conditions in childhood acute leukaemia survivors. Medicina clinica 2019. link 30 Carnevale ML, Phair J, Yau P, Garg K. Blast Cell Arterial Embolus in Acute Myelogenous Leukemia. Annals of vascular surgery 2019. link 31 Rodin G, Deckert A, Tong E, Le LW, Rydall A, Schimmer A et al.. Traumatic stress in patients with acute leukemia: A prospective cohort study. Psycho-oncology 2018. link 32 Girard S, Fenneteau O, Mestrallet F, Troussard X, Lesesve JF. Recommendations for cerebrospinal fluid examination in acute leukemia. Annales de biologie clinique 2017. link 33 Arber DA, Borowitz MJ, Cessna M, Etzell J, Foucar K, Hasserjian RP et al.. Initial Diagnostic Workup of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology. Archives of pathology & laboratory medicine 2017. link 34 George TI, Tworek JA, Thomas NE, Fatheree LA, Souers RJ, Nakhleh RE et al.. Evaluation of Testing of Acute Leukemia Samples: Survey Result From the College of American Pathologists. Archives of pathology & laboratory medicine 2017. link 35 Koroglu M, Erkurt MA, Kuku I, Kaya E, Berber I, Nizam I et al.. Assessing Safety of Pneumatic Tube System (PTS) for Patients with Very Low Hematologic Parameters. Medical science monitor : international medical journal of experimental and clinical research 2016. link 36 Piao Z, Kim HJ, Choi JY, Hong CR, Lee JW, Kang HJ et al.. Effect of FOXP3 polymorphism on the clinical outcomes after allogeneic hematopoietic stem cell transplantation in pediatric acute leukemia patients. International immunopharmacology 2016. link 37 Maldonado J, Lopez Candales A. High Output Cardiac Failure in a Patient Presenting with Acute Myeloid Leukemia and Leukostasis. Boletin de la Asociacion Medica de Puerto Rico 2016. link 38 Vu K, Luong NV, Hubbard J, Zalpour A, Faderl S, Thomas DA et al.. A retrospective study of venous thromboembolism in acute leukemia patients treated at the University of Texas MD Anderson Cancer Center. Cancer medicine 2015. link 39 Rose-Inman H, Kuehl D. Acute leukemia. Emergency medicine clinics of North America 2014. link 40 Elliot K, Tooze JA, Geller R, Powell BL, Pardee TS, Ritchie E et al.. The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML). Leukemia research 2014. link 41 Skou AS, Tranebjærg L, Jensen T, Hasle H. Mitochondrial 12S ribosomal RNA A1555G mutation associated with cardiomyopathy and hearing loss following high-dose chemotherapy and repeated aminoglycoside exposure. The Journal of pediatrics 2014. link 42 Zimmermann C, Yuen D, Mischitelle A, Minden MD, Brandwein JM, Schimmer A et al.. Symptom burden and supportive care in patients with acute leukemia. Leukemia research 2013. link 43 Rodin G, Yuen D, Mischitelle A, Minden MD, Brandwein J, Schimmer A et al.. Traumatic stress in acute leukemia. Psycho-oncology 2013. link 44 Collado C, Medina L, Zorraquino A, Baeza T, Ferrer C, Plazas J et al.. Cutaneous fusariosis by a species of the Fusarium dimerum species complex in a patient with acute myeloblastic leukemia. Revista iberoamericana de micologia 2013. link 45 Ruvolo PP. The Herculean task of killing cancer cells: suppression of FOXO3A in acute leukemia involves a hydra of multiple survival kinases. Cell cycle (Georgetown, Tex.) 2012. link 46 Kim JE, Kim BR, Woo KS, Han JY. Evaluation of the leukocyte differential on a new automated flow cytometry hematology analyzer. International journal of laboratory hematology 2012. link 47 Björklund E, Matinlauri I, Tierens A, Axelsson S, Forestier E, Jacobsson S et al.. Quality control of flow cytometry data analysis for evaluation of minimal residual disease in bone marrow from acute leukemia patients during treatment. Journal of pediatric hematology/oncology 2009. link 48 Ku GH, White RH, Chew HK, Harvey DJ, Zhou H, Wun T. Venous thromboembolism in patients with acute leukemia: incidence, risk factors, and effect on survival. Blood 2009. link 49 Mignano JE, Chan MD, Rosenwald IB, Kimmelstiel CD, Wolfe LC. Intracardiac chloroma. Journal of pediatric hematology/oncology 2009. link 50 Erdur B, Yilmaz S, Oren H, Demircioğlu F, Cakmakç H, Irken G. Evaluating pulmonary complications in childhood acute leukemias. Journal of pediatric hematology/oncology 2008. link 51 Park HY, Suh GY, Jeon K, Koh WJ, Chung MP, Kim H et al.. Outcome and prognostic factors of patients with acute leukemia admitted to the intensive care unit for septic shock. Leukemia & lymphoma 2008. link 52 Chakraborty A, Wells R, Doherty M, Huynh C, Selby D. Joint pain in AML: successful pain control with radiotherapy. Journal of pain and symptom management 2008. link 53 Tso AC, Olavarria E, Matutes E, Bain BJ. Case 33. Diagnostic difficulty in a patient with acute leukemia. Leukemia & lymphoma 2007. link 54 Lam WA, Rosenbluth MJ, Fletcher DA. Chemotherapy exposure increases leukemia cell stiffness. Blood 2007. link 55 Horacek JM, Pudil R, Jebavy L, Tichy M, Zak P, Maly J. Assessment of anthracycline-induced cardiotoxicity with biochemical markers. Experimental oncology 2007. link 56 Satoh N, Takenouchi S, Hashimoto S, Fujiwara M, Koike T. Switching of donor cells after urgent second cord blood transplantation for suspected graft failure. International journal of hematology 2007. link 57 Reisch N, Roehnisch T, Sadeghi M, Greiner L, Regenbogen C, Rieger J et al.. AML M1 presenting with recurrent acute large arterial vessel thromboembolism. Leukemia research 2007. link 58 Ishikawa N, Tajima G, Yofune N, Nishimura S, Kobayashi M. Moyamoya syndrome after cranial irradiation for bone marrow transplantation in a patient with acute leukemia. Neuropediatrics 2006. link 59 Sullivan R, Clowers-Webb H, Davis MD. Erythema nodosum: a presenting sign of acute myelogenous leukemia. Cutis 2005. link 60 Filippatos TD, Milionis HJ, Elisaf MS. Alterations in electrolyte equilibrium in patients with acute leukemia. European journal of haematology 2005. link 61 Nadir Y, Katz T, Sarig G, Hoffman R, Oliven A, Rowe JM et al.. Hemostatic balance on the surface of leukemic cells: the role of tissue factor and urokinase plasminogen activator receptor. Haematologica 2005. link 62 Schuler D, Szende B. Apoptosis in acute leukemia. Leukemia research 2004. link 63 Kakkar N, Kaur R. Utility of white blood cell suspect flags and histogram pattern in the detection of acute leukemia by Advia-60 automated hematology analyzer. Indian journal of pathology & microbiology 2004. link 64 Ortín X, Escoda L, Llorente A, Rodriguez R, Martínez S, Boixadera J et al.. Cunninghamella bertholletiae infection (mucormycosis) in a patient with acute T-cell lymphoblastic leukemia. Leukemia & lymphoma 2004. link 65 Penson RT, Rauch PK, McAfee SL, Cashavelly BJ, Clair-Hayes K, Dahlin C et al.. Between parent and child: negotiating cancer treatment in adolescents. The oncologist 2002. link 66 Kawanami T, Kurita K, Yamakawa M, Omoto E, Kato T. Cerebrovascular disease in acute leukemia: a clinicopathological study of 14 patients. Internal medicine (Tokyo, Japan) 2002. link 67 Cohen Y, Amir G, Da'as N, Gillis S, Rund D, Polliack A. Acute myocardial infarction as the presenting symptom of acute myeloblastic leukemia with extreme hyperleukocytosis. American journal of hematology 2002. link 68 Oren I, Haddad N, Finkelstein R, Rowe JM. Invasive pulmonary aspergillosis in neutropenic patients during hospital construction: before and after chemoprophylaxis and institution of HEPA filters. American journal of hematology 2001. link 69 Rowley SD, Yu J, Gooley T, Heimfeld S, Holmberg L, Maloney D et al.. Trafficking of CD34+ cells into the peripheral circulation during collection of peripheral blood stem cells by apheresis. Bone marrow transplantation 2001. link 70 Gould J, Iqbal A, Heath M, Monk A, Russell NH, Davies JM. Pentasomy 8 in acute monoblastic leukemia. Cancer genetics and cytogenetics 2000. link00164-8) 71 Lakhkar BN, Banavali S, Philip P. Orbital granulocytic sarcoma in acute myelogenous leukemia. Indian journal of pediatrics 2000. link 72 Rubinstein DB, Rubinstein AI. Short note: a novel approach for treating early-stage acute leukemias. Medical hypotheses 2000. link 73 Aydogdu I, Turhan O, Sari R, Ates M, Türk M. Coincidental acute myeloblastic leukemia in a patient with renal angiosarcoma. Haematologia 1999. link 74 Cimaz R, Lippi A, Falcini F. Elbow arthritis: a rare inaugural manifestation of acute leukemia. Revue du rhumatisme (English ed.) 1999. link 75 Golstein PE, Boom A, van Geffel J, Jacobs P, Masereel B, Beauwens R. P-glycoprotein inhibition by glibenclamide and related compounds. Pflugers Archiv : European journal of physiology 1999. link 76 Zalewska-Szewczyk B, Lipiec J, Bodalski J. Late cardiotoxicity of anthracyclines in children with acute leukemia. Klinische Padiatrie 1999. link 77 Stamatopoulos K, Kanellopoulou G, Vaiopoulos G, Stamatellos G, Yataganas X. Evidence for sinoatrial blockade associated with high dose cytarabine therapy. Leukemia research 1998. link00008-3) 78 Lefebvre D, Gala JL, Heusterspreute M, Delhez H, Philippe M. Introduction of a normal retinoblastoma (Rb) gene into Rb-deficient lymphoblastoid cells delays tumorigenicity in immunodefective mice. Leukemia research 1998. link00079-4) 79 Woodlock TJ, Lifton R, DiSalle M. Coincident acute myelogenous leukemia and ischemic heart disease: use of the cardioprotectant dexrazoxane during induction chemotherapy. American journal of hematology 1998. link1096-8652(199811)59:3<246::aid-ajh12>3.0.co;2-h) 80 . Acute childhood leukemia--Columbus, Ohio. MMWR. Morbidity and mortality weekly report 1997. link 81 Otsuka M, Kanamori H, Sasaki S, Taguchi J, Harano H, Ogawa K et al.. Torsades de pointes complicating pentamidine therapy of Pneumocystis carinii pneumonia in acute myelogenous leukemia. Internal medicine (Tokyo, Japan) 1997. link 82 Mok T, Koehler AP, Yu MY, Ellis DH, Johnson PJ, Wickham NW. Fatal Penicillium citrinum pneumonia with pericarditis in a patient with acute leukemia. Journal of clinical microbiology 1997. link 83 Handa R, Bhatia S, Wali JP, Kumar L, Kochupillai V, Mohindra M et al.. Acute leukemia presenting as pericardial effusion--a case report. Singapore medical journal 1997. link 84 Lin KP, Yeh TP, Wang S, Liao KK, Kao KP, Shan DE. Polyneuropathy associated with acute monoblastic leukemia: a case report. Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 1996. link 85 Hoyer JD, Fisher CP, Soppa VM, Lantis KL, Hanson CA. Detection and classification of acute leukemia by the Coulter STKS Hematology Analyzer. American journal of clinical pathology 1996. link 86 Nagata T, Higashigawa M, Nagai M, Zhang XL, Azuma E, Komada Y et al.. A child case of CD34+, CD33-, HLA-DR-, CD7+, CD56+ stem cell leukemia with thymic involvement. Leukemia research 1996. link00056-2) 87 den Ouden D, van den Heuvel M, Schoester M, van Rens G, Sonneveld P. In vitro effect of GF120918, a novel reversal agent of multidrug resistance, on acute leukemia and multiple myeloma cells. Leukemia 1996. link 88 Hsu KF, Chang CH, Chou CY. Sinusoidal fetal heart rate pattern during chemotherapy in a pregnant woman with acute myelogenous leukemia. Journal of the Formosan Medical Association = Taiwan yi zhi 1995. link 89 Johannes JM, Garcia ER, De Vaan GA, Weening RS. Noonan's syndrome in association with acute leukemia. Pediatric hematology and oncology 1995. link 90 Ha SY, Chan LC. Biphenotypic leukemia with t(9;11)(p22;p15). Cancer genetics and cytogenetics 1994. link90460-x) 91 Martino R, Nomdedéu J, Sureda A, Mateu R, Brunet S, Domingo-Albós A. Acute rhabdomyolysis complicating viridans streptococcal shock syndrome. Acta haematologica 1994. link 92 Fernandez AM, Abeles M, Wong RL. Recurrent leukocytoclastic vasculitis as the initial manifestation of acute myelomonocytic leukemia. The Journal of rheumatology 1994. link 93 Abbaszadegan MR, Futscher BW, Klimecki WT, List A, Dalton WS. Analysis of multidrug resistance-associated protein (MRP) messenger RNA in normal and malignant hematopoietic cells. Cancer research 1994. link 94 Harakati MS. Cutaneous granulocytic sarcoma at the exit site of Hickman indwelling venous catheter. International journal of hematology 1993. link 95 Baer MR. Management of unusual presentations of acute leukemia. Hematology/oncology clinics of North America 1993. link 96 Enani MA, Harakati MS, Almohareb FI, Rahman NU, Fawzy EM. Brain granulocytic sarcoma at the site of previous cerebral hemorrhage in a patient with acute myelogenous leukemia. International journal of hematology 1993. link 97 Friedman GD. Cigarette smoking, leukemia, and multiple myeloma. Annals of epidemiology 1993. link90071-b) 98 Dow G, Reid GD, Horsman DE, Barnett MJ. Unusual rheumatological and cardiological manifestations of acute myelogenous leukemia in a patient with Klinefelter's syndrome. Leukemia & lymphoma 1993. link 99 Maschmeyer G, Willborn K, Heit W. AMSA combination chemotherapy in patients with acute myelogenous leukemia unsuitable for standard antileukemic treatment. Leukemia & lymphoma 1992. link 100 Myers SA, Prose NS, Garcia JA, Wilson KH, Dunsmore KP, Kamino H. Bacillary angiomatosis in a child undergoing chemotherapy. The Journal of pediatrics 1992. link81148-5)