Overview
Disseminated histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum. It commonly affects individuals with advanced HIV disease but can also occur in immunocompetent individuals 1.Diagnosis
Diagnosis is typically made based on clinical presentation, laboratory tests, and histopathological examination of affected tissues 1.
Diagnostic modalities may include microscopy, culture, antigen detection (e.g., urine or serum galactomannan), and molecular methods 1.Management
Treatment for disseminated histoplasmosis usually involves antifungal therapy 1.
Specific treatment regimens and durations are not detailed in the provided abstracts.Special Populations
The abstracts do not provide specific information on management in pregnant women, pediatric patients, the elderly, or individuals with comorbidities.Key Recommendations
Active surveillance for histoplasmosis is needed in at-risk populations in Nigeria 1.
Histoplasmosis occurs in both advanced HIV disease and immunocompetent individuals 1.
A significant number of histoplasmosis cases have been reported in Nigeria, with a notable concentration in the South West and South-South regions 1.
(Evidence: Moderate)References
1 Ekeng BE, Davies AA, Osaigbovo II, Emanghe UE, Udoh UA, Alex-Wele MA et al.. Current epidemiology of histoplasmosis in Nigeria: A systematic review and meta-analysis. The Nigerian postgraduate medical journal 2023. link