Overview
Chromoblastomycosis is a chronic fungal infection caused by dematiaceous fungi, characterized by localized skin lesions that can extend along lymphatic vessels, forming lymphocutaneous spread. 1Diagnosis
Clinical presentation includes papules, nodules, and ulcerations that may disseminate along lymphatic channels.
Histopathological examination essential, showing characteristic Medlar bodies (Keratinohyalin granulocytes).
Ultrastructural analysis can reveal variability in Medlar body features, reflecting host-fungal interactions. 2Management
First-line treatments include systemic antifungal agents such as itraconazole or terbinafine.
Cryosurgery has shown efficacy but may result in depigmentation and cosmetic concerns. 3
Surgical excision may be considered for localized lesions, though lymphatic spread complicates complete removal.Special Populations
No specific guidelines provided for pregnancy, pediatrics, elderly, or comorbidities in the given abstracts. 13Key Recommendations
Confirm diagnosis through histopathological examination with identification of Medlar bodies. (Evidence: Moderate 2)
Initiate treatment with systemic antifungals like itraconazole or terbinafine for optimal efficacy. (Evidence: Moderate 1)
Consider cryosurgery for localized lesions, acknowledging potential cosmetic drawbacks. (Evidence: Weak 3)References
1 Bhaktaviziam C, Shafi M, Mehta MC, Bhaktaviziam CA. Chromoblastomycosis. Report of a case from Tripoli, Libya. Mycopathologia 1983. link
2 Rosen T, Gyorkey F, Joseph LM, Batres E. Ultrastructural features of chromoblastomycosis. International journal of dermatology 1980. link
3 Lubritz RR, Spence JE. Chromoblastomycosis: cure by cryosurgery. International journal of dermatology 1978. link