Epidemiology
Individuals with more than 8,000 mf/mL of Loa loa microfilariae are at higher risk of severe adverse reactions to ivermectin, with risks escalating dramatically with microfilarial density [PMID:41557726].
Differential Diagnosis
The risk of severe adverse reactions following ivermectin administration increases significantly with Loa loa microfilarial density, reaching up to 37.0% in individuals with 100,000 mf/mL [PMID:41557726].
Management
Two albendazole regimens were evaluated for treating hypermicrofilaraemic loiasis in adults, indicating potential as a safer alternative to ivermectin in high-parasitic-load cases [PMID:41557726].
References
1 M'Bondoukwé NP, Ndong Akomezoghe L, Moutombi Ditombi BC, Ndong Ngomo JM, Sibi Matotou HR, Zang Ondo GS et al.. Assessment of the efficacy and safety of two albendazole regimens for the treatment of hypermicrofilaraemic loiasis in adults in Woleu-Ntem Province, Gabon: A phase IIb single-blind randomised controlled trial. PLoS neglected tropical diseases 2026. link
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