Epidemiology
Primary occurrences of ITAC in extra-sinonasal locations like major salivary glands or the oral cavity are exceedingly rare, with poorly understood histogenesis [PMID:41273750].
Clinical Presentation
ITAC affecting the head and neck presents as aggressive tumors that invade and destroy adjacent tissues, predominantly arising in the ethmoid sinuses, with overall poor prognosis [PMID:41273750].
Management
Surgery remains the primary modality of treatment for ITAC in the head and neck, reflecting its aggressive nature and the need for local control [PMID:41273750].
References
1 Vieira GS, Gonçalves MW, Tincani PC, Tincani AJ, Chone CT, Antolini-Tavares A et al.. Clinicopathological spectrum of non-sinonasal intestinal-type adenocarcinomas of the head and neck: Systematic review of case reports, case series, and cross-sectional studies. Medicina oral, patologia oral y cirugia bucal 2026. link
1 papers cited of 3 indexed.