Overview
Brenner tumors are rare, benign ovarian neoplasms typically found in postmenopausal women, though they can occur in other populations 1. A variant known as proliferating Brenner tumor is rarer still, with limited case reports available 2.Diagnosis
Characterized by a biphasic pattern with transitional epithelium and stromal elements 2.
Diagnosis primarily through imaging (ultrasound, CT, MRI) and confirmed histologically 12.
No standardized grading system exists specifically for Brenner tumors; however, histological features help differentiate benign from proliferating types 2.Management
Surgical excision (often unilateral salpingo-oophorectomy) is the mainstay of treatment 12.
No specific adjuvant therapies are typically required for benign Brenner tumors 2.
For proliferating Brenner tumors, surgical management remains the primary approach, with close follow-up due to potential for recurrence 2.Special Populations
Pregnancy: First reported case of unilateral Brenner tumor during a normal pregnancy suggests surgical intervention can be managed safely 1.
Elderly: Typically affects postmenopausal women, but management principles remain similar regardless of age 1.
Comorbidities: Specific considerations for comorbidities are not detailed in the provided abstracts 12.Key Recommendations
Confirm diagnosis histologically after imaging suggests a Brenner tumor 12 (Evidence: Moderate).
Perform surgical excision for both benign and proliferating Brenner tumors 12 (Evidence: Moderate).
Monitor pregnant patients with Brenner tumors closely, considering safe surgical intervention if necessary 1 (Evidence: Weak).References
1 Beckmann CR. Brenner tumor during pregnancy. A case report. The Journal of reproductive medicine 1983. link
2 Baratz M, Gitstein SZ, David MP, Avni A. Proliferating Brenner tumour. Postgraduate medical journal 1979. link