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Pediatrics44 papers

Megacystis, microcolon, hypoperistalsis syndrome

Last edited: 4/15/2026

Overview

Congenital megacystis, microcolon, hypoperistalsis syndrome (MHS) is characterized by an abnormally large bladder (megacystis), reduced colonic diameter (microcolon), and impaired bowel motility (hypoperistalsis). This condition often leads to urinary retention and gastrointestinal dysfunction. 1

Diagnosis

  • Large, unobstructed bladder on imaging
  • Microcolon observed endoscopically or radiographically
  • Hypoperistalsis confirmed via contrast studies or clinical presentation
  • Urinary tract infections recurrent due to retention 1
  • Management

  • Reduction cystoplasty for symptomatic relief and to manage recurrent UTIs 1
  • Antibiotic prophylaxis to prevent urinary tract infections 1
  • Bowel management strategies tailored to individual needs, though specific protocols not detailed 1
  • Special Populations

  • Pediatrics: Reduction cystoplasty has shown efficacy in alleviating symptoms in children 1
  • Key Recommendations

  • Consider reduction cystoplasty for symptomatic relief and to reduce recurrent urinary tract infections in patients with megacystis, microcolon, hypoperistalsis syndrome (Evidence: Moderate) 1
  • Implement antibiotic prophylaxis to manage and prevent urinary tract infections associated with urinary retention (Evidence: Moderate) 1
  • References

    1 Inamdar S, Mallouh C, Ganguly R. Vesical gigantism or congenital megacystis. Urology 1984. link90111-0)

    Original source

    1. [1]
      Vesical gigantism or congenital megacystis.Inamdar S, Mallouh C, Ganguly R Urology (1984)

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