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Pediatrics3 papers

Small left colon syndrome

Last edited: 4/15/2026

Overview

Small left colon syndrome (NSLCS) is characterized by an abnormally small or hypoplastic left colon, often presenting in neonates with symptoms like abdominal distension and feeding intolerance 1.

Diagnosis

  • Clinical signs include abdominal distension and feeding difficulties 1.
  • Radiographic imaging (e.g., abdominal X-ray) shows characteristic findings of a small or hyperplastic left colon 1.
  • Suspect in infants of diabetic mothers presenting with intrauterine complications 2.
  • Management

  • No specific drug treatments mentioned; management focuses on supportive care 12.
  • Address underlying conditions such as meconium peritonitis if present, requiring surgical intervention 2.
  • Monitor for complications like intestinal perforation and manage accordingly 2.
  • Special Populations

  • Pregnancy and Neonatal Period: Increased vigilance in infants of diabetic mothers due to potential intrauterine complications 2.
  • Comorbidities: Consider NSLCS in differential diagnosis for infants presenting with meconium peritonitis 2.
  • Key Recommendations

  • Consider small left colon syndrome in the differential diagnosis for neonates, especially those of diabetic mothers, presenting with abdominal distension or meconium peritonitis (Evidence: Moderate 2).
  • Perform radiographic imaging to confirm the diagnosis of small left colon syndrome (Evidence: Moderate 1).
  • Be alert for potential complications such as intestinal perforation and meconium peritonitis, requiring prompt surgical evaluation and management (Evidence: Weak 2).
  • References

    1 Cohen MD, Beck J, Weber T, Harper J. Neonatal small left colon syndrome in twins. Gastrointestinal radiology 1982. link 2 Kanto WP, Morales V, Parrish R. Antenatal intestinal perforation and meconium peritonitis associated with the neonatal small left colon syndrome. Southern medical journal 1979. link

    Original source

    1. [1]
      Neonatal small left colon syndrome in twins.Cohen MD, Beck J, Weber T, Harper J Gastrointestinal radiology (1982)
    2. [2]

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