Overview
Cervical cancer (CC) is the fourth most common cancer and cause of mortality in women globally, strongly associated with high-risk human papillomavirus (HPV) infection 1. Implementation of HPV vaccination and screening programs has led to significant reductions in CC incidence in high-income countries 13.Diagnosis
No specific diagnostic criteria, tests, or grading are detailed in the provided abstracts.Management
For early-stage CC, primary treatment is surgery or radiotherapy 1.
For early-stage tumors with local risk factors, brachytherapy can be a preoperative option 2.
Postoperative radiotherapy is indicated based on histopathological criteria 2.
Concurrent chemoradiotherapy (CRT) is the conventional approach for locally advanced stages 1.
For advanced local tumors, CRT is the standard treatment, followed by a brachytherapy boost 2.
In recurrent or metastatic CC, immunotherapy combined with chemotherapy (with or without bevacizumab) in the first line, and as monotherapy in the second line after platinum-based chemotherapy, has improved overall survival 1.Special Populations
No information is provided on special populations.Key Recommendations
Concurrent chemoradiotherapy (CRT) is the conventional approach in locally advanced stages of cervical cancer 1. (Evidence: Moderate)
For advanced local tumors, chemoradiation is the standard treatment, followed by a brachytherapy boost 2. (Evidence: Moderate)
The incorporation of immunotherapy in combination with chemotherapy (with or without bevacizumab) in first line and as monotherapy in second line after platinum-based chemotherapy has significantly increased overall survival in recurrent or metastatic CC 1. (Evidence: Strong)References
1 Manso L, Ramchandani-Vaswani A, Romero I, Sánchez-Lorenzo L, Bermejo-Pérez MJ, Estévez-García P et al.. SEOM-GEICO Clinical Guidelines on cervical cancer (2023). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024. link
2 Chargari C, Peignaux K, Escande A, Renard S, Lafond C, Petit A et al.. Radiotherapy of cervical cancer. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 2022. link
3 . Practice Bulletin No. 168: Cervical Cancer Screening and Prevention. Obstetrics and gynecology 2016. link