Overview
Testicular tumors in prepubertal boys are rare, accounting for 1-2% of all solid pediatric tumors, often benign, and differing histologically from those in older individuals 1.Diagnosis
Clinical Presentation: Painless scrotal mass 1.
Imaging: High-resolution ultrasound for evaluation with near 100% detection rate 1.
Tumor Markers: Alpha-fetoprotein (AFP) used, though age-dependent sensitivity 1.
Not Useful: Human chorionic gonadotropin (HCG) is not a reliable tumor marker in this population 1.Management
Primary Approach: Partial orchiectomy recommended for tumors with favorable characteristics 1.
No Specific Drug Therapy Mentioned: No specific drug classes or doses detailed for regressed malignant tumors in prepubertal boys 1.Special Populations
Pediatric Considerations: Tailored approach due to differences in tumor characteristics compared to older patients 1.Key Recommendations
Perform high-resolution ultrasound for evaluation of testicular masses in prepubertal boys (Evidence: Strong) 1.
Utilize alpha-fetoprotein (AFP) as a tumor marker, considering its age-dependent sensitivity (Evidence: Moderate) 1.
Opt for partial orchiectomy as the primary surgical intervention for regressed malignant testicular tumors in prepubertal boys (Evidence: Expert opinion) 1.References
1 Stein R, Quaedackers J, Bhat NR, Dogan HS, Nijman RJM, Rawashdeh YF et al.. EAU-ESPU pediatric urology guidelines on testicular tumors in prepubertal boys. Journal of pediatric urology 2021. link