Management
Pretreatment with buprenorphine and morphine in mice prevented death from clostridial myonecrosis caused by Clostridium perfringens [PMID:24550443]. Treatment with buprenorphine after infection onset also arrested disease progression.
The protective effect of buprenorphine was specific to C. perfringens-mediated myonecrosis and did not extend to infections caused by C. septicum [PMID:24550443].
Key Recommendations
These findings suggest a novel therapeutic strategy for C. perfringens-mediated myonecrosis, warranting investigation in clinical settings [PMID:24550443]. (Evidence: Expert opinion)
References
1 Chakravorty A, Awad MM, Hiscox TJ, Cheung JK, Choo JM, Lyras D et al.. Opioid analgesics stop the development of clostridial gas gangrene. The Journal of infectious diseases 2014. link
1 papers cited of 11 indexed.