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Infectious Disease4 papers

Pneumococcal lobar pneumonia

Last edited: 4/10/2026

Overview

Pneumococcal lobar pneumonia is a common bacterial pneumonia characterized by inflammation of a single lobe of the lung. It is typically caused by Streptococcus pneumoniae.

Diagnosis

Diagnosis is based on clinical presentation, chest radiography showing lobar consolidation, and identification of Streptococcus pneumoniae* in respiratory secretions or blood 1.

Management

  • Ceftriaxone (2 g every 12 hours for 3 days) may reduce the incidence of early-onset pneumonia in comatose patients following out-of-hospital cardiac arrest 1.
  • Open-label antibiotics were administered to a majority of patients receiving ceftriaxone prophylaxis 1.
  • Key Recommendations

  • Prophylactic ceftriaxone may reduce the incidence of early-onset pneumonia in comatose survivors of out-of-hospital cardiac arrest 1. (Evidence: Strong)
  • Prophylactic ceftriaxone in this population did not appear to increase the acquisition of antibiotic resistance genes 1. (Evidence: Strong)
  • References

    1 Gagnon DJ, Burkholder KM, Weissman AJ, Riker RR, Ryzhov S, May TL et al.. Ceftriaxone to Prevent Early-Onset Pneumonia in Comatose Patients Following Out-of-Hospital Cardiac Arrest: A Pilot Randomized Controlled Trial and Resistome Assessment (PROTECT). Chest 2026. link

    Original source

    1. [1]

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