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Cardiology1 paper

Bulbus cordis and cardiac septal closure anomalies

Last edited: 4/23/2026

Overview

Interatrial septal anomalies encompass conditions such as atrial septal defect, patent foramen ovale, and atrial septal aneurysm, often detected incidentally and potentially associated with right bundle branch block on ECG. These anomalies can lead to hemodynamic complications and thromboembolic events if undetected 1.

Diagnosis

  • ECG Findings: Right bundle branch block may indicate interatrial septal abnormalities 1.
  • Recommended Tests: Transoesophageal echocardiography for definitive diagnosis of interatrial septal anomalies 1.
  • Prevalence: Patent foramen ovale is the most common anomaly, followed by atrial septal aneurysm and atrial septal defect in patients with right bundle branch block 1.
  • Management

  • First-Line: Closure of significant defects using devices such as Amplatzer or Cardia occluders, guided by echocardiography 1.
  • Adjunctive: Anticoagulation therapy may be considered in patients with thromboembolic risk factors 1.
  • Special Populations

  • Pregnancy: Specific management strategies for pregnant women with interatrial septal anomalies are not detailed in the provided abstracts 1.
  • Pediatrics: No specific pediatric considerations mentioned in the abstracts 1.
  • Elderly: Considerations for elderly patients regarding surgical risks and benefits are not addressed 1.
  • Comorbidities: Management adjustments for patients with comorbidities like hypertension or heart failure are not specified 1.
  • Key Recommendations

  • Screen for interatrial septal anomalies in patients presenting with right bundle branch block using transoesophageal echocardiography 1 (Evidence: Moderate).
  • Consider closure procedures for significant defects identified in asymptomatic adults to prevent future complications 1 (Evidence: Expert opinion).
  • Monitor thromboembolic risk in patients with detected anomalies, especially those with atrial septal aneurysm or patent foramen ovale 1 (Evidence: Moderate).
  • References

    1 Bakalli A, Koçinaj D, Georgievska-Ismail L, Bekteshi T, Pllana E, Sejdiu B. Right bundle branch block as a marker for interatrial septal abnormalities. Cardiology in the young 2012. link

    Original source

    1. [1]
      Right bundle branch block as a marker for interatrial septal abnormalities.Bakalli A, Koçinaj D, Georgievska-Ismail L, Bekteshi T, Pllana E, Sejdiu B Cardiology in the young (2012)

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