Overview
Malignant neoplasms of the lip, oral cavity, and pharynx are cancers originating from the epithelial cells lining these regions, often associated with tobacco and alcohol use. 1Diagnosis
Imaging studies (CT, MRI) to assess extent and metastasis 1
Biopsy for histopathological confirmation 1
Endoscopy for detailed examination of oral cavity and pharynx 1
Angiography may be indicated in cases with suspected vascular complications 1Management
Surgical resection (e.g., radical neck dissection) for localized disease 1
Adjuvant radiotherapy post-surgery to reduce recurrence risk 1
Chemotherapy, particularly in advanced stages or metastatic disease 1
Targeted therapies and immunotherapy based on molecular profiling 1 (specific drug classes/doses not detailed in provided abstracts)Special Populations
Elderly: Consider functional status and comorbidities when planning treatment intensity 1
Comorbidities: Manage concurrent conditions to optimize treatment tolerance 1Key Recommendations
Perform thorough imaging (CT, MRI) and biopsy for definitive diagnosis of malignant neoplasms in the oral cavity and pharynx (Evidence: Moderate 1)
Radical neck dissection should be considered for localized disease, with careful surgical technique to avoid iatrogenic complications like dAVFs 1 (Evidence: Expert opinion)
Post-surgical adjuvant radiotherapy is recommended to improve outcomes and reduce recurrence rates 1 (Evidence: Moderate)References
1 Ngerageza JG, Horiuchi T, Murata T, Aoyama T, Hongo K. Iatrogenic dural arteriovenous fistula after radical neck dissection for metastatic malignant disease: A case report. Head & neck 2016. link