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Oncology18 papers

Non-venereal endemic syphilis

Last edited: 4/10/2026

Overview

Non-venereal endemic syphilis is a chronic infectious disease that affects specific populations. Historically, it was considered untreatable but has seen significant advancements in understanding and management 1.

Diagnosis

Management

  • Vincristine sulphate monotherapy is the recommended first-line treatment for canine transmissible venereal tumour 1.
  • Intravenous administration of vincristine at a dosage of 0.5-0.75 mg/m² is suggested 1.
  • Chemotherapy treatments have shown superior outcomes compared to surgical interventions for canine transmissible venereal tumour 1.

    • Special Populations

    Key Recommendations

  • Vincristine sulphate monotherapy is recommended as the first-line treatment for canine transmissible venereal tumour 1. (Evidence: Strong)
  • Intravenous administration of vincristine at a dosage of 0.5-0.75 mg/m² is suggested for treatment 1. (Evidence: Moderate)
  • Chemotherapy treatments are superior to surgical interventions for canine transmissible venereal tumour 1. (Evidence: Moderate)

    • References

    1 Pimentel PAB, Giuliano A, Odatzoglou P, Ignatenko N, Wenceslau RR, Almeida IO et al.. Clinical Guidelines for Canine Transmissible Venereal Tumour Treatment: Systematic Review and Meta-Analysis. Veterinary and comparative oncology 2025. link 2 Zheng Y, Ye K, Ying M, He Y, Yu Q, Lan L et al.. Syphilis epidemic among men who have sex with men: A global systematic review and meta-analysis of prevalence, incidence, and associated factors. Journal of global health 2024. link

    Original source

    1. [1]
      Clinical Guidelines for Canine Transmissible Venereal Tumour Treatment: Systematic Review and Meta-Analysis. — Pimentel PAB, Giuliano A, Odatzoglou P, Ignatenko N, Wenceslau RR, Almeida IO et al. Veterinary and comparative oncology (2025)
    2. [2]
      Syphilis epidemic among men who have sex with men: A global systematic review and meta-analysis of prevalence, incidence, and associated factors. — Zheng Y, Ye K, Ying M, He Y, Yu Q, Lan L et al. Journal of global health (2024)
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