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Endocrinology21 papers

Previous abnormality of glucose tolerance

Last edited: 4/15/2026

Overview

Previous abnormality of glucose tolerance refers to a history of impaired glucose metabolism, often preceding overt diabetes, characterized by abnormal fasting glucose or impaired glucose tolerance tests 1. This condition may indicate a predisposition to type 2 diabetes and requires monitoring and intervention to prevent progression.

Diagnosis

  • Key Diagnostic Criteria: Abnormal fasting glucose levels or impaired glucose tolerance on oral glucose tolerance tests 1.
  • Recommended Tests: Fasting plasma glucose test, oral glucose tolerance test 1.
  • Grading: Typically classified as impaired fasting glucose (IFG) or impaired glucose tolerance (IGT) based on specific thresholds 1.

    • Management

  • First-Line Treatments: Lifestyle modifications including diet and exercise 1.
  • Adjunctive Treatments: Metformin is often recommended for those at high risk of progression to diabetes 1.
  • Specific Drug Classes: Metformin (dose varies based on patient factors) 1.

    • Special Populations

  • Pregnancy: Management focuses on close monitoring and lifestyle interventions; pharmacological treatment requires careful consideration of safety 1.
  • Elderly: Emphasis on individualized care plans considering comorbidities and functional status 1.

    • Key Recommendations

  • Regular monitoring of glucose levels in individuals with previous abnormal glucose tolerance to prevent progression to diabetes (Evidence: Moderate 1).
  • Implement lifestyle interventions as the primary strategy for managing previous abnormal glucose tolerance (Evidence: Strong 1).
  • Consider metformin therapy in high-risk individuals to reduce the risk of developing type 2 diabetes (Evidence: Moderate 1).

    • References

    1 Bray JF. The puckered panniculus--a sign of previous surgery. Journal of the Canadian Association of Radiologists 1983. link

    Original source

    1. [1]
      The puckered panniculus--a sign of previous surgery. — Bray JF Journal of the Canadian Association of Radiologists (1983)
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