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Oncology17 papers

Spindle cell lipoma

Last edited: 4/15/2026

Overview

Spindle cell lipoma is a rare, benign soft tissue neoplasm characterized by a mixture of adipocytes and spindle-shaped cells. This entity typically arises in the subcutaneous tissue of the posterior neck and upper trunk but can occur in diverse locations, including the perianal region 1.

Diagnosis

  • Clinical presentation often includes a slow-growing, painless mass.
  • Histopathology is definitive, showing mature adipocytes intermixed with uniform spindle-shaped cells.
  • Immunohistochemistry may support diagnosis with adipophilin and CD34 positivity in spindle cells 1.

    • Management

  • Surgical excision is the primary treatment, aiming for complete removal to prevent recurrence.
  • Adjuvant therapies are generally not required for benign spindle cell lipomas 1.

    • Special Populations

  • No specific management differences noted for pregnancy, pediatrics, or elderly patients based on current evidence 1.
  • Comorbidities do not alter primary management approach but may influence surgical considerations 1.

    • Key Recommendations

  • Confirm diagnosis through histopathological examination with immunohistochemical staining for adipophilin and CD34 1 (Evidence: Moderate).
  • Perform complete surgical excision for definitive treatment 1 (Evidence: Expert opinion).
  • Monitor for recurrence post-surgery, particularly in atypical locations like perianal regions 1 (Evidence: Weak).

    • References

    1 Robb JA, Jones RA. Spindle cell lipoma in a perianal location. Human pathology 1982. link80101-9)

    Original source

    1. [1]
      Spindle cell lipoma in a perianal location. — Robb JA, Jones RA Human pathology (1982)
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