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Infectious Disease27 papers

Neonatal clinical infection

Last edited: 4/10/2026

Overview

Neonatal clinical infection refers to infections occurring in newborns, particularly low-birthweight infants, which can lead to significant morbidity and mortality. These infections can manifest as sepsis or invasive conditions like necrotizing enterocolitis, pneumonia, and meningitis 1.

Diagnosis

  • Primary outcomes include all-cause mortality, sepsis, and invasive infection (composite of necrotizing enterocolitis, pneumonia, meningitis, and other severe infections) 1.
  • Adverse events assessed include hypothermia and apnea 1.
  • Management

  • Kangaroo care is a method for stabilizing preterm infants and protecting low-birthweight newborns from mortality 1.
  • Hospital-initiated kangaroo care is being evaluated for its role in preventing mortality, sepsis, and invasive infection in low-birthweight infants 1.
  • Special Populations

  • Focus on low-birthweight infants (<2500 g) 1.
  • Key Recommendations

  • Hospital-initiated kangaroo care may play a role in preventing mortality, sepsis, and invasive infection in low-birthweight infants 1. (Evidence: Moderate)
  • Kangaroo care has a well-established role in preterm infant stabilization 1. (Evidence: Moderate)
  • Kangaroo care is effective in protecting low-birthweight newborns from mortality 1. (Evidence: Moderate)
  • References

    1 Minotti C, Jost K, Aghlmandi S, Schlaeppi C, Sieswerda E, van Werkhoven CH et al.. All-cause mortality and infection-related outcomes of hospital-initiated kangaroo care versus conventional neonatal care for low-birthweight infants: a systematic review and meta-analysis. The Lancet. Child & adolescent health 2025. link00130-0)

    Original source

    1. [1]
      All-cause mortality and infection-related outcomes of hospital-initiated kangaroo care versus conventional neonatal care for low-birthweight infants: a systematic review and meta-analysis.Minotti C, Jost K, Aghlmandi S, Schlaeppi C, Sieswerda E, van Werkhoven CH et al. The Lancet. Child & adolescent health (2025)
    2. [2]

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