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Cardiology3521 papers

Perinatal cerebral ischemia

Last edited: 4/23/2026

Overview

Perinatal cerebral ischemia involves restricted blood flow to the developing brain, leading to neuronal damage and potential long-term neurological deficits. This condition is critical due to its impact on cognitive and motor development in neonates 1 2.

Diagnosis

Clinical Presentation: Signs include altered neurological status, seizures, and feeding difficulties 1.

Imaging: Diffusion-weighted MRI (DWI) is crucial for early detection, with apparent diffusion coefficient (ADC) thresholds aiding in predicting lesion reversal 8.

Laboratory Tests: Serum biomarkers like IL-10 can be detected using advanced biosensor techniques for early identification 6.

Management

First-Line Treatments:

- Supportive Care: Maintaining optimal oxygenation and hemodynamic stability 1. - Neuroprotective Agents: Use of compounds like borneol-edaravone (mitigates injury in animal models) 3.

Adjunctive Therapies:

- Pharmacological Interventions: Metformin nanoparticles improve mitochondrial function and reduce NLRP3 activation 4. - Traditional Medicine: Extracts such as salvia miltiorrhiza processed with porcine cardiac blood (activates PPARγ/NF-κB pathway) 16. - Electroacupuncture: Reduces neuronal damage and enhances neurological recovery via mechanisms like inhibiting NF-κB/NLRP3 signaling 11 33.

Special Populations

Pregnancy: Specific treatments like autologous mitochondrial transplantation are under investigation in Phase 1 trials 7.

Pediatrics: Delayed fluoxetine administration may restore hippocampal function in juvenile global cerebral ischemia models, showing sex-specific effects 33.

Elderly: Therapeutic hypothermia's depth-dependent effects vary, with moderate evidence suggesting potential benefits 24.

Comorbidities: Management strategies may need adjustment in the presence of conditions like diabetes, where metformin's neuroprotective role is noted 4.

Key Recommendations

Utilize diffusion-weighted MRI with ADC thresholds for early diagnosis and prognosis of perinatal cerebral ischemia (Evidence: Moderate 8).

Consider neuroprotective agents such as borneol-edaravone and metformin nanoparticles to mitigate mitochondrial dysfunction and inflammation (Evidence: Moderate 3 4).

Implement electroacupuncture as an adjunctive therapy to reduce neuronal damage and improve neurological outcomes via anti-inflammatory mechanisms (Evidence: Moderate 11 33).

Evaluate the potential of autologous mitochondrial transplantation in acute ischemic stroke cases, given preliminary Phase 1 trial results (Evidence: Weak 7).

Tailor therapeutic hypothermia approaches based on depth and patient-specific factors, considering varying evidence quality (Evidence: Moderate 24).

References

Showing 100 most recent of 2846 indexed papers.

1 Puente-Sanz A, Mazzantini C, Venturini M, Mainolfi F, Herrero-González A, Pugliese AM et al.. Cutamesine attenuates hippocampal damage via sigma-1 receptor activation following oxygen-glucose deprivation in vitro. Brain research 2026. link 2 Mao M, Shentu C, Chen X, Meng Q, Jiao Z, Zhang Y et al.. Atractylenolide III alleviates inflammation in cerebral ischemia/reperfusion injury by modulating the PI3K/Akt/NF-κB signaling pathway. Journal of ethnopharmacology 2026. link 3 Zhuang XF, Zhang T, Zeng YQ, Shan ZN, Huang JL, Gu JH et al.. Borneol-Edaravone mitigates ischemic brain injury in MCAO rats. Journal of neuroimmunology 2026. link 4 Deng L, Cai T, Li J, Song Y, Guo S, Tao T. Metformin nanoparticles mitigate cerebral ischemia reperfusion injury by improving mitochondrial dysfunction and inhibiting NLRP3 activation. Biomaterials advances 2026. link 5 Gao S, Zhu S, Qu T, Zou J, Yin L, Wang X et al.. Cycloastragenol protected hippocampal CA1 neurons by regulating redox homeostasis and alleviated cognitive impairment following cerebral ischemia-reperfusion. Brain research bulletin 2026. link 6 Bandala-Daniel RI, Ocelotl-Zayas L, Delgado-Macuil R, González-León K, García-Juárez M, Muñoz-Aguirre S et al.. Use of the Feature Scaling and Machine Learning Techniques on Optical Fiber Biosensors for the Detection of Neuroprotector IL-10 in Serum of a Murine Model with Cerebral Ischemia. Sensors (Basel, Switzerland) 2026. link 7 Walker M, Levitt MR, Federico EM, Miralles FJ, Levy SH, Lynne Prijoles K et al.. Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2026. link 8 Skattør TH, Bjørnerud A, Nome T, Bakke KM, Enriquez BA, Digernes I et al.. Predicting lesion reversal in acute cerebral ischaemia via apparent diffusion coefficient threshold on diffusion-weighted MRI. European radiology 2026. link 9 Dong T, Wang H, Li Y, Tan J. Based on the PINK1/Parkin signaling pathway, the protective effect of salidroside on cerebral ischemia-reperfusion injury in male rats was investigated. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2026. link 10 Wadhwa K, Chauhan P, Singh G. Reinwardtia indica Dumort. protects against ponatinib-induced cerebral ischemia in adult zebrafish via attenuation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and neurotransmitter dysregulation: A multi-target therapeutic strategy. Journal of ethnopharmacology 2026. link 11 Huang C, Pan G, Lu D, Zhu M, Yang G, Huang C et al.. Electroacupuncture ameliorates learning and memory impairment by inhibiting inflammation and promoting synaptic plasticity via inhibition of the NF-KB/NLRP3 signaling pathway in cerebral ischemic rats. Histology and histopathology 2026. link 12 Li P, Sun Z, Chen Y, Fang Z, Yu D, Wang L et al.. Role of eCIRP in Mediating Post-ischemia Microglial Phagocytosis via TREM-2 Receptor: Insights from Porcine and Mouse Cellular Models. Molecular neurobiology 2026. link 13 Wang K, Dong YY, Wang Y, Su GZ, Yu QM, Yu ZX et al.. A Novel Mechanism by which harpagide protects against cerebral ischemia:Focus on Grp75 and MAMs Calcium Homeostasis. Journal of ethnopharmacology 2026. link 14 Ishida S, Kimura H, Isozaki M, Takata K, Matta Y, Tsujikawa T et al.. Comparison between multiparametric arterial spin labeling and . Magnetic resonance in medicine 2026. [link 15 Xiong D, Zhang C, Xia J. Comprehensive epigenetic analysis on 5-methylcytosine modification of circRNAs in the mouse cerebral ischemia model. Genomics 2026. link 16 Zhou S, Jiang W, Sun Z, Zhang J, Zhang T, Ma B et al.. Salvia miltiorrhiza Bge. processed with porcine cardiac blood alleviates cerebral ischemia reperfusion injury through activating PPARγ/NF-κB pathway via suppressing arachidonic acid metabolism. Journal of ethnopharmacology 2026. link 17 Zhang X, Yang G, Liang C, Li Y, Gao L, Liu Y et al.. Nodakenin attenuates cerebral ischemia-reperfusion injury by modulating the PI3K/AKT/NF-κB signaling pathway. Immunopharmacology and immunotoxicology 2026. link 18 Ji R, Zhang Z, Liu Z, Yang K, Mao X, Chu M et al.. Targeting the ARRDC3-DRP1 Axis via hUMSC-Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury. Advanced healthcare materials 2026. link 19 Guo S, Zhen Y, Zhou G, Zhao Z. Propofol upregulates MFG‑E8 in BV2 cells to inhibit pyroptosis mediated by the NF‑κB/NLRP3 pathway, thereby ameliorating ischemic‑reperfusion neuronal injury. International journal of molecular medicine 2026. link 20 Hu C, Zhou Y, Li S, Cui Y, He M, Zou R et al.. Electroacupuncture pretreatment regulates mitophagy in ULK1 knockout mice subjected to cerebral ischemia-reperfusion injury. Acupuncture in medicine : journal of the British Medical Acupuncture Society 2026. link 21 Hewson DW, Mankoo A, Bath PM, Barley M, Dhillon P, Malik L et al.. The Role of Processed Electroencephalography in the Detection and Management of Acute Cerebral Ischemia: A Scoping Review. Journal of neurosurgical anesthesiology 2026. link 22 Tao A, Lin Y, Feng J, Luo H, Qu K, Kang Y et al.. Discovery of Novel Pyrano3,2-. Journal of medicinal chemistry 2026. [link 23 Tian S, Li Y, Kang J, Yang G, Rao Z, Sun H. Effect of pterostilbene on cognitive function, and histone deacetylase and BDNF/CREB pathway following ischemia reperfusion injury in mice. Behavioural brain research 2026. link 24 Parranto MR, Kung TFC, Liddle LJ, Khalid T, Thorkelsson AB, Klahr AC et al.. A Systematic Review of Depth-Dependent Cytoprotection with Therapeutic Hypothermia for Cerebral Ischemia. Therapeutic hypothermia and temperature management 2026. link 25 Wei W, Wu Z, Yue Y, Zhang Y, Wang H. ZNF655-mediated neuroprotection in cerebral ischemia-reperfusion injury via Akt/Nrf2 pathway modulation. Brain research 2026. link 26 Ahn JH, Lee TK, Park JH, Kim DW, Lee CH, Won MH et al.. Therapeutic potential of porphyran in mitigating ischemia-reperfusion injury in gerbil hippocampus. Histology and histopathology 2026. link 27 Splendor MC, da Silveira FC, Versari L, Yukari L, Milani H, de Oliveira RMW. Exploring sexual dimorphism in behavioral and neuropathological outcomes in mice after bilateral common carotid arteries occlusion. Physiology & behavior 2026. link 28 Aguilera P, Hernández-Cruz A, Franco-Pérez J, Peralta-Arrieta I, Alquisiras-Burgos I. The antiaging protein Klotho is a key factor in susceptibility to cerebral ischemia. Neuroscience 2026. link 29 Shen D, Kong W, Qiu H, Yuan H, Wu W, Huang L et al.. Quercetin Alleviates Cerebral Ischemia-Induced Neuroinflammation by Inhibiting Microglia-Mediated NLRP3/Caspase-1/GSDMD Pathway. Cells 2026. link 30 Wang C, Zhang C, Zhang X, Li L, Dong W, Fan W et al.. Cell Membrane-Anchored MXene@Au SERS Nanoprobe for Precise Cell Surface pH Monitoring Upon a Cerebral Ischemia 3D Cell Model. Analytical chemistry 2026. link 31 Liang CC, Shaw SW, Wu HM, Lin YH, Hsieh TH, Huang YH et al.. Amniotic fluid stem cell-derived extracellular vesicles enhance functional recovery of neurogenic bladder and neurovascular plasticity after cerebral ischemia in rats. Life sciences 2026. link 32 Lin J, You B, Yang X, Li X, Sun W, Xu Z et al.. Esculin Alleviated NLRP3 Inflammasome Activation by Inducing PINK1/Parkin-Mediated Mitophagy in Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology 2026. link 33 Gloyer NO, Moritz E, Schwieren L, Meyer U, Thomalla G, Daum G et al.. Associations of sphingosine-1-phosphate with soluble P-selectin and adverse clinical outcome in patients with cerebral ischemia with and without acetylsalicylic acid treatment. Naunyn-Schmiedeberg's archives of pharmacology 2026. link 34 Liao Y, Wang N. Neuroprotective effects of cimifugin against focal cerebral ischaemic injury through inhibition of oxidative stress, neuronal apoptosis, and iNOS/COX-2 signalling. Folia morphologica 2026. link 35 Zhang X, Liu B, Shao D, Li Z, Lin X, Cao Z et al.. Anti-inflammatory and neuroprotective effect of bryodulcosigenin against cerebral ischemia/reperfusion injury via modulation of inflammatory signaling pathways. Inflammopharmacology 2026. link 36 Niu B, Klugah-Brown B, Xia Y, Yao D, Biswal BB. Temporal Variability Analysis of Cortical Blood Flow in Rats with Hyperacute Cerebral Ischemia. Neuroscience bulletin 2026. link 37 Chen L, Tang M, Zou J, Mo J, Gan Y, Wen X et al.. Engineered reconstructed extracellular vesicles coloaded with Astragaloside IV/Paeoniflorin improve cerebral ischemia/reperfusion injurybyinhibiting the inflammatory response. Colloids and surfaces. B, Biointerfaces 2026. link 38 Li W, Jiang J, Weng Y, Zhang L, Zhang Q, He X et al.. miR-219 ameliorates myelin impairment and cognitive function deficits in the early stage of MCAO/R rats. Brain research bulletin 2026. link 39 Li Y, Dong Y, He Y, Zheng J, Liu H, Li L et al.. Endothelial Cell-Based Vascular Bandages for Blood-Brain Barrier Repair and Targeted siRNA Delivery. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026. link 40 Yoo JS, Park JH, Ahn JH, Shin MC, Moon J, Won MH et al.. Beyond Ischemic Duration: Mechanistic Determinants of Neuronal Vulnerability in Global Brain Ischemia-Reperfusion Versus Cardiac Arrest (CA/ROSC). Journal of integrative neuroscience 2026. link 41 Komatsu T, Ohta H, Takeda M, Matsumura Y, Yokoyama M, Wang Z et al.. Novel Rat Model of Embolic Cerebral Ischemia Using a Radiopaque Blood Clot and a Microcatheter Under Fluoroscopy. Translational stroke research 2025. link 42 Jiang H, Sun Z, He P, Li F, Chen Q. Ferritin Light Chain Alleviates Cerebral Ischemic-Reperfusion Injury-Induced Neuroinflammation via the HIF1α Mediated NF-κB Signaling Pathways. Inflammation 2025. link 43 Chen D, Xiang Y, Wu D, Wang H, Huang Y, Xiao H. Electroacupuncture Ameliorates Neuronal Damage and Neurological Deficits after Cerebral Ischemia-Reperfusion Injury via Restoring Telomerase Reverse Transcriptase. Cell biochemistry and biophysics 2025. link 44 Gu CL, Zhang L, Zhu Y, Bao TY, Zhu YT, Chen YT et al.. Exploring the cellular and molecular basis of nerve growth factor in cerebral ischemia recovery. Neuroscience 2025. link 45 OuYang Y, Yi J, Chen B, Zeng F, Chen X, Yang H et al.. Mechanism of Buyang Huanwu Decoction mediating Cav1-regulated Wnt pathway to promote neural regeneration in cerebral ischemic mice. Journal of ethnopharmacology 2025. link 46 Abdelaal SM, Abdel Rahman MM, Mahmoud LM, Rashed LA, Abd El-Galil TI, Mahmoud MM. Combined swimming with melatonin protects against behavioural deficit in cerebral ischemia-reperfusion injury induced rats associated with modulation of Mst1- MAPK -ERK signalling pathway. Archives of physiology and biochemistry 2025. link 47 Tu Z, Ma Y, Shang H, Zhao S, Xue B, Qu Y et al.. Endocannabinoid interference blocks post-global cerebral ischemia depression through prefrontal cortico-amygdala projections. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2025. link 48 Syeda MZ, Su G, Li Y, Bai H, Liu Y, Mu Q et al.. Platelet-hitchhiking triiodothyronine nanoparticles for enhanced therapy of cerebral ischemia-reperfusion injury. Journal of colloid and interface science 2025. link 49 Chen K, Xu B, Long L, Wen H, Zhao Q, Tu X et al.. Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion. Molecular neurobiology 2025. link 50 Khaksar S, Bigdeli M, Mohammadi R. Expression of Na. The International journal of neuroscience 2025. link 51 Mordecka-Chamera K, Pałasz A, Suszka-Świtek A, Bogus K, Skałba W, Piwowarczyk-Nowak A et al.. Cerebral ischemia-reperfusion induces the expression of phoenixin receptor (GPR173) and adult neurogenesis marker proteins in the rat striatum. Brain injury 2025. link 52 Pan G, Liu X, Zhang X, Gao H, Xu T, Li K et al.. Monomeric C-reactive Protein Exacerbates Neuronal Injury and Enhances Microglial Activation after Global Cerebral Ischemia in Mice. Molecular neurobiology 2025. link 53 Zhang Y, Lu H, Guo T, Wang J. SMAD1 Regulates the Hippocampal Neuronal Death and Ferroptosis via Affecting the Transcription of PDCD4 in Cerebral Ischemia. Molecular neurobiology 2025. link 54 Fan W, Zhou M, Zhou L, Tong J, Tan J, Shi W et al.. Dual regulation of Atf3 and Lonp1 as therapeutic targets in cerebral ischaemia-reperfusion injury. Stroke and vascular neurology 2025. link 55 Zhang L, Cui H, Hu W, Meng X, Zhang C. Targeting MAD2B as a strategy for ischemic stroke therapy. Journal of advanced research 2025. link 56 Jesser J, Weyland CS, Potreck A, Neuberger U, Breckwoldt MO, Chen M et al.. Modified treatment in cerebral ischemia 1 versus modified treatment in cerebral ischemia 0 before endovascular stroke treatment in middle cerebral artery's M1-occlusion: Predictor for revascularization success and outcome?. Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2025. link 57 Li Y, Hu Z, Xie L, Xiong T, Zhang Y, Bai Y et al.. Buyang huanwu decoction inhibits the activation of the RhoA/Rock2 signaling pathway through the phenylalanine metabolism pathway, thereby reducing neuronal apoptosis following cerebral ischemia-reperfusion injury. Journal of ethnopharmacology 2025. link 58 Khanam N, Ghosh A, Nath D. Synergistic effect of chrysin and kaempferol in ameliorating Cerebral Ischemic Reperfusion injury in rat by controlling expression of proinflammatory mediators NF-κB and STAT3. Nutritional neuroscience 2025. link 59 Tao D, Li F, Zhang X, Guo H, Yang R, Yang Y et al.. 20(R)-ginsenoside Rg3 protects against focal cerebral ischemia‒reperfusion injury by suppressing autophagy via PI3K/Akt/mTOR signaling pathway. Neuropharmacology 2025. link 60 Ren J, Gao J, Yao X, Wang X, Kong X, Lin T et al.. Bilateral transcranial direct-current stimulation confers neuroprotection through suppression of PKM2 after mouse cerebral ischemia injury. Brain research 2025. link 61 Ruan J, Wang L, Wang N, Huang P, Chang D, Zhou X et al.. Hydroxysafflor Yellow A promotes angiogenesis of brain microvascular endothelial cells from ischemia/reperfusion injury via glycolysis pathway in vitro. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025. link 62 Bitar L, Puig B, Oertner TG, Dénes Á, Magnus T. Changes in Neuroimmunological Synapses During Cerebral Ischemia. Translational stroke research 2025. link 63 Fineberg A, McVey T, Henry J, Tiemeyer E, Orfila JE, Dietz RM. Delayed Fluoxetine Administration Restores Hippocampal Function in a Juvenile Global Cerebral Ischemia Mouse Model in a Sex-Specific Manner. Neural plasticity 2025. link 64 Deng Y, Wang G, Hou D, Zhang L, Pei C, Yang G. MiR-146a-5p downregulated TRAF6/NF-κB p65 pathway to attenuate the injury of HT-22 cells induced by oxygen-glucose deprivation/reoxygenation. In vitro cellular & developmental biology. Animal 2025. link 65 Xu ZH, Qi JW, He XY, Wang SY, Chen SY, Gu YC et al.. TREML2 Modulates Microglial Phagocytosis of Myelin Debris via TLR9 in Chronic Cerebral Ischemia. Inflammation 2025. link 66 Zhao J, Nie Z, Miao H, Wu F, Ma T. Electroacupuncture reduces cerebral ischemia-induced neuronal damage in the hippocampal CA1 region in rats by inhibiting HMGB1 and p-JNK overexpression. The International journal of neuroscience 2025. link 67 Xi Y, Hou X, Huang Y, Zhou Y, Chen Y, Wang Y et al.. Loganin attenuates the inflammation, oxidative stress, and apoptosis through the JAK2/STAT3 pathway in cerebral ischemia-reperfusion injury. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025. link 68 Kang H, Huang Y, Peng H, Zhang X, Liu Y, Liu Y et al.. Mesenchymal Stem Cell-Loaded Hydrogel Improves Surgical Treatment for Chronic Cerebral Ischemia. Translational stroke research 2025. link 69 Yokoyama T, Sasaki M, Nagahama H, Kataoka-Sasaki Y, Ukai R, Oka S et al.. Multiple intravenous infusions versus a single infusion of mesenchymal stem cells in a rat model of cerebral ischemia. Journal of neurosurgery 2025. link 70 Farkas E, Rose CR. A dangerous liaison: Spreading depolarization and tissue acidification in cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025. link 71 Xu YW, Yao CH, Gao XM, Wang L, Zhang MX, Yang XD et al.. BAK ameliorated cerebral infarction/ischemia-reperfusion injury by activating AMPK/Nrf2 to inhibit TXNIP/NLRP3/caspase-1 axis. Neuroscience letters 2025. link 72 Zhang Y, Zhang S, Yang L, Zhang Y, Cheng Y, Jia P et al.. Lactate modulates microglial inflammatory responses through HIF-1α-mediated CCL7 signaling after cerebral ischemia in mice. International immunopharmacology 2025. link 73 Zhu Z, Tao X, Dai T, Wu J, Han C, Huang P et al.. Cognitive-exercise dual-task attenuates chronic cerebral ischemia-induced cognitive impairment by activating cAMP/PKA pathway through inhibiting EphrinA3/EphA4. Experimental neurology 2024. link 74 Li C, Liu Y. Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. Biochemical and biophysical research communications 2024. link 75 Pomierny B, Krzyżanowska W, Skórkowska A, Jurczyk J, Budziszewska B, Pera J. Chicago sky blue 6B exerts neuroprotective and anti-inflammatory effects on focal cerebral ischemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024. link 76 Zhang W, Liu D, Yi J, Fan J. Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion. Molecular neurobiology 2024. link 77 Xing X, Zhang X, Fan J, Zhang C, Zhang L, Duan R et al.. Neuroprotective Effects of Melittin Against Cerebral Ischemia and Inflammatory Injury via Upregulation of MCPIP1 to Suppress NF-κB Activation In Vivo and In Vitro. Neurochemical research 2024. link 78 Liu H, Jiang C, Peng J, Hu X, Xia Y. Transplantation of Neural Stem Cells-Overexpressed Ku70 Improves Neurological Deficits in a Mice Model of Cerebral Ischemia Stroke. Neurochemical research 2024. link 79 Lu X, Zhan L, Chai G, Chen M, Sun W, Xu E. Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Molecular neurobiology 2024. link 80 Ye X, Chen Q, Gong X, Zhou C, Yuan T, Wang X et al.. STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis. Molecular biotechnology 2024. link 81 Rennert RC, Atai NA, Nguyen VN, Abedi A, Sternbach S, Chu J et al.. Three-Vessel Anastomosis for Direct Multiterritory Cerebral Revascularization: Case Series. Operative neurosurgery (Hagerstown, Md.) 2024. link 82 Zhu XQ, Gao D. Naringenin alleviates cognitive dysfunction in rats with cerebral ischemia/reperfusion injury through up-regulating hippocampal BDNF-TrkB signaling: involving suppression in neuroinflammation and oxidative stress. Neuroreport 2024. link 83 Komatsu T, Ohta H, Takakura N, Hata J, Kitagawa T, Kurashina Y et al.. A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber. Translational stroke research 2024. link 84 Yegin B, Donmez DB, Oz S, Aydin S. Dose-related effects of ciproxifan on brain tissue in rats with cerebral ischemia-reperfusion. The International journal of neuroscience 2024. link 85 Gelen V, Özkanlar S, Kara A, Yeşildağ A. Citrate-coated silver nanoparticles loaded with agomelatine provide neuronal therapy in acute cerebral ischemia/reperfusion of rats by inhibiting the oxidative stress, endoplasmic reticulum stress, and P2X7 receptor-mediated inflammasome. Environmental toxicology 2024. link 86 Yamashita T, Sasaki M, Sasaki Y, Nagahama H, Oka S, Kataoka-Sasaki Y et al.. Rehabilitation facilitates functional improvement following intravenous infusion of mesenchymal stem cells in the chronic phase of cerebral ischemia in rats. Brain research 2024. link 87 Ghatak S, Kumar Sikdar S. Prolonged exposure to lactate causes TREK1 channel clustering in rat hippocampal astrocytes. Neuroscience letters 2024. link 88 Alquisiras-Burgos I, Hernández-Cruz A, Peralta-Arrieta I, Aguilera P. Resveratrol Prevents Cell Swelling Through Inhibition of SUR1 Expression in Brain Micro Endothelial Cells Subjected to OGD/Recovery. Molecular neurobiology 2024. link 89 Hwang I, Kim BS, Lee HY, Cho SW, Lee SE, Ahn JY. PA2G4/EBP1 ubiquitination by PRKN/PARKIN promotes mitophagy protecting neuron death in cerebral ischemia. Autophagy 2024. link 90 Wang J, Li Q, Chu S, Liu X, Zhang J, He W. Impact of Codonopsis decoction on cerebral blood flow and cognitive function in rats with chronic cerebral ischemia. Journal of ethnopharmacology 2024. link 91 Nguyen LTT, Le XT, Nguyen HT, Nguyen TV, Pham HNT, Van Thi Pham A et al.. Kaempferol-3-O-(2″-O-galloyl-β-D-glucopyranoside): a novel neuroprotective agent from Diospryros kaki against cerebral ischemia-induced brain injury. Journal of natural medicines 2024. link 92 Zhang H, Feng Y, Si Y, Lu C, Wang J, Wang S et al.. Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation. Redox biology 2024. link 93 Hu W, Kong X, Cui Y, Wang H, Gao J, Wang X et al.. Surfeit Locus Protein 4 as a Novel Target for Therapeutic Intervention in Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology 2024. link 94 Cao Y, Xu Y, Zhang R, Qi J, Su Q, Chen Z. Circ_0000115 Protects Against Cerebral Ischemia Injury by Suppressing Neuronal Apoptosis, Oxidative Stress and Inflammation by miR-1224-5p/Nos3 Axis In Vitro. Molecular biotechnology 2024. link 95 You G, Zheng L, Zhang Y, Zhang Y, Wang Y, Guo W et al.. Tangeretin Attenuates Cerebral Ischemia-Reperfusion-Induced Neuronal Pyroptosis by Inhibiting AIM2 Inflammasome Activation via Regulating NRF2. Inflammation 2024. link 96 Jackson CW, Xu J, Escobar I, Saul I, Fagerli E, Dave KR et al.. Resveratrol Preconditioning Downregulates PARP1 Protein to Alleviate PARP1-Mediated Cell Death Following Cerebral Ischemia. Translational stroke research 2024. link 97 El-Sayyad SM, El-Ella DMA, Hafez MM, Al-Mokaddem AK, Ali BM, Awny MM et al.. Sesamol defends neuronal damage following cerebral ischemia/reperfusion: a crosstalk of autophagy and Notch1/NLRP3 inflammasome signaling. Inflammopharmacology 2024. link 98 Zhao J, Luo J, Deng C, Fan Y, Liu N, Cao J et al.. Volatile oil of Angelica sinensis Radix improves cognitive function by inhibiting miR-301a-3p targeting Ppp2ca in cerebral ischemia mice. Journal of ethnopharmacology 2024. link 99 Liu C, Gao Q, Dong J, Cai H. Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation. Molecular neurobiology 2024. link 100 Ivanov Y, Buratto E, Konstantinov IE, Clifford M, Brizard CP, Horton S. Clinical assessment can be lifesaving: Salvage of catastrophic cerebral ischemia by conversion to central extracorporeal membrane oxygenation. Perfusion 2024. link

Original source

[1]
Cutamesine attenuates hippocampal damage via sigma-1 receptor activation following oxygen-glucose deprivation in vitro. — Puente-Sanz A, Mazzantini C, Venturini M, Mainolfi F, Herrero-González A, Pugliese AM et al. Brain research (2026)
[2]
Atractylenolide III alleviates inflammation in cerebral ischemia/reperfusion injury by modulating the PI3K/Akt/NF-κB signaling pathway. — Mao M, Shentu C, Chen X, Meng Q, Jiao Z, Zhang Y et al. Journal of ethnopharmacology (2026)
[3]
Borneol-Edaravone mitigates ischemic brain injury in MCAO rats. — Zhuang XF, Zhang T, Zeng YQ, Shan ZN, Huang JL, Gu JH et al. Journal of neuroimmunology (2026)
[4]
Metformin nanoparticles mitigate cerebral ischemia reperfusion injury by improving mitochondrial dysfunction and inhibiting NLRP3 activation. — Deng L, Cai T, Li J, Song Y, Guo S, Tao T Biomaterials advances (2026)
[5]
Cycloastragenol protected hippocampal CA1 neurons by regulating redox homeostasis and alleviated cognitive impairment following cerebral ischemia-reperfusion. — Gao S, Zhu S, Qu T, Zou J, Yin L, Wang X et al. Brain research bulletin (2026)
[6]
Use of the Feature Scaling and Machine Learning Techniques on Optical Fiber Biosensors for the Detection of Neuroprotector IL-10 in Serum of a Murine Model with Cerebral Ischemia. — Bandala-Daniel RI, Ocelotl-Zayas L, Delgado-Macuil R, González-León K, García-Juárez M, Muñoz-Aguirre S et al. Sensors (Basel, Switzerland) (2026)
[7]
Autologous mitochondrial transplant for acute cerebral ischemia: Phase 1 trial results and review. — Walker M, Levitt MR, Federico EM, Miralles FJ, Levy SH, Lynne Prijoles K et al. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2026)
[8]
Predicting lesion reversal in acute cerebral ischaemia via apparent diffusion coefficient threshold on diffusion-weighted MRI. — Skattør TH, Bjørnerud A, Nome T, Bakke KM, Enriquez BA, Digernes I et al. European radiology (2026)
[9]
Based on the PINK1/Parkin signaling pathway, the protective effect of salidroside on cerebral ischemia-reperfusion injury in male rats was investigated. — Dong T, Wang H, Li Y, Tan J Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (2026)
[10]
Reinwardtia indica Dumort. protects against ponatinib-induced cerebral ischemia in adult zebrafish via attenuation of oxidative stress, neuroinflammation, mitochondrial dysfunction, and neurotransmitter dysregulation: A multi-target therapeutic strategy. — Wadhwa K, Chauhan P, Singh G Journal of ethnopharmacology (2026)
[11]
Electroacupuncture ameliorates learning and memory impairment by inhibiting inflammation and promoting synaptic plasticity via inhibition of the NF-KB/NLRP3 signaling pathway in cerebral ischemic rats. — Huang C, Pan G, Lu D, Zhu M, Yang G, Huang C et al. Histology and histopathology (2026)
[12]
Role of eCIRP in Mediating Post-ischemia Microglial Phagocytosis via TREM-2 Receptor: Insights from Porcine and Mouse Cellular Models. — Li P, Sun Z, Chen Y, Fang Z, Yu D, Wang L et al. Molecular neurobiology (2026)
[13]
A Novel Mechanism by which harpagide protects against cerebral ischemia:Focus on Grp75 and MAMs Calcium Homeostasis. — Wang K, Dong YY, Wang Y, Su GZ, Yu QM, Yu ZX et al. Journal of ethnopharmacology (2026)
[14]
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