Overview
Gastric cancer, particularly in its late stages, represents a significant global health issue with high mortality rates. It predominantly manifests as adenocarcinoma and is strongly associated with Helicobacter pylori infection, chronic atrophic gastritis, and intestinal metaplasia 1678102026304050.Diagnosis
Management
Special Populations
Key Recommendations
References
Showing 100 most recent of 243 indexed papers.
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AGA Clinical Practice Update on Screening and Surveillance in Individuals at Increased Risk for Gastric Cancer in the United States: Expert Review. Gastroenterology 2025. link 6 Ajani JA, D'Amico TA, Bentrem DJ, Corvera CU, Das P, Enzinger PC et al.. Gastric Cancer, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology. Journal of the National Comprehensive Cancer Network : JNCCN 2025. link 7 Ford AC, Yuan Y, Park JY, Forman D, Moayyedi P. Eradication Therapy to Prevent Gastric Cancer in Helicobacterpylori-Positive Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies. Gastroenterology 2025. link 8 Rezapour A, Irandoust K, Eri M, Foruzanfar F, Souresrafil A, Afshari S et al.. Economic Evaluation of Gastric Cancer Screening Strategies: A Systematic Review. Journal of gastrointestinal cancer 2025. link 9 Zhang H, Meng X, Gou D, Liu X, Huang Y, Liu S et al.. A meta-analysis of the effects of proton pump inhibitors on the risk of gastric cancer. Medicine 2025. link 10 Salvador I, Arau B, Andújar X, Ferrer C, Zabana Y, Ruiz L et al.. Intravenous sedation during esophagogastroduodenoscopy is associated with a reduced risk of missed gastric cancer. BMC gastroenterology 2025. link 11 Qi L, Zhou Z, Peng K, Yu N, Wang L, Ji X et al.. A retrospective analysis of the effects of moderate sedation on the degree of cardia exposure in overweight elderly patients. BMC anesthesiology 2025. link 12 Tan-Garcia A, Chua TH, Leow WQ. Computational pathology in the age of artificial intelligence - embrace not fear. The journal of pathology. Clinical research 2025. link 13 Daterdiwala NF, Memon HF, Erum A, Osmani AH. Gastric carcinoma leading to metastatic spinal cord compression. JPMA. The Journal of the Pakistan Medical Association 2025. link 14 Komba EV, Nyakiha M, Lyuu T. Prevalence of gastric cancer and its associated mortality among patients undergoing upper gastrointestinal endoscopy at a tertiary level hospital in Tanzania. BMC gastroenterology 2025. link 15 Li D, Zhao M, Cheng X, Tao Z, You Y, Fu Y et al.. The strategy of vitamin supplementation in Chinese patients with gastric cancer after gastrectomy: a prospective cohort study. Scientific reports 2025. link 16 Zhang YL, Zhao JL, Qu KJ, Jiao ZL, Chen YR, Zhou J et al.. Nivolumab in gastric cancer with liver metastasis complicated by immune-mediated hepatitis: a case report and FAERS database analysis. Frontiers in immunology 2025. link 17 Nagase T, Shinozaki K. Risk factors for zolbetuximab-associated nausea and vomiting: a pharmacovigilance analysis using the Japanese Adverse Drug Event Report (JADER) database. Die Pharmazie 2025. link 18 Verdaguer J, Chouchana L, Robert M, Bergeron S, Montastruc F, Barus R. Ischemic cardiopathy induced by capecitabine in gastric cancer: The role of dihydropyrimidine dehydrogenase metabolites. Therapie 2025. link 19 Engin Delipoyraz E, Mildanoglu MM, Sürül B, Olmuşçelik O, Erkanlı K, Bilici A. An Unusual Case of Metastatic Gastric Cancer Presenting with Right Heart Failure and Cardiac Metastasis. Medicina (Kaunas, Lithuania) 2025. link 20 Rivera F, Longo F, Martín Richard M, Richart P, Alsina M, Carmona A et al.. SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of gastric cancer (2023). Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2024. link 21 Shitara K, Fleitas T, Kawakami H, Curigliano G, Narita Y, Wang F et al.. Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with gastric cancer. 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The road to a world-unified approach to the management of patients with gastric intestinal metaplasia: a review of current guidelines. Gut 2024. link 26 Luo X, Qi S, Chen M, Gan T, Lv X, Yang J et al.. Maintaining H. pylori Negativity After Eradication Can Consolidate Its Benefit in Gastric Cancer Prevention: A Meta-Analysis. Clinical and translational gastroenterology 2024. link 27 Yang X, Zeng Z, Liao Z, Zhu C, Wang H, Wu H et al.. Comparison of proximal gastrectomy and total gastrectomy in proximal gastric cancer: a meta-analysis of postoperative health condition using the PGSAS-45. BMC cancer 2024. link 28 Zhai W, Jin Y. OTUD7B: A potential therapeutic target in the treatment of gastric cancer?. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2024. link 29 Wong S, Tan P. A tough act to swallow: Streptococcusanginosus and gastric cancer. Cell host & microbe 2024. link 30 Lei C, Xu Y, Zhang S, Huang C, Qin J. The role of microbiota in gastric cancer: A comprehensive review. Helicobacter 2024. link 31 Normile D. Eliminating a gut microbe could slash gastric cancers. Science (New York, N.Y.) 2024. link 32 Lochman P. Navigating the complexities of developing a classification of esophagogastric junction tumors suitable for preoperative setting. Bratislavske lekarske listy 2024. link 33 Li G, Lu T. A Case of Abnormal Elevation of Serum CA 72-4 Caused by Colchicine. Clinical laboratory 2024. link 34 Kim SY, Lee JK, Lee KH, Jang JY, Kim BW. The Impact of Sedation on Cardio-Cerebrovascular Adverse Events after Surveillance Esophagogastroduodenoscopy in Patients with Gastric Cancer: A Nationwide Population-Based Cohort Study. Gut and liver 2024. link 35 Salnikov MY, MacNeil KM, Mymryk JS. The viral etiology of EBV-associated gastric cancers contributes to their unique pathology, clinical outcomes, treatment responses and immune landscape. Frontiers in immunology 2024. link 36 Sun T, Chen Y, Ge S, Ma J, Li B, Zhang H et al.. Analysis of upper gastrointestinal bleeding complicated with deep vein thrombosis in elderly gastric cancer patients by gastric cancer imaging. Biotechnology & genetic engineering reviews 2024. link 37 Shimizu S, Matsunaga T, Sakano Y, Makinoya M, Shishido Y, Miyatani K et al.. A gastroduodenal artery that branched from the celiac artery in gastrectomy: A rare case of an anatomical variant. Asian journal of endoscopic surgery 2024. link 38 Shirani M, Pakzad R, Haddadi MH, Akrami S, Asadi A, Kazemian H et al.. The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis. BMC infectious diseases 2023. link 39 Xu XH, Shao SL, Guo D, Ge LN, Wang Z, Liu P et al.. Roles of microRNAs and exosomes in Helicobacter pylori associated gastric cancer. Molecular biology reports 2023. link 40 Duan F, Liu L, Chen X, Yang Q, Wang Y, Zhang Y et al.. Genetic risk and gastric cancer: polygenic risk scores in population-based case-control study. Expert review of molecular diagnostics 2023. link 41 He S, Sun D, Li H, Cao M, Yu X, Lei L et al.. Real-World Practice of Gastric Cancer Prevention and Screening Calls for Practical Prediction Models. Clinical and translational gastroenterology 2023. link 42 . Driver Events of Gastric Cancer Differ According to Subtype and Ancestry. Cancer discovery 2023. link 43 Ma X, Huang S, Shi H, Tan Z, Zhang H, Shi L et al.. Gender authorship trends of gastric cancer in the top journals of gastroenterology: A 20-year perspective. Medicine 2023. link 44 Ao M, Awane M, Asao Y, Kita S, Miyawaki T, Tanaka K. High prevalence of vitamin B-12 deficiency before and early after gastrectomy in patients with gastric cancer. Asia Pacific journal of clinical nutrition 2023. link.0010) 45 Oh SE, Youn HG, Oh SJ, Choi MG, Lee JH, Sohn TS et al.. Trends in vitamin D level and risk of vitamin D deficiency after gastrectomy for gastric cancer: A retrospective study of a single high-volume center experience. Clinical nutrition ESPEN 2023. link 46 Gamble LA, Lopez R, Rajasimhan S, Samaranayake SG, Bowden C, Famiglietti AL et al.. Micronutrient Supplementation and Bone Health After Prophylactic Total Gastrectomy in Patients With CDH1 Variants. The Journal of clinical endocrinology and metabolism 2023. link 47 Li XP, Wang YY, Sun YS, Zhang LJ, Zhao XY, Liu ZQ et al.. Preoperative and postoperative clinical signatures of postgastrectomy venous thromboembolism in patients with gastric cancer: A retrospective cohort study. Asian journal of surgery 2023. link 48 Ajani JA, D'Amico TA, Bentrem DJ, Chao J, Cooke D, Corvera C et al.. Gastric Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN 2022. link 49 Liu C, Ng SK, Ding Y, Lin Y, Liu W, Wong SH et al.. Meta-analysis of mucosal microbiota reveals universal microbial signatures and dysbiosis in gastric carcinogenesis. Oncogene 2022. link 50 Yan L, Chen Y, Chen F, Tao T, Hu Z, Wang J et al.. Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention: Updated Report From a Randomized Controlled Trial With 26.5 Years of Follow-up. Gastroenterology 2022. link 51 Arai J, Aoki T, Sato M, Niikura R, Suzuki N, Ishibashi R et al.. Machine learning-based personalized prediction of gastric cancer incidence using the endoscopic and histologic findings at the initial endoscopy. Gastrointestinal endoscopy 2022. link 52 Morais S, Costa A, Albuquerque G, Araújo N, Pelucchi C, Rabkin CS et al.. Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project. Cancer causes & control : CCC 2022. link 53 Dabo B, Pelucchi C, Rota M, Jain H, Bertuccio P, Bonzi R et al.. The association between diabetes and gastric cancer: results from the Stomach Cancer Pooling Project Consortium. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 2022. link 54 Li M, Wu S, Luo H, Niu J, Yan Y, Fang Y et al.. Serological and Molecular Characterization of Hepatitis B Virus Infection in Gastric Cancer. Frontiers in cellular and infection microbiology 2022. link 55 Li N, Pang Y, Sang J, Sun Y, Hou W. The controversial expression of SOX2 in gastric cancer and its correlation with Helicobacter pylori infection: A meta-analysis. Medicine 2022. link 56 Qu X, Shi Y. Bile reflux and bile acids in the progression of gastric intestinal metaplasia. Chinese medical journal 2022. link 57 Mazzei MA, Bagnacci G, Gentili F, Capitoni I, Mura G, Marrelli D et al.. Structured and shared CT radiological report of gastric cancer: a consensus proposal by the Italian Research Group for Gastric Cancer (GIRCG) and the Italian Society of Medical and Interventional Radiology (SIRM). European radiology 2022. link 58 Shi C, Badgwell BD, Grabsch HI, Gibson MK, Hong SM, Kumarasinghe P et al.. Data Set for Reporting Carcinoma of the Stomach in Gastrectomy. Archives of pathology & laboratory medicine 2022. link 59 Kawamoto T, Saito T, Kosugi T, Nakamura N, Wada H, Tonari A et al.. Temporal Profiles of Symptom Scores After Palliative Radiotherapy for Bleeding Gastric Cancer With Adjustment for the Palliative Prognostic Index: An Exploratory Analysis of a Multicentre Prospective Observational Study (JROSG 17-3). Clinical oncology (Royal College of Radiologists (Great Britain)) 2022. link 60 Tsuruta Y, Maeda Y, Kitaguchi Y, Hayama M, Nojima S, Tsuda T et al.. A Case of Endonasal Endoscopic Surgery for Intraorbital Metastasis of Gastric Ring Cell Carcinoma. Ear, nose, & throat journal 2022. link 61 Puia A, Schlanger D, Fetti A, Popa C, Necula A, Al Hajjar N. Do Patient Delay and Diagnostic Delay Influence Long Term Survival in Patients with Gastric Cancer?. Journal of gastrointestinal and liver diseases : JGLD 2022. link 62 Yuguchi T, Sano H, Nakajima K, Ikura Y. Pulmonary Tumor Thrombotic Microangiopathy Caused by Recurrent Gastric Cancer 26 Years After Total Gastrectomy. Internal medicine (Tokyo, Japan) 2022. link 63 Suzuki K, Shibasaki S, Nakauchi M, Nakamura K, Akimoto S, Tanaka T et al.. Impact of routine preoperative sonographic screening with early intervention for deep venous thrombosis in lower extremities on preventing postoperative venous thromboembolism in patients with gastric cancer scheduled for minimally invasive surgery. Langenbeck's archives of surgery 2022. link 64 Wroblewski LE, Peek RM. Helicobacter pylori: a stealth assassin. Trends in cancer 2021. link 65 Ono H, Yao K, Fujishiro M, Oda I, Uedo N, Nimura S et al.. Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition). Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2021. link 66 Buscarini E, Benedetti A, Monica F, Pasquale L, Buttitta F, Cameletti M et al.. Changes in digestive cancer diagnosis during the SARS-CoV-2 pandemic in Italy: A nationwide survey. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2021. link 67 Kawakami K, Aoyama T, Yokokawa T, Kobayashi K, Takahari D, Chin K et al.. The Combined Use of 5 or More Drugs Is a Factor Related to Lower Adherence to S-1 in S-1 and Oxaliplatin Treatment for Advanced Gastric Cancer. Biological & pharmaceutical bulletin 2021. link 68 Takayama Y, Kaneoka Y, Maeda A, Takahashi T, Kiriyama M, Seita K. Assessment of Perioperative Symptoms of Patients with Gastric Cancer Using The Edmonton Symptom Assessment System Revised Japanese version (ESAS-r-J). The journal of medical investigation : JMI 2021. link 69 Li Y, Cui L, Chen Y, Wang F. Carcinosarcoma and sarcomatoid carcinoma of the stomach: Two case reports. Medicine 2021. link 70 Li Q, Li Y, Jiang H, Xiao Z, Wu X, Zhang H et al.. Vitamin D suppressed gastric cancer cell growth through downregulating CD44 expression in vitro and in vivo. Nutrition (Burbank, Los Angeles County, Calif.) 2021. link 71 Chen Y, Katayose T, Nagaoka S, Piao Y, Yamaguchi K, Asou H. A post-marketing observational study of ramucirumab in patients with gastric cancer in Japan. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2021. link 72 Saito K, Yamagata Y, Hakozaki Y, Nakata M, Oya M. Early gastric cancer with splenic artery aneurysm successfully treated with laparoscopic distal gastrectomy after endovascular coil embolization: A case report. Asian journal of endoscopic surgery 2021. link 73 . Gastrin Blocks Symmetric Stem-Cell Division and Gastric Tumorigenesis. Cancer discovery 2020. link 74 Yang C, Yang Y, Huang X, Li H, Cheng H, Tong S et al.. A Nomogram Based on Clinicopathologic Features and Preoperative Hematology Parameters to Predict Occult Peritoneal Metastasis of Gastric Cancer: A Single-Center Retrospective Study. Disease markers 2020. link 75 Yao K, Uedo N, Kamada T, Hirasawa T, Nagahama T, Yoshinaga S et al.. Guidelines for endoscopic diagnosis of early gastric cancer. Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society 2020. link 76 Namikawa T, Iwabu J, Munekage M, Uemura S, Maeda H, Kitagawa H et al.. Laparoscopic-endoscopic cooperative surgery for early gastric cancer with gastroesophageal varices. Asian journal of endoscopic surgery 2020. link 77 Kosaraju SC, Hao J, Koh HM, Kang M. Deep-Hipo: Multi-scale receptive field deep learning for histopathological image analysis. Methods (San Diego, Calif.) 2020. link 78 Parizadeh SM, Ghandehari M, Jafarzadeh-Esfehani R, Parizadeh SM, Hassanian SM, Ghayour-Mobarhan M et al.. The Relationship Between Vitamin D Status and Risk of Gastric Cancer. Nutrition and cancer 2020. link 79 Niu R, Chen Y, Xiang Y, Liu Y, Guo J, Feng B. Comparison of Three Different Data Sources of Adverse Drug Reactions Using Adverse Drug Reaction Data of Fluorouracil for Gastric Cancer as an Example. Biological & pharmaceutical bulletin 2020. link 80 Kobashi R, Hikichi T, Imamura H, Hashimoto T, Mukai S, Ohira H. A case of gastric pseudoaneurysm following endoscopic submucosal dissection of early gastric cancer. Clinical journal of gastroenterology 2020. link 81 Zhang Z, Mei Y, Cheng H, Wu X. Portal vein thrombosis secondary to postoperative gastric cancer: Report of two cases. The Journal of international medical research 2020. link 82 Park JH, Lee HJ, Oh SY, Park SH, Berlth F, Son YG et al.. Prediction of Postoperative Mortality in Patients with Organ Failure After Gastric Cancer Surgery. World journal of surgery 2020. link 83 Kaye P, Lindsay D, Madhusudan S, Vohra R, Catton J, Platt C et al.. Upper GI biopsies for adenocarcinoma - how many biopsies should endoscopists take?. Histopathology 2019. link 84 Cheng CS, Chen L, Xie J, Chen Z. Multimodality palliative treatment with transarterial chemoembolization and high-intensity focused ultrasound for gastric leiomyosarcoma multiple liver metastasis pain: A case report. Medicine 2019. link 85 Asaumi Y, Sakatoku M, Okamoto J, Hayashi S, Ota N, Yoshida K et al.. Laparoscopic decompression of a stricture of the celiac artery caused by the median arcuate ligament in a gastric cancer patient: A case of report. 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HER2 testing of gastro-oesophageal adenocarcinoma: a commentary and guidance document from the Association of Clinical Pathologists Molecular Pathology and Diagnostics Committee. Journal of clinical pathology 2018. link 90 Kawamura T, Makuuchi R, Tokunaga M, Tanizawa Y, Bando E, Yasui H et al.. Long-Term Outcomes of Gastric Cancer Patients with Preoperative Sarcopenia. Annals of surgical oncology 2018. link 91 Fuentes HE, Paz LH, Wang Y, Oramas DM, Simons CR, Tafur AJ. Performance of Current Thromboembolism Risk Assessment Tools in Patients With Gastric Cancer and Validity After First Treatment. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2018. link 92 Osaki T, Saito H, Fukumoto Y, Kono Y, Murakami Y, Shishido Y et al.. Risk and incidence of perioperative deep vein thrombosis in patients undergoing gastric cancer surgery. Surgery today 2018. link 93 Zhang C, Fan HW, Yi WW, Zheng ZQ. Hidden Blood Loss and Its Influential Factors After Laparoscopy-Assisted Gastrectomy for Gastric Cancer. Journal of laparoendoscopic & advanced surgical techniques. Part A 2018. link 94 Xiao H, Xiao Y, Quan H, Liu W, Pan S, Ouyang Y. Intra-abdominal infection after radical gastrectomy for gastric cancer: Incidence, pathogens, risk factors and outcomes. International journal of surgery (London, England) 2017. link 95 Huang KS, Wang SH, Chuah SK, Rau KM, Lin YH, Hsieh MC et al.. The effects of hospice-shared care for gastric cancer patients. PloS one 2017. link 96 Ota T, Makihara M, Tsukuda H, Kajikawa R, Inamori M, Miyatake N et al.. Pain Management of Malignant Psoas Syndrome Under Epidural Analgesia During Palliative Radiotherapy. Journal of pain & palliative care pharmacotherapy 2017. link 97 Tey J, Soon YY, Koh WY, Leong CN, Choo BA, Ho F et al.. Palliative radiotherapy for gastric cancer: a systematic review and meta-analysis. 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