Diagnosis
In a retrospective study of 112 astroglioma patients [PMID:24557705], maximal fractional anisotropy and its ratio showed significant differences between IDH1 mutated and non-mutated tumors in grades II and III, with high area under the curve values (0.92 and 0.80 respectively).
The study by Tan et al. [PMID:24557705] demonstrated that minimal ADC values and their ratios were statistically significant differentiators between IDH1 mutated and non-mutated astrogliomas across all glioma grades.
Management
Given the potential of DTI to noninvasively detect IDH1 mutations [PMID:24557705], this imaging technique could support tailored therapeutic strategies based on molecular characteristics of the tumor.
References
1 Tan WL, Huang WY, Yin B, Xiong J, Wu JS, Geng DY. Can diffusion tensor imaging noninvasively detect IDH1 gene mutations in astrogliomas? A retrospective study of 112 cases. AJNR. American journal of neuroradiology 2014. link
1 papers cited of 3 indexed.