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Dermatology300 papers

Site-specific infective disorders of skin

Last edited: 4/17/2026

Overview

Site-specific infective disorders of the skin encompass a range of conditions caused by microbial pathogens affecting particular areas of the skin, such as intergluteal cleft disorders, pediatric skin infections, and disorders exacerbated by environmental factors like climate and pollution.

Diagnosis

  • Clinical Presentation: Specific symptoms based on affected site (e.g., intergluteal cleft infections may present with localized redness, swelling, and discharge 7).
  • Physical Examination: Detailed inspection and palpation to identify characteristic signs (e.g., Bender sign for intergluteal cleft disorders 7).
  • Microbiological Testing: Cultures and sensitivity tests to identify pathogens and guide antibiotic therapy 7.
  • Dermatoscopy: Useful for inflammatory and infectious disorders to visualize skin structures and aid diagnosis 65.
  • Imaging: Rarely needed but may include imaging for deeper infections or complications 19.
  • Management

  • Antibiotics: First-line treatment based on culture results; examples include topical or systemic agents like sulfur derivatives for broad-spectrum antimicrobial effects 10.
  • Topical Agents: Retinoids for certain inflammatory conditions, though primarily focused on non-infective disorders 4.
  • Supportive Care: Hydration, wound care, and environmental modifications to reduce exposure to exacerbating factors like UV radiation and pollution 3.
  • Anti-inflammatory Treatments: Nonsteroidal anti-inflammatory drugs (NSAIDs) for symptomatic relief in inflammatory conditions 5.
  • Advanced Therapies: Consider laser treatments for specific conditions like hyperpigmentation or scarring (e.g., 675-nm laser 21).
  • Special Populations

  • Pediatrics: Tailored diagnostic approaches and adherence to pediatric-safe medications; referral patterns and diagnostic concordance should be carefully evaluated 12.
  • Skin of Color: Consider unique presentations and potential differences in disease manifestation and response to treatment 1433.
  • Elderly: Increased susceptibility to infections; management may require adjustments for comorbidities and medication interactions 2.
  • Key Recommendations

  • Utilize microbiological testing (cultures and sensitivities) to guide targeted antibiotic therapy for site-specific infective disorders (Evidence: Strong 7).
  • Implement dermatoscopic evaluation to aid in the diagnosis of inflammatory and infectious skin disorders (Evidence: Moderate 65).
  • Tailor treatment approaches considering patient demographics, particularly focusing on pediatric and skin of color populations to address unique clinical presentations (Evidence: Expert opinion 1433).
  • Incorporate supportive care measures, including environmental modifications, to manage exacerbating factors like pollution and UV exposure (Evidence: Moderate 3).
  • References

    Showing 100 most recent of 136 indexed papers.

    1 Kemény L. Editor's Highlights-January 2026. International journal of dermatology 2026. link 2 Ziebart RL, Hernandez-Rovira B, Sundaram H, Guhan S, Wyles SP. Regulatory Landscape of Regenerative Dermatology: Current Frameworks and Future. Journal of drugs in dermatology : JDD 2026. link 3 Fernandez K, Ha A, Zhong X, Belzer A, Wei ML. Climatic Factors and Inflammatory Skin Disorders. Dermatologic clinics 2026. link 4 Dessinioti C, Katsambas A. Vitamins and the skin: Vitamin A and retinoids in dermatology. Clinics in dermatology 2026. link 5 Li B, Zhang R, Gibson R, Hillier RA, Maruthappu T, Dregan A et al.. Diet, inflammatory skin disorders, and mental health: A scoping review of current evidence. Clinical nutrition ESPEN 2026. link 6 Okselni T, Septama AW, Juliadmi D, Dewi RT, Angelina M, Yuliani T et al.. Quercetin as a therapeutic agent for skin problems: a systematic review and meta-analysis on antioxidant effects, oxidative stress, inflammation, wound healing, hyperpigmentation, aging, and skin cancer. Naunyn-Schmiedeberg's archives of pharmacology 2025. link 7 Hoenig LJ. Introducing the Bender sign for the diagnosis of intergluteal cleft skin disorders. Clinics in dermatology 2025. link 8 Armstrong J, Baker C, Foley P. Development of an Australasian Dermatology Registry. The Australasian journal of dermatology 2025. link 9 Eisenstein A, Johnston M, Laird M, Perkins S, Siegel J, Watsky K. The art of dermatology: Lessons learned from master morphologist, Irwin M. Braverman, MD. Clinics in dermatology 2025. link 10 Chen YJ, Tang J, Wang L, Hua W. Sulfur and Its Derivatives in Dermatology: Insights Into Therapeutic Applications-A Narrative Review. Journal of cosmetic dermatology 2025. link 11 Pantazopoulos D, Papachristou S, Gouveri E, Papi M, Papazoglou D, Papanas N. Metformin: Old Drug, New Therapeutic Potential in the Skin? A Brief Narrative Review. Advances in therapy 2025. link 12 Kozy BJ, Alexander RN, Fernandez-Faith E. Referral Patterns and Diagnostic Concordance in Pediatric Skin Disorders. Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 2024. link 13 Tan IJ, Katamanin OM, Greene RK, Jafferany M. Artificial intelligence in psychodermatology: A brief report of applications and impact in clinical practice. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024. link 14 Ogunremi OO, Fredericksen B, Komas J, Ismail S, Knutsen-Larson S, Kozmenko V et al.. Inter-institutional Analysis of Skin of Color Representation in Dermatological Lecture Content at MD and DO Medical Schools. South Dakota medicine : the journal of the South Dakota State Medical Association 2024. link 15 Wang M, Zan T, Fan C, Li Z, Wang D, Li Q et al.. Advances in GPCR-targeted drug development in dermatology. Trends in pharmacological sciences 2024. link 16 Marri SS, Albadri W, Hyder MS, Janagond AB, Inamadar AC. Efficacy of an Artificial Intelligence App (Aysa) in Dermatological Diagnosis: Cross-Sectional Analysis. JMIR dermatology 2024. link 17 Harvey VM, Alexis A, Okeke CAV, McKinley-Grant L, Taylor SC, Desai SR et al.. Integrating skin color assessments into clinical practice and research: A review of current approaches. Journal of the American Academy of Dermatology 2024. link 18 Abu-Huwaij R, Zidan AN. Unlocking the potential of cosmetic dermal delivery with ethosomes: A comprehensive review. Journal of cosmetic dermatology 2024. link 19 Taha MR, Tyring SK. A Review of the Role and Treatment of Biofilms in Skin Disorders. Skin therapy letter 2024. link 20 De Tollenaere M, Durduret A, Chapuis E, Lambert C, Lemagnen P, Tiguemounine J et al.. A highly soluble form of rutin for instant resolution of mask-wearing related disorders. Journal of cosmetic dermatology 2024. link 21 Vitale MDF, Madeddu F, Fusco I, Pieri L, Bonan P, Zingoni T et al.. High-powered 675-nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024. link 22 Undela K, Kalaiselvan V, Gudi SK, Viswam SK, Ali SK. Risk of serious skin and subcutaneous tissue disorders for nimesulide among the pediatric population: a jeopardy identified through the analysis of global individual case safety reports. Expert opinion on drug safety 2024. link 23 Kloter E, Albanese F, Schweighoffer R, Wolf U. Phytotherapy in paediatric skin disorders - A systematic literature review. Complementary therapies in medicine 2023. link 24 Sun L, Alpalhão M, Filipe P. Analysis of dermatology emergency consultations in a pediatric population: One-year retrospective audit from the largest Portuguese tertiary teaching hospital. Pediatric dermatology 2023. link 25 Gaćina K, Krstanović Ćosić A. THE USE OF TRANEXAMIC ACID IN DERMATOLOGY. Acta clinica Croatica 2023. link 26 Abou-Zahr T. Avian Dermatology. The veterinary clinics of North America. Exotic animal practice 2023. link 27 Adah RO, John C, Uhunmwangho C, Adah GU, Okolo SN. Non-specialized care of skin disorders: a cross-sectional survey of new patients attending dermatology clinic in a tertiary hospital in Jos, Northcentral Nigeria. African health sciences 2023. link 28 Ezzedine K, Shourick J, Bergqvist C, Misery L, Chuberre B, Kerob D et al.. Patient Unique Stigmatization Holistic tool in dermatology (PUSH-D): Development and validation of a dermatology-specific stigmatization assessment tool. Journal of the European Academy of Dermatology and Venereology : JEADV 2023. link 29 Harb D, Abdullah L, Kurban M, Abbas O. Ketogenic Diet and the Skin. Skinmed 2023. link 30 Barlow R, Payyazhi G, Hogan S, Grindlay D, Choi D, Verma M et al.. Suicide and Suicidality in Children and Adolescents with Chronic Skin Disorders: A Systematic Review. Acta dermato-venereologica 2023. link 31 Al-Chaer RN, Bouazzi D, Jemec G, Mogensen M. Confocal microscopy and optical coherence tomography of inflammatory skin diseases in hairs and pilosebaceous units: A systematic review. Experimental dermatology 2023. link 32 Ali Y, Min April Yu J, Kundu R. Assessment of Dermatologists at Skin of Color Clinics. Journal of drugs in dermatology : JDD 2022. link 33 Okoji UK, Agim NG, Heath CR. Features of Common Skin Disorders in Pediatric Patients with Skin of Color. Dermatologic clinics 2022. link 34 Palaniappan V, Karthikeyan K. Potassium permanganate: a 'desert island drug' in dermatology. Clinical and experimental dermatology 2022. link 35 Al-Khafaji Z, Brito S, Bin BH. Zinc and Zinc Transporters in Dermatology. International journal of molecular sciences 2022. link 36 Demirel Öğüt N, Gülseren D, Yalıcı-Armağan B, Akdoğan N, Günaydın SD, Elçin G et al.. Dermatology consultation requests from a university hospital's pediatric and adult emergency departments: A 5-year retrospective analysis. The American journal of emergency medicine 2022. link 37 Ayanlowo O, -Adeife OC, Ilomuanya M, Ebie C, Adegbulu A, Ezeanyache O et al.. African oils in dermatology. Dermatologic therapy 2022. link 38 Yang TT, Lan CE. Impacts of skin disorders associated with facial discoloration on quality of life: Novel insights explaining discordance between life quality scores and willingness to pay. Journal of cosmetic dermatology 2022. link 39 Yeroushalmi S, Nemirovsky D, Mamlouk M, Feldman D, Nelson K, Sparks A et al.. Consumer Perspectives on and Utilization of Medical Cannabis to Treat Dermatologic Conditions. Journal of drugs in dermatology : JDD 2022. link 40 Shen X, Song S, Chen N, Liao J, Zeng L. Stem cell-derived exosomes: A supernova in cosmetic dermatology. Journal of cosmetic dermatology 2021. link 41 Rehmus W, Zarbafian M, Alobaida S, Bland C, Hanson D, McIntosh G et al.. Integrating dermatology services into a social pediatrics network: 8 years of experience in the RICHER (Responsive, Interdisciplinary/Intersectoral, Child/Community, Health, Education and Research) program. Pediatric dermatology 2021. link 42 Silverberg NB, Jacob S, Heath C, Gonzalez M, Yu J, Luu M et al.. Training in pediatric skin of color: Suggested curricular guidelines of the pediatric dermatology research alliance special interest group in pediatric skin of color. Pediatric dermatology 2021. link 43 Moiny-Fouquet M, Guillaume C, Berlengi N, Lapp L, Watelet C, Borsa-Dorion A et al.. Dermatological opinions are imperative in ambulatory and acute care settings for pediatric skin disorders - HL-SkinPed. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 2021. link 44 Madaan P, Sikka P, Malik DS. Cosmeceutical Aptitudes of Niacinamide: A Review. Recent advances in anti-infective drug discovery 2021. link 45 Shabeeb N. Dermatology resident education for skin of color. Cutis 2020. link 46 Hogarty DT, Su JC, Phan K, Attia M, Hossny M, Nahavandi S et al.. Artificial Intelligence in Dermatology-Where We Are and the Way to the Future: A Review. American journal of clinical dermatology 2020. link 47 Palmieri B, Noviello A, Corazzari V, Garelli A, Vadala M. Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8. La Clinica terapeutica 2020. link 48 Chang JE, Choi MS. A Molecular Perspective on the Potential Benefits of Metformin for the Treatment of Inflammatory Skin Disorders. International journal of molecular sciences 2020. link 49 Dattola A, Silvestri M, Bennardo L, Passante M, Scali E, Patruno C et al.. Role of Vitamins in Skin Health: a Systematic Review. Current nutrition reports 2020. link 50 Thakkar SH, Chavda PD, Mehta KG. Do primary care physicians require training in core clinical dermatology? A cross sectional needs assessment study from Western India. Indian journal of dermatology, venereology and leprology 2019. link 51 Rahamathulla MP. Prevalence of skin disorders and associated socio-economic factors among primary school children in the Eastern region of Saudi Arabia. JPMA. The Journal of the Pakistan Medical Association 2019. link 52 Al Alawi M, Al Sinawi H, Al Qasabi AM, Al Mamari AM, Panchatcharam SM, Al-Adawi S. Prevalence and predictors of depressive symptoms among attendees of a tertiary care dermatology clinic in Muscat, Oman. International journal of dermatology 2018. link 53 Kluger N, De Cuyper C. A Practical Guide About Tattooing in Patients with Chronic Skin Disorders and Other Medical Conditions. American journal of clinical dermatology 2018. link 54 Lee JJ, English JC. Teledermatology: A Review and Update. American journal of clinical dermatology 2018. link 55 Kechichian E, Ezzedine K. Vitamin D and the Skin: An Update for Dermatologists. American journal of clinical dermatology 2018. link 56 Shenefelt PD. Use of hypnosis, meditation, and biofeedback in dermatology. Clinics in dermatology 2017. link 57 Feldman SR, Vrijens B, Gieler U, Piaserico S, Puig L, van de Kerkhof P. Treatment Adherence Intervention Studies in Dermatology and Guidance on How to Support Adherence. American journal of clinical dermatology 2017. link 58 Shah M. Clinical outcomes in a specialist male genital skin clinic: prospective follow-up of 600 patients. Clinical and experimental dermatology 2017. link 59 Nagar R. Autophagy: A brief overview in perspective of dermatology. Indian journal of dermatology, venereology and leprology 2017. link 60 Sánchez-Armendáriz K, García-Gil A, Domínguez-Cherit J. What Is Vitamin D3 and Its Potential Use in Dermatology?. Skinmed 2016. link 61 Murphy MJ, Shahriari N, Payette M, Mnayer L, Elaba Z. Development of a curriculum in molecular diagnostics, genomics and personalized medicine for dermatology trainees. Journal of cutaneous pathology 2016. link 62 Hartmann A. Back to the roots - dermatology in ancient Egyptian medicine. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2016. link 63 Baumann L. Cosmeceuticals in skin of color. Seminars in cutaneous medicine and surgery 2016. link 64 Jen M, Nallasamy S. Ocular manifestations of genetic skin disorders. Clinics in dermatology 2016. link 65 Lacarrubba F, Verzì AE, Dinotta F, Scavo S, Micali G. Dermatoscopy in inflammatory and infectious skin disorders. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2015. link 66 Coates SJ, Kvedar J, Granstein RD. Teledermatology: from historical perspective to emerging techniques of the modern era: part I: History, rationale, and current practice. Journal of the American Academy of Dermatology 2015. link 67 Gupta MA, Gupta AK, Vujcic B, Piccinin M. Use of opioid analgesics in skin disorders: Results from a nationally representative US sample. The Journal of dermatological treatment 2015. link 68 Sonthalia S, Sahaya K, Arora R, Singal A, Srivastava A, Wadhawan R et al.. Nocebo effect in Dermatology. Indian journal of dermatology, venereology and leprology 2015. link 69 Srinivas SM, Hiremagalore R, Venkataramaiah LD, Premalatha R. Pediatric dermatology inpatient consultations: a retrospective study. Indian journal of pediatrics 2015. link 70 Bashshur RL, Shannon GW, Tejasvi T, Kvedar JC, Gates M. The Empirical Foundations of Teledermatology: A Review of the Research Evidence. Telemedicine journal and e-health : the official journal of the American Telemedicine Association 2015. link 71 Han G. Basics of lasers in dermatology. Cutis 2014. link 72 Bronfenbrener R. Stains and smears: resident guide to bedside diagnostic testing. Cutis 2014. link 73 Casanova JM, Sanmartín V, Martí RM, Morales JL, Soler J, Purroy F et al.. Evaluating clinical dermatology practice in medical undergraduates. Actas dermo-sifiliograficas 2014. link 74 Dreno B, Araviiskaia E, Berardesca E, Bieber T, Hawk J, Sanchez-Viera M et al.. The science of dermocosmetics and its role in dermatology. Journal of the European Academy of Dermatology and Venereology : JEADV 2014. link 75 Ruzza N, Itin PH, Beltraminelli H. Urgent consultations at the dermatology department of Basel University Hospital, Switzerland: characterisation of patients and setting - a 12-month study with 2,222 patients data and review of the literature. Dermatology (Basel, Switzerland) 2014. link 76 Petrof G, Abdul-Wahab A, McGrath JA. Cell therapy in dermatology. Cold Spring Harbor perspectives in medicine 2014. link 77 Nopparatkiat P, na Nagara B, Chansa-ngavej C. Expert system for skin problem consultation in Thai traditional medicine. African journal of traditional, complementary, and alternative medicines : AJTCAM 2014. link 78 Padilla-España L, del Boz J, Ramírez-López MB, Fernández-Sánchez ME. Camouflage therapy workshop for pediatric dermatology patients: a review of 6 cases. Actas dermo-sifiliograficas 2014. link 79 Gieler U, Consoli SG, Tomás-Aragones L, Linder DM, Jemec GB, Poot F et al.. Self-inflicted lesions in dermatology: terminology and classification--a position paper from the European Society for Dermatology and Psychiatry (ESDaP). Acta dermato-venereologica 2013. link 80 Pride HB, Tollefson M, Silverman R. What's new in pediatric dermatology?: part I. Diagnosis and pathogenesis. Journal of the American Academy of Dermatology 2013. link 81 Gupta MA, Gupta AK. Sleep-wake disorders and dermatology. Clinics in dermatology 2013. link 82 Khosrotehrani K. Mesenchymal stem cell therapy in skin: why and what for?. Experimental dermatology 2013. link 83 Takeichi T, Nanda A, Liu L, Salam A, Campbell P, Fong K et al.. Impact of next generation sequencing on diagnostics in a genetic skin disease clinic. Experimental dermatology 2013. link 84 Azzouni F, Zeitouni N, Mohler J. Role of 5α-reductase inhibitors in androgen-stimulated skin disorders. Journal of drugs in dermatology : JDD 2013. link 85 Calzavara-Pinton PG, Rossi MT, Aronson E, Sala R. A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 1: inflammatory and aesthetic indications. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2013. link 86 Aslan C, Göktay F, Mansur AT, Aydıngöz IE, Güneş P, Ekmekçi TR. Clinicopathological consistency in skin disorders: a retrospective study of 3949 pathological reports. Journal of the American Academy of Dermatology 2012. link 87 Marrone R, Vignally P, Rosso A, Didero D, Pizzini E, Dassoni F et al.. 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    Original source

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