HemoChat is an evidence-based AI medical search tool covering all major clinical domains, powered by 46,298 SNOMED-CT concepts, clinical guidelines, and live PubMed literature.

What medical domains does HemoChat cover?

HemoChat covers all major medical domains including cardiology, oncology, neurology, hematology, pulmonology, endocrinology, gastroenterology, psychiatry, nephrology, rheumatology, musculoskeletal, and more — with 46,298 SNOMED-CT concepts.

Is HemoChat a replacement for clinical judgment?

No. HemoChat is for clinical reference only and is not a substitute for professional medical judgment. Always consult qualified healthcare professionals for medical decisions.

What AI technology does HemoChat use?

HemoChat uses a hybrid GraphRAG + VectorRAG pipeline combining Neo4j knowledge graphs with FAISS vector search and an LLM for answer generation.

← Back to guidelines

Orthopedics16685 papers

Disorder of fracture healing

Last edited: 4/23/2026

Overview

Disorder of fracture healing refers to complications that impede the normal process of bone repair, leading to delayed union, non-union, or malunion. These issues can arise due to factors such as infection, inadequate blood supply, or impaired cellular processes.

Diagnosis

Clinical Presentation: Persistent pain, swelling, limited mobility, and radiographic evidence of delayed healing 33 37.

Radiographic Imaging: X-rays to assess bone healing progression; CT or MRI for detailed assessment of soft tissue involvement 33 37.

Biomechanical Testing: Stress tests or bone density scans to evaluate healing integrity 33 37.

Laboratory Tests: Blood tests to rule out systemic issues like infection or metabolic disorders 33 37.

Management

First-Line Treatments:

- Biological Agents: Use of platelet-rich plasma (PRP) to enhance growth factor delivery 9 33. - Extracellular Matrices: Application of small intestinal submucosa extracellular matrix (SIS-ECM) to provide a scaffold for healing 23 26.

Adjunctive Therapies:

- Electrical Stimulation: Intermittent pneumatic compression (IPC) and electrical stimulation to promote angiogenesis and tissue regeneration 60 67. - Nutritional Support: Ensuring adequate vitamin D and calcium levels to support bone healing 27 49. - Infection Control: Antibiotics if infection is present, guided by culture and sensitivity tests 1 18.

Special Populations

Elderly: Increased risk of delayed healing due to comorbidities and reduced healing capacity; consider PRP and nutritional support 27 33.

Diabetes: Higher incidence of infection and impaired healing; emphasize strict glycemic control and advanced wound care modalities like PRP 3 27.

Comorbidities: Presence of conditions like osteoporosis or vascular disease may necessitate tailored approaches, including biomechanical support and enhanced biological interventions 33 49.

Key Recommendations

Use Platelet-Rich Plasma (PRP) for Enhanced Healing: Apply PRP to stimulate growth factor release and promote bone healing (Evidence: Moderate) 9 33.

Implement Electrical Stimulation for Chronic Cases: Incorporate intermittent pneumatic compression or electrical stimulation to accelerate healing in non-healing fractures (Evidence: Moderate) 60 67.

Ensure Adequate Nutritional Support: Maintain optimal levels of vitamin D and calcium to support bone healing processes (Evidence: Moderate) 27 49.

Monitor and Treat Infections Promptly: Utilize appropriate antibiotics based on culture and sensitivity results to prevent infection-related healing delays (Evidence: Strong) 1 18.

Consider Extracellular Matrix Products: Employ small intestinal submucosa extracellular matrix as a scaffold to facilitate bone regeneration (Evidence: Moderate) 23 26.

References

Showing 100 most recent of 193 indexed papers.

1 Kapp D, Ferguson A, Denmark TK, Johnson J, Naqvi S, Carpenter S et al.. Efficacy of a dual-layer pre-hydrated amniotic membrane allograft in the treatment of hard-to-heal wounds. Journal of wound care 2026. link 2 Polak A, Szołtys-Brzezowska B, Piejko L. Effect of Electrical Stimulation on Cytokines and Growth Factors Active in the Process of Wound Healing: A Systematic Review of In Vivo Animal Studies and Randomized Clinical Trials. Advances in skin & wound care 2026. link 3 Pan T, Zhu X, Sui Y, Zhang Z, Su Y. Tanshinone IIA accelerates diabetic wound healing via suppression of macrophage NLRP3 inflammasome activity. Biochemical and biophysical research communications 2026. link 4 Potluru A, Pawlik O, Barlow R, Veitch D, Wernham A. A review of secondary intention healing in dermatology and dermatological surgery: part 1. Clinical and experimental dermatology 2025. link 5 Beraja GE, Gruzmark F, Pastar I, Lev-Tov H. What's New in Wound Healing: Treatment Advances and Microbial Insights. American journal of clinical dermatology 2025. link 6 Sekar D, Nagarajan P, Ekambaram G, Port Louis LR, Bazeer AB. From slime to sublime: the impact of snail mucin on scar therapy and wound healing in dermatology. Cutaneous and ocular toxicology 2025. link 7 Ranire-Maguire M, Caprioli R, Taylor C, Rodger R, Thomas A, Oropallo A. Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study. Journal of wound care 2025. link 8 Hodge NE, Dahl CB, Liljenquist BB, Thomas EJ. Clinical experience depicting wound regression trends with carePATCH: a case series. Journal of wound care 2025. link 9 Perussolo J, Calciolari E, Dereka X, Donos N. Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care. Periodontology 2000 2025. link 10 Janowska A, Fidanzi C, Romanelli M, Iannone M, Oranges T, Montaquila F et al.. Fractional Epidermal Skin Grafts in Hard-to-Heal Wounds: Case Series. The international journal of lower extremity wounds 2025. link 11 Mendivil J, McMahon AE, Ojelade OT, Hobson K, Marballie M, Alvarez S et al.. Clinical use of DermaBind TL/FM as a wound covering for hard-to-heal wounds of various aetiologies: a case series. Journal of wound care 2025. link 12 Abdel Azim S, Whiting C, Friedman AJ. Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing. Nitric oxide : biology and chemistry 2024. link 13 Neyens J, Heusden WV, Veenendaal DV, Schols J. Effects of concurrent optical and magnetic stimulation in hard-to-heal wounds: a real-world evidence case series. Journal of wound care 2024. link 14 Swain D, Cole W, Barrett C, Black G, Hudson C, Lacqua M et al.. The use of a multimodal wound matrix to treat a variety of hard-to-heal wounds: a case series surveillance. Journal of wound care 2024. link 15 Cole W. Treatment of bacterially contaminated lower extremity ulcers with a fatty acid-containing wound matrix: a case series. Journal of wound care 2024. link 16 Townsend EC, Cheong JZA, Radzietza M, Fritz B, Malone M, Bjarnsholt T et al.. What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2024. link 17 Bozkurt AS, Yılmaz ŞG. Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats. Current gene therapy 2024. link 18 Tang TY, Mak MYQ, Yap CJQ, Boey JEC, Chan SL, Soon SXY et al.. An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox. The international journal of lower extremity wounds 2024. link 19 Xu C, Hu L, Zeng J, Wu A, Deng S, Zhao Z et al.. Gynura divaricata (L.) DC. promotes diabetic wound healing by activating Nrf2 signaling in diabetic rats. Journal of ethnopharmacology 2024. link 20 Meng X, Xiao X, Jeon S, Kim D, Park BJ, Kim YJ et al.. An Ultrasound-Driven Bioadhesive Triboelectric Nanogenerator for Instant Wound Sealing and Electrically Accelerated Healing in Emergencies. Advanced materials (Deerfield Beach, Fla.) 2023. link 21 Davies OG, Williams S, Goldie K. The therapeutic and commercial landscape of stem cell vesicles in regenerative dermatology. Journal of controlled release : official journal of the Controlled Release Society 2023. link 22 Suhandi C, Mohammed AFA, Wilar G, El-Rayyes A, Wathoni N. Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis. Tissue engineering and regenerative medicine 2023. link 23 Jeffery S. Clinical benefits of small intestinal submucosa extracellular matrix and review of the evidence. Journal of wound care 2023. link 24 Kurz P, Danner G, Lembelembe JP, Nair HKR, Martin R. Activation of healing and reduction of pain by single-use automated microcurrent electrical stimulation therapy in patients with hard-to-heal wounds. International wound journal 2023. link 25 Dissemond J, Aare K, Ozer K, Gandhi D, Ryan JL, DeKoven M. Aquacel Ag Advantage/Ag+ Extra and Cutimed Sorbact in the management of hard-to-heal wounds: a cohort study. Journal of wound care 2023. link 26 Jeffery S. Clinical benefits of small intestinal submucosa extracellular matrix and review of the evidence. Journal of wound care 2023. link 27 Bikle DD. Role of vitamin D and calcium signaling in epidermal wound healing. Journal of endocrinological investigation 2023. link 28 Cogo A, Bignozzi AC, Hermans MH, Quint BJ, Snels JP, Schultz G. A desiccation compound as a biofilm- and necrosis-removing agent: a case series. Journal of wound care 2022. link 29 Herron K. Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds. Journal of wound care 2022. link 30 Senkowsky J, Li S, Nair A, Pal S, Hu W, Tang L. A wound alkalinity measurement to predict non-healing wound outcomes. Journal of wound care 2022. link 31 Janowska A, Romanelli M, Oranges T, Davini G, Iannone M, Dini V. Prognostic Indicators of Wound Healing in Atypical Wounds: A Case Series. The international journal of lower extremity wounds 2022. link 32 Grada A, Phillips TJ. Nutrition and cutaneous wound healing. Clinics in dermatology 2022. link 33 Popescu MN, Iliescu MG, Beiu C, Popa LG, Mihai MM, Berteanu M et al.. Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control. BioMed research international 2021. link 34 Milne J, Swift A, Smith J, Martin R. Electrical stimulation for pain reduction in hard-to-heal wound healing. Journal of wound care 2021. link 35 Dini V, Romanelli M, Oranges T, Davini G, Janowska A. Blue light emission in the management of hard-to-heal wounds. Italian journal of dermatology and venereology 2021. link 36 Bolton L. Platelet-Rich Plasma: Optimal Use in Surgical Wounds. Wounds : a compendium of clinical research and practice 2021. link 37 Bachar-Wikstrom E, Manchanda M, Bansal R, Karlsson M, Kelly-Pettersson P, Sköldenberg O et al.. Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4-phenylbutyrate. International wound journal 2021. link 38 Wilmink JM, Ladefoged S, Jongbloets A, Vernooij JCM. The evaluation of the effect of probiotics on the healing of equine distal limb wounds. PloS one 2020. link 39 Poljšak N, Kreft S, Kočevar Glavač N. Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. Phytotherapy research : PTR 2020. link 40 Nguyen JK, Huang A, Siegel DM, Jagdeo J. Variability in Wound Care Recommendations Following Dermatologic Procedures. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2020. link 41 Landsman A. Visualization of Wound Healing Progression With Near Infrared Spectroscopy: A Retrospective Study. Wounds : a compendium of clinical research and practice 2020. link 42 González-de la Torre H, Verdú-Soriano J, Quintana-Lorenzo ML, Berenguer-Pérez M, Lavín RS, Soldevilla-Ágreda J. Specialised wound care clinics in Spain: distribution and characteristics. Journal of wound care 2020. link 43 Calcei JG, Rodeo SA. Orthobiologics for Bone Healing. Clinics in sports medicine 2019. link 44 Schneider HP, Landsman A. Preclinical and Clinical Studies of Hyaluronic Acid in Wound Care: A Case Series and Literature Review. Wounds : a compendium of clinical research and practice 2019. link 45 Mosca RC, Ong AA, Albasha O, Bass K, Arany P. Photobiomodulation Therapy for Wound Care: A Potent, Noninvasive, Photoceutical Approach. Advances in skin & wound care 2019. link 46 Hirotsu K, Kannan S, Brian Jiang SI. Treatment of Hypertrophic Granulation Tissue: A Literature Review. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2019. link 47 Givol O, Kornhaber R, Visentin D, Cleary M, Haik J, Harats M. A systematic review of Calendula officinalis extract for wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2019. link 48 Zeleníková R, Vyhlídalová D. Applying honey dressings to non-healing wounds in elderly persons receiving home care. Journal of tissue viability 2019. link 49 Zinder R, Cooley R, Vlad LG, Molnar JA. Vitamin A and Wound Healing. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2019. link 50 Pavlovčič U, Jezeršek M. Handheld 3-dimensional wound measuring system. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2018. link 51 Grada A, Mervis J, Falanga V. Research Techniques Made Simple: Animal Models of Wound Healing. The Journal of investigative dermatology 2018. link 52 Chernoff G, Bryan N, Park AM. Mesothelial Stem Cells and Stromal Vascular Fraction: Use in Functional Disorders, Wound Healing, Fat Transfer, and Other Conditions. Facial plastic surgery clinics of North America 2018. link 53 Kogan S, Sood A, Granick MS. Amniotic Membrane Adjuncts and Clinical Applications in Wound Healing: A Review of the Literature. Wounds : a compendium of clinical research and practice 2018. link 54 Mayer D, Armstrong D, Schultz G, Percival S, Malone M, Romanelli M et al.. Cell salvage in acute and chronic wounds: a potential treatment strategy. Experimental data and early clinical results. Journal of wound care 2018. link 55 Rembe JD, Fromm-Dornieden C, Stuermer EK. Effects of Vitamin B Complex and Vitamin C on Human Skin Cells: Is the Perceived Effect Measurable?. Advances in skin & wound care 2018. link 56 Pérez-Recalde M, Ruiz Arias IE, Hermida ÉB. Could essential oils enhance biopolymers performance for wound healing? A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology 2018. link 57 Kahn S. Highlights from the advanced wound healing stream at the LINK Congress. British journal of nursing (Mark Allen Publishing) 2017. link 58 Keen MA. Hyaluronic Acid in Dermatology. Skinmed 2017. link 59 Kimmel H, Gittleman H. Retrospective observational analysis of the use of an architecturally unique dermal regeneration template (Derma Pure®) for the treatment of hard-to-heal wounds. International wound journal 2017. link 60 Arvesen K, Nielsen CB, Fogh K. Accelerated wound healing with combined NPWT and IPC: a case series. British journal of community nursing 2017. link 61 Ferrer-Sola M, Sureda-Vidal H, Altimiras-Roset J, Fontsere-Candell E, Gonzalez-Martinez V, Espaulella-Panicot J et al.. Hydrosurgery as a safe and efficient debridement method in a clinical wound unit. Journal of wound care 2017. link 62 Sridharan K, Sivaramakrishnan G. Efficacy of topical insulin in wound healing: A preliminary systematic review and meta-analysis of randomized controlled trials. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2017. link 63 Zhou X, Patel D, Sen S, Shanmugam V, Sidawy A, Mishra L et al.. Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis. Journal of vascular surgery 2017. link 64 Müller CS, Burgard B, Zimmerman M, Vogt T, Pföhler C. On the significance of negative-pressure wound therapy with instillation in dermatology. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 2016. link 65 Ud-Din S, Bayat A. Non-invasive objective devices for monitoring the inflammatory, proliferative and remodelling phases of cutaneous wound healing and skin scarring. Experimental dermatology 2016. link 66 Fronzo C. Compression, collagen and bacteria-binding: different approaches for wound management. Journal of wound care 2016. link 67 Zhou K, Schenk R, Brogan MS. The wound healing trajectory and predictors with combined electric stimulation and conventional care: one outpatient wound care clinic's experience. European journal of clinical investigation 2016. link 68 Bianchi T, Wolcott RD, Peghetti A, Leaper D, Cutting K, Polignano R et al.. Recommendations for the management of biofilm: a consensus document. Journal of wound care 2016. link 69 Dryden M, Dickinson A, Brooks J, Hudgell L, Saeed K, Cutting KF. A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds. Journal of wound care 2016. link 70 Hoffmann G, Hartel M, Mercer JB. Heat for wounds - water-filtered infrared-A (wIRA) for wound healing - a review. German medical science : GMS e-journal 2016. link 71 Ding J, Kwan P, Ma Z, Iwashina T, Wang J, Shankowsky HA et al.. Synergistic effect of vitamin D and low concentration of transforming growth factor beta 1, a potential role in dermal wound healing. Burns : journal of the International Society for Burn Injuries 2016. link 72 Lubowitz JH. Editorial commentary: healing requires scaffolds, growth factors, and cells. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2015. link 73 Perdikouri C, Tägil M, Isaksson H. Characterizing the composition of bone formed during fracture healing using scanning electron microscopy techniques. Calcified tissue international 2015. link 74 Fiorentino S, Roffi A, Filardo G, Marcacci M, Kon E. European definitions, current use, and EMA stance of platelet-rich plasma in sports medicine. The journal of knee surgery 2015. link 75 Picard F, Hersant B, Bosc R, Meningaud JP. Should we use platelet-rich plasma as an adjunct therapy to treat "acute wounds," "burns," and "laser therapies": A review and a proposal of a quality criteria checklist for further studies. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2015. link 76 Avrahami R, Rosenblum J, Gazes M, Rosenblum S, Litman L. The Effect of Combined Ultrasound and Electric Field Stimulation on Wound Healing in Chronic Ulcerations. Wounds : a compendium of clinical research and practice 2015. link 77 AbouIssa A, Mari W, Simman R. Clinical Usage of an Extracellular, Collagen-rich Matrix: A Case Series. Wounds : a compendium of clinical research and practice 2015. link 78 Wolcott R. Disrupting the biofilm matrix improves wound healing outcomes. Journal of wound care 2015. link 79 Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N. Honey as a topical treatment for wounds. The Cochrane database of systematic reviews 2015. link 80 Quain AM, Khardori NM. Nutrition in Wound Care Management: A Comprehensive Overview. Wounds : a compendium of clinical research and practice 2015. link 81 Belcher J. Dressings and healing with honey. British journal of nursing (Mark Allen Publishing) 2014. link 82 Rot C, Stern T, Blecher R, Friesem B, Zelzer E. A mechanical Jack-like Mechanism drives spontaneous fracture healing in neonatal mice. Developmental cell 2014. link 83 Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M. Centella asiatica in dermatology: an overview. Phytotherapy research : PTR 2014. link 84 Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2014. link 85 Hu M, Ludlow D, Alexander JS, McLarty J, Lian T. Improved wound healing of postischemic cutaneous flaps with the use of bone marrow-derived stem cells. The Laryngoscope 2014. link 86 Foltynski P, Ladyzynski P, Wojcicki JM. A new smartphone-based method for wound area measurement. Artificial organs 2014. link 87 Kunimoto BT. Catastrophic wounds. Journal of cutaneous medicine and surgery 2013. link 88 Broussard KC, Powers JG. Wound dressings: selecting the most appropriate type. American journal of clinical dermatology 2013. link 89 Frankova J, Diamantova D, Vrbkova J, Ulrichova J. Influence of hydrogencalcium salts of oxidized cellulose on MMP-2, MMP-9 and TNF-α production and wound healing in non-healing wounds. Acta dermatovenerologica Croatica : ADC 2013. link 90 Jull AB, Walker N, Deshpande S. Honey as a topical treatment for wounds. The Cochrane database of systematic reviews 2013. link 91 Sorg H, Harder Y, Krueger C, Reimers K, Vogt PM. The nonhematopoietic effects of erythropoietin in skin regeneration and repair: from basic research to clinical use. Medicinal research reviews 2013. link 92 Valacchi G, Zanardi I, Sticozzi C, Bocci V, Travagli V. Emerging topics in cutaneous wound repair. Annals of the New York Academy of Sciences 2012. link 93 Desai KK, Hahn E, Pulikkottil B, Lee E. Negative pressure wound therapy: an algorithm. Clinics in plastic surgery 2012. link 94 Ashcroft GS, Jeong MJ, Ashworth JJ, Hardman M, Jin W, Moutsopoulos N et al.. Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2012. link 95 Jackson WM, Nesti LJ, Tuan RS. Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem cells translational medicine 2012. link 96 Tran D. Ruffled wound suturing - closing wounds with sides of unequal lengths. Australian family physician 2011. link 97 Sanders AJ, Jiang DG, Jiang WG, Harding KG, Patel GK. Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. International wound journal 2011. link 98 Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM. Dynamic reciprocity in the wound microenvironment. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2011. link 99 Werner A, Laccourreye O. Honey in otorhinolaryngology: when, why and how?. European annals of otorhinolaryngology, head and neck diseases 2011. link 100 Wannous H, Lucas Y, Treuillet S. Enhanced assessment of the wound-healing process by accurate multiview tissue classification. IEEE transactions on medical imaging 2011. link

Original source

[1]
Efficacy of a dual-layer pre-hydrated amniotic membrane allograft in the treatment of hard-to-heal wounds. — Kapp D, Ferguson A, Denmark TK, Johnson J, Naqvi S, Carpenter S et al. Journal of wound care (2026)
[2]
Effect of Electrical Stimulation on Cytokines and Growth Factors Active in the Process of Wound Healing: A Systematic Review of In Vivo Animal Studies and Randomized Clinical Trials. — Polak A, Szołtys-Brzezowska B, Piejko L Advances in skin & wound care (2026)
[3]
Tanshinone IIA accelerates diabetic wound healing via suppression of macrophage NLRP3 inflammasome activity. — Pan T, Zhu X, Sui Y, Zhang Z, Su Y Biochemical and biophysical research communications (2026)
[4]
A review of secondary intention healing in dermatology and dermatological surgery: part 1. — Potluru A, Pawlik O, Barlow R, Veitch D, Wernham A Clinical and experimental dermatology (2025)
[5]
What's New in Wound Healing: Treatment Advances and Microbial Insights. — Beraja GE, Gruzmark F, Pastar I, Lev-Tov H American journal of clinical dermatology (2025)
[6]
From slime to sublime: the impact of snail mucin on scar therapy and wound healing in dermatology. — Sekar D, Nagarajan P, Ekambaram G, Port Louis LR, Bazeer AB Cutaneous and ocular toxicology (2025)
[7]
Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study. — Ranire-Maguire M, Caprioli R, Taylor C, Rodger R, Thomas A, Oropallo A Journal of wound care (2025)
[8]
Clinical experience depicting wound regression trends with carePATCH: a case series. — Hodge NE, Dahl CB, Liljenquist BB, Thomas EJ Journal of wound care (2025)
[9]
Platelet-rich plasma and plasma rich in growth factors in extra-oral wound care. — Perussolo J, Calciolari E, Dereka X, Donos N Periodontology 2000 (2025)
[10]
Fractional Epidermal Skin Grafts in Hard-to-Heal Wounds: Case Series. — Janowska A, Fidanzi C, Romanelli M, Iannone M, Oranges T, Montaquila F et al. The international journal of lower extremity wounds (2025)
[11]
Clinical use of DermaBind TL/FM as a wound covering for hard-to-heal wounds of various aetiologies: a case series. — Mendivil J, McMahon AE, Ojelade OT, Hobson K, Marballie M, Alvarez S et al. Journal of wound care (2025)
[12]
Applications of nitric oxide-releasing nanomaterials in dermatology: Skin infections and wound healing. — Abdel Azim S, Whiting C, Friedman AJ Nitric oxide : biology and chemistry (2024)
[13]
Effects of concurrent optical and magnetic stimulation in hard-to-heal wounds: a real-world evidence case series. — Neyens J, Heusden WV, Veenendaal DV, Schols J Journal of wound care (2024)
[14]
The use of a multimodal wound matrix to treat a variety of hard-to-heal wounds: a case series surveillance. — Swain D, Cole W, Barrett C, Black G, Hudson C, Lacqua M et al. Journal of wound care (2024)
[15]
Treatment of bacterially contaminated lower extremity ulcers with a fatty acid-containing wound matrix: a case series. — Cole W Journal of wound care (2024)
[16]
What is slough? Defining the proteomic and microbial composition of slough and its implications for wound healing. — Townsend EC, Cheong JZA, Radzietza M, Fritz B, Malone M, Bjarnsholt T et al. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2024)
[17]
Effect of Bovine Lactoferrin Treatment on Iron Homeostasis and Gene Expression Changes in Multiple Organ Dysfunctions During Wound Healing Process in Rats. — Bozkurt AS, Yılmaz ŞG Current gene therapy (2024)
[18]
An Observational Clinical Trial Examining the Effect of Topical Oxygen Therapy (Natrox — Tang TY, Mak MYQ, Yap CJQ, Boey JEC, Chan SL, Soon SXY et al. The international journal of lower extremity wounds (2024)
[19]
Gynura divaricata (L.) DC. promotes diabetic wound healing by activating Nrf2 signaling in diabetic rats. — Xu C, Hu L, Zeng J, Wu A, Deng S, Zhao Z et al. Journal of ethnopharmacology (2024)
[20]
An Ultrasound-Driven Bioadhesive Triboelectric Nanogenerator for Instant Wound Sealing and Electrically Accelerated Healing in Emergencies. — Meng X, Xiao X, Jeon S, Kim D, Park BJ, Kim YJ et al. Advanced materials (Deerfield Beach, Fla.) (2023)
[21]
The therapeutic and commercial landscape of stem cell vesicles in regenerative dermatology. — Davies OG, Williams S, Goldie K Journal of controlled release : official journal of the Controlled Release Society (2023)
[22]
Effectiveness of Mesenchymal Stem Cell Secretome on Wound Healing: A Systematic Review and Meta-analysis. — Suhandi C, Mohammed AFA, Wilar G, El-Rayyes A, Wathoni N Tissue engineering and regenerative medicine (2023)
[23]
Clinical benefits of small intestinal submucosa extracellular matrix and review of the evidence. — Jeffery S Journal of wound care (2023)
[24]
Activation of healing and reduction of pain by single-use automated microcurrent electrical stimulation therapy in patients with hard-to-heal wounds. — Kurz P, Danner G, Lembelembe JP, Nair HKR, Martin R International wound journal (2023)
[25]
Aquacel Ag Advantage/Ag+ Extra and Cutimed Sorbact in the management of hard-to-heal wounds: a cohort study. — Dissemond J, Aare K, Ozer K, Gandhi D, Ryan JL, DeKoven M Journal of wound care (2023)
[26]
Clinical benefits of small intestinal submucosa extracellular matrix and review of the evidence. — Jeffery S Journal of wound care (2023)
[27]
Role of vitamin D and calcium signaling in epidermal wound healing. — Bikle DD Journal of endocrinological investigation (2023)
[28]
A desiccation compound as a biofilm- and necrosis-removing agent: a case series. — Cogo A, Bignozzi AC, Hermans MH, Quint BJ, Snels JP, Schultz G Journal of wound care (2022)
[29]
Impact of a novel synthetic nanofibre matrix to treat hard-to-heal wounds. — Herron K Journal of wound care (2022)
[30]
A wound alkalinity measurement to predict non-healing wound outcomes. — Senkowsky J, Li S, Nair A, Pal S, Hu W, Tang L Journal of wound care (2022)
[31]
Prognostic Indicators of Wound Healing in Atypical Wounds: A Case Series. — Janowska A, Romanelli M, Oranges T, Davini G, Iannone M, Dini V The international journal of lower extremity wounds (2022)
[32]
Nutrition and cutaneous wound healing. — Grada A, Phillips TJ Clinics in dermatology (2022)
[33]
Autologous Platelet-Rich Plasma Efficacy in the Field of Regenerative Medicine: Product and Quality Control. — Popescu MN, Iliescu MG, Beiu C, Popa LG, Mihai MM, Berteanu M et al. BioMed research international (2021)
[34]
Electrical stimulation for pain reduction in hard-to-heal wound healing. — Milne J, Swift A, Smith J, Martin R Journal of wound care (2021)
[35]
Blue light emission in the management of hard-to-heal wounds. — Dini V, Romanelli M, Oranges T, Davini G, Janowska A Italian journal of dermatology and venereology (2021)
[36]
Platelet-Rich Plasma: Optimal Use in Surgical Wounds. — Bolton L Wounds : a compendium of clinical research and practice (2021)
[37]
Endoplasmic reticulum stress in human chronic wound healing: Rescue by 4-phenylbutyrate. — Bachar-Wikstrom E, Manchanda M, Bansal R, Karlsson M, Kelly-Pettersson P, Sköldenberg O et al. International wound journal (2021)
[38]
The evaluation of the effect of probiotics on the healing of equine distal limb wounds. — Wilmink JM, Ladefoged S, Jongbloets A, Vernooij JCM PloS one (2020)
[39]
Vegetable butters and oils in skin wound healing: Scientific evidence for new opportunities in dermatology. — Poljšak N, Kreft S, Kočevar Glavač N Phytotherapy research : PTR (2020)
[40]
Variability in Wound Care Recommendations Following Dermatologic Procedures. — Nguyen JK, Huang A, Siegel DM, Jagdeo J Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2020)
[41]
Visualization of Wound Healing Progression With Near Infrared Spectroscopy: A Retrospective Study. — Landsman A Wounds : a compendium of clinical research and practice (2020)
[42]
Specialised wound care clinics in Spain: distribution and characteristics. — González-de la Torre H, Verdú-Soriano J, Quintana-Lorenzo ML, Berenguer-Pérez M, Lavín RS, Soldevilla-Ágreda J Journal of wound care (2020)
[43]
Orthobiologics for Bone Healing. — Calcei JG, Rodeo SA Clinics in sports medicine (2019)
[44]
Preclinical and Clinical Studies of Hyaluronic Acid in Wound Care: A Case Series and Literature Review. — Schneider HP, Landsman A Wounds : a compendium of clinical research and practice (2019)
[45]
Photobiomodulation Therapy for Wound Care: A Potent, Noninvasive, Photoceutical Approach. — Mosca RC, Ong AA, Albasha O, Bass K, Arany P Advances in skin & wound care (2019)
[46]
Treatment of Hypertrophic Granulation Tissue: A Literature Review. — Hirotsu K, Kannan S, Brian Jiang SI Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (2019)
[47]
A systematic review of Calendula officinalis extract for wound healing. — Givol O, Kornhaber R, Visentin D, Cleary M, Haik J, Harats M Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2019)
[48]
Applying honey dressings to non-healing wounds in elderly persons receiving home care. — Zeleníková R, Vyhlídalová D Journal of tissue viability (2019)
[49]
Vitamin A and Wound Healing. — Zinder R, Cooley R, Vlad LG, Molnar JA Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition (2019)
[50]
Handheld 3-dimensional wound measuring system. — Pavlovčič U, Jezeršek M Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2018)
[51]
Research Techniques Made Simple: Animal Models of Wound Healing. — Grada A, Mervis J, Falanga V The Journal of investigative dermatology (2018)
[52]
Mesothelial Stem Cells and Stromal Vascular Fraction: Use in Functional Disorders, Wound Healing, Fat Transfer, and Other Conditions. — Chernoff G, Bryan N, Park AM Facial plastic surgery clinics of North America (2018)
[53]
Amniotic Membrane Adjuncts and Clinical Applications in Wound Healing: A Review of the Literature. — Kogan S, Sood A, Granick MS Wounds : a compendium of clinical research and practice (2018)
[54]
Cell salvage in acute and chronic wounds: a potential treatment strategy. Experimental data and early clinical results. — Mayer D, Armstrong D, Schultz G, Percival S, Malone M, Romanelli M et al. Journal of wound care (2018)
[55]
Effects of Vitamin B Complex and Vitamin C on Human Skin Cells: Is the Perceived Effect Measurable? — Rembe JD, Fromm-Dornieden C, Stuermer EK Advances in skin & wound care (2018)
[56]
Could essential oils enhance biopolymers performance for wound healing? A systematic review. — Pérez-Recalde M, Ruiz Arias IE, Hermida ÉB Phytomedicine : international journal of phytotherapy and phytopharmacology (2018)
[57]
Highlights from the advanced wound healing stream at the LINK Congress. — Kahn S British journal of nursing (Mark Allen Publishing) (2017)
[58]
Hyaluronic Acid in Dermatology. — Keen MA Skinmed (2017)
[59]
Retrospective observational analysis of the use of an architecturally unique dermal regeneration template (Derma Pure®) for the treatment of hard-to-heal wounds. — Kimmel H, Gittleman H International wound journal (2017)
[60]
Accelerated wound healing with combined NPWT and IPC: a case series. — Arvesen K, Nielsen CB, Fogh K British journal of community nursing (2017)
[61]
Hydrosurgery as a safe and efficient debridement method in a clinical wound unit. — Ferrer-Sola M, Sureda-Vidal H, Altimiras-Roset J, Fontsere-Candell E, Gonzalez-Martinez V, Espaulella-Panicot J et al. Journal of wound care (2017)
[62]
Efficacy of topical insulin in wound healing: A preliminary systematic review and meta-analysis of randomized controlled trials. — Sridharan K, Sivaramakrishnan G Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2017)
[63]
Poly-ADP-ribose polymerase inhibition enhances ischemic and diabetic wound healing by promoting angiogenesis. — Zhou X, Patel D, Sen S, Shanmugam V, Sidawy A, Mishra L et al. Journal of vascular surgery (2017)
[64]
On the significance of negative-pressure wound therapy with instillation in dermatology. — Müller CS, Burgard B, Zimmerman M, Vogt T, Pföhler C Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG (2016)
[65]
Non-invasive objective devices for monitoring the inflammatory, proliferative and remodelling phases of cutaneous wound healing and skin scarring. — Ud-Din S, Bayat A Experimental dermatology (2016)
[66]
Compression, collagen and bacteria-binding: different approaches for wound management. — Fronzo C Journal of wound care (2016)
[67]
The wound healing trajectory and predictors with combined electric stimulation and conventional care: one outpatient wound care clinic's experience. — Zhou K, Schenk R, Brogan MS European journal of clinical investigation (2016)
[68]
Recommendations for the management of biofilm: a consensus document. — Bianchi T, Wolcott RD, Peghetti A, Leaper D, Cutting K, Polignano R et al. Journal of wound care (2016)
[69]
A multi-centre clinical evaluation of reactive oxygen topical wound gel in 114 wounds. — Dryden M, Dickinson A, Brooks J, Hudgell L, Saeed K, Cutting KF Journal of wound care (2016)
[70]
Heat for wounds - water-filtered infrared-A (wIRA) for wound healing - a review. — Hoffmann G, Hartel M, Mercer JB German medical science : GMS e-journal (2016)
[71]
Synergistic effect of vitamin D and low concentration of transforming growth factor beta 1, a potential role in dermal wound healing. — Ding J, Kwan P, Ma Z, Iwashina T, Wang J, Shankowsky HA et al. Burns : journal of the International Society for Burn Injuries (2016)
[72]
Editorial commentary: healing requires scaffolds, growth factors, and cells. — Lubowitz JH Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association (2015)
[73]
Characterizing the composition of bone formed during fracture healing using scanning electron microscopy techniques. — Perdikouri C, Tägil M, Isaksson H Calcified tissue international (2015)
[74]
European definitions, current use, and EMA stance of platelet-rich plasma in sports medicine. — Fiorentino S, Roffi A, Filardo G, Marcacci M, Kon E The journal of knee surgery (2015)
[75]
Should we use platelet-rich plasma as an adjunct therapy to treat "acute wounds," "burns," and "laser therapies": A review and a proposal of a quality criteria checklist for further studies. — Picard F, Hersant B, Bosc R, Meningaud JP Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2015)
[76]
The Effect of Combined Ultrasound and Electric Field Stimulation on Wound Healing in Chronic Ulcerations. — Avrahami R, Rosenblum J, Gazes M, Rosenblum S, Litman L Wounds : a compendium of clinical research and practice (2015)
[77]
Clinical Usage of an Extracellular, Collagen-rich Matrix: A Case Series. — AbouIssa A, Mari W, Simman R Wounds : a compendium of clinical research and practice (2015)
[78]
Disrupting the biofilm matrix improves wound healing outcomes. — Wolcott R Journal of wound care (2015)
[79]
Honey as a topical treatment for wounds. — Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N The Cochrane database of systematic reviews (2015)
[80]
Nutrition in Wound Care Management: A Comprehensive Overview. — Quain AM, Khardori NM Wounds : a compendium of clinical research and practice (2015)
[81]
Dressings and healing with honey. — Belcher J British journal of nursing (Mark Allen Publishing) (2014)
[82]
A mechanical Jack-like Mechanism drives spontaneous fracture healing in neonatal mice. — Rot C, Stern T, Blecher R, Friesem B, Zelzer E Developmental cell (2014)
[83]
Centella asiatica in dermatology: an overview. — Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M Phytotherapy research : PTR (2014)
[84]
Clinical application of growth factors and cytokines in wound healing. — Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2014)
[85]
Improved wound healing of postischemic cutaneous flaps with the use of bone marrow-derived stem cells. — Hu M, Ludlow D, Alexander JS, McLarty J, Lian T The Laryngoscope (2014)
[86]
A new smartphone-based method for wound area measurement. — Foltynski P, Ladyzynski P, Wojcicki JM Artificial organs (2014)
[87]
Catastrophic wounds. — Kunimoto BT Journal of cutaneous medicine and surgery (2013)
[88]
Wound dressings: selecting the most appropriate type. — Broussard KC, Powers JG American journal of clinical dermatology (2013)
[89]
Influence of hydrogencalcium salts of oxidized cellulose on MMP-2, MMP-9 and TNF-α production and wound healing in non-healing wounds. — Frankova J, Diamantova D, Vrbkova J, Ulrichova J Acta dermatovenerologica Croatica : ADC (2013)
[90]
Honey as a topical treatment for wounds. — Jull AB, Walker N, Deshpande S The Cochrane database of systematic reviews (2013)
[91]
The nonhematopoietic effects of erythropoietin in skin regeneration and repair: from basic research to clinical use. — Sorg H, Harder Y, Krueger C, Reimers K, Vogt PM Medicinal research reviews (2013)
[92]
Emerging topics in cutaneous wound repair. — Valacchi G, Zanardi I, Sticozzi C, Bocci V, Travagli V Annals of the New York Academy of Sciences (2012)
[93]
Negative pressure wound therapy: an algorithm. — Desai KK, Hahn E, Pulikkottil B, Lee E Clinics in plastic surgery (2012)
[94]
Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing. — Ashcroft GS, Jeong MJ, Ashworth JJ, Hardman M, Jin W, Moutsopoulos N et al. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2012)
[95]
Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. — Jackson WM, Nesti LJ, Tuan RS Stem cells translational medicine (2012)
[96]
Ruffled wound suturing - closing wounds with sides of unequal lengths. — Tran D Australian family physician (2011)
[97]
Activated leukocyte cell adhesion molecule impacts on clinical wound healing and inhibits HaCaT migration. — Sanders AJ, Jiang DG, Jiang WG, Harding KG, Patel GK International wound journal (2011)
[98]
Dynamic reciprocity in the wound microenvironment. — Schultz GS, Davidson JM, Kirsner RS, Bornstein P, Herman IM Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2011)
[99]
Honey in otorhinolaryngology: when, why and how? — Werner A, Laccourreye O European annals of otorhinolaryngology, head and neck diseases (2011)
[100]
Enhanced assessment of the wound-healing process by accurate multiview tissue classification. — Wannous H, Lucas Y, Treuillet S IEEE transactions on medical imaging (2011)

Share:Twitter Reddit LinkedIn