Overview
Astrovirus gastroenteritis primarily affects humans and animals, causing gastrointestinal symptoms. In certain animal species, particularly chickens and geese, astroviruses can lead to severe extra-intestinal manifestations such as visceral gout and high mortality rates 123.Diagnosis
Detection of astrovirus RNA through RT-PCR in fecal samples 12.
Histopathological examination showing characteristic lesions, notably in kidneys in cases of visceral gout 2.
Isolation and characterization of astrovirus strains through cell culture and genomic sequencing 23.Management
Supportive care including fluid resuscitation to manage dehydration 1.
No specific antiviral treatments mentioned; focus on symptomatic relief and supportive measures 123.Special Populations
Pediatrics: Not specifically addressed in the provided abstracts.
Elderly: Not specifically addressed in the provided abstracts.
Comorbidities: No specific guidance provided for comorbid conditions in the abstracts 123.Key Recommendations
Conduct RT-PCR testing on fecal samples for astrovirus detection in cases of suspected gastroenteritis or visceral gout 12 (Evidence: Moderate).
Implement supportive care measures, including hydration, for managing symptoms in affected animals 1 (Evidence: Expert opinion).
Monitor and report novel astrovirus strains through genomic analysis to understand emerging disease patterns 23 (Evidence: Moderate).References
1 Okamoto O, Hirano S, Miyoshi H, Ichinohe N. Detection and molecular phylogenetic analysis of chicken astrovirus in Saga prefecture, Japan. Archives of virology 2022. link
2 Zhang Q, Cao Y, Wang J, Fu G, Sun M, Zhang L et al.. Isolation and characterization of an astrovirus causing fatal visceral gout in domestic goslings. Emerging microbes & infections 2018. link
3 Niu X, Tian J, Yang J, Jiang X, Wang H, Chen H et al.. Novel Goose Astrovirus Associated Gout in Gosling, China. Veterinary microbiology 2018. link