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Infectious disease of placenta

Last edited: 4/15/2026

Overview

Abruptio placentae is a serious obstetric condition characterized by premature separation of the placenta from the uterine wall, often leading to maternal and fetal complications including hemorrhage and potential fetal demise 1.

Diagnosis

  • Key Diagnostic Criteria: Clinical signs include vaginal bleeding, abdominal pain, uterine tenderness, and fetal distress 1.
  • Recommended Tests:
  • - Ultrasound: Essential for diagnosis, often showing abnormal placental position and retroplacental hematoma 2. - Fetomaternal Hemorrhage: Detected via laboratory tests, found in 75% of noncatastrophic cases 2.
  • Grading: Typically not formally graded but severity assessed by extent of hemorrhage and fetal well-being 2.
  • Management

  • First-Line Treatments:
  • - Conservative Management: Monitoring and supportive care, especially in noncatastrophic cases 2.
  • Adjunctive Treatments:
  • - Intravenous Nitroglycerin: Used in emergency situations for managing hypertension; caution advised due to potential fetal risks 1.

    Special Populations

  • Pregnancy: Conservative management preferred in noncatastrophic cases to preserve fetal viability 2.
  • Comorbidities: Management strategies may need adjustment based on coexisting conditions like hypertension, though specific guidelines are not provided in the abstracts 1.
  • Key Recommendations

  • Utilize ultrasound for diagnosing abruptio placentae and assessing fetomaternal hemorrhage (Evidence: Moderate 2).
  • Consider conservative management in noncatastrophic cases of abruptio placentae to evaluate fetal viability (Evidence: Moderate 2).
  • Use intravenous nitroglycerin cautiously in obstetric emergencies, weighing risks against maternal benefits (Evidence: Weak 1).
  • References

    1 Dessard P, d'Halluin G, de Meeûs JB. Intravenous nitroglycerin in obstetrics: a new indication. American journal of obstetrics and gynecology 1998. link70088-2) 2 Cardwell MS. Ultrasound diagnosis of abruptio placentae with fetomaternal hemorrhage. American journal of obstetrics and gynecology 1987. link80171-0)

    Original source

    1. [1]
      Intravenous nitroglycerin in obstetrics: a new indication.Dessard P, d'Halluin G, de Meeûs JB American journal of obstetrics and gynecology (1998)
    2. [2]
      Ultrasound diagnosis of abruptio placentae with fetomaternal hemorrhage.Cardwell MS American journal of obstetrics and gynecology (1987)

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