HemoChat

Evidence-Based AI Medical Search

← Back to guidelines
Psychiatry1003 papers

Opioid-induced mood disorder

Last edited: 4/10/2026

Overview

Opioid-induced mood disorder is a complex condition that can arise from chronic opioid use. While not explicitly defined in the provided abstracts, opioid use is associated with increased pain sensitivity, termed opioid-induced hyperalgesia 1. This heightened sensitivity may contribute to psychological distress and mood disturbances in patients.

Diagnosis

  • Diagnosis is primarily based on clinical presentation and history of opioid use.
  • No specific diagnostic tests are mentioned in the abstracts.
  • Opioid-induced hyperalgesia, a related phenomenon, can be assessed through pain sensitivity tests like the cold pressor test (CPT) 1.

    • Management

  • Treatment of opioid use disorder (OUD) often involves maintenance therapy with methadone or buprenorphine 1.
  • Observations of heightened cold pain sensitivity among patients are considered evidence of opioid-induced hyperalgesia and may inform management 1.

    • Key Recommendations

  • Consider opioid-induced hyperalgesia as a potential contributor to pain sensitivity in patients with a history of opioid use disorder 1.
  • Maintenance treatment with methadone and buprenorphine is a primary approach for managing opioid use disorder 1.
  • Heightened cold pain sensitivity in patients with OUD history may be an indicator of opioid-induced hyperalgesia 1.

    • References

    1 Trøstheim M, Eikemo M. Hyperalgesia in Patients With a History of Opioid Use Disorder: A Systematic Review and Meta-Analysis. JAMA psychiatry 2024. link

    Original source

    1. [1]
      Hyperalgesia in Patients With a History of Opioid Use Disorder: A Systematic Review and Meta-Analysis. — Trøstheim M, Eikemo M JAMA psychiatry (2024)
    Share:TwitterRedditLinkedIn

    HemoChat

    by SPINAI

    Evidence-based clinical decision support powered by SNOMED-CT, Neo4j GraphRAG, and NASS/AO/NICE guidelines.

    ⚕ For clinical reference only. Not a substitute for professional judgment.

    © 2026 HemoChat. All rights reserved.
    Research·Pricing·Privacy & Terms·Refund·SNOMED-CT · NASS · AO Spine · NICE · GraphRAG