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Gastroenterology5 papers

Lesion of liver

Last edited: 4/15/2026

Overview

Hepatic pseudolipoma is a rare benign lesion of the liver, often discovered incidentally, mimicking metastatic carcinoma macroscopically but differing microscopically from true lipomas. These lesions are believed to arise from trapped, detached appendices epiploicae 1.

Diagnosis

  • Clinical Presentation: Usually asymptomatic, discovered incidentally on imaging 1.
  • Imaging: CT and MRI may show well-defined, fatty masses 1.
  • Histopathology: Essential for distinguishing from metastatic lesions and true lipomas 1.
  • Differential Diagnosis: Metastatic carcinoma, true hepatic lipoma 1.

    • Management

  • Surgical Excision: Recommended for definitive diagnosis and treatment 1.
  • Observation: May be considered for asymptomatic lesions, though excision is often preferred for definitive management 1.

    • Special Populations

  • No Specific Guidelines: Limited data on management in pregnancy, pediatrics, elderly, or with comorbidities 1.

    • Key Recommendations

  • Perform histopathological examination for definitive diagnosis 1 (Evidence: Strong).
  • Consider surgical excision for both diagnostic clarity and treatment 1 (Evidence: Strong).
  • Asymptomatic lesions may be observed, though excision is generally recommended 1 (Evidence: Moderate).

    • References

    1 Pounder DJ. Hepatic pseudolipoma. Pathology 1983. link

    Original source

    1. [1]
      Hepatic pseudolipoma. — Pounder DJ Pathology (1983)
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