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Oncology12 papers

Lesion of lung

Last edited: 4/14/2026

Overview

Lesions of the lung encompass a variety of pathological entities, including benign conditions like cystic hamartoma and malignant tumors, requiring accurate diagnosis and management strategies 4.

Diagnosis

  • Ultrathin Bronchoscopy: Useful for diagnosing peripheral pulmonary lesions with a pooled diagnostic yield of 65% (95% CI, 60-70%). Higher channel size (1.7 mm) shows better yield (70%, 95% CI, 66-74%) compared to smaller sizes 1.
  • Endobronchial Ultrasound (EBUS) with BIS Monitoring: Reduces propofol dosage and adverse events, suggesting enhanced safety and efficacy in sedation for diagnostic procedures 2.
  • Ultrasound-Guided Percutaneous Needle Aspiration (PFNA): Valuable for pulmonologists; higher diagnostic yield with suspected malignancy, larger lesion size, and absence of pleural sliding 3.
  • Needle Biopsy: Percutaneous aspiration under image guidance is recommended for localized pulmonary lesions, enhancing diagnostic accuracy and minimizing complications 56.
  • Management

  • Surgical Resection: Indicated for definitive treatment of certain lesions, such as cystic hamartoma when symptomatic or complicated by hemorrhage 4.
  • Sedation Techniques: Use of BIS monitoring during EBUS procedures to optimize sedation and reduce adverse events 2.
  • Image-Guided Biopsies: Essential for accurate diagnosis, particularly in peripheral lesions, with careful attention to minimizing complications 356.
  • Special Populations

  • Comorbidities: No specific guidelines provided in abstracts regarding management adjustments for comorbidities.
  • Pediatrics and Elderly: Management strategies not detailed in provided abstracts; individualized care based on lesion characteristics and patient status recommended.
  • Pregnancy: Not addressed in the provided abstracts.
  • Key Recommendations

  • Utilize ultrathin bronchoscopy with larger channel sizes (1.7 mm) for improved diagnostic yield in peripheral pulmonary lesions (Evidence: Moderate) 1.
  • Implement bispectral index (BIS) monitoring during EBUS procedures to reduce propofol dosage and adverse events (Evidence: Moderate) 2.
  • Employ ultrasound-guided percutaneous needle aspiration for pulmonologists, considering lesion characteristics like size and pleural sliding to optimize diagnostic yield (Evidence: Moderate) 3.
  • References

    1 Kim SH, Kim J, Pak K, Eom JS. Ultrathin Bronchoscopy for the Diagnosis of Peripheral Pulmonary Lesions: A Meta-Analysis. Respiration; international review of thoracic diseases 2023. link 2 Quesada N, Júdez D, Martínez Ubieto J, Pascual A, Chacón E, De Pablo F et al.. Bispectral Index Monitoring Reduces the Dosage of Propofol and Adverse Events in Sedation for Endobronchial Ultrasound. Respiration; international review of thoracic diseases 2016. link 3 Meena N, Bartter T. Ultrasound-guided Percutaneous Needle Aspiration by Pulmonologists: A Study of Factors With Impact on Procedural Yield and Complications. Journal of bronchology & interventional pulmonology 2015. link 4 Demos TC, Armin A, Chandrasekhar AJ, Barron J. Cystic hamartoma of the lung. Journal of the Canadian Association of Radiologists 1983. link 5 Grech P, Clark RA. Radiology of needle biopsy of pulmonary lesions. Clinical radiology 1978. link80215-3) 6 Stevens GM, Lillington GA, Weigen JF. Needle aspiration biopsy of localized pulmonary lesions. California medicine 1967. link

    Original source

    1. [1]
      Ultrathin Bronchoscopy for the Diagnosis of Peripheral Pulmonary Lesions: A Meta-Analysis.Kim SH, Kim J, Pak K, Eom JS Respiration; international review of thoracic diseases (2023)
    2. [2]
      Bispectral Index Monitoring Reduces the Dosage of Propofol and Adverse Events in Sedation for Endobronchial Ultrasound.Quesada N, Júdez D, Martínez Ubieto J, Pascual A, Chacón E, De Pablo F et al. Respiration; international review of thoracic diseases (2016)
    3. [3]
    4. [4]
      Cystic hamartoma of the lung.Demos TC, Armin A, Chandrasekhar AJ, Barron J Journal of the Canadian Association of Radiologists (1983)
    5. [5]
      Radiology of needle biopsy of pulmonary lesions.Grech P, Clark RA Clinical radiology (1978)
    6. [6]
      Needle aspiration biopsy of localized pulmonary lesions.Stevens GM, Lillington GA, Weigen JF California medicine (1967)

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